Differential expressions of microRNA between young and senescent endothelial cells

National Medical Journal of China

Volumn 92, Issue 31, 2012, Pages 2205-2209

  Zhang, Jun Bin ^a   Zhu, Xiao Nan ^b   Cui, Jin ^a   Chen, Peng ^a   Wang, Shen Ming ^a   Wang, Jin Song ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b NONE

Author keywords

Endothelial cells; ENOS; MicroRNA; Senescence

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; MICRORNA; MICRORNA 126; MICRORNA 135A; MICRORNA 182; MICRORNA 31; MICRORNA 335; MICRORNA 362; MICRORNA 96; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL AGING; CELL GROWTH; CONTROLLED STUDY; ENDOTHELIUM CELL; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

AGE FACTORS; ANIMALS; CELLS, CULTURED; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; MALE; MICE; MICE, INBRED C57BL; MICRORNAS; NITRIC OXIDE SYNTHASE TYPE III; TRANSFECTION;

EID: 84869235106     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2012.31.015     Document Type: Article

References (13)

1. Hoffmann J, Haendeler J, Aicher A, et al. Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide. Circ Res, 2001, 89: 709-715.
2. Peng X, Wang J, Lassance-Soares R M, et al. Gender differences affect blood flow recovery in a mouse model of hindlimb ischemia. Am J Physiol Heart Circ Physiol, 2011, 300: H2027-H2034.
3. Lahteenvuo J, Rosenzweig A. Effects of aging on angiogenesis. Circ Res, 2012, 110; 1252-1264.
4. Vazquez-Padron R I, Lasko D, Li S, et al. Aging exacerbates neointimal formation, and increases proliferation and reduces susceptibility to apoptosis of vascular smooth muscle cells in mice. J Vase Surg, 2004, 40: 1199-1207.
5. Urbich C, Kuehbacher A, Dimmeler S. Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res, 2008, 79: 581-588.
6. Förstermann U, Sessa W C. Nitric oxide synthases: regulation and function. Eur Heart J, 2012, 33: 829-837.
7. Chou T C, Yen M H, Li C Y, et al. Alterations of nitric oxide synthase expression with aging and hypertension in rats. Hypertension, 1998, 31: 643-648.
8. Zhang M X, Ou H, Shen Y H, et al. Regulation of endothelial nitric oxide synthase by small RNA. Proc Natl Acad Sci USA, 2005, 102: 16967-16972.
9. Bonauer A, Carmona G, Iwasaki M, et al. MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science, 2009, 324: 1710-1713.
10. Suárez Y, Fernández-Hernando C, Pober J S, et al. Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells. Circ Res, 2007,100: 1164-1173.
11. Stangl V, Lorenz M, Meiners S, et al. Long-term up-regulation of eNOS and improvement of endothelial function by inhibition of the ubiquitin-proteasome pathway. FASEB J, 2004, 18: 272-279.
12. Jin Y, Wu J, Songet X, et al. RTEF-1, an upstream gene of hypoxia-inducible factor-1 alpha, accelerates recovery from ischemia. J Biol Chem, 2011, 286: 22699-22705.
13. Appukuttan B, McFarland T J, Davieset M H, et al. Identification of novel alternatively spliced isoforms of RTEF-1 within human ocular vascular endothelial cells and murine retina. Invest Ophthalmol Vis Sci, 2007, 48: 3775-3782.