-
2
-
-
77955291967
-
The altered metabolism of tumors: HIF-1 and its role in the Warburg effect
-
Stubbs M, Griffiths JR (2010) The altered metabolism of tumors: HIF-1 and its role in the Warburg effect. Adv Enzyme Regul 50:44-55
-
(2010)
Adv Enzyme Regul
, vol.50
, pp. 44-55
-
-
Stubbs, M.1
Griffiths, J.R.2
-
4
-
-
84929292655
-
Preface
-
Keun K, Steger-Hartmann T, Petersen K et al (eds), Springer, Berlin
-
Riefke B, Mumberg D, Kroemer G et al (2007) Preface. In: Keun K, Steger-Hartmann T, Petersen K et al (eds) Oncogenes meet metabolism. From deregulated genes to a broader understanding of tumour physiology. Springer, Berlin
-
(2007)
Oncogenes Meet Metabolism. from Deregulated Genes to A Broader Understanding of Tumour Physiology
-
-
Riefke, B.1
Mumberg, D.2
Kroemer, G.3
-
5
-
-
0030691795
-
Oncogenes in tumor metabolism, tumorigenesis, and apoptosis
-
Dang CV, Lewis BC, Dolde C, Dang G, Shim H (1997) Oncogenes in tumor metabolism, tumorigenesis, and apoptosis. J Bioenerg Biomembr 29:345-354
-
(1997)
J Bioenerg Biomembr
, vol.29
, pp. 345-354
-
-
Dang, C.V.1
Lewis, B.C.2
Dolde, C.3
Dang, G.4
Shim, H.5
-
6
-
-
78651245860
-
Detrimental effects of adenosine signaling in sickle cell disease
-
Zhang Y, Dai Y, Wen J et al (2011) Detrimental effects of adenosine signaling in sickle cell disease. Nat Med 17:79-86
-
(2011)
Nat Med
, vol.17
, pp. 79-86
-
-
Zhang, Y.1
Dai, Y.2
Wen, J.3
-
7
-
-
78549250742
-
Ethylene glycol monomethyl ether-induced toxicity is mediated through the inhibition offlavoprotein dehydrogenase enzyme family
-
Takei M, Ando Y, Saitoh W et al (2010) Ethylene glycol monomethyl ether-induced toxicity is mediated through the inhibition offlavoprotein dehydrogenase enzyme family. Toxicol Sci 118:643-652
-
(2010)
Toxicol Sci
, vol.118
, pp. 643-652
-
-
Takei, M.1
Ando, Y.2
Saitoh, W.3
-
8
-
-
77956562150
-
Assessment of the effects of dentifrice on periodontal disease biomarkers in gingival crevicular fluid
-
Barnes VM, Teles R, Trivedi HM et al (2010) Assessment of the effects of dentifrice on periodontal disease biomarkers in gingival crevicular fluid. J Periodontol 81:1273-1279
-
(2010)
J Periodontol
, vol.81
, pp. 1273-1279
-
-
Barnes, V.M.1
Teles, R.2
Trivedi, H.M.3
-
9
-
-
68849083050
-
Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems
-
Evans AM, Dehaven CD, Barrett T, Mitchell M, Milgram E (2009) Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal Chem 81:6656-6667
-
(2009)
Anal Chem
, vol.81
, pp. 6656-6667
-
-
Evans, A.M.1
Dehaven, C.D.2
Barrett, T.3
Mitchell, M.4
Milgram, E.5
-
10
-
-
78649702566
-
Organization of GC/MS and LC/MS metabolomics data into chemical libraries
-
Dehaven CD, Evans AM, Dai H, Lawton KA (2010) Organization of GC/MS and LC/MS metabolomics data into chemical libraries. J Cheminf 2:9
-
(2010)
J Cheminf
, vol.2
, pp. 9
-
-
Dehaven, C.D.1
Evans, A.M.2
Dai, H.3
Lawton, K.A.4
-
11
-
-
77951931229
-
Revisiting the Warburg effect in cancer cells with proteomics. the emergence of new approaches to diagnosis, prognosis and therapy
-
Scatena R, Bottoni P, Pontoglio A, Giardina B (2010) Revisiting the Warburg effect in cancer cells with proteomics. The emergence of new approaches to diagnosis, prognosis and therapy. Proteomics Clin Appl 4:143-158
-
(2010)
Proteomics Clin Appl
, vol.4
, pp. 143-158
-
-
Scatena, R.1
Bottoni, P.2
Pontoglio, A.3
Giardina, B.4
-
12
-
-
37449034854
-
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
-
Deberardinis RJ, Mancuso A, Daikhin E et al (2007) Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci USA 104:19345-19350
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19345-19350
