Multiple micronutrient supplementation in Tanzanian infants born to HIV-infected mothers: A randomized, double-blind, placebo-controlled clinical trial

American Journal of Clinical Nutrition

Volumn 96, Issue 6, 2012, Pages 1437-1446

  Duggan, Christopher ^a,d   Manji, Karim P ^b   Kupka, Roland ^a,c   Bosch, Ronald J ^a   Aboud, Said ^b   Kisenge, Rodrick ^b   Okuma, James ^a   Fawzi, Wafaie W ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^c Regional Office for West and Central Africa   (Senegal)

^d BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIRETROVIRUS AGENT; ASCORBIC ACID; CYANOCOBALAMIN; FOLIC ACID; MULTIVITAMIN; NICOTINIC ACID; PLACEBO; PYRIDOXINE; RIBOFLAVIN; THIAMINE;

ANTIVIRAL THERAPY; ARTICLE; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; FEVER; FOLLOW UP; HOSPITALIZATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; INFANT MORTALITY; MAJOR CLINICAL STUDY; MALE; MORBIDITY; RANDOMIZED CONTROLLED TRIAL; TANZANIA; VITAMIN SUPPLEMENTATION; VOMITING;

ANTI-RETROVIRAL AGENTS; BREAST FEEDING; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; FEVER; HIV SEROPOSITIVITY; HUMANS; INFANT; INFANT MORTALITY; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INFANT, NEWBORN; INFECTION CONTROL; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; MICRONUTRIENTS; POVERTY AREAS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; TANZANIA; VOMITING;

EID: 84869779136     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.112.044263     Document Type: Article

References (31)

