Bacterial resistance to antisense peptide phosphorodiamidate morpholino oligomers

Antimicrobial Agents and Chemotherapy

Volumn 56, Issue 12, 2012, Pages 6147-6153

  Puckett, Susan E ^a,c   Reese, Kaleb A ^a   Mitev, Georgi M ^a   Mullen, Valerie ^a   Johnson, Rudd C ^a   Pomraning, Kyle R ^a   Mellbye, Brett L ^a,b   Tilley, Lucas D ^b,d   Iversen, Patrick L ^b   Freitag, Michael ^a   Geller, Bruce L ^a,b  

^a OREGON STATE UNIVERSITY   (United States)

^b AVI BIOPHARMA INC   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

(ARGINYLPHENYLALANYL PHENYLALANINE) ARGININE 6 AMINOHEXANOIC ACID BETA ALANINE ACYL CARRIER PROTEIN; ACYL CARRIER PROTEIN; ANTIBIOTIC AGENT; MORPHOLINO OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; CELL DIVISION; ESCHERICHIA COLI; GENE INSERTION; GENE MUTATION; GENE SEQUENCE; MINIMUM INHIBITORY CONCENTRATION; MUTATION; NONHUMAN; PRIORITY JOURNAL;

ALLELES; ANTI-BACTERIAL AGENTS; BIOLOGICAL TRANSPORT; DNA TRANSPOSABLE ELEMENTS; DNA, ANTISENSE; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENETIC COMPLEMENTATION TEST; GENOME, BACTERIAL; LUCIFERASES; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; MORPHOLINES; ORGANOPHOSPHORUS COMPOUNDS; PEPTIDES; POLYMERS; SEQUENCE ANALYSIS, DNA;

EID: 84869234720     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00850-12     Document Type: Article

References (43)

