-
1
-
-
0030882856
-
Alpha-synuclein in Lewy bodies
-
10.1038/42166, 9278044
-
Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ, Jakes R, Goedert M. Alpha-synuclein in Lewy bodies. Nature 1997, 388:839-840. 10.1038/42166, 9278044.
-
(1997)
Nature
, vol.388
, pp. 839-840
-
-
Spillantini, M.G.1
Schmidt, M.L.2
Lee, V.M.3
Trojanowski, J.Q.4
Jakes, R.5
Goedert, M.6
-
2
-
-
33750594065
-
Genetics of Parkinson's disease and parkinsonism
-
10.1002/ana.21022, 17068789
-
Hardy J, Cai H, Cookson MR, Gwinn-Hardy K, Singleton A. Genetics of Parkinson's disease and parkinsonism. Ann Neurol 2006, 60:389-398. 10.1002/ana.21022, 17068789.
-
(2006)
Ann Neurol
, vol.60
, pp. 389-398
-
-
Hardy, J.1
Cai, H.2
Cookson, M.R.3
Gwinn-Hardy, K.4
Singleton, A.5
-
3
-
-
0030744876
-
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
-
10.1126/science.276.5321.2045, 9197268
-
Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 1997, 276:2045-2047. 10.1126/science.276.5321.2045, 9197268.
-
(1997)
Science
, vol.276
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
Stenroos, E.S.11
Chandrasekharappa, S.12
Athanassiadou, A.13
Papapetropoulos, T.14
Johnson, W.G.15
Lazzarini, A.M.16
Duvoisin, R.C.17
Di Iorio, G.18
Golbe, L.I.19
Nussbaum, R.L.20
more..
-
4
-
-
0023789193
-
Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
-
10.1212/WNL.38.8.1285, 3399080
-
McGeer PL, Itagaki S, Boyes BE, McGeer EG. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988, 38:1285-1291. 10.1212/WNL.38.8.1285, 3399080.
-
(1988)
Neurology
, vol.38
, pp. 1285-1291
-
-
McGeer, P.L.1
Itagaki, S.2
Boyes, B.E.3
McGeer, E.G.4
-
5
-
-
58849107919
-
Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease
-
2613467, 19104149
-
Brochard V, Combadiere B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D, Callebert J, Launay JM, Duyckaerts C, Flavell RA, Hirsch EC, Hunot S. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 2009, 119:182-192. 2613467, 19104149.
-
(2009)
J Clin Invest
, vol.119
, pp. 182-192
-
-
Brochard, V.1
Combadiere, B.2
Prigent, A.3
Laouar, Y.4
Perrin, A.5
Beray-Berthat, V.6
Bonduelle, O.7
Alvarez-Fischer, D.8
Callebert, J.9
Launay, J.M.10
Duyckaerts, C.11
Flavell, R.A.12
Hirsch, E.C.13
Hunot, S.14
-
6
-
-
0242384667
-
Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration
-
10.1002/ana.10728, 14595649
-
McGeer PL, Schwab C, Parent A, Doudet D. Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. Ann Neurol 2003, 54:599-604. 10.1002/ana.10728, 14595649.
-
(2003)
Ann Neurol
, vol.54
, pp. 599-604
-
-
McGeer, P.L.1
Schwab, C.2
Parent, A.3
Doudet, D.4
-
7
-
-
62549133546
-
Neuroinflammation in Parkinson's disease: a target for neuroprotection?
-
10.1016/S1474-4422(09)70062-6, 19296921
-
Hirsch EC, Hunot S. Neuroinflammation in Parkinson's disease: a target for neuroprotection?. Lancet Neurol 2009, 8:382-397. 10.1016/S1474-4422(09)70062-6, 19296921.
-
(2009)
Lancet Neurol
, vol.8
, pp. 382-397
-
-
Hirsch, E.C.1
Hunot, S.2
-
8
-
-
84864770092
-
Association between Parkinson's disease and the HLA-DRB1 locus
-
10.1002/mds.25035, 22807207
-
Ahmed I, Tamouza R, Delord M, Krishnamoorthy R, Tzourio C, Mulot C, Nacfer M, Lambert JC, Beaune P, Laurent-Puig P, Loriot MA, Charron D, Elbaz A. Association between Parkinson's disease and the HLA-DRB1 locus. Mov Disord 2012, 27:1104-1110. 10.1002/mds.25035, 22807207.