-
-
Deberardinis, R.J.1
Mancuso, A.2
Daikhin, E.3
-
13
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324:1029-1033
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
14
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
Gatenby RA, Gillies RJ (2004) Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4:891-899
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
15
-
-
0035925098
-
Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
-
Hockel M, Vaupel P (2001) Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 93:266-276
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 266-276
-
-
Hockel, M.1
Vaupel, P.2
-
16
-
-
57449097020
-
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
-
Sonveaux P, Vegran F, Schroeder T et al (2008) Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 118:3930-3942
-
(2008)
J Clin Invest
, vol.118
, pp. 3930-3942
-
-
Sonveaux, P.1
Vegran, F.2
Schroeder, T.3
-
17
-
-
34748912615
-
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
-
Menendez JA, Lupu R (2007) Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 7:763-777
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 763-777
-
-
Menendez, J.A.1
Lupu, R.2
-
18
-
-
34547785566
-
Targeting mitochondria in the treatment of human cancer: A coordinated attack against cancer cell energy metabolism and signalling
-
Hagland H, Nikolaisen J, Hodneland LI et al (2007) Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling. Expert Opin Ther Targets 11:1055-1069
-
(2007)
Expert Opin Ther Targets
, vol.11
, pp. 1055-1069
-
-
Hagland, H.1
Nikolaisen, J.2
Hodneland, L.I.3
-
19
-
-
60949083613
-
The molecular determinants of de novo nucleotide biosynthesis in cancer cells
-
Tong X, Zhao F, Thompson CD (2009) The molecular determinants of de novo nucleotide biosynthesis in cancer cells. Curr Opin Genet Dev 19:32-37
-
(2009)
Curr Opin Genet Dev
, vol.19
, pp. 32-37
-
-
Tong, X.1
Zhao, F.2
Thompson, C.D.3
-
20
-
-
79952280229
-
P53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
-
Jiang P, Du W, Wang X et al (2011) p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol 13:310-316
-
(2011)
Nat Cell Biol
, vol.13
, pp. 310-316
-
-
Jiang, P.1
Du, W.2
Wang, X.3
-
21
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan H, Parsons DW, Jin G et al (2009) IDH1 and IDH2 mutations in gliomas. N Engl J Med 360:765-773
-
(2009)
N Engl J Med
, vol.360
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
-
22
-
-
66149136456
-
IDH1 and IDH2 mutations in gliomas
-
Ducray F, Marie Y, Sanson M (2009) IDH1 and IDH2 mutations in gliomas. N Engl J Med 360:2248-2249
-
(2009)
N Engl J Med
, vol.360
, pp. 2248-2249
-
-
Ducray, F.1
Marie, Y.2
Sanson, M.3
-
23
-
-
66149136456
-
IDH1 and IDH2 mutations in gliomas
-
De Carli E, Wang X, Puget S (2009) IDH1 and IDH2 mutations in gliomas. N Engl J Med 360:2248-2249
-
(2009)
N Engl J Med
, vol.360
, pp. 2248-2249
-
-
De Carli, E.1
Wang, X.2
Puget, S.3
-
24
-
-
67449099808
-
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
-
Kang MR, Kim MS, Oh JE et al (2009) Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers. Int J Cancer 125:353-355
-
(2009)
Int J Cancer
, vol.125
, pp. 353-355
-
-
Kang, M.R.1
Kim, M.S.2
Oh, J.E.3
-
25
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
Sjoblom T, Jones S, Wood LD et al (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314:268-274
-
(2006)
Science
, vol.314
, pp. 268-274
-
-
Sjoblom, T.1
Jones, S.2
Wood, L.D.3
-
26
-
-
77955273843
-
IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain
-
