Assessment of the effects of dentifrice on periodontal disease biomarkers in gingival crevicular fluid

Journal of Periodontology

Volumn 81, Issue 9, 2010, Pages 1273-1279

  Barnes, Virginia M ^a   Teles, Ricardo ^b   Trivedi, Harsh M ^a   Devizio, William ^a   Xu, Tao ^a   Lee, Douglas P ^c   Mitchell, Matthew W ^c   Wulff, Jacob E ^c   Milburn, Michael V ^c   Guo, Lining ^c  

^a Technology Center   (United States)

^b FORSYTH INSTITUTE   (United States)

^c METABOLON INC   (United States)

Author keywords

Biological markers; Gingivitis; Metabolomics; Periodontitis

Indexed keywords

BIOLOGICAL MARKER; INOSINE; LYSINE; PUTRESCINE; TOOTHPASTE; TRICLOSAN; XANTHINE;

ADULT; AGED; ARTICLE; CHEMISTRY; CHRONIC PERIODONTITIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; GINGIVITIS; HUMAN; MALE; METABOLISM; METABOLOME; MIDDLE AGED; RANDOMIZED CONTROLLED TRIAL; VALIDATION STUDY;

ADULT; AGED; BIOLOGICAL MARKERS; CHRONIC PERIODONTITIS; DOUBLE-BLIND METHOD; FEMALE; GINGIVAL CREVICULAR FLUID; GINGIVITIS; HUMANS; INOSINE; LYSINE; MALE; METABOLOME; MIDDLE AGED; PUTRESCINE; TOOTHPASTES; TRICLOSAN; XANTHINE; YOUNG ADULT;

EID: 77956562150     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2010.100070     Document Type: Article

References (24)

1. Albandar JM, Brunelle JA, Kingman A. Destructive periodontal disease in adults 30 years of age and older in the United States, 1988-1994. J Periodontol 1999; 70: 13-29 (erratum 1999; 70: 351).
2. Papapanou PN. Epidemiology of periodontal diseases: An update. J Int Acad Periodontol 1999;1:110-116.
3. Seymour GJ, Ford PJ, Cullinan MP, Leishman S, Yamazaki K. Relationship between periodontal infections and systemic disease. Clin Microbiol Infect 2007; 13 (Suppl. 4): S3-S10.
4. Gunsolley JC. A meta-analysis of six-month studies of antiplaque and antigingivitis agents. J Am Dent Assoc 2006; 137: 1649-1657.
5. Embery G, Waddington R. Gingival crevicular fluid: Biomarkers of periodontal tissue activity. Adv Dent Res 1994; 8: 329-336.
6. Nakashima K, Giannopoulou C, Andersen E, et al. A longitudinal study of various crevicular fluid components as markers of periodontal disease activity. J Clin Periodontol 1996; 23: 832-838.
7. Perinetti G, Paolantonio M, Femminella B, Serra E, Spoto G. Gingival crevicular fluid alkaline phosphatase activity reflects periodontal healing/recurrent inflammation phases in chronic periodontitis patients. J Periodontol 2008; 79: 1200-1207.
8. Lamster IB. Evaluation of components of gingival crevicular fluid as diagnostic tests. Ann Periodontol 1997; 2: 123-137.
9. Lamster IB, Ahlo JK. Analysis of gingival crevicular fluid as applied to the diagnosis of oral and systemic diseases. Ann N Y Acad Sci 2007; 1098: 16-229.
10. Lamster IB, Mandella RD, Zove SM, Harper DS. The polyamines putrescine, spermidine and spermine in human gingival crevicular fluid. Arch Oral Biol 1987; 32: 329-333.
11. Sharma CG, Pradeep AR. Gingival crevicular fluid osteopontin levels in periodontal health and disease. J Periodontol 2006; 77: 1674-1680.
12. Frodge BD, Ebersole JL, Kryscio RJ, Thomas MV, Miller CS. Bone remodeling biomarkers of periodontal disease in saliva. J Periodontol 2008; 79: 1913-1919.
13. Golub LM, Lee HM, Stoner JA, et al. Subantimicrobialdose doxycycline modulates gingival crevicular fluid biomarkers of periodontitis in postmenopausal osteopenic women. J Periodontol 2008; 79: 1409-1418.
14. Pradeep AR, Raj S, Aruna G, Chowdhry S. Gingival crevicular fluid and plasma levels of neuropeptide Substance-P in periodontal health, disease and after nonsurgical therapy. J Periodontal Res 2009; 44: 232-237.
15. Pradeep AR, Daisy H, Hadge P. Gingival crevicular fluid levels of monocyte chemoattractant protein-1 in periodontal health and disease. Arch Oral Biol 2009; 54: 503-509.
16. Thaweboon B, Laohapand P, Amornchat C, et al. Host beta-globin gene fragments in crevicular fluid as a biomarker in periodontal health and disease. J Periodontol Res 2010; 45: 38-44.
17. Prapulla DV, Sujatha PB, Pradeep AR. Gingival crevicular fluid VEGF levels in periodontal health and disease. J Periodontol 2007; 78: 1783-1787.
18. Barnes VM, Teles R, Trivedi HM, et al. Acceleration of purine degradation by periodontal diseases. J Dent Res 2009; 88: 851-855.
19. Evans AM, Dehaven CD, Barrett T, Mitchell M, Milgram E. Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems. Anal Chem 2009; 81: 6656-6667
20. Panagakos FS, Volpe AR, Petrone ME, DeVizio W, Davies RM, Proskin HM. Advanced oral antibacterial/anti-inflammatory technology: A comprehensive review of the clinical benefits of a triclosan/copolymer/fluoride dentifrice. J Clin Dent 2005; 16 (Suppl.): S1-S19.
21. Blinkhorn A, Bartold PM, Cullinan MP, et al. Is there a role for triclosan/copolymer toothpaste in the management of periodontal disease? Br Dent J 2009; 207: 117-125.
22. Bruhn G, Netuschil L, Richter S, Brecx M, Hoffmann T. Effect of a toothpaste containing triclosan on dental plaque, gingivitis, and bleeding on probing-An investigation in periodontitis patients over 28 weeks. Clin Oral Investig 2002; 6: 124-127.
23. Davies RM. The clinical efficacy of triclosan/copolymer and other common therapeutic approaches to periodontal health. Clin Microbiol Infect 2007; 13 (Suppl. 4): S25-S29.
24. Vered Y, Zini A, Mann J, et al. Comparison of a dentifrice containing 0.243% sodiumfluoride, 0.3% triclosan, and 2.0% copolymer in a silica base, and a dentifrice containing 0.243% sodium fluoride in a silica base: A three-year clinical trial of root caries and dental crowns among adults. J Clin Dent 2009; 20: 62-65.