Virusinfections of the respiratory tract in horses - Etiology, epidemiology, clinical manfestation,vaccination and defense - Part 1: Equine Influenza and Equine Herpesviruses;Virusinfektionen der Atemwege des Pferdes - Ätiologie, Epidemiologie, Kilnik Immunpräventive - Tell 1: Equine Influenzaviren Equine Herpesviren

Pferdeheilkunde

Volumn 28, Issue 6, 2012, Pages 675-696

  Thein, Peter ^a  

^a Fachtierarzt für Mikrobiologie   (Germany)

Author keywords

Clinical manifestation; Diagnostic; EHV2; EHV4; EHV5; Epidemiology; Equine Herpesviruses (EHV) EHV1; Equine Influenza A Viruses (H7 N7, H3 N8); Pathogenesis; Respiratory tract infections; Vaccinations; national international programmes of control and prevention

Indexed keywords

EID: 84869758164     PISSN: 01777726     EISSN: None     Source Type: Journal    
DOI: 10.21836/pem20120606     Document Type: Article

References (131)

1. Agius C. T, Nagesha H. S. and Studded M. J. (1992) Equine herpesvirus 5: comparison with EHV2 (equine cytomegalovirus), cloning, and mopping of a new equine herpesvirus with novel genome structure. Virology 191, 176-186
2. Agius C. T. und Studdert M. J. (1994) Equine herpesvirus 2 and 5: comparison with other members of the subfamily gammaherpesvirinoe. Adv. Virus Res. 44, 357-379
3. Allen G. P. Yeragen M. R.,Turtinen W., Byans L. T. und McCollum W. H. (1983) Moleculor epizootiologic studies of equine herpevirus 1 infections by restriction endonucleose fingerprinting of viral DNA. Am. J. Vet. Med. Res. 44, 263-27 1
4. Allen G. P. (2002) Respiratory infections by Equine Herpesvirus Types 1 and 4 Equine Respirotory Diseases, Intern. Vet. Info. Service, Ithaca, New York
5. Allen G. P., Kyddi. H., Slater. D. und Smith K. C. (2004) Equid herpesvirus 1 and equid herpesvirus 4 infections Inf. Dis. Livest., Oxford Press, Chapter 76, 829- 859
6. Ataseven V S., Bilge-Dagai S., Oguzaglu P T C, KarapinarZ., Güzel M. und Ton M. T. (2010) Detection and sequence analysis of equine gammaherpesvirus from horses with respiratory disease in Turkey. Transround. Emerg. Dis. 57, 271-276
7. Bagust T J., Pascac R. R. und Harden T J. (1972) Studies of equine herpesviruses. 3. The incidence iii Queensland of three different equine herpesvirus infections. Aust. Vet. J. 48, 4 7-53
8. Borquero N., Daly J. M. und Newton J. R. (2007) Risk factors for influenza infection in vaccinated racehorses: lessions from an outbreak in Newmorket, UK in 2003. Vaccine 25, 7520-7529
9. Bean B., Moore B. M.,Stemer B., Peterson L. R., Gerding D. N. Baifour H. H. Jr (1982) Survival of influenza viruses on environmental surface. J. Infect. Dis. 14, 47-51 (Pubitemid 12045334)
10. Belok S., Palfl V. Tuboly S. und Bortha L. (1980) Passive immunization of foals to prevent respiratory disease caused by equine herpesvirus type 2. Zentralbl. Veterinörmed. Reihe B 27, 826-830
11. Borchers K., Walfinger U., Goltz M., Broil H. Ludwig H. (1997) Distribution and relevance of equine herpesvirus type 2 (EHV-2) infections. Arch. Virol. 142, 917-928 (Pubitemid 27218414)
12. Borchers K., Wolfinger U., Ludwig H., Thein P., Boxi S., Field H. J. und Slateri. D. (1998) Virological and molecular biological investigations into equine herpesirus type 2 (EHV-2) experimental infections. Virus Res. 55, 10-16
13. Borchers K.(1998) lnfektionen mit Equinen Herpesviren des Typs 1, 2, und 5: Verbreitung, Pathogenese, lmmunontwort und Latenz. Virologische, molekulorbiologische, histologische und immunologische Studien an experimentell und natOrlich infizierten Tieren. Vet. Med. Habilschrift, Fachbereich Virologie, FU Berlin.
