Upscaling and in-line process monitoring via spectroscopic techniques of ethylene vinyl acetate hot-melt extruded formulations

International Journal of Pharmaceutics

Volumn 439, Issue 1-2, 2012, Pages 223-229

  Almeida, A ^a   Saerens, L ^a   De Beer, T ^a   Remon, J P ^a   Vervaet, C ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Ethylene vinyl acetate; Hot melt extrusion; NIR; Raman spectroscopy; Sustained release

Indexed keywords

ETHYLENE VINYL ACETATE COPOLYMER; METOPROLOL TARTRATE;

ARTICLE; COOLING; CRYSTALLIZATION; DRUG FORMULATION; DRUG MANUFACTURE; DRUG QUALITY; DRUG RELEASE; HOT MELT EXTRUSION; INFRARED SPECTROSCOPY; MELTING POINT; PRESSURE; PRIORITY JOURNAL; PROCESS MONITORING; RAMAN SPECTROMETRY; SCALE UP; SCREW SPEED; SOLID; TEMPERATURE; VELOCITY;

DRUG COMPOUNDING; HOT TEMPERATURE; METOPROLOL; POLYETHYLENE GLYCOLS; POLYVINYLS; SPECTROSCOPY, NEAR-INFRARED; SPECTRUM ANALYSIS, RAMAN;

EID: 84869496700     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.09.037     Document Type: Article

References (14)

1. A. Almeida, S. Possemiers, M.N. Boone, T. De Beer, T. Quinten, L. Van Hoorebeke, J.P. Remon, and C. Vervaet Ethylene vinyl acetate as matrix for oral sustained release dosage forms produced via hot-melt extrusion Eur. J. Pharm. Biopharm. 77 2011 297 305
2. A. Almeida, L. Brabant, F. Siepmann, T. De Beer, W. Bouquet, L. Van Hoorebeke, J. Siepmann, J.P. Remon, and C. Vervaet Sustained release from hot-melt extruded matrices based on ethylene vinyl acetate and polyethylene oxide Eur. J. Pharm. Biopharm. 2012 10.1016/j.ejpb.2012.08.008
3. T. De Beer, A. Burggraeve, M. Fonteyne, L. Saerens, J.P. Remon, and C. Vervaet Near infra red and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes Int. J. Pharm. 417 2010 32 47
4. L. Eriksson, P.L. Andersson, E. Johansson, and M. Tysklind Megavariate analysis of environmental QSAR data. Part I - a basic framework founded on principal component analysis (PCA), partial least squares (PLS), and statistical molecular design (SMD) Mol. Divers. 10 2006 169 186
5. D. Fischer, T. Bayer, K.J. Eichhorn, and M. Otto In-line process monitoring on polymer melts by NIR-spectroscopy Fresenius J. Anal. Chem. 359 1997 74 77
6. D.E. Honings Near Infra-red analysis Anal. Instrum. 14 1985 1 62
7. S. Jeung, and M.K. Mishra Hot melt reactive extrusion of chitosan with poly(acrylic acid) Int. J. Polym. Mater. 60 2010 102 113
8. H. Potente Existing scale-up rules for single-screw plasticating extruders Int. Polym. Proc. 6 1991 267 278
9. C. Rauwendaal Polymer Extrusion 2001 Hanser Gardner Publishers Cincinnati, OH
10. L. Saerens, L. Dierickx, B. Lenain, C. Vervaet, J.P. Remon, and T. De Beer Raman spectroscopy for the in-line polymer-drug quantification and solid state characterization during a pharmaceutical hot-melt extrusion process Eur. J. Pharm. Biopharm. 77 2011 158 163
11. L. Saerens, L. Dierickx, T. Quinten, P. Adriaensens, R. Carleer, C. Vervaet, and J.P. Remon In-line NIR spectroscopy for the understanding of polymer-drug interaction during pharmaceutical hot-melt extrusion Eur. J. Pharm. Biopharm. 81 2012 230 237
12. M. Shimoyama, H. Maeda, K. Matsukawa, H. Inoue, T. Ninomiya, and Y. Ozaki Discrimination of ethylene vinyl acetate copolymers with different composition and prediction of the vinyl acetate content in the copolymers using Fourier-transform Raman spectroscopy and multivariate data analysis Vib. Spectrosc. 14 1997 253 259
13. G. Socrates Infrared and Raman Characteristic Group Frequencies: Tables and Charts third ed. 2001 John Wiley and Sons Ltd. UK
14. L.S.C.L. Weyner Handbook of Vibrational Spectroscopy 2006 Wiley UK