West Nile alternative open reading frame (N-NS4B/WARF4) is produced in infected West Nile Virus (WNV) cells and induces humoral response in WNV infected individuals

Virology Journal

Volumn 9, Issue , 2012, Pages

  Faggioni, Giovanni ^a   Pomponi, Alice ^a   De Santis, Riccardo ^a   Masuelli, Laura ^b   Ciammaruconi, Andrea ^a   Monaco, Federica ^c   Di Gennaro, Annapia ^c   Marzocchella, Laura ^d   Sambri, Vittorio ^e   Lelli, Rossella ^c   Rezza, Giovanni ^f   Bei, Roberto ^d   Lista, Florigio ^a  

^a Army Medical and Veterinary Research Center   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c ISTITUTO ZOOPROFILATTICO SPERIMENTALE DELL ABRUZZO E DEL MOLISE G CAPORALE   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e UNIVERSITY OF BOLOGNA   (Italy)

^f ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

Alternative open reading frame; N NS4B WARF4; WARF4; West Nile Virus; WNV

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 3A12; NONSTRUCTURAL PROTEIN 4B; UNCLASSIFIED DRUG; VIRUS ANTIBODY; VIRUS PROTEIN; WARF4 PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BIOINFORMATICS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; HUMORAL IMMUNITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RIBOSOMAL FRAMESHIFTING; SEROLOGY; UNINDEXED SEQUENCE; VERO CELL; VIRUS CELL INTERACTION; WEST NILE FEVER; WEST NILE FLAVIVIRUS; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; CERCOPITHECUS AETHIOPS; COMPUTATIONAL BIOLOGY; GENOME, VIRAL; HORSE DISEASES; HORSES; HUMANS; OPEN READING FRAMES; SENSITIVITY AND SPECIFICITY; SPECIES SPECIFICITY; VERO CELLS; VIRAL PROTEINS; WEST NILE FEVER; WEST NILE VIRUS;

EQUIDAE; FLAVIVIRUS; WEST NILE VIRUS;

EID: 84869878467     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/1743-422X-9-283     Document Type: Article

References (50)

