Role of miRNA and cancer stem cells in chemoresistance and pancreatic cancer treatment

Expert Opinion on Drug Delivery

Volumn 9, Issue 12, 2012, Pages 1443-1447

  Danquah, Michael ^a   Singh, Saurabh ^a   Behrman, Stephen W ^a   Mahato, Ram I ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Cancer stem cells; Chemoresistance; MiRNA; Pancreatic cancer

Indexed keywords

ABC TRANSPORTER; CISPLATIN; FLUOROURACIL; GEMCITABINE; MICRORNA; MICRORNA 141; MICRORNA 155; MICRORNA 200; MICRORNA 200A; MICRORNA 200B; MICRORNA 200C; MICRORNA 203; MICRORNA 21; MICRORNA 22; MICRORNA 221; MICRORNA 520; QUERCETIN; RNA INDUCED SILENCING COMPLEX; TRANSCRIPTION FACTOR ZEB1; UNCLASSIFIED DRUG; UVOMORULIN;

ANTINEOPLASTIC ACTIVITY; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER GROWTH; CANCER INVASION; CANCER PATIENT; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER RESISTANCE; CANCER STEM CELL; CANCER THERAPY; CARCINOGENESIS; DNA REPAIR; DOWN REGULATION; DRUG MEGADOSE; DRUG TARGETING; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; METASTASIS; NONHUMAN; ONCOGENE; PANCREAS CANCER; PROTEIN EXPRESSION; QUALITY OF LIFE; REVIEW; TUMOR SUPPRESSOR GENE;

DRUG RESISTANCE, NEOPLASM; HUMANS; MICRORNAS; NEOPLASTIC STEM CELLS; PANCREATIC NEOPLASMS;

EID: 84869855780     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2012.722079     Document Type: Review

References (19)

1. Bailey JM, Swanson BJ, Hamada T, et al. Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clin Cancer Res 2008;14(19):5995-6004
2. Hermann PC, Huber SL, Herrler T, et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 2007;1(3):313-23 (Pubitemid 47355323)
3. Sarkar FH, Li Y, Wang Z, et al. Implication of micrornas in drug resistance for designing novel cancer therapy. Drug Resist Updat 2010;13(3):57-66
4. Singh S, Chitkara D, Mehrazin R, et al. Chemoresistance in prostate cancer cells is regulated by mirnas and hedgehog pathway. PLoS One 2012;7(6):e40021
5. Szakacs G, Paterson JK, Ludwig JA, et al. Targeting multidrug resistance in cancer. Nat Rev Drug Discov 2006;5(3):219-34 (Pubitemid 43336035)
6. Wang Z, Li Y, Kong D, et al. Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. Cancer Res 2009;69(6):2400-7
7. Arumugam T, Ramachandran V, Fournier KF, et al. Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. Cancer Res 2009;69(14):5820-8
8. Ruckert F, Joensson P, Saeger HD, et al. Functional analysis of loxl2 in pancreatic carcinoma. Int J Colorectal Dis 2010;25(3):303-11
9. Li C, Heidt DG, Dalerba P, et al. Identification of pancreatic cancer stem cells. Cancer Res 2007;67(3):1030-7
10. Dean M, Fojo T, Bates S. Tumour stem cells and drug resistance. Nat Rev Cancer 2005;5(4):275-84 (Pubitemid 40488633)
11. Kim M, Turnquist H, Jackson J, et al. The multidrug resistance transporter abcg2 (breast cancer resistance protein 1) effluxes hoechst 33342 and is overexpressed in hematopoietic stem cells. Clin Cancer Res 2002;8(1):22-8 (Pubitemid 34101455)
12. Cheng G, Danquah M, Mahato RI. Micrornas as therapeutics targets for cancer. In: Lu Y, Mahato RI, editors. Pharmaceutical perspectives of cancer therapeutics. Springer; New York: 399 441-474.
13. Singh S, Narang AS, Mahato RI. Subcellular fate and off-target effects of sirna, shrna, and mirna. Pharm Res 2011;28(12):2996-3015
14. Wang Z, Li Y, Ahmad A, et al. Pancreatic cancer: understanding and overcoming chemoresistance. Nat Rev Gastroenterol Hepatol 2011;8(1):27-33
15. Singh S, Chitkara D, Mehrazin R, et al. Chemoresistance in prostate cancer cells is regulated by mirnas and hedgehog pathway. PLoS One 2012;In Press
16. Li Y, Kong D, Wang Z, Sarkar FH. Regulation of micrornas by natural agents: an emerging field in chemoprevention and chemotherapy research. Pharm Res 2010;27(6):1027-41
17. Li Y, Vandenboom TG II, Wang Z, et al. Mir-146a suppresses invasion of pancreatic cancer cells. Cancer Res 2010;70(4):1486-95
18. Sun M, Estrov Z, Ji Y, et al. Curcumin (diferuloylmethane) alters the expression profiles of micrornas in human pancreatic cancer cells. Mol Cancer Ther 2008;7(3):464-73 (Pubitemid 351482129)
19. Zhou W, Kallifatidis G, Baumann B, et al. Dietary polyphenol quercetin targets pancreatic cancer stem cells. Int J Oncol 2010;37(3):551-61