14. Borchers K., Thein P Sterner-Kock A. (2006) Pathogenesis of equine herpesvirus - associated neurological disease: a revised explanation. Equine Vet. J. 38, 283-287 (Pubitemid 44440895)
15. Breathnoth C. C., Yeargan M. R., Shoron A. S. Alien G. P. (2001) The mucosal humoral immune response of the horse challenge and vaccination with Equine- herpesvirus- 1 antigens. Equine Vet. J. 33, 651-657 (Pubitemid 33640023)
16. Bryant N. A., Rush A. S.,Russell C. A., Ross J., Cooke A., Bowman S. MacRae S., Lewis N. S., Paillat R. Zanoni R., Meier H., Griffith L. A., Daly J. M., liwarl A., Chambers T. M., Newton J. R. und Elton D. M. (2009) Antigenic and genetic variations in European and North American equine influenza virus strains (H3N8) isolated from 2006 to 2007. Vet Microbiol. 138, 41-52
17. Bryant N. A., Paillot R., Rash A. S., Medcalf E., Montesso F, Ross J., Watson I, Jeggo M., Lewis N. S., Newton J. R. und Elton D. M. (2010) Comparison of two modern vaccines and previous influenza infection against challenge with an equine influenza virus from the Australian 2007 outbreak. Vet. Res. 41, 19
18. Bürki F. (1987) Rhinopneumonitis vaccination - an unsettled problem. XIII World Vet. Conf., Montreal, Canada, Section XI
19. Bürki F, Skenec J., Nowotny N., Reichler R., Ruso O. und Lussy H. (1991) Zur Ätiologie der epidemischen Pferdeinfluenza von 1989/90 - Schutzwert von Marktimpfstoffen und geübte lmpfpraxis. Wien. Tierärztl. Mschr. 78, 237-246
20. Callinan I. (2008) The August 2007 Outbreak in Australia. Commonwealth of Australia. Available from:
21. Cathcart M.P. und Murcia P R. (2012) Hide and seek. Diagnosing equine viral diseases using molecular biological techniques. Equine Vet. J. 44, 379-381
22. Chambers T. M., Shortrige K. F, Li. P H., Powell D. G. and Watkins K.W (1994) Rapid diagnosis of equine influenza by Directgen FLU-A enzyme immunoassay Vet. Rec. 135, 275-279 (Pubitemid 24287849)
23. Chester PM., Ailsop R., Purewal, A und Edington N. (1997) Detection of latency- associated transcripts of equid herpesvirus 1 in equine leucocytes but not in trigeminal ganglia. J. Virol. 71, 3437-3443
24. Cullinane A., Weld J., Osborne M., Nelly M. und McBride C. (1994) The interference of maternal antibodies with the immune response of thoroughbred foals and yearlings to vaccination against equine influenza. Equine lnf. Dis. VII, 240-244
25. Cullinane A., Weld J., Osborne M., Nelly M., McBride C. Walsh C. (2001) Field studies on equine influenza vaccination regimes in thoroughbred foals and yearlings. Vet. J. 161, 174-185 (Pubitemid 32532173)
26. Cullinane A. (2009) Equine Influenza - A constantly evolving challenge. Equine Vet. Educ. 8, 1-7
27. Cullinane A., Elton D. und Mumford J. (2010) Equine influenza - surveillance and control. Influenza Resp. Virus. 4, 339-344
28. Daly J. M., Lai A. C., Binns M. M., Chambers T M. Borrandeguy M. Mumford J. A. (1996) Antigenic and genetic evolution of equine H3N8 influenza A viruses. J. Gen. Virol. 77, 661-671 (Pubitemid 26121798)
29. Daly J. M., Yates R. J., Browse G., Swann Z., Newton J. R., Jesselt D., Davis -Poynter N. und Mumford J. A. (2003) Comparison of hamster and pony challenge models for evaluation of effect of antigenic drift on cross protection afforded by equine influenza vaccines. Equine Vet. J. 35, 458-462 (Pubitemid 38698707)