1. Flaviviruses. Monath TP, Virology New York: Raven Press, Fields BN, Knipe DM, 1990 763 814
2. A Neurotropic Virus Isolated from the Blood of a Native of Uganda. Smithburn KC, Hughes TP, Burke AW, Paul JH, Am J Trop Med 1940 4 471 492
3. Epidemiology of west nile in europe and in the mediterranean basin. Calistri P, Giovannini A, Hubalek Z, Ionescu A, Monaco F, Savini G, Lelli R, Open Virol J 2010 4 29 37 20517490
4. The ecology and epidemiology of Kunjin virus. Hall RA, Broom AK, Smith DW, Mackenzie JS, Curr Top Microbiol Immunol 2002 267 253 269 10.1007/978-3-642-59403-8-13 12082993 (Pubitemid 34411368)
5. The ecology and epidemiology of West Nile virus in Africa, Europe and Asia. Murgue B, Zeller H, Deubel V, Curr Top Microbiol Immunol 2002 267 195 221 10.1007/978-3-642-59403-8-10 12082990 (Pubitemid 34411365)
6. West Nile encephalitis epidemic in southeastern Romania. Tsai TF, Popovici F, Cernescu C, Campbell GL, Nedelcu NI, Lancet 1998 352 767 771 10.1016/S0140-6736(98)03538-7 9737281 (Pubitemid 28404558)
7. West Nile virus circulation in Emilia-Romagna, Italy: the integrated surveillance system 2009. Angelini P, Tamba M, Finarelli AC, Bellini R, Albieri A, Bonilauri P, Cavrini F, Dottori M, Gaibani P, Martini E, Mattivi A, Pierro AM, Rugna G, Sambri V, Squintani G, Macini P, Euro Surveill 2010 15 ii: 19547
8. Ongoing outbreak of West Nile virus infections in humans in Greece, July-August 2010. Papa A, Danis K, Baka A, Bakas A, Dougas G, Lytras T, Theocharopoulos G, Chrysagis D, Vassiliadou E, Kamaria F, Liona A, Mellou K, Saroglou G, Panagiotopoulos T, Euro Surveill 2010 15 ii: 19644
9. Isolation of West Nile virus from mosquitoes, crows, and a Cooper's hawk in Connecticut. Anderson JF, Andreadis TG, Vossbrinck CR, Tirrell S, Wakem EM, French RA, Garmendia AE, Van Kruiningen HJ, Science 1999 286 2331 2333 10.1126/science.286.5448.2331 10600741 (Pubitemid 30016892)
10. Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States. Lanciotti RS, Roehrig JT, Deubel V, Smith J, Parker M, Steele K, Crise B, Volpe KE, Crabtree MB, Scherret JH, Hall RA, MacKenzie JS, Cropp CB, Panigrahy B, Ostlund E, Schmitt B, Malkinson M, Banet C, Weissman J, Komar N, Savage HM, Stone W, McNamara T, Gubler DJ, Science 1999 286 2333 2337 10.1126/science.286.5448.2333 10600742 (Pubitemid 30016893)
11. West Nile virus: a growing concern? Gould LH, Fikrig E, J Clin Invest 2004 113 1102 1107 15085186 (Pubitemid 38544092)
12. West Nile virus. Kramer LD, Li J, Shi PY, Lancet Neurol 2007 6 171 181 10.1016/S1474-4422(07)70030-3 17239804 (Pubitemid 46099081)
13. Structure of West Nile virus. Mukhopadhyay S, Kim BS, Chipman PR, Rossmann MG, Kuhn RJ, Science 2003 302 248 10.1126/science.1089316 14551429 (Pubitemid 37248748)
14. Virus taxonomy, classification and nomenclature of viruses. Murphy FA, Fauquet CM, Bishop DHL, Ghabrial SA, Jarvis AW, Martelli GP, Summers MD, M.A.M, Arch Virol 1995 10 Suppl.) 1 586
15. Complete genome sequences and phylogenetic analysis of West Nile virus strains isolated from the United States, Europe, and the Middle East. Lanciotti RS, Ebel GD, Deubel V, Kerst AJ, Murri S, Meyer R, Bowen M, McKinney N, Morrill WE, Crabtree MB, Kramer LD, Roehrig JT, Virology 2002 298 96 105 10.1006/viro.2002.1449 12093177 (Pubitemid 34734883)
16. Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype. Beasley DW, Li L, Suderman MT, Barrett AD, Virology 2002 296 17 23 10.1006/viro.2002.1372 12036314
17. Outbreak of West Nile virus infection, Volgograd Region, Russia, 1999. Platonov AE, Shipulin GA, Shipulina OY, Tyutyunnik EN, Frolochkina TI, Lanciotti RS, Yazyshina S, Platonova OV, Obukhov IL, Zhukov AN, Vengerov YY, Pokrovskii VI, Emerg Infect Dis 2001 7 128 132 10.3201/eid0701.010118 11266303 (Pubitemid 32173342)
18. Nucleotide and complete amino acid sequences of Kunjin virus: definitive gene order and characteristics of the virus-specified proteins. Coia G, Parker MD, Speight G, Byrne ME, Westaway EG, J Gen Virol 1988 69 Pt 1 1 21 2826659 (Pubitemid 18064140)
19. Oligomeric rearrangement of tick-borne encephalitis virus envelope proteins induced by an acidic pH. Allison SL, Schalich J, Stiasny K, Mandl CW, Kunz C, Heinz FX, J Virol 1995 69 695 700 7529335