-
(2012)
Mov Disord
, vol.27
, pp. 1104-1110
-
-
Ahmed, I.1
Tamouza, R.2
Delord, M.3
Krishnamoorthy, R.4
Tzourio, C.5
Mulot, C.6
Nacfer, M.7
Lambert, J.C.8
Beaune, P.9
Laurent-Puig, P.10
Loriot, M.A.11
Charron, D.12
Elbaz, A.13
-
9
-
-
70549088602
-
Genome-wide association study reveals genetic risk underlying Parkinson's disease
-
10.1038/ng.487, 2787725, 19915575
-
Simon-Sanchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Kruger R, Federoff M, Klein C, Goate A, Perlmutter J, Bonin M, Nalls MA, Illiq T, Gieger C, Houlden H, Steffens M, Okun MS, Racette BA, Cookson MR, Foote KD, Fernandez HH, Traynor BJ, Schreiber S, Arepalli S, Zonozi R, et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet 2009, 41:1308-1312. 10.1038/ng.487, 2787725, 19915575.
-
(2009)
Nat Genet
, vol.41
, pp. 1308-1312
-
-
Simon-Sanchez, J.1
Schulte, C.2
Bras, J.M.3
Sharma, M.4
Gibbs, J.R.5
Berg, D.6
Paisan-Ruiz, C.7
Lichtner, P.8
Scholz, S.W.9
Hernandez, D.G.10
Kruger, R.11
Federoff, M.12
Klein, C.13
Goate, A.14
Perlmutter, J.15
Bonin, M.16
Nalls, M.A.17
Illiq, T.18
Gieger, C.19
Houlden, H.20
Steffens, M.21
Okun, M.S.22
Racette, B.A.23
Cookson, M.R.24
Foote, K.D.25
Fernandez, H.H.26
Traynor, B.J.27
Schreiber, S.28
Arepalli, S.29
Zonozi, R.30
more..
-
10
-
-
77956646167
-
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
-
10.1038/ng.642, 2930111, 20711177
-
Hamza TH, Zabetian CP, Tenesa A, Laederach A, Montimurro J, Yearout D, Kay DM, Doheny KF, Paschall J, Pugh E, Kusel VI, Collura R, Roberts J, Griffith A, Samii A, Scott WK, Nutt J, Factor SA, Payami H. Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease. Nat Genet 2010, 42:781-785. 10.1038/ng.642, 2930111, 20711177.
-
(2010)
Nat Genet
, vol.42
, pp. 781-785
-
-
Hamza, T.H.1
Zabetian, C.P.2
Tenesa, A.3
Laederach, A.4
Montimurro, J.5
Yearout, D.6
Kay, D.M.7
Doheny, K.F.8
Paschall, J.9
Pugh, E.10
Kusel, V.I.11
Collura, R.12
Roberts, J.13
Griffith, A.14
Samii, A.15
Scott, W.K.16
Nutt, J.17
Factor, S.A.18
Payami, H.19
-
11
-
-
58149380755
-
Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease
-
10.1097/NEN.0b013e31818e5e99, 2753200, 19018246
-
Theodore S, Cao S, McLean PJ, Standaert DG. Targeted overexpression of human alpha-synuclein triggers microglial activation and an adaptive immune response in a mouse model of Parkinson disease. J Neuropathol Exp Neurol 2008, 67:1149-1158. 10.1097/NEN.0b013e31818e5e99, 2753200, 19018246.
-
(2008)
J Neuropathol Exp Neurol
, vol.67
, pp. 1149-1158
-
-
Theodore, S.1
Cao, S.2
McLean, P.J.3
Standaert, D.G.4
-
12
-
-
0030210271
-
Soluble Fcgamma receptor type III (FcgammaRIII, CD16) triggers cell activation through interaction with complement receptors
-
Galon J, Gauchat JF, Mazieres N, Spagnoli R, Storkus W, Lotze M, Bonnefoy JY, Fridman WH, Sautes C. Soluble Fcgamma receptor type III (FcgammaRIII, CD16) triggers cell activation through interaction with complement receptors. J Immunol 1996, 157:1184-1192.
