Hexane extract from Uncaria sinensis exhibits anti-apoptotic properties against glutamate-induced neurotoxicity in primary cultured cortical neurons

International Journal of Molecular Medicine

Volumn 30, Issue 6, 2012, Pages 1465-1472

  Jang, Ji Yeon ^a   Kim, Ha Neui ^a   Kim, Yu Ri ^a   Hong, Jin Woo ^a   Choi, Young Whan ^a   Choi, Yung Hyun ^b   Shin, Hwa Kyoung ^a   Choi, Byung Tae ^a  

^a Pusan National University   (South Korea)

^b Dong Eui University   (South Korea)

Author keywords

Bcl 2; Caspase; Cortical neurons; Death receptor 4; Glutamate; Uncaria sinensis; XIAP

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; DEATH RECEPTOR 4; GLUTAMIC ACID; HEXANE; LACTATE DEHYDROGENASE; PLANT EXTRACT; PROTEIN BCL 2; PROTEIN BID; UNCARIA SINENSIS EXTRACT; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CELL CULTURE; CELL DEATH; CELL STRUCTURE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME RELEASE; FETUS; FLOW CYTOMETRY; MEDICINAL PLANT; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; UNCARIA SINENSIS;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASES; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; ENZYME ACTIVATION; GLUTAMIC ACID; HEXANES; L-LACTATE DEHYDROGENASE; NEURONS; NEUROPROTECTIVE AGENTS; PLANT EXTRACTS; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; SOLVENTS; UNCARIA;

EID: 84869408322     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.1134     Document Type: Article

References (28)

