Deriving an explicit hepatic clearance equation accounting for plasma protein binding and hepatocellular uptake

Toxicology in Vitro

Volumn 27, Issue 1, 2013, Pages 11-15

  Yoon, Miyoung ^a   Clewell, Harvey J ^a   Andersen, Melvin E ^a  

^a HAMNER INSTITUTES FOR HEALTH SCIENCES   (United States)

Author keywords

Active efflux rate constants; Dissociation association; Fraction unbound; Hepatic clearance; Plasma protein binding; Steady state equations

Indexed keywords

PLASMA PROTEIN;

ARTICLE; CELL TRANSPORT; COMPUTER PROGRAM; LIVER BLOOD FLOW; LIVER CELL; LIVER CLEARANCE; MATHEMATICAL COMPUTING; MEMBRANE TRANSPORT; PROTEIN BINDING; STEADY STATE;

BLOOD PROTEINS; LIVER; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PROTEIN BINDING;

EID: 84869462348     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2012.10.003     Document Type: Article

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