-
(1996)
J Immunol
, vol.157
, pp. 1184-1192
-
-
Galon, J.1
Gauchat, J.F.2
Mazieres, N.3
Spagnoli, R.4
Storkus, W.5
Lotze, M.6
Bonnefoy, J.Y.7
Fridman, W.H.8
Sautes, C.9
-
13
-
-
0034141874
-
C-reactive protein binding to murine leukocytes requires Fc gamma receptors
-
Stein MP, Mold C, Du Clos TW. C-reactive protein binding to murine leukocytes requires Fc gamma receptors. J Immunol 2000, 164:1514-1520.
-
(2000)
J Immunol
, vol.164
, pp. 1514-1520
-
-
Stein, M.P.1
Mold, C.2
Du Clos, T.W.3
-
14
-
-
77956393132
-
Involvement of Fc receptors in disorders of the central nervous system
-
10.1007/s12017-009-8099-5, 2878892, 19844812
-
Okun E, Mattson MP, Arumugam TV. Involvement of Fc receptors in disorders of the central nervous system. Neuromolecular Med 2010, 12:164-178. 10.1007/s12017-009-8099-5, 2878892, 19844812.
-
(2010)
Neuromolecular Med
, vol.12
, pp. 164-178
-
-
Okun, E.1
Mattson, M.P.2
Arumugam, T.V.3
-
15
-
-
77958132307
-
Fcgamma receptors are required for NF-kappaB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease
-
10.1186/1750-1326-5-42, 2975641, 20977765
-
Cao S, Theodore S, Standaert DG. Fcgamma receptors are required for NF-kappaB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease. Mol Neurodegener 2010, 5:42. 10.1186/1750-1326-5-42, 2975641, 20977765.
-
(2010)
Mol Neurodegener
, vol.5
, pp. 42
-
-
Cao, S.1
Theodore, S.2
Standaert, D.G.3
-
16
-
-
0028042424
-
FcR gamma chain deletion results in pleiotrophic effector cell defects
-
10.1016/0092-8674(94)90115-5, 8313472
-
Takai T, Li M, Sylvestre D, Clynes R, Ravetch JV. FcR gamma chain deletion results in pleiotrophic effector cell defects. Cell 1994, 76:519-529. 10.1016/0092-8674(94)90115-5, 8313472.
-
(1994)
Cell
, vol.76
, pp. 519-529
-
-
Takai, T.1
Li, M.2
Sylvestre, D.3
Clynes, R.4
Ravetch, J.V.5
-
17
-
-
51649113215
-
Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response
-
10.1523/JNEUROSCI.1806-08.2008, 2739568, 18716210
-
Lee JK, McCoy MK, Harms AS, Ruhn KA, Gold SJ, Tansey MG. Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response. J Neurosci 2008, 28:8517-8528. 10.1523/JNEUROSCI.1806-08.2008, 2739568, 18716210.
-
(2008)
J Neurosci
, vol.28
, pp. 8517-8528
-
-
Lee, J.K.1
McCoy, M.K.2
Harms, A.S.3
Ruhn, K.A.4
Gold, S.J.5
Tansey, M.G.6
-
18
-
-
20144389524
-
Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease
-
10.1096/fj.04-2751com, 15791003
-
Zhang W, Wang T, Pei Z, Miller DS, Wu X, Block ML, Wilson B, Zhou Y, Hong JS, Zhang J. Aggregated alpha-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J 2005, 19:533-542. 10.1096/fj.04-2751com, 15791003.
-
(2005)
FASEB J
, vol.19
, pp. 533-542
-
-
Zhang, W.1
Wang, T.2
Pei, Z.3
Miller, D.S.4
Wu, X.5
Block, M.L.6
Wilson, B.7
Zhou, Y.8
Hong, J.S.9
Zhang, J.10
-
19
-
-
0035874494
-
Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB
-
10.1182/blood.V97.10.2932, 11342414
-
Rezzonico R, Imbert V, Chicheportiche R, Dayer JM. Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB. Blood 2001, 97:2932-2940. 10.1182/blood.V97.10.2932, 11342414.
