Scatter spectroscopic imaging distinguishes between breast pathologies in tissues relevant to surgical margin assessment

Clinical Cancer Research

Volumn 18, Issue 22, 2012, Pages 6315-6325

  Laughney, Ashley M ^a   Krishnaswamy, Venkataramanan ^a   Rizzo, Elizabeth J ^b   Schwab, Mary C ^b   Barth, Richard J ^b   Pogue, Brian W ^a,b,c   Paulsen, Keith D ^a,b   Wells, Wendy A ^b  

^a DARTMOUTH COLLEGE   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c DARTMOUTH COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BENIGN TUMOR; BREAST CANCER; CANCER TISSUE; CLINICAL ASSESSMENT; CLINICAL FEATURE; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; LIGHT SCATTERING; MICROSCOPE IMAGE; PARTIAL MASTECTOMY; PREDICTIVE VALUE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SENSITIVITY AND SPECIFICITY; SPECTROSCOPY;

BREAST NEOPLASMS; CARCINOMA, INTRADUCTAL, NONINFILTRATING; FEMALE; HUMANS; LASERS; LIGHT; LINEAR MODELS; MASTECTOMY, SEGMENTAL; ROC CURVE; SCATTERING, RADIATION; SPECTRUM ANALYSIS;

EID: 84869236299     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-12-0136     Document Type: Article

References (58)

