ATP binding cassette transporters in two distinct compartments of the skin contribute to transdermal absorption of a typical substrate

Journal of Controlled Release

Volumn 165, Issue 1, 2013, Pages 54-61

  Hashimoto, Naoto ^a,b   Nakamichi, Noritaka ^a   Uwafuji, Shinya ^a   Yoshida, Kohei ^a   Sugiura, Tomoko ^a   Tsuji, Akira ^a   Kato, Yukio ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b Maruho Co   (Japan)

Author keywords

Breast cancer resistant protein; P glycoprotein; Skin; Transdermal drug delivery; Transporter

Indexed keywords

ABC TRANSPORTER; ATP BINDING CASSETTE TRANSPORTERS; BREAST CANCER; BREAST CANCER RESISTANCE PROTEINS; CHAMBER EXPERIMENTS; DETECTION LIMITS; FUNCTIONAL ACTIVITIES; FUNCTIONAL EXPRESSION; HUMAN EPIDERMIS; IMMUNOHISTOCHEMICAL LOCALIZATION; IN-VIVO; ITRACONAZOLE; MOUSE SKIN; P-GLYCOPROTEIN; PLASMA CONCENTRATION; SPECIFIC INHIBITORS; SYSTEMIC CIRCULATION; TRANSDERMAL ABSORPTIONS; TRANSDERMAL DRUG DELIVERY; TRANSPORTER; WILD TYPES;

DISEASES; ENDOTHELIAL CELLS; GLYCOPROTEINS; PROTEINS; SKIN;

MAMMALS;

BREAST CANCER RESISTANCE PROTEIN; ITRACONAZOLE; MULTIDRUG RESISTANCE PROTEIN; RHODAMINE 123;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DERMIS; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG TISSUE LEVEL; ENDOTHELIUM CELL; EPIDERMIS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SKIN ABSORPTION; SKIN PERMEABILITY;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; FLUORESCENT DYES; HUMANS; MALE; MICE; MICE, KNOCKOUT; P-GLYCOPROTEIN; RHODAMINE 123; SKIN; SKIN ABSORPTION;

EID: 84869869191     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.10.011     Document Type: Article

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