30. Daly J. M., Newton J. R. und Mumford J. A. (2004) Current perspectives on control of equine influenza. Vet. Res. 35, 411-423 (Pubitemid 39161931)
31. Daly J. M., Newton J. R., Smith K. C. und Mumford J. A. (2006) Epidemiology of equine influenza viruses: pathogenicity and transmissibility. Rod. Med. Sci. 30, 87-94
32. Daly J., Daas A. und Behr-Gross M. E. (2007) Collaborative study for the establishment of a candidate equine influenza subtype 2 American-like strain AJEQ/South Africo/4/03 horse antiserum biological reference preparation. Pharmaeuropa Bio., 7-14
33. Doll E. und Bryans J. (1963) A planned infection programme for immunizing mares against viral rhinopneumonitis. Cornell Vet. 53, 249-253
34. Drummer H. E., Reubel G. H. Studdert M. J. (1996) Equine gammaherpesvirus 2 (EHV2) is latent in B lymphocytes. Arch. Virol. 141, 495-504 (Pubitemid 126706511)
35. Dunawska M., Meers J. und Wilks C. R. (1999) Isolation of equine herpesviws type 5 in New Zealand. N Z Vet. J., 47 (2), 44-46
36. Edington N. and Bridges C. (1990) One way protection between equid herpesvirus 1 and 4 in vivo. Res. Vet. Sci. 48, 235-239
37. Edington N., Welch H. M. und Griffiths L. (1994) The prevalence of latent Equid herpesvirus in the tissues of 40 abattoir horses. Equine Vet. J. 26, 140-142
38. Floer W, von Lepeli. D., Merkt H. und Petzold K. (1972) Exantheme bei herpesviwsinfizierten Pferden. Dtsch. Tierörztl. Wschr. 79, 97-101
39. Floer W, Schmidt R. und Petzold K. (1973) Mikrobiologische Untersuchungen zur Frage der Herpesvirusinfektion des oberen Respirationstraktes des Pferdes. Dtsch. Tierärztl. Wschr. 80, 49-53
40. Folson R. W, Littlefield-Chobaud M. A., French D. O. und Purcian S. S. (2001) Exercise alters the immune response to equine influenza virus and increased susceptibility to infection. Equine Vet. J. 33, 664-669
41. Fortier G., Pronost S., Miszczak F, Fortier C., Leon A., Richard E., Van Erck E., Thiry E. und Lekeux P (2009) Identification of equid herpesvirus -5 in respiratory liquids: a retrospective study of 785 samples taken in 2006-2007. Vet. J. 182, 346-348
42. Garner M. G., Cowled B., East I. J., Moloney B. J. und Kung N. Y. (2011) Evaluatind the effectiveness of early vaccination in the control and eradication of equine influneza-a modelling aproach. Prey. Vet. Med. 99, 15-27
43. Gildeo S. (2011) Equine influenza virus: Characterisation, epidemiology and vaccination. PHD-Thesis, University of Limerick, Ireland
44. Goerlich P (1988) Serologische Untersuchungen auf Virus- Antikörper bei Atemwegserkrankungen des Pferdes. Vet. Med. Diss. GieBen
45. Gross D. K., Hinchcliff K. W, French P 5., Goclan S. A., Lahmers K.K., Lauderdale M., Ellis J. A., Homes D. M., Slemons R. D. Morley P 5. (1998) Effect of moderate exercise on the severity of clinical signs associated with influenza virus infection in horses. Equine Vet. J. 30, 489-497 (Pubitemid 128527084)
46. Guthrie A. J., Stevens K. B. Bosman P P (1999) The circumstances surroing the outbreak and spread of equine influenza in South Africa. Rev. Sci. Tech. 18, 179-185 (Pubitemid 129335810)
47. Hannant D., Mumford J. A. and Jesset D. M. (1988) Duration of circulating antibody and immunity following infection with equine influenza virus. Vet. Rec. 122, 125-128