1. Ferreiro J, Gisvold J, Bostwick D. Accuracy of frozen section diagnosis of mammographically detected breast biopsies; results of 1,490 consecutive cases. Am J Surg Path 1995;19:1267-71.
2. Tinnemans J, Wobbes T, Holland R. Mammographic and histopathologic correlation of non-palpable lesions of the breast and reliability of frozen section diagnosis. Surg Gynecol Obstet 1987;165:523-9. (Pubitemid 18005646)
3. Scopa CD, Aroukatos P, Tsamandas AC, Aletra C. Evaluation of margin status in lumpectomy specimens and residual breast carcinoma. Breast J 2006;12:150-3.
4. Schnitt SJ, Abner A, Gelman R, Connolly JL, Recht A, Duda RB, et al. The relationship between microscopic margins of resection and the risk of local recurrence in patients with breast cancer treated with breast-conserving surgery and radiation therapy. Cancer 1994;74:1746-51. (Pubitemid 24301829)
5. Spivack B, Khanna MM, Tafra L, Juillard G, Giuliano AE. Margin status and local recurrence after breast-conserving surgery. Arch Surg-Chicago 1994;129:952-6.
6. Krishnaswamy V, Laughney AM, Paulsen KD, Pogue BW. A scanning in situ spectroscopy platform for imaging morphological contrast in lumpectomy specimens. Opt Express. In press 2012.
7. Krishnaswamy V, Laughney AM, Paulsen KD, Pogue BW. Dark-field scanning in situ spectroscopy platform for broadband imaging of resected tissue. Opt Lett 2011;36:1911-3.
8. Kennedy S, Geradts J, Bydlon T, Brown JQ, Gallagher J, Junker M, et al. Optical breast cancer margin assessment: an observational study of the effects of tissue heterogeneity on optical contrast. Breast Cancer Res 2010;12:R91.
9. Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. New Engl J Med 2002;347:1227-32. (Pubitemid 35176241)
10. Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. New Engl J Med 2002;347:1233-41. (Pubitemid 35176242)
11. Gibson GR, Lesnikoski BA, Yoo J, Mott LA, Cady B, Barth RJ. A comparison of ink-directed and traditional whole-cavity re-excision for breast lumpectomy specimens with positive margins. Ann Surg Oncol 2001;8:693-704. (Pubitemid 32952483)
12. Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans E, et al. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005;366:2087-106.
13. Pleijhuis R, Graafland M, de Vries J, Bart J, de Jong J, van Dam G. Obtaining adequate surgical margins in breast-conserving therapy for patients with early-stage breast cancer: current modalities and future directions. Ann Surg Oncol 2009;16:2717-30.
14. Wazer DE, Dipetrillo T, Schmidtullrich R, Weld L, Smith TJ, Marchant DJ, et al. Factors influencing cosmetic outcome and complication risk after conservative surgery and radiotherapy for early-stage breast-carcinoma. J Clin Oncol 1992;10:356-63.
15. Olivotto IA, Rose MA, Osteen RT, Love S, Cady B, Silver B, et al. Late cosmetic outcome after conservative surgery and radiotherapy - analysis of causes of cosmetic failure. Int J Radiat Oncol Biol Phys 1989;17:747-53. (Pubitemid 19250527)
16. Laucirica R. Intraoperative assessment of the breast. Arch Pathol Lab Med 2005;129:1565-74.
17. Balch G, Mithani S, Simpson J, Kelley M. Accuracy of intraoperative gross examination of surgical margin status in women undergoing partial mastectomy for breast malignancy. Am J Surg 2005;71:22-7.
18. Wick MR, Mills SE. Evaluation of surgical margins in anatomic pathology: technical, conceptual, and clinical considerations. Semin Diagn Pathol 2002;19:207-18. (Pubitemid 35365267)
19. Saarela A, Paloneva T, Rissanen T, Kiminiemi H. Determinants of positive histologic margins and residual tumor after lumpectomy for early breast cancer: a prospective study with special reference to touch preparation cytology. J Surg Oncol 1997;66.
20. Cao D, Lin C, Woo S, Vang R, Tsnagaris T, Argani P. Separate cavity margin sampling at the time of initial breast lumpectomy significantly reduced the need for re-excisions. Am J Surg Path 2005;29.
21. Brown J, Wilke L, Geradts J, Kennedy S, Palmer G, Ramanujam N. Quantitative optical spectroscopy: a robust tool for direct measurement of breast cancer vascular oxygenation and total hemoglobin content in vivo. Cancer Res 2009;69:2919-26.
22. Bigio I, Bown S, Briggs G, Kelley C, Lakhani S, Pickard D, et al. Diagnosis of breast cancer using elastic-scattering spectroscopy: preliminary clinical results. J Biomed Opt 2000;5:221-8.
23. van Veen RLP, Amelink A, Menke-Pluymers M, van der Pol C, Sterenborg H. Optical biopsy of breast tissue using differential path-length spectroscopy. Phys Med Biol 2005;50:2573-81.
24. Wilke L, Brown J, Bydlon T, Kennedy S, Richards L, Junker M, et al. Rapid non-invasive optical imaging of tissue composition in breast tumor margins. Am J Surg 2009;198:566-74.
25. Brown JQ, Bydlon TM, Kennedy SA, Richards L, Junker MS, Palmer GM, et al. Intraoperative optical breast tissue characterization device for tumor margin assessment. Cancer Res 2009;69:101s-101s.
26. Haka AS, Volynskaya Z, Gardecki JA, Nazemi J, Lyons J, Hicks D, et al. In vivo margin assessment during partial mastectomy breast surgery using Raman spectroscopy. Cancer Res 2006;66:3317-22.
27. Bydlon T, Kennedy S, Richards L, Brown J, Yu B, Junker M, et al. Performance metrics of an optical spectral imaging system for intraoperative assessment of breast tumor margins. Opt Express 2010;18:8058-76.
28. Yu C-C, Lau C, O'Donoghue G, Mirkovic J, McGee S, Galindo L, et al. Quantitative spectroscopic imaging for non-invasive early cancer detection. Opt Lett 2008;16:16227-39.