Lopez GY, Reitman ZJ, Solomon D et al (2010) IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain. Biochem Biophys Res Commun 398:585-587
-
(2010)
Biochem Biophys Res Commun
, vol.398
, pp. 585-587
-
-
Lopez, G.Y.1
Reitman, Z.J.2
Solomon, D.3
-
27
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S et al (2009) Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature 462:739-744
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
-
28
-
-
79953287708
-
IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo
-
Bralten LB, Kloosterhof NK, Balvers R et al (2011) IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo. Ann Neurol 69:455-463
-
(2011)
Ann Neurol
, vol.69
, pp. 455-463
-
-
Bralten, L.B.1
Kloosterhof, N.K.2
Balvers, R.3
-
29
-
-
78149249554
-
IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas
-
Houillier C, Wang X, Kaloshi G et al (2010) IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas. Neurology 75:1560-1566
-
(2010)
Neurology
, vol.75
, pp. 1560-1566
-
-
Houillier, C.1
Wang, X.2
Kaloshi, G.3
-
30
-
-
73149109062
-
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
-
Nomura DK, Long JZ, Niessen S et al (2010) Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell 140:49-61
-
(2010)
Cell
, vol.140
, pp. 49-61
-
-
Nomura, D.K.1
Long, J.Z.2
Niessen, S.3
-
31
-
-
33645962844
-
Choline kinase: An important target for cancer
-
Janardhan S, Srivani P, Sastry GN (2006) Choline kinase: an important target for cancer. Curr Med Chem 13:1169-1186
-
(2006)
Curr Med Chem
, vol.13
, pp. 1169-1186
-
-
Janardhan, S.1
Srivani, P.2
Sastry, G.N.3
-
32
-
-
33750435528
-
Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism
-
Glunde K, Serkova NJ (2006) Therapeutic targets and biomarkers identified in cancer choline phospholipid metabolism. Pharmacogenomics 7:1109-1123
-
(2006)
Pharmacogenomics
, vol.7
, pp. 1109-1123
-
-
Glunde, K.1
Serkova, N.J.2
-
34
-
-
79951820132
-
Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators
-
Sorensen RB, Hadrup SR, Svane IM et al (2011) Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators. Blood 117:2200-2210
-
(2011)
Blood
, vol.117
, pp. 2200-2210
-
-
Sorensen, R.B.1
Hadrup, S.R.2
Svane, I.M.3
-
35
-
-
34249788738
-
Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders
-
Sas K, Robotka H, Toldi J, Vecsei L (2007) Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders. J Neurol Sci 257:221-239
-
(2007)
J Neurol Sci
, vol.257
, pp. 221-239
-
-
Sas, K.1
Robotka, H.2
Toldi, J.3
Vecsei, L.4
-
36
-
-
77956621031
-
Indoleamine 2,3-dioxygenase (IDO) activity in fluence tumor growth in the TRAMP prostate cancer model
-
Kallberg E, Wikstrom P, Bergh A, Ivars F, Leanderson T (2010) Indoleamine 2,3-dioxygenase (IDO) activity in fluence tumor growth in the TRAMP prostate cancer model. Prostate 70:1461-1470
-
(2010)
Prostate
, vol.70
, pp. 1461-1470
-
-
Kallberg, E.1
Wikstrom, P.2
Bergh, A.3
Ivars, F.4
Leanderson, T.5
-
37
-
-
0026698871
-
Differential induction of indoleamine- 2,3-dioxygenase (IDO) by interferon-gamma in human gynecologic cancer cells
-
Leung BS, Stout LE, Shaskan EG, Thompson RM (1992) Differential induction of indoleamine- 2,3-dioxygenase (IDO) by interferon-gamma in human gynecologic cancer cells. Cancer Lett 66:77-81
-
(1992)
Cancer Lett
, vol.66
, pp. 77-81
-
-
Leung, B.S.1
Stout, L.E.2
Shaskan, E.G.3
Thompson, R.M.4
-
38
-
-
39749103576
-
Indoleamine 2,3-dioxygenase (IDO) expression in lung cancer
-
Karanikas V, Zamanakou M, Kerenidi T et al (2007) Indoleamine 2,3-dioxygenase (IDO) expression in lung cancer. Cancer Biol Ther 6:1258-1262
-
(2007)
Cancer Biol Ther
, vol.6
, pp. 1258-1262
-