48. Hannant D., O'Neill T, Ostlund E. N., Kydd J. H., Hopkin P J. und Mumfordi. A. (1996) Equid herpesvirus induced immunosuppression is associated with lymphoid cells and not circulating antigen/immune complexes. 35th British Equ. Vet. Conf., University of Warwick, 48
49. Heldens J., Hannant D., Cullinane A., Predergast M. J., Mumford J. A., Nelly N., Kydd J. H., Westrate M. W. von den Hoven R. (2001) Clinical and virological evaluation of the efficacy of an inactivated EHV1 and EHV4 whole virus vaccine (Duvaxyn EHV1/4). Vaccination/Challenge experiments in foals and pregnant mares. Vaccine 19, 4307-4317 (Pubitemid 32703653)
50. Heldens J. G., Pouwels H. G., Derks C. G., Van de Zande S. M. und Hoeijmakers M. J. (2009) The first safe inactivated equine influenza vaccine formulation adjuvanted with ISCOM-Matrix that closes the immunity gap. Vaccine, 27, 5530-5537
51. Heldens J. G., Pouwels H. G., Derks C. G., Van de Zande S. M. und Hoeijmakers M. J. (2010) Duration of immunity induced by an equine influenza and tetanus combination vaccine formulation adjuvanted with ISCOM- Matrix. Voccine, 28, 6989-6996
52. Holmes M. A., Townsend H. G., Kohler A. K., Hussey S. Breathnach C., Barnett C., Holland R.und Lunn D. P. (2006) Immune response to commercial equine vaccine against herpesvirus- 1, equine influneza virus, eastern equine encephalomyelitis, and tetanus. Vet. Immunol. Immunopothol. 15, 111, 67-80
53. Jensen-Waem M., Persson S. G., Nordengrahn A., Merza M. Possum C. (1998) Temporary suppression of cell-mediated immunity in standardbred horses with decreased athletic capacity. Acta. Vet. Scand. 39, 25-33 (Pubitemid 128521913)
54. Jirjis F F, Deshpande M. S., Tubbs A.L., Jayappa H., Lakshmanen A. und Wasmoen T L. (2910) Transmission of canine influenza virus (H3/N8) among susceptible dogs. Vet. Microbial. 144, 303- 309
55. Kershaw O. (2001) Dos equine Herpesvirus Typ 2: Pathogenese-, Gewebeiropismus- und Latenzstudien unter besonderer BerOcksichtigung der Keratokonjunktivitis beim Pferd. Med. Vet. Diss. Berlin
56. Kershaw O., von Oppen T, Glitz F, Deegen E., Ludwig H. Borchers B. (2001) Detection of equine herpesvirus type 2 (EHV-2) in horses with keratoconjunctivitis. Virus Research 80, 93-99 (Pubitemid 32971947)
57. Kydd J. H., Smith K. C., Hannot D., Livesay G. und Mumford J. A. (1994) Distribution of Equid herpesvirus-1 (EHV-1) in respiratory tract associated lymphoid tissue implications for cellular immunity. Equine Vet. J. 26, 470-473
58. Kydd J. H., Townsend H. G. und Hannant D. (2006) The equine immune response to equine herpesvirus-1: the virus ond its vaccines. Vet. Immunol. Immunopathol. 15, 111, 15-30
59. Lange C. (2005) Prufung von lnfluenzaimpfstoffen an jungen Pferden. Vet. Med. Diss. Bern
60. Lange W (2007) Pferde- Influenza, Virologie, Epidemiologie, Klinik, Therapie und Prophylaxe 2. AufI., W. Longe Hrsgb., MVS- Medizinverlag Stuttgart
61. Liu K., Pascoe D. R., Chang L. W und Zee Y C. (1995) Duration of maternally derived antibodies against influenza in newborn foals. Am. J. Vet. Res. 46, 2078- 2080
62. Ludwig H., Thein P und Chowdury S. J. (1988) Herpesvirus infections of equine animals,Virus Dis. In Lab. And Capt. Animals, Ed. G. Darai, Martinus Nijhoff Publishers, Boston