20. Replication and gene function in Kunjin virus. Westaway EG, Mackenzie JM, Khromykh AA, Curr Top Microbiol Immunol 2002 267 323 351 10.1007/978-3-642- 59403-8-16 12082996 (Pubitemid 34411371)
21. West Nile virus inhibits the signal transduction pathway of alpha interferon. Guo JT, Hayashi J, Seeger C, J Virol 2005 79 1343 1350 10.1128/JVI.79.3.1343-1350.2005 15650160 (Pubitemid 40459081)
22. Pathogenesis of West Nile Virus infection: a balance between virulence, innate and adaptive immunity, and viral evasion. Samuel MA, Diamond MS, J Virol 2006 80 9349 9360 10.1128/JVI.01122-06 16973541 (Pubitemid 44435614)
23. Differential effects of mutations in NS4B on West Nile virus replication and inhibition of interferon signaling. Evans JD, Seeger C, J Virol 2007 81 11809 11816 10.1128/JVI.00791-07 17715229 (Pubitemid 47623813)
24. NS1' of flaviviruses in the Japanese encephalitis virus serogroup is a product of ribosomal frameshifting and plays a role in viral neuroinvasiveness. Melian EB, Hinzman E, Nagasaki T, Firth AE, Wills NM, Nouwens AS, Blitvich BJ, Leung J, Funk A, Atkins JF, Hall R, Khromykh AA, J Virol 2010 84 1641 1647 10.1128/JVI.01979-09 19906906
25. Evidence of a humoral response to a novel protein WARF4 embedded in the West Nile virus NS4B gene encoded by an alternative open reading frame. Faggioni G, Ciammaruconi A, De Santis R, Pomponi A, Scicluna MT, Barbaro K, Masuelli L, Autorino G, Bei R, Lista F, Int J Mol Med 2009 23 509 512 19288027
26. Evidence for a new hepatitis C virus antigen encoded in an overlapping reading frame. Walewski JL, Keller TR, Stump DD, Branch AD, RNA 2001 7 710 721 10.1017/S1355838201010111 11350035 (Pubitemid 32405868)
27. Memory T-cell-mediated immune responses specific to an alternative core protein in hepatitis C virus infection. Bain C, Parroche P, Lavergne JP, Duverger B, Vieux C, Dubois V, Komurian-Pradel F, Trépo C, Gebuhrer L, Paranhos-Baccala G, Penin F, Inchauspé G, J Virol 2004 78 10460 10469 10.1128/JVI.78.19.10460-10469.2004 15367612 (Pubitemid 39258371)
28. A conserved predicted pseudoknot in the NS2A-encoding sequence of West Nile and Japanese encephalitis flaviviruses suggests NS1' may derive from ribosomal frameshifting. Firth AE, Atkins JF, Virol J 2009 6 14 10.1186/1743-422X-6-14 19196463
29. The structural immunology of antibody protection against West Nile virus. Diamond MS, Pierson TC, Fremont DH, Immunol Rev 2008 225 212 225 10.1111/j.1600-065X.2008.00676.x 18837784
30. Maturation of West Nile virus modulates sensitivity to antibody-mediated neutralization. Nelson S, Jost CA, Xu Q, Ess J, Martin JE, Oliphant T, Whitehead SS, Durbin AP, Graham BS, Diamond MS, Pierson TC, PLoS Pathog 2008 4 1000060 10.1371/journal.ppat.1000060 18464894 (Pubitemid 351811531)
31. Efficiency of a programmed -1 ribosomal frameshift in the different subtypes of the human immunodeficiency virus type 1 group M. Baril M, Dulude D, Gendron K, Lemay G, Brakier-Gingras L, RNA 2003 9 1246 1253 10.1261/rna.5113603 13130138 (Pubitemid 37151678)
32. An RNA cap (nucleoside-2'-O-)-methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization. Egloff MP, Benarroch D, Selisko B, Romette JL, Canard B, EMBO J 2002 21 2757 2768 10.1093/emboj/21.11.2757 12032088 (Pubitemid 34619391)
33. Programmed translational frameshifting. Farabaugh PJ, Microbiol Rev 1996 60 103 134 8852897 (Pubitemid 26087764)
34. Structure, stability and function of RNA pseudoknots involved in stimulating ribosomal frameshifting. Giedroc DP, Theimer CA, Nixon PL, J Mol Biol 2000 298 167 185 10.1006/jmbi.2000.3668 10764589
35. Frameshifting RNA pseudoknots: structure and mechanism. Giedroc DP, Cornish PV, Virus Res 2009 139 193 208 10.1016/j.virusres.2008.06.008 18621088
36. Recoding elements located adjacent to a subset of eukaryal selenocysteine-specifying UGA codons. Howard MT, Aggarwal G, Anderson CB, Khatri S, Flanigan KM, Atkins JF, EMBO J 2005 24 1596 1607 10.1038/sj.emboj.7600642 15791204 (Pubitemid 40646449)
37. Cell mediated cytotoxicity of human colon carcinoma cells by a monoclonal antibody (R4) recognizing the carcinoembryonic antigen (CEA) and CEA-related molecules. Bei R, Moretti A, Visco V, Defilippi R, Tsang K, Frati L, Muraro R, Int J Oncol 1996 8 1127 1135 21544473 (Pubitemid 26179572)
