SorLA is a molecular link for retromer-dependent sorting of the Amyloid precursor protein

Communicative and Integrative Biology

Volumn 5, Issue 6, 2012, Pages 616-619

  Fjorback, Anja W ^a   Andersen, Olav M ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

App; Retrograde trafficking; Retromer; Sorla

Indexed keywords

EID: 84869795914     PISSN: 19420889     EISSN: 19420889     Source Type: Journal    
DOI: 10.4161/cib.21433     Document Type: Article

References (28)

1. Small SA, Gandy S. Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron 2006; 52:15-31; http://dx.doi.org/10.1016/j.neuron. 2006.09.001.
2. Sannerud R, Annaert W. Trafficking, a key player in regulated intramembrane proteolysis. Semin Cell Dev Biol 2009; 20:183-90; http://dx.doi.org/10.1016/j.semcdb.2008.11.004.
3. Seaman MN. Recycle your receptors with retromer. Trends Cell Biol 2005; 15:68-75; http://dx.doi.org/10.1016/j.tcb.2004.12.004.
4. Collins BM. The structure and function of the retromer protein complex. Traffic 2008; 9:1811-22; http://dx.doi.org/10.1111/j.1600-0854.2008.00777.x.
5. Bonifacino JS, Hurley JH. Retromer. Curr Opin Cell Biol 2008; 20:427-36; http://dx.doi.org/10.1016/j.ceb.2008.03.009.
6. Bonifacino JS, Rojas R. Retrograde transport from endosomes to the trans-Golgi network. Nat Rev Mol Cell Biol 2006; 7:568-79; http://dx.doi.org/10.1038/nrm1985.
7. Cullen PJ. Endosomal sorting and signalling: an emerging role for sorting nexins. Nat Rev Mol Cell Biol 2008; 9:574-82; http://dx.doi.org/10.1038/nrm2427.
8. Small SA. Retromer sorting: a pathogenic pathway in late-onset Alzheimer disease. Arch Neurol 2008; 65:323-8; http://dx.doi.org/10.1001/archneurol.2007.64.
9. Vardarajan BN, Bruesegem SY, Harbour ME, George-Hyslop PS, Seaman MN, Farrer LA. Identification of Alzheimer disease-associated variants in genes that regulate retromer function. Neurobiol Aging 2012; 33:2231, e15-30; http://dx.doi.org/10.1016/j.neurobiolaging.2012.04.020.
10. Small SA, Kent K, Pierce A, Leung C, Kang MS, Okada H, et al. Model-guided microarray implicates the retromer complex in Alzheimer's disease. Ann Neurol 2005; 58:909-19; http://dx.doi.org/10.1002/ana.20667.
11. Muhammad A, Flores I, Zhang H, Yu R, Staniszewski A, Planel E, et al. Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proc Natl Acad Sci U S A 2008; 105:7327-32; http://dx.doi.org/10.1073/pnas.0802545105.
12. Wen L, Tang FL, Hong Y, Luo SW, Wang CL, He W, et al. VPS35 haploinsufficiency increases Alzheimer's disease neuropathology. J Cell Biol 2011; 195:765-79; http://dx.doi.org/10.1083/jcb.201105109.
13. Vieira SI, Rebelo S, Esselmann H, Wiltfang J, Lah J, Lane R, et al. Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated. Mol Neurodegener 2010; 5:40; http://dx.doi.org/10.1186/1750-1326-5-40.
14. Sullivan CP, Jay AG, Stack EC, Pakaluk M, Wadlinger E, Fine RE, et al. Retromer disruption promotes amyloidogenic APP processing. Neurobiol Dis 2011; 43:338-45; http://dx.doi.org/10.1016/j.nbd.2011.04.002.
15. Bhalla A, Vetanovetz CP, Morel E, Chamoun Z, Di Paolo G, Small SA. The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport. Neurobiol Dis 2012; 47:126-34; http://dx.doi. org/10.1016/j.nbd.2012.03.030.
16. Andersen OM, et al. SorLA/LR11, a neuronal sorting receptor that regulates processing of the amyloid precursor protein. Proc Natl Acad Sci USA 2005; 102:13461-6; http://dx.doi.org/10.1073/pnas.0503689102.
17. Offe K, Dodson SE, Shoemaker JT, Fritz JJ, Gearing M, Levey AI, et al. The lipoprotein receptor LR11 regulates amyloid β production and amyloid precursor protein traffic in endosomal compartments. J Neurosci 2006; 26:1596-603; http://dx.doi.org/10.1523/JNEUROSCI.4946-05.2006.
18. Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nat Genet 2007; 39:168-77; http://dx.doi.org/10.1038/ng1943.
19. Reitz C, Cheng R, Rogaeva E, Lee JH, Tokuhiro S, Zou F, et al. Genetic and Environmental Risk in Alzheimer Disease 1 Consortium. Meta-analysis of the association between variants in SORL1 and Alzheimer disease. Arch Neurol 2011; 68:99-106; http://dx.doi.org/10.1001/archneurol. 2010.346.
20. Nielsen MS, Gustafsen C, Madsen P, Nyengaard JR, Hermey G, Bakke O, et al. Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA. Mol Cell Biol 2007; 27:6842-51; http://dx.doi.org/10.1128/ MCB.00815-07.
21. Fjorback AW, Seaman M, Gustafsen C, Mehmedbasic A, Gokool S, Wu C, et al. Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing. J Neurosci 2012; 32:1467-80; http://dx.doi. org/10.1523/JNEUROSCI.2272-11.2012.
22. McGough IJ, Cullen PJ. Recent advances in retromer biology. Traffic 2011; 12:963-71; http://dx.doi.org/10.1111/j.1600-0854.2011.01201.x.
23. Nothwehr SF, Ha SA, Bruinsma P. Sorting of yeast membrane proteins into an endosome-to-Golgi pathway involves direct interaction of their cytosolic domains with Vps35p. J Cell Biol 2000; 151:297-310; http://dx.doi.org/10.1083/ jcb.151.2.297.
24. Arighi CN, Hartnell LM, Aguilar RC, Haft CR, Bonifacino JS. Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J Cell Biol 2004; 165:123-33; http://dx.doi.org/10.1083/jcb.200312055.
25. Shi H, Rojas R, Bonifacino JS, Hurley JH. The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain. Nat Struct Mol Biol 2006; 13:540-8; http://dx.doi.org/10.1038/nsmb1103.
26. Seaman MN. Endosome protein sorting: motifs and machinery. Cell Mol Life Sci 2008; 65:2842-58; http://dx.doi.org/10.1007/s00018-008-8354-1.
27. Schmidt V, Sporbert A, Rohe M, Reimer T, Rehm A, Andersen OM, et al. SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1. J Biol Chem 2007; 282:32956-64; http://dx.doi.org/10.1074/jbc.M705073200.
28. Schmidt V, Baum K, Lao A, Rateitschak K, Schmitz Y, Teichmann A, et al. Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease. EMBO J 2012; 31:187-200; http://dx.doi.org/10.1038/emboj.2011.352.