63. Lunn D. P. Holmers M. A., Kydd J. H., Gibson J. S. and Field H. J. (1991) Haematological and lymphocyte subset changes during primary EHV1 -infection in specific pathogen free foals. Sixth mt. Conf.Equ. Int. Dis., 7-1 1-July 1991, 95
64. Van Maanen C., Bruin G. De Boer- Luutze G., Smolders G. und De Boer G. F (1992) Interference of maternal antibodies with the immuneresponse of foals after vaccination against equine influenza.Vet. 14, 13-17
65. Mager F. (2012) Der Lebendimpfstoff gegen Herpes. Prakt. Tierarzt, 93, 758
66. Marenzoni M. L., Coppola G., Maranesi M., Passamonti F, Coppelli K., Capomaccio S., Verini Supplizi A., Thiry E. und Colelti M. (2010) Age-dependent prevalence of equid herpesvirus 5 infection. Vet. Res.Com. 34, 703-708
67. Matsumara T, Sugiura T, Imagana H., Fukunasa Y. und Kamada M. (1991) Differences in age and seasonal distribution between equine herpesvirus 1 - and 4-infection among horse populations in Japan. Sixth Int. Conf. Equ. lnf. Dis., 7-11 July 1991, 100
68. Matthews A. G. und Handscombe M. C. (1983) Superficial keratitis in the horse: treatment with the antiviral drug idoxuridine. Equine Vet. J. Suppl. 2, 138-140
69. Miller W C. (1965) Equine Influenza. Further Observations on the,Coughing" Outbreak 1965. Vet. Rec. 77, 455-456
70. Miller T R., Goskin J. M., Whitley R. D. und Wittcoff M. L. (1990) Herpetic keratitis in a horse. Equine Vet. J. Suppl. 15-17
71. Minke J. M., Fischer L., Baudu P., Guigol P, Sindle T, Mumford J. A. und Audonneti. C. (2006) Use of DNA and recombinant canarypox viral (ALVAC) vectors for equine herpes virus vaccination. Vet. Immunol. lmmunopathol. 15, 111, 47-57
72. Minke J. M., Toulemonde C. E., Coupier H., Guigal PM., Di S., Sindle T, Jesselt D., Block L., Bublot M., Pordo M. C. Audonnet J. C. (2007) Efficacy of a canarypox- vectored recombinant vaccine expressing the hemagglutinin gene of equine influenza H3N8 virus in the protection of ponies from viral challenge. Am. J. Vet. Res. 68, 213-219 (Pubitemid 46358701)
73. Mumford J. A., Hannant D. und Jesset D. M.D(1990) Experimental infection of ponies with equine influenza (H3N8) viruses by intranasal inoculation or exposure to aerosols. Equine Vet. J. 22, 93-98
74. Mumford J. A. und Wood J. (1992) Establishing an acceptability thresold for equine influenza vaccines. Dev. Biol. Stand. 79, 137-146
75. Mumford J. A., Jesselt D., Dunleavy U., Wood J., Hannant D., SuDdquist B. and Cook R. F. (1994) Antigenicity and immunogenicity of experimantal equine influenza ISCOM vaccines. Vaccine, 12, 857-863 (Pubitemid 24190569)
76. Mumford J. A. (2001) Biology, epidemiology and vaccinology of equine influenza. Proceedings of the International Symposium, Budapest, 10-11 Dezember 2001
77. Murray J. R., Eichhorn E. S., Dubovi E. J., Ley W B. und Covey D. M. (1996) Equine herpesvirus type 2: prevalence and seroepidemiology in foals. Equine Vet. J. 28, 432-443
78. Newton J. R., Verheyen K., Wood I L., Yates P J. Mumford J. A. (1999) Equine influenza in the United Kingdom in 1998. Vet. Rec. 145, 449-452 (Pubitemid 29486076)
79. Newtoni. R., Townsend H. G., Wood J. L., SinclairR., HannatD. und Mumfordi. A. (2000) Immunity to equine influenza: relationship of vaccine-induced antibody in young thoroughbred racehorses to protection against field infection with influenza Ajequine-2 viruses (H3/N8). Equine Vet. J. 32, 65-74