-
Karanikas, V.1
Zamanakou, M.2
Kerenidi, T.3
-
39
-
-
77952061202
-
Towards a genetic definition of cancer-associated in flammation: Role of the IDO pathway
-
Prendergast GC, Metz R, Muller AJ (2010) Towards a genetic definition of cancer-associated in flammation: role of the IDO pathway. Am J Pathol 176:2082-2087
-
(2010)
Am J Pathol
, vol.176
, pp. 2082-2087
-
-
Prendergast, G.C.1
Metz, R.2
Muller, A.J.3
-
40
-
-
67650721438
-
Highlights at the gate of tryptophan catabolism: A review on the mechanisms of activation and regulation of indoleamine 2,3- dioxygenase (IDO), a novel target in cancer disease
-
Macchiarulo A, Camaioni E, Nuti R, Pellicciari R (2009) Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3- dioxygenase (IDO), a novel target in cancer disease. Amino Acids 37:219-229
-
(2009)
Amino Acids
, vol.37
, pp. 219-229
-
-
Macchiarulo, A.1
Camaioni, E.2
Nuti, R.3
Pellicciari, R.4
-
41
-
-
65549154975
-
The immune tolerance of cancer is mediated by IDO that is inhibited by COX-2 inhibitors through regulatory T cells
-
Lee SY, Choi HK, Lee KJ et al (2009) The immune tolerance of cancer is mediated by IDO that is inhibited by COX-2 inhibitors through regulatory T cells. J Immunother 32:22-28
-
(2009)
J Immunother
, vol.32
, pp. 22-28
-
-
Lee, S.Y.1
Choi, H.K.2
Lee, K.J.3
-
42
-
-
77951938172
-
Indoleamine 2,3-dioxygenase expression predicts impaired survival of invasive cervical cancer patients treated with radical hysterectomy
-
Inaba T, Ino K, Kajiyama H et al (2010) Indoleamine 2,3-dioxygenase expression predicts impaired survival of invasive cervical cancer patients treated with radical hysterectomy. Gynecol Oncol 117:423-428
-
(2010)
Gynecol Oncol
, vol.117
, pp. 423-428
-
-
Inaba, T.1
Ino, K.2
Kajiyama, H.3
-
43
-
-
74849101015
-
Indoleamine 2,3-dioxygenase, an emerging target for anti-cancer therapy
-
Liu X, Newton RC, Friedman SM, Scherle PA (2009) Indoleamine 2,3-dioxygenase, an emerging target for anti-cancer therapy. Curr Cancer Drug Targets 9:938-952
-
(2009)
Curr Cancer Drug Targets
, vol.9
, pp. 938-952
-
-
Liu, X.1
Newton, R.C.2
Friedman, S.M.3
Scherle, P.A.4
-
44
-
-
3142767508
-
Anticancer agent CHS 828 suppresses nuclear factor-kappa B activity in cancer cells through downregulation of IKK activity
-
Olsen LS, Hjarnaa PJ, Latini S et al (2004) Anticancer agent CHS 828 suppresses nuclear factor-kappa B activity in cancer cells through downregulation of IKK activity. Int J Cancer 111:198-205
-
(2004)
Int J Cancer
, vol.111
, pp. 198-205
-
-
Olsen, L.S.1
Hjarnaa, P.J.2
Latini, S.3
-
45
-
-
70350538957
-
The small molecule GMX1778 is a potent inhibitor of NAD + biosyn thesis: Strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors
-
Watson M, Roulston A, Belec L et al (2009) The small molecule GMX1778 is a potent inhibitor of NAD + biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors. Mol Cell Biol 29:5872-5888
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5872-5888
-
-
Watson, M.1
Roulston, A.2
Belec, L.3
-
47
-
-
67650318141
-
Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777
-
Beauparlant P, Bedard D, Bernier C et al (2009) Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777. Anticancer Drugs 20:346-354
-
(2009)
Anticancer Drugs
, vol.20
, pp. 346-354
-
-
Beauparlant, P.1
Bedard, D.2
Bernier, C.3
-
48
-
-
60149091657
-
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
-
Sreekumar A, Poisson LM, Rajendiran TM et al (2009) Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 457:910-914
-
(2009)
Nature
, vol.457
, pp. 910-914
-
-
Sreekumar, A.1
Poisson, L.M.2
Rajendiran, T.M.3
|