-
(2001)
Blood
, vol.97
, pp. 2932-2940
-
-
Rezzonico, R.1
Imbert, V.2
Chicheportiche, R.3
Dayer, J.M.4
-
20
-
-
29744432137
-
Requirement of the Fc receptor common gamma-chain for gamma delta T cell-mediated promotion of murine experimental autoimmune encephalomyelitis
-
10.1002/eji.200535285, 16278814
-
Szalai AJ, Hu X, Raman C, Barnum SR. Requirement of the Fc receptor common gamma-chain for gamma delta T cell-mediated promotion of murine experimental autoimmune encephalomyelitis. Eur J Immunol 2005, 35:3487-3492. 10.1002/eji.200535285, 16278814.
-
(2005)
Eur J Immunol
, vol.35
, pp. 3487-3492
-
-
Szalai, A.J.1
Hu, X.2
Raman, C.3
Barnum, S.R.4
-
21
-
-
60549088702
-
Fc-independent phagocytosis: implications for intravenous IgG therapy in immune thrombocytopenia
-
10.2174/187152908786786223, 19075638
-
Webster ML, Zhu G, Li Y, Ni H. Fc-independent phagocytosis: implications for intravenous IgG therapy in immune thrombocytopenia. Cardiovasc Hematol Disord Drug Targets 2008, 8:278-282. 10.2174/187152908786786223, 19075638.
-
(2008)
Cardiovasc Hematol Disord Drug Targets
, vol.8
, pp. 278-282
-
-
Webster, M.L.1
Zhu, G.2
Li, Y.3
Ni, H.4
-
22
-
-
84860337162
-
Activation of the Classical Complement Pathway by Bacillus anthracis Is the Primary Mechanism for Spore Phagocytosis and Involves the Spore Surface Protein BclA
-
10.4049/jimmunol.1102092, 22442442
-
Gu C, Jenkins SA, Xue Q, Xu Y. Activation of the Classical Complement Pathway by Bacillus anthracis Is the Primary Mechanism for Spore Phagocytosis and Involves the Spore Surface Protein BclA. J Immunol 2012, 188:4421-4431. 10.4049/jimmunol.1102092, 22442442.
-
(2012)
J Immunol
, vol.188
, pp. 4421-4431
-
-
Gu, C.1
Jenkins, S.A.2
Xue, Q.3
Xu, Y.4
-
23
-
-
51449099473
-
Synuclein activates microglia in a model of Parkinson's disease
-
10.1016/j.neurobiolaging.2007.04.006, 2621109, 17537546
-
Su X, Maguire-Zeiss KA, Giuliano R, Prifti L, Venkatesh K, Federoff HJ. Synuclein activates microglia in a model of Parkinson's disease. Neurobiol Aging 2008, 29:1690-1701. 10.1016/j.neurobiolaging.2007.04.006, 2621109, 17537546.
-
(2008)
Neurobiol Aging
, vol.29
, pp. 1690-1701
-
-
Su, X.1
Maguire-Zeiss, K.A.2
Giuliano, R.3
Prifti, L.4
Venkatesh, K.5
Federoff, H.J.6
-
24
-
-
84862809855
-
Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Abeta by microglia
-
10.1002/glia.22331, 22438044
-
Fu H, Liu B, Frost JL, Hong S, Jin M, Ostaszewski B, Shankar GM, Costantino IM, Carroll MC, Mayadas TN, Lemere CA. Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Abeta by microglia. Glia 2012, 60:993-1003. 10.1002/glia.22331, 22438044.
-
(2012)
Glia
, vol.60
, pp. 993-1003
-
-
Fu, H.1
Liu, B.2
Frost, J.L.3
Hong, S.4
Jin, M.5
Ostaszewski, B.6
Shankar, G.M.7
Costantino, I.M.8
Carroll, M.C.9
Mayadas, T.N.10
Lemere, C.A.11
-
25
-
-
84865863969
-
Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in alpha-synucleinopathy
-
10.1007/s00401-012-0975-7, 22484440
-
Odagiri S, Tanji K, Mori F, Kakita A, Takahashi H, Wakabayashi K. Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in alpha-synucleinopathy. Acta Neuropathol 2012, 124:173-186. 10.1007/s00401-012-0975-7, 22484440.
