Aspartic acid substitutions in monoamine oxidase-A reveal both catalytic-dependent and -independent influences on cell viability and proliferation

Journal of Neural Transmission

Volumn 119, Issue 11, 2012, Pages 1285-1294

  Wei, Zelan ^a   Satram Maharaj, Tamara ^a   Chaharyn, Bradley ^a   Kuski, Kelly ^a   Pennington, Paul R ^a   Cao, Xia ^a   Chlan, Jennifer ^b   Mousseau, Darrell D ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Akt; Alzheimer's disease; Cancer; Catalytic dead; Monoamine oxidase; P38 MAP kinase; P42 44; Parkinson's disease; Proliferation

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B; ASPARTIC ACID; BROXURIDINE; CALCIUM; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE 14; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM BINDING; CATALYSIS; CELL LINE; CELL PROLIFERATION; CELL VIABILITY; CYTOTOXICITY; DNA SYNTHESIS; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; ASPARTIC ACID; BCL-X PROTEIN; BROMODEOXYURIDINE; CALCIUM; CATALYSIS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; IMMUNOPRECIPITATION; MICE; MONOAMINE OXIDASE; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEUROBLASTOMA; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRIDINES; SEROTONIN; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; TRANSFECTION; TRITIUM;

EID: 84869492268     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-012-0779-x     Document Type: Article

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