80. Newton J. R., Daly J. M., Spencer L. and Mumford J. A. (2006) Description of the outbreak of equine influenza (H3/N8) in the United Kingdom in 2003, during which recently vaccinated horses in New- market developed respiratory diseases. Vet. Rec. 158, 185-192 (Pubitemid 43263756)
81. Nordengrahn A., Rusval M., Mersa M., Ekstrom J., Morein B. und Belok S. (1996) Equine herpesvirus type 2 as a predisposing factor for Rhodococcus equi pneumonia in foals: prevention of the bifactoral disease with EHV-2 immunostimulating complexes. Vet. Microbiol. 51, 56-68
82. O.I.E. (2008) Equine Influenza. O.I.E. Terrestrial Manual, Chapter 2.5.7., 87 1-883
83. O.I.E. (2008) Equine Rhinopneuminitis. O.I.E. Terrestrial Manual, Chapter 2.5.9., 894-903
84. Van Oirschot J. T., Bruin G., de Boer L. und Smolders (1991) Mate rnal antibodies against equine influenza virus in foals and their interference with vaccination. J. Vet. Med. Series B, 38, 391-396
85. Paillot R., Kydd J. H., Sindle T Hannat D., Edl Toulemonde C., Audonnet J., Minke J. M. Daly J. M (2006) Antibody and IFNgamma responses induced by a recombinant canarypox vaccine and challenge infections with equine influenza virus. Vet Immunol Immunopathol 112, 225-233 (Pubitemid 43996860)
86. Paillot R., Hannant D., Kyddi. H. und Daly J. M. (2006a) Vaccination against equine influneza: Quid novi? Vaccine 24, 404 7-4061
87. Paillot R., Ellis S. A., Daly J. M., Audonnet J. C., Minke J. M., DavisPoynterN., HannantD. und Kyddi. H. (2006) Charocterisation of CTL and IFN- gamma synthesis in ponies following vaccination with a NYVAC- based construct coding for EHV-1 immidiate early gene, followed by challenge infection. Vaccine 6, 1490-500 (Pubitemid 43238223)
88. Paillot R., Grimmet H., Elton D. and Daly J. M. (2008) Protection, systemic IFNgamma, and antibody responses induced by an ISOM- based vaccine against a recent equine influenza virus in its natural host. Vet. Res. 39, 21-26
89. Paillot R., Prowse L., Donald C., Medcalf E., Montesso F, Bryant N., Watson I, Jeggo M., Elton D., Newton R., Trail P. und Barnes H. (2010) Efficacy of a whole inactivated El vaccine against a recent EIV outbreak isolate and comparative detection of virus shedding. Vet. Immunol. Immunopathol. 136, 272-283
90. Palfi V. Belak S. und Molnar T (1978) Isolation of equine herpesvirus type 2 from foals, showing respiratory symptoms. Zentralbl. Verterinarmed. Reihe B 25, 165-167
91. Park A. W, Woog J. L., Daly I M., Newton J. R., Glass K., Henley W, MumfordJ. A. und Gren fell B. T (2004) The effect of strain heterology on the epidemiology of equine influenza in a vaccinated population. Proc. Biol. Sd. 271, 1547-55 (Pubitemid 38998754)
92. Poth T, Niedermoler G. und Hermanns (2009) Equine multinodular pulmonary fibrosis in association with an EHV-5 infection in horses. Wien. Tierarztl. Monatsschr. 96, 203-208
93. Rode H. J., Janssen W, Rosen W A., Bugert J. J., Thein P. Becker Y und Dorai G. (1993) The genome of equine herpesvirus type 2 harbors an interleukin 10/ILl 0-like gene. Virus Genes 7, 111-116 (Pubitemid 23063276)