1. Meldrum BS: Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 130 (Suppl 4): 1007S-1015S, 2000.
2. Coyle JT and Puttfarcken P: Oxidative stress, glutamate, and neurodegenerative disorders. Science 262: 689-695, 1993. (Pubitemid 23350687)
3. Nishizawa Y: Glutamate release and neuronal damage in ischemia. Life Sci 69: 369-381, 2001.
4. Stout AK, Raphael HM, Kanterewicz BI, Klann E and Reynolds IJ: Glutamate-induced neuron death requires mitochondrial calcium uptake. Nat Neurosci 5: 366-373, 1998.
5. Zhang Y and Bhavnani BR: Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release. BMC Neurosci 24: 6-13, 2005.
6. Atlante A, Calissano P, Bobba A, Azzariti A, Marra E and Passarella S: Cytochrome c is released from mitochondria in a reactive oxygen species (ROS)-dependent fashion and can operate as a ROS scavenger and as a respiratory substrate in cerebellar neurons undergoing excitotoxic death. J Biol Chem 47: 37159-37166, 2000. (Pubitemid 32002134)
7. Paschen W: Glutamate excitotoxicity in transient global cerebral ischemia. Acta Neurobiol Exp (Wars) 56: 313-322, 1996.
8. Hynd MR, Scott HL and Dodd PR: Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease. Neurochem Int 45: 583-595, 2004. (Pubitemid 38844879)
9. May PC and Gray PN: The mechanism of glutamate-induced degeneration of cultured Huntington's disease and control fibroblasts. J Neurol Sci 70: 101-112, 1985. (Pubitemid 15019904)
10. Lin YW and Hsieh CL: Oral Uncaria rhynchophylla (UR) reduces kainic acid-induced epileptic seizures and neuronal death accompanied by attenuating glial cell proliferation and S100B proteins in rats. J Ethnopharmacol 135: 313-320, 2011.
11. Kuramochi T, Chu J and Suga T: Gou-teng (from Uncaria rhynchophylla Miquel)-induced endothelium-dependent and -independent relaxations in the isolated rat aorta. Life Sci 26: 2061-2069, 1994. (Pubitemid 24193354)
12. Itoh T, Shimada Y and Terasawa K: Efficacy of Choto-san on vascular dementia and the protective effect of the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death. Mech Ageing Dev 111: 155-173, 1999.
13. Zhou J and Zhou S: Antihypertensive and neuroprotective activities of rhynchophylline: the role of rhynchophylline in neurotransmission and ion channel activity. J Ethnopharmacol 132: 15-27, 2010.
14. Suk K, Kim SY, Leem K, Kim YO, Park SY, Hur J, Baek J, Lee KJ, Zheng HZ and Kim H: Neuroprotection by methanol extract of Uncaria rhynchophylla against global cerebral ischemia in rats. Life Sci 70: 2467-2480, 2002. (Pubitemid 34267036)
15. Shimada Y, Goto H, Kogure T, Shibahara N, Sakakibara I, Sasaki H and Terasawa K: Protective effect of phenolic compounds isolated from the hooks and stems of Uncaria sinensis on glutamateinduced neuronal death. Am J Chin Med 29: 173-180, 2001. (Pubitemid 33775410)
16. Park SH, Kim JH, Park SJ, Bae SS, Choi YW, Hong JW, Choi BT and Shin HK: Protective effect of hexane extracts of Uncaria sinensis against photothrombotic ischemic injury in mice. J Ethnopharmacol 138: 774-779, 2011.
17. Brewer GJ, Torricelli JR, Evege EK and Price PJ: Optimized survival of hippocampal neurons in B27-supplemented Neurobasal, a new serum-free medium combination. J Neurosci Res 35: 567-576, 1993. (Pubitemid 23215708)
18. Nicotera P, Ankarcrona M, Bonfoco E, Orrenius S and Lipton SA: Neuronal necrosis and apoptosis: two distinct events induced by exposure to glutamate or oxidative stress. Adv Neurol 72: 95-101, 1997.
19. Fulda S and Debatin KM: Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene 25: 4798-4811, 2006. (Pubitemid 44187627)
20. Hirashima Y, Kurimoto M, Nogami K, Endo S, Saitoh M, Ohtani O, Nagata T, Muraguchi A and Takaku A: Correlation of glutamate-induced apoptosis with caspase activities in cultured rat cerebral cortical neurons. Brain Res 849: 109-118, 1999.
21. Lau A and Tymianski M: Glutamate receptors, neurotoxicity and neurodegeneration. Pflugers Arch 460: 525-542, 2010.
22. Shimada Y, Goto H, Itoh T, Sakakibara I, Kubo M, Sasaki H and Terasawa K: Evaluation of the protective effects of alkaloids isolated from the hooks and stems of Uncaria sinensis on glutamate-induced neuronal death in cultured cerebellar granule cells from rats. J Pharm Pharmacol 51: 715-722, 1999. (Pubitemid 29346714)
23. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA and Nicotera P: Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15: 961-973, 1995.
24. Huang Y, Erdmann N, Peng H, Zhao Y and Zheng J: The role of TNF related apoptosis-inducing ligand in neurodegenerative diseases. Cell Mol Immunol 2: 113-122, 2005.
25. Uberti D, Ferrari-Toninelli G, Bonini SA, Sarnico I, Benarese M, Pizzi M, Benussi L, Ghidoni R, Binetti G, Spano P, Facchetti F and Memo M: Blockade of the tumor necrosis factor-related apoptosis inducing ligand death receptor DR5 prevents betaamyloid neurotoxicity. Neuropsychopharmacology 4: 872-880, 2006.
26. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP and Wang X: Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275: 1129-1132, 1997. (Pubitemid 27097312)
27. Li XY, Liang J, Tang YB, Zhou JG and Guan YY: Ginsenoside Rd prevents glutamate-induced apoptosis in rat cortical neurons. Clin Exp Pharmacol Physiol 37: 199-204, 2010.
28. Wang X, Zhu G, Yang S, Wang X, Cheng H, Wang F, Li X and Li Q: Paeonol prevents excitotoxicity in rat pheochromocytoma PC12 cells via downregulation of ERK activation and inhibition of apoptosis. Planta Med 77: 1695-1701, 2011.