38. The ribosomal P0 protein induces a spontaneous immune response in patients with head and neck advanced stage carcinoma that is not dependent on its overexpression in carcinomas. Bei R, Masuelli L, Trono P, Orvietani PL, Losito S, Marzocchella L, Vitolo D, Albonici L, Mrozek MA, Di Gennaro E, Lista F, Faggioni G, Ionna F, Binaglia L, Manzari V, Budillon A, Modesti A, Int J Oncol 2007 31 1301 1308 17982655
39. Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. De Smaele E, Di Marcotullio L, Moretti M, Pelloni M, Occhione MA, Infante P, Cucchi D, Greco A, Pietrosanti L, Todorovic J, Coni S, Canettieri G, Ferretti E, Bei R, Maroder M, Screpanti I, Gulino A, Neoplasia 2011 13 374 385 21472142
40. Gene-specific inhibition of breast carcinoma in BALB-neuT mice by active immunization with rat Neu or human ErbB receptors. Masuelli L, Focaccetti C, Cereda V, Lista F, Vitolo D, Trono P, Gallo P, Amici A, Monaci P, Mattei M, Modesti M, Forni G, Kraus MH, Muraro R, Modesti A, Bei R, Int J Oncol 2007 30 381 392 17203220
41. Local delivery of recombinant vaccinia virus encoding for neu counteracts growth of mammary tumors more efficiently than systemic delivery in neu transgenic mice. Masuelli L, Marzocchella L, Focaccetti C, Lista F, Nardi A, Scardino A, Mattei M, Turriziani M, Modesti M, Forni G, Schlom J, Modesti A, Bei R, Cancer Immunol Immunother 2010 59 1247 1258 10.1007/s00262-010-0850-0 20364378
42. Frequent overexpression of multiple ErbB receptors by head and neck squamous cell carcinoma contrasts with rare antibody immunity in patients. Bei R, Budillon A, Masuelli L, Cereda V, Vitolo D, Di Gennaro E, Ripavecchia V, Palumbo C, Ionna F, Losito S, Modesti A, Kraus MH, Muraro R, J Pathol 2004 204 317 325 10.1002/path.1642 15476268 (Pubitemid 39430092)
43. Caveolin-1 overexpression is associated with simultaneous abnormal expression of the E-cadherin/-β catenins complex and multiple ErbB receptors and with lymph nodes metastasis in head and neck squamous cell carcinomas. Masuelli L, Budillon A, Marzocchella L, Mrozek MA, Vitolo D, Di Gennaro E, Losito S, Sale P, Longo F, Ionna F, Lista F, Muraro R, Modesti A, Bei R, J Cell Physiol 2012 227 3344 3353 10.1002/jcp.24034 22213373
44. Immunity to extracellular matrix antigens is associated with ultrastructural alterations of the stroma and stratified epithelium basement membrane in the skin of Hashimotos thyroiditis patients. Bei R, Mentuccia D, Trono P, Masuelli L, Cereda V, Palumbo C, Marzocchella L, Mrozek MA, Pallotta P, Di Lella G, Modesti M, Cerilli M, Frajese GV, Frajese G, Zambruno G, Modesti A, Int J Immunopathol Pharmacol 2006 19 661 674 17026851
45. Apigenin induces apoptosis and impairs head and neck carcinomas EGFR/ErbB2 signaling. Masuelli L, Marzocchella L, Quaranta A, Palumbo C, Pompa G, Izzi V, Canini A, Modesti A, Galvano F, Bei R, Front Biosci 2011 16 1060 1068 10.2741/3735 21196218
46. Beta-catenin accumulates in intercalated disks of hypertrophic cardiomyopathic hearts. Masuelli L, Bei R, Sacchetti P, Scappaticci I, Francalanci P, Albonici L, Coletti A, Palumbo C, Minieri M, Fiaccavento R, Carotenuto F, Fantini C, Carosella L, Modesti A, Di Nardo P, Cardiovasc Res 2003 60 376 387 10.1016/j.cardiores.2003.08.005 14613867 (Pubitemid 37412371)
47. ErbB2 immune response in breast cancer patients with soluble receptor ectodomain. Visco V, Bei R, Moriconi E, Gianni W, Kraus MH, Muraro R, Am J Pathol 2000 156 1417 1424 10.1016/S0002-9440(10)65010-9 10751365 (Pubitemid 30662076)
48. Immune responses to all ErbB family receptors detectable in serum of cancer patients. Bei R, Masuelli L, Moriconi E, Visco V, Moretti A, Kraus MH, Muraro R, Oncogene 1999 18 1267 1275 10.1038/sj.onc.1202442 10022808 (Pubitemid 29094878)
49. Resveratrol and diallyl disulfide enhance curcumin-induced sarcoma cell apoptosis. Masuelli L, Marzocchella L, Focaccetti C, Tresoldi I, Palumbo C, Izzi V, Benvenuto M, Fantini M, Lista F, Tarantino U, Modesti A, Galvano F, Bei R, Front Biosci 2012 17 498 508 10.2741/3940 22201757
50. Italian Transplant Network: Retrospective screening of solid organ donors in Italy, 2009, reveals unpredicted circulation of West Nile virus. Capobianchi MR, Sambri V, Castilletti C, Pierro AM, Rossini G, Gaibani P, Cavrini F, Selleri M, Meschi S, Lapa D, Di Caro A, Grossi P, De Cillia C, Venettoni S, Landini MP, Ippolito G, Nanni Costa A, Euro Surveill 2010 15 ii: 19648