94. Sergeant E. S. G., Kirkland P D. und Cowled B. D. (2009) Field evaluation of an equine influenza ELISA used in New South Wales during the 2007 Australian outbreak response. Prey. Vet. Med. 92, 382-385
95. Steinboch F, Bocher K., Ricciardi-Costagnoli P, Ludwig H., Stingl G. und Elbe-Burger A. (1998) Dendritic cells presenting equine herpesvirus- antigens induce protective anti-viral immunity. J. Gen. Virol. 79, 3005-3014
96. Studdert M. J. (1974) Comparative aspects of equine herpesviruses. Cornell Vet. 64, 94-122
97. Telford E. A., Watson M. S., Aird H. C., Perry J. und Davison (1995) The DNA squence of equine herpesviruses-2 J. Mol. Biol. 249, 520-528
98. Thein P. und Bentele B. (1973) Seroepizootiologische Untersuchungen Ober die Verbreitung von Influenza A/Hongkong/1/68 und Ajequi2/ Miami 63-Infektionen in deutschen Pferdebeständen. Zentralbl. Vet. Med. B. 20, 85-93
99. Thein P (1974) Herpesvirus bedingte lnfektionen des Respirationstraktes beim Pferd. Gli Herpesvirus Degli Equini. Soc. Ital. De Sc. Vet., Vol) XXVIII, 50-55
100. Thein P (1974a) Schutzimpfung gegen Rhinopneumonitis unter besonderer Berücksichtigung der Virusausscheidung. Tierarztliche Umsch. 7, 363-372
101. Thein P (1976) Virusbedingte Keratitis beim Pferd. Fortschritte der Veterinärmedizin 25, 235-239
102. Thein P und Bähm D. (1976) Atiologie und Klinik einer virusbedingten Keratokonjuntivitis beim Fohien. Zentralbl. Veterinarmed. Reihe B 23, 507-519
103. Thein P und Hartl G. (1976) Untersuchungen zur Virusotiologie respiratorischer Erkrankungen des Pferdes. Praktischer Tierorzt Colleg. Vet. 57, 24-29
104. Thein P (1978) The association of EI-IV-2 infection with keratitis and research on the occurence of equine coital exanthema (EHV-3) of horses in Germany. In: Equine Infectious Disease IV, J. T. Bryans and H. Gerber (Eds), Veterinary Publications, Princeton, New Jersey, USA, pp.33-41
105. Thein P (1978a) lnfektionen der Atemwege des Pferdes und MOglichkeiten ihrer Bekampfung. Der prakt. Tierarzt 59, 733-740
106. Thein P. (1979) Experimentelle Untersuchungen Ober Reoviren beim Pferd. Vorkommen, Verbreitung, Klinik, Pathogenese, lnfektketten, Schutzimpfung. Vet. Med. Habil. München
107. Thein P, Eßich G. und Schulze Hockenbeck W (1983) Zur Atiologie von Fohlenerkrankungen. Tierarztl. Umsch. 38, 239-250
108. Thein P (1994) Therapieansätze bei lnfektionen mit Pferdeherpesviren. Der prakt. Tierorzt 9, 786-792
109. Thein P (1996) Herpesvirusinfektionen des Pferdes. In: Handlexikon der tierarztlichen Praxis, Enke Verlag, pp. 349-349ze
110. Thein P. und Huselstein P. (2000) Untersuchungen zur Stammvariabilität von Pferdeherpesviren des Typs EHV-4. Pferdeheilkunde 16, 5, 579-486
111. Thein P (2002) Vaccination and vaccination strategies against Equine Herpes Viruses. Intervet Symp. On Resp. Dis. In Horses 15-17 Oct., Sweden
112. Thein P. (2003) Wie impft man Fohien richtig? Tierärztl. Praxis 31 (G), 231-236
113. Thein P, Eßich G. und Rähm A. (2005) Fohlenerkrankungen und Fohlenverluste. Em Beitrag zur Ursache von Aborten im Zeitraum von 1972 bis 2002 im Haupt- und Landgestut Marbach an der Lauter. Tierarztl. Umsch. 60, 115-127 (Pubitemid 40459349)
114. Thein P (2006) Zur lnfektion des Pferdes mit Herpesviren. Vollblut, 2, 64-68