1. WHO. The global burden of disease: 2004 update. Geneva, Switzerland: World Health Organization, 2008.
2. Liu L, Johnson HL, Cousens S, Perin J, Scott S, Lawn JE, Rudan I, Campbell H, Cibulskis R, Li M, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet 2012;379:2151-61.
3. Joint United Nations Program on HIV/AIDS/World Health Organization (UNAIDS/WHO). AIDS epidemic update 2009. Geneva, Switzerland: UNAIDS/WHO, 2009.
4. Yakoob MY, Theodoratou E, Jabeen A, Imdad A, Eisele TP, Ferguson J, Jhass A, Rudan I, Campbell H, Black RE, et al. Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria. BMC Public Health 2011;11(suppl 3):S23.
5. Mayo-Wilson E, Imdad A, Herzer K, Yakoob MY, Bhutta ZA. Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis. BMJ 2011;343:d5094.
6. Haider BA, Bhutta ZA. The effect of therapeutic zinc supplementation among young children with selected infections: a review of the evidence. Food Nutr Bull 2009;30(Suppl):S41-59.
7. Bhutta ZA, Ahmed T, Black RE, Cousens S, Dewey K, Giugliani E, Haider BA, Kirkwood B, Morris SS, Sachdev HP, et al. What works? Interventions for maternal and child undernutrition and survival. Lancet 2008;371:417-40.
8. Duggan C, Fawzi W. Micronutrients and child health: studies in international nutrition and HIV infection. Nutr Rev 2001;59:358-69. (Pubitemid 33055147)
9. Lunney KM, Jenkins AL, Tavengwa NV, Majo F, Chidhanguro D, Iliff P, Strickland GT, Piwoz E, Iannotti L, Humphrey JH. HIV-positive poor women may stop breast-feeding early to protect their infants from HIV infection although available replacement diets are grossly inadequate. J Nutr 2008;138:351-7.
10. Fawzi WW, Msamanga GI, Spiegelman D, Urassa EJ, McGrath N, Mwakagile D, Antelman G, Mbise R, Herrera G, Kapiga S, et al. Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. Lancet 1998;351:1477-82. (Pubitemid 28227039)
11. Fawzi WW, Msamanga GI, Spiegelman D, Wei R, Kapiga S, Villamor E, Mwakagile D, Mugusi F, Essex M, Hunter D. A randomized trial of multivitamin supplements and HIV disease progression and mortality. N Engl J Med 2004;351:23-32. (Pubitemid 38857244)
12. Fawzi WW, Msamanga GI, Wei R, Spiegelman D, Antelman G, Villamor E, Manji K, Hunter D. Effect of providing vitamin supplements to human immunodeficiency virus-infected, lactating mothers on the child's morbidity and CD4+ cell counts. Clin Infect Dis 2003;36:1053-62. (Pubitemid 36513292)
13. Villamor E, Saathoff E, Bosch RJ, Hertzmark E, Baylin A, Manji K, Msamanga G, Hunter DJ, Fawzi WW. Vitamin supplementation of HIV-infected women improves postnatal child growth. Am J Clin Nutr 2005;81:880-8. (Pubitemid 41724998)
14. Baylin A, Villamor E, Rifai N, Msamanga G, Fawzi WW. Effect of vitamin supplementation to HIV-infected pregnant women on the micronutrient status of their infants. Eur J Clin Nutr 2005;59:960-8. (Pubitemid 41195213)
15. Aboud S, Urassa W, Lyamuya E, Mhalu F, Biberfeld G. Evaluation of HIV antibody and antigen/antibody combination ELISAs for use in an alternative confirmatory HIV testing strategy in Dar es Salaam, Tanzania. J Virol Methods 2006;135:192-6. (Pubitemid 44183830)
16. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, and fluoride. Washington, DC: National Academy Press, 1997.
17. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids. Washington, DC: National Academy Press, 2000.
18. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington, DC: National Academy Press, 2000.
19. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press, 2002.
20. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids (macronutrients). Washington, DC: National Academy Press, 2002.
21. Guay LA, Musoke P, Fleming T, Bagenda D, Allen M, Nakabiito C, Sherman J, Bakaki P, Ducar C, Deseyve M, et al. Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial. Lancet 1999;354:795-802. (Pubitemid 29415583)
22. Papathakis PC, Rollins NC, Chantry CJ, Bennish ML, Brown KH. Micronutrient status during lactation in HIV-infected and HIV-uninfected South African women during the first 6 mo after delivery. Am J Clin Nutr 2007;85:182-92. (Pubitemid 46067633)
23. Scrimshaw NS. Historical concepts of interactions, synergism and antagonism between nutrition and infection. J Nutr 2003;133:316S-21S. (Pubitemid 36070627)
24. Ndeezi G, Tylleskar T, Ndugwa CM, Tumwine JK. Effect of multiple micronutrient supplementation on survival of HIV-infected children in Uganda: a randomized, controlled trial. J Int AIDS Soc 2010;13:18.
25. Luabeya KK, Mpontshane N, Mackay M, Ward H, Elson I, Chhagan M, Tomkins A, Van den Broeck J, Bennish ML. Zinc or multiple micronutrient supplementation to reduce diarrhea and respiratory disease in South African children: a randomized controlled trial. PLoS ONE 2007;2:e541.
26. Chhagan MK, Van den Broeck J, Luabeya KK, Mpontshane N, Tucker KL, Bennish ML. Effect of micronutrient supplementation on diarrhoeal disease among stunted children in rural South Africa. Eur J Clin Nutr 2009;63:850-7.
27. Nielsen-Saines K, Komarow L, Cu-Uvin S, Jourdain G, Klingman KL, Shapiro DE, Mofenson L, Moran L, Campbell TB, Hitti J, et al. Infant outcomes after maternal antiretroviral exposure in resource-limited settings. Pediatrics 2012;129(6):e1525-32.
28. Shankar AH, Jahari AB, Sebayang SK, Aditiawarman, Apriatni M, Harefa B, Muadz H, Soesbandoro SD, Tjiong R, Fachry A, et al. Effect of maternal multiple micronutrient supplementation on fetal loss and infant death in Indonesia: a double-blind cluster-randomised trial. Lancet 2008;371:215-27.
29. Masanja H, de Savigny D, Smithson P, Schellenberg J, John T, Mbuya C, Upunda G, Boerma T, Victora C, Smith T, et al. Child survival gains in Tanzania: analysis of data from demographic and health surveys. Lancet 2008;371:1276-83. (Pubitemid 351506452)
30. McDonald C, Kupka R, Manji KP, Okuma J, Bosch RJ, Fawzi WW, Duggan C. Predictors of stunting, wasting, and underweight among infants born to HIV-infected women in Tanzania. FASEB J 2011;25:216.3.
31. Olafsdottir AS, Wagner K-H, Thorsdottir I, Elmadfa I. Fat-soluble vitamins in the maternal diet, influence of cod liver oil supplementation and impact of the maternal diet on human milk composition. Ann Nutr Metab 2001;45:265-72. (Pubitemid 34062861)