-
(2012)
Acta Neuropathol
, vol.124
, pp. 173-186
-
-
Odagiri, S.1
Tanji, K.2
Mori, F.3
Kakita, A.4
Takahashi, H.5
Wakabayashi, K.6
-
26
-
-
65549094988
-
Activation of antibacterial autophagy by NADPH oxidases
-
10.1073/pnas.0811045106, 2664152, 19339495
-
Huang J, Canadien V, Lam GY, Steinberg BE, Dinauer MC, Magalhaes MA, Glogauer M, Grinstein S, Brumell JH. Activation of antibacterial autophagy by NADPH oxidases. Proc Natl Acad Sci USA 2009, 106:6226-6231. 10.1073/pnas.0811045106, 2664152, 19339495.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 6226-6231
-
-
Huang, J.1
Canadien, V.2
Lam, G.Y.3
Steinberg, B.E.4
Dinauer, M.C.5
Magalhaes, M.A.6
Glogauer, M.7
Grinstein, S.8
Brumell, J.H.9
-
27
-
-
77958577389
-
Divergent intracellular sorting of Fc{gamma}RIIA and Fc{gamma}RIIB2
-
10.1074/jbc.M110.143834, 2962523, 20736173
-
Zhang CY, Booth JW. Divergent intracellular sorting of Fc{gamma}RIIA and Fc{gamma}RIIB2. J Biol Chem 2010, 285:34250-34258. 10.1074/jbc.M110.143834, 2962523, 20736173.
-
(2010)
J Biol Chem
, vol.285
, pp. 34250-34258
-
-
Zhang, C.Y.1
Booth, J.W.2
-
28
-
-
39849085821
-
Nitrated alpha-synuclein-activated microglial profiling for Parkinson's disease
-
10.1111/j.1471-4159.2007.05087.x, 18036154
-
Reynolds AD, Glanzer JG, Kadiu I, Ricardo-Dukelow M, Chaudhuri A, Ciborowski P, Cerny R, Gelman B, Thomas MP, Mosley RL, Gendelman HE. Nitrated alpha-synuclein-activated microglial profiling for Parkinson's disease. J Neurochem 2008, 104:1504-1525. 10.1111/j.1471-4159.2007.05087.x, 18036154.
-
(2008)
J Neurochem
, vol.104
, pp. 1504-1525
-
-
Reynolds, A.D.1
Glanzer, J.G.2
Kadiu, I.3
Ricardo-Dukelow, M.4
Chaudhuri, A.5
Ciborowski, P.6
Cerny, R.7
Gelman, B.8
Thomas, M.P.9
Mosley, R.L.10
Gendelman, H.E.11
-
29
-
-
78149441914
-
Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants
-
10.1371/journal.pone.0013481, 2964342, 21048992
-
Roodveldt C, Labrador-Garrido A, Gonzalez-Rey E, Fernandez-Montesinos R, Caro M, Lachaud CC, Waudby CA, Delgado M, Dobson CM, Pozo D. Glial innate immunity generated by non-aggregated alpha-synuclein in mouse: differences between wild-type and Parkinson's disease-linked mutants. PLoS One 2010, 5:e13481. 10.1371/journal.pone.0013481, 2964342, 21048992.
-
(2010)
PLoS One
, vol.5
-
-
Roodveldt, C.1
Labrador-Garrido, A.2
Gonzalez-Rey, E.3
Fernandez-Montesinos, R.4
Caro, M.5
Lachaud, C.C.6
Waudby, C.A.7
Delgado, M.8
Dobson, C.M.9
Pozo, D.10
-
30
-
-
77956194977
-
Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1
-
10.4049/jimmunol.0903480, 20511551
-
Lee EJ, Woo MS, Moon PG, Baek MC, Choi IY, Kim WK, Junn E, Kim HS. Alpha-synuclein activates microglia by inducing the expressions of matrix metalloproteinases and the subsequent activation of protease-activated receptor-1. J Immunol 2010, 185:615-623. 10.4049/jimmunol.0903480, 20511551.
-
(2010)
J Immunol
, vol.185
, pp. 615-623
-
-
Lee, E.J.1
Woo, M.S.2
Moon, P.G.3
Baek, M.C.4
Choi, I.Y.5
Kim, W.K.6
Junn, E.7
Kim, H.S.8
|