115. Thein P (2006a) Infektionen der Atemwege. Pferdehustenkomplex. Handbuch der Pferdepraxis, Hrgb. Dietz, D. ubnd B. Huskamp. 3. Auflage, Ferdinand Enke Verlag, Stuttgart, 349-352
116. Thein P. (2006b) Infektionskrankheiten der Atemwege. Pferdeinfluenza. Handbuch der Pferdepraxis, Hrgb. Dietz, D. und B. Huskamp. 3. Auflage, Ferdinand Enke Verlag, Stuttgart, 363-37 1
117. Thein P (2007) Schutzimpfungen beim Pferd. Der prakt. Tierorzt, ATF-Supplement, 3,88, 3-24
118. Thein P (2008) Die Influenza des Pferdes: Aktuelle Ubersicht. Duvaxyn lmpfstoffsymposium, Fort Dodge, Travernünde, 24.07.2008
119. Thein P (2012) Infektiose Aborte der Stuten-Atiologie, lmmunpraventive und Bekampfung. Pferdeheilkunde 28, 171-186
120. Tizardi. R. (1981) EinfOhrung in die veterinärmedizinische Immunologie. Pareys Studientexte 30, Paul Parey Verlag, Berlin und Hamburg
121. Townsend H. G., Penner S. J., Watts T C., Cook J., Haines D. M., Griffin S., Chambers T, Holland R. E., Whitoker-Dowling P, Younger J. S. und Sebring R. W. (2001) Efficacy of a cold-adapted, intranasal, equine influenza vaccine: challenge trails. Equine Vet. J. 33, 637-643 (Pubitemid 33640021)
122. Toulemonde C., Daly J., Smndle T, Guigal P M., Audonnet J. C. und Minke J. M. (2005) Efficacy of a recombinant equine influenza vaccine against challenge with American lineage H3N8 influenza virus responsible for the 2003 outbreak in the United Kingdom. Vet. Rec. 156, 367-371 (Pubitemid 40520859)
123. TurnerA. J. und Studded M. J. (1970) Equine herpesviruses. 3. Isolation and epizootiology of slowly cytopathic viruses and the serological incidence of equine rhinopneumonitis. Ausi. Vet. J. 46, 581-586
124. Vahlenkomp T W. (2011) Immunologie Hund Katze Pferd 01. 7-10
125. Vargo H.M., Bridges C.G., Lyon A.M., Griffith L. und Edington N. (1992) Latent herpesvirus 1 and 4 detection and distinction using the polymerase chain reaktion and co-cultivation from lymphoid tissue. J. Gen. Viral. 73, 261-268
126. Wilks C. R. und Studdert M. J. (1974) Equine herpesviruses. 5. Epizootiology of slowly cythopathic viruses in foals. Aust. Vet. J. 52, 199-203
127. Williams K. J., Maes R., Del Piero F, Wise A., Bolin D. C., Coswell J., Jackson C., Robinson N. E.,Derksen F, Scott M. A., Uha! B. D., Li X., Youssef S. A. und Balm S. R. (2007) Equine multinodular pulmary fibrosis: a newly recognized herpesvirus- associated fibrotic lung disease. Vet. Pathol. 44, 849-862 (Pubitemid 350260705)
128. Willough R., Ecker G., McKee S., Roddolls L., Vernaillen C., Dubovi E., Lein D., Mahony J. B., Chernesky M. und Nagy E. (1992) The effects of equine rhinovirus, influenza virus and herpesvirus infection on tracheal clearance rate in horses. Can. J. Vet. Res. 56, 115-121
129. Wilson W. D., Mihalyi J. E., Hussey S. und Lunn P D. (2001) Passive transfer of maternal antibodies against tetanus and influenza and their effect on the response of foals. Equine Vet. J. 33, 644-665
130. Wissing E. (1993) Vorkommen von Antikorpern gegen Equine Herpesviren, lnfluenzaviren, Reoviren, Equines Rhinovirus, Equines Arteritisvirus und Streptococcus equi in der deutschen Vollblutpopulation. Diss. Agr. Landw. Fakultot Rhein. Friedr. Wilh. Univ. Bonn
131. Wolfinger U. (1998) Verbreitung und Bedeutung von lnfektionen mit equinen Herpesviren vom Typ 1,2 und 4 (EHV-1-2-4) beim Pferd. Diss. Med. Vet. Berlin