29. Krishnaswamy V, Hoopes PJ, Samkoe KS, O'Hara JA, Hasan T, Pogue BW. Quantitative imaging of scattering changes associated with epithelial proliferation, necrosis, and fibrosis in tumors using microsampling reflectance spectroscopy. J Biomed Opt 2009;14:014004.
30. Laughney AM, Krishnaswamy V, Garcia-Allende PB, Conde OM, Wells WA, Paulsen KD, et al. Automated classification of breast pathology using local measures of broadband reflectance. J Biomed Opt 2010;15:066019.
31. Keshtgar MRS, Chicken DW, Austwick MR, Somasundaram SK, Mosse CA, Zhu Y, et al. Optical scanning for rapid intraoperative diagnosis of sentinel node metastases in breast cancer. Brit J Surg 2010;97:1232-9.
32. Keller MD, Majumder SK, Mahadevan-Jansen A. Spatially offset Raman spectroscopy of layered soft tissues. Opt Lett 2009;34:926-8.
33. Nguyen F, Zysk A, Chaney E, Kotynek J, Oliphant U, Bellafiore F, et al. Intraoperative evaluation of breast tumor margins with optical coherence tomography. Cancer Res 2009;69:8790-6.
34. Ti Y, Lin W-C. Effects of probe contact pressure on in vivo optical spectroscopy. Opt Express 2008;16:4250-62. (Pubitemid 351434393)
35. Pogue BW, Burke G: Fiber-optic bundle design for quantitative fluorescence measurement from tissue. Appl Opt 1998;37:7429-36. (Pubitemid 128659489)
36. Vanstaveren HJ, Moes CJM, Vanmarle J, Prahl SA, Vangemert MJC. Light-scattering in intralipid-10-percent in the wavelength range of 400-1100 Nm. Appl Opt 1991;30:4507-14.
37. Backman V, Gopal V, Kalashnikov M, Badizadegan K, Gurjar R, Wax A, et al. Measuring cellular structure at submicrometer scale with light scattering spectroscopy. IEEE J Sel Top Quant Electr 2001;7:887-93. (Pubitemid 34191804)
38. Perelman LT, Backman V, Wallace M, Zonios G, Manoharan R, Nusrat A, et al. Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution. Phys Rev Lett 1998;80:627-30. (Pubitemid 128622229)
39. Subramanian H, Pradhan P, Liu Y, Capoglu IR, Li X, Rogers JD, et al. Optical methodology for detecting histologically unapparent nanoscale consequences of genetic alterations in biological cells. Proc Natl Acad Sci U S A 2008;105:20118-23.
40. Garcia-Allende PB, Krishnaswamy V, Hoopes PJ, Samkoe KS, Conde OM, Pogue BW. Automated identification of tumor microscopic morphology based on macroscopically measured scatter signatures. J Biomed Opt 2009;14:034034.
41. Edgerton ME, Chuang Y-L, Macklin P, Yang W, Bearer EL, Cristini V. A novel, patient-specific mathematical pathology approach for assessment of surgical volume: application to ductal carcinoma in situ of the breast. Anal Cell Pathol (Amsterdam) 2011;34:247-63.
42. Haralick RM, Shanmuga K, Dinstein I. Textural features for image classification. IEEE Syst Man Cyb 1973;SMC3:610-21.
43. PrattWK. Digital image processing: William K. Pratt. New York: Wiley; 1991.
44. Moisy F. boxcount. In., 1.10 edn: Matlab Central File Exchange; 2008.
45. Chaudhuri BB, Sarkar N. Texture segmentation using fractal dimension. IEEE Trans Patt Anal Mach Intell 1995;17:72-7.
46. Liebovitch LS, Toth T. A fast algorithm to determine fractal dimensions by box counting. Phys Lett A 1989;141:386-90.
47. Nachabe R, Evers DJ, Hendriks BHW, Lucassen GW, van der Voort M, Rutgers EJ, et al. Diagnosis of breast cancer using diffuse optical spectroscopy from 500 to 1600 nm: comparison of classification methods. J Biomed Opt 2011;16:087010.
48. Wallis S. Binomial distributions, probability and Wilson's confidence interval. University College London; 2009.
49. Ghosh N, Mohanty S, Majumder S, Gupta P. Measurement of optical transport properties of normal and malignant human breast tissue. Appl Opt 2001;40:176-84.
50. Palmer G, Zhu C, Breslin T, Xu F, Gilchrist K, Ramanujam N. Monte Carlo-based inverse model for calculating tissue optical properties. Part II: Application to breast cancer diagnosis. Appl Opt 2006;45:1072-8.
51. Subramanian H, Roy HK, Pradhan P, Goldberg MJ, Muldoon J, Brand RE, et al. Nanoscale cellular changes in field carcinogenesis detected by partial wave spectroscopy. Cancer Res 2009;69:5357-63.
52. Mirza NQ, Vlastos G, Meric F, Sahin AA, Singletary SE, Newman LA, et al. Ductal carcinoma-in situ: long-term results of breast-conserving therapy. Ann Surg Oncol 2000;7:656-64.
53. Goldstein NS, Kestin L, Vicini F. Intraductal carcinoma of the breast - pathologic features associated with local recurrence in patients treated with breast-conserving therapy. Am J Surg Pathol 2000;24:1058-67. (Pubitemid 30612827)
54. Bani MR, Lux MP, Heusinger K, Wenkel E, Magener A, Schulz-Wendtland R, et al. Factors correlating with reexcision after breast-conserving therapy. Eur J Surg Oncol 2009;35:32-7.
55. Gomez-Chova L, Calpe J, Camps-Valls G, Martín JD, Soria E, Vila J, et al. Feature selection of hyperspectral data through local correlation and SFFS for crop classification. IEEE Int Geosci Rem Sens Symp 2003;1:555-7.
56. Younes M. Frozen section of the gastrointestinal tract, appendix, and peritoneum. Arch Path Lab Med 2005;129:1558-64. (Pubitemid 41772629)
57. Wieder JA, Soloway MS. Incidence, etiology, location, prevention and treatment of positive surgical margins after radical prostatectomy for prostate cancer. J Urol 1998;160:299-315. (Pubitemid 29476668)
58. Abulafi AM, Williams NS. Local recurrence of colorectal cancer - the problem, mechanics, management and adjuvant therapy. Br J Surg 1994;81:7-19. (Pubitemid 24048923)