1. Ausubel FM, et al. 1998. Current protocols in molecular biology. John Wiley & Sons, Inc, New York, NY.
2. Baba T, et al. 2006. Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol. Syst. Biol. 2:2006.0008. doi:10.1038/msb4100050.
3. Boucher HW, et al. 2009. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin. Infect. Dis. 48:1-12.
4. Campos MA, et al. 2004. Capsule polysaccharide mediates bacterial resistance to antimicrobial peptides. Infect. Immun. 72:7107-7114.
5. Clinical and Laboratory Standards Institute. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, p 10.2-10.3. Approved standard, 7th ed. Clinical and Laboratory Standards Institute, Wayne, PA.
6. Drake J, Charlesworth WB, Charlesworth D, Crow JF. 1998. Rates of spontaneous mutation. Genetics 148:1667-1686.
7. Ernst RK, Guina T, Miller SI. 2001. Salmonella typhimurium outer membrane remodeling: role in resistance to host immunity. Microbes Infect. 3:1327-1334.
8. Fischback MA, Walsh CT. 2009. Antibiotics for emerging pathogens. Science 325:1089-1093.
9. Gazebrook J, Ichige A, Walker GC. 1993. A Rhizobium meliloti homolog of the Escherichia coli peptide antibiotic-transport protein SbmA is essential for bacteroid development. Genes Dev. 7:1485-1497.
10. Geller BL. 2005. Antisense antibiotics. Curr. Opin. Mol. Ther. 7:109-113.
11. Geller BL, et al. 2003. Inhibition of gene expression in Escherichia coli by antisense phosphorodiamidate morpholino oligomers. Antimicrob. Agents Chemother. 47:3233-3239.
12. Geller BL, Deere J, Tilley L, Iversen PL. 2005. Antisense phosphorodiamidate morpholino oligomer inhibits viability of Escherichia coli in pure culture and in mouse peritonitis. J. Antimicrob. Chemother. 55:983-988.
13. Good L, Awasthi SK, Dryselius R, Larsson O, Nielsen PE. 2001. Bactericidal antisense effects of peptide-PNA conjugates. Nat. Biotechnol. 19:360-364.
14. Good L, Nielsen PE. 1998. Antisense inhibition of gene expression in bacteria by PNA targeted to mRNA. Nat. Biotechnol. 16:355-358.
15. Greenberg DE, et al. 2010. Antisense phosphorodiamidate morpholino oligomers targeted to an essential gene inhibit Burkholderia cepacia complex. J. Infect. Dis. 201:1822-1830.
16. Harth G, Zamecnik PC, Tabatadze D, Pierson K, Horwitz MA. 2007. Hairpin extensions enhance the efficacy of mycolyl transferase-specific antisense oligonucleotides targeting Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U. S. A. 104:7199-7204.
17. Henriques ST, Melo MN, Castanho MARB. 2006. Cell-penetrating peptides and antimicrobial peptides: how different are they? Biochem. J. 399:1-7.
18. Kramer MF, Coen DM. 2001. Enzymatic amplification of DNA by PCR: standard procedures and optimization, unit 15.1. In Ausubel FM, et al. (ed), Current protocols in molecular biology. John Wiley & Sons, Inc, New York, NY.
19. Lavina M, Pugsley AP, Moreno F. 1986. Identification, mapping, cloning and characterization of a gene (sbmA) required for mirocin B17 action on E. coli K12. J. Gen. Microbiol. 132:1685-1693.
20. LeVier K, Phillips RW, Gripper VK, Roop RM II, Walker GC. 2000. Similar requirements of a plant symbiont and a mammalian pathogen for prolonged intracellular survival. Science 287:2492-2493.
21. Li XZ, Nikaido H. 2009. Efflux-mediated drug resistance in bacteria: an update. Drugs 69:1555-1623.
22. Livermore DM. 2009. Has the era of untreatable infections arrived? J. Antimicrob. Chemother. 64(Suppl 1):i29-i36.
23. Luria SE, Delbruck M. 1943. Mutations of bacteria from virus sensitivity to virus resistance. Genetics 28:491-511.
24. Maloy S. 2011. Mutation rates. http://www.sci.sdsu.edu/~smaloy/ MicrobialGenetics/topics/mutations/fluctuation.html.
25. Martinez JL, Baquero F. 2000. Mutation frequencies and antibiotic resistance. Antimicrob. Agents Chemother. 44:1771-1777.
26. Mattimuzzo M, et al. 2007. Role of the Escherichia coli SbmA in the antimicrobial activity of proline-rich peptides. Mol. Microbiol. 66:151-163.
27. Mellbye BL, Puckett SE, Tilley LD, Iversen PL, Geller BL. 2009. Variations in amino acid composition of antisense peptide-phosphorodiamidate morpholino oligomers affect potency against Escherichia coli in vitro and in vivo. Antimicrob. Agents Chemother. 53:525-530.
28. Neuman BW, et al. 2005. Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers. J. Virol. 79:9665-9676.
29. New England Biolabs, Inc. Rubidium chloride method. New England Biolabs, Inc, Ipswich, MA.
30. Nikaido H. 2003. Molecular basis of bacterial outer membrane permeability revisited. Microbiol. Mol. Biol. Rev. 67:593-656.
31. Pomraning KR, Smith KM, Freitag M. 2009. Genome-wide high throughput analysis of DNA methylation in eukaryotes. Methods 47:142-150.
32. Pomraning KR, Smith KM, Freitag M. 2011. Bulk segregant analysis followed by high-throughput sequencing reveals the Neurospora cell cycle gene, ndc-1, to be allelic with the gene for ornithine decarboxylase, spe-1. Eukaryot. Cell 10:724-733.
33. Rosche WA, Foster PL. 2000. Determining mutation rates in bacterial populations. Methods 20:4-17.
34. Saka K, et al. 2005. A complete set of Escherichia coli open reading frames in mobile plasmids facilitating genetic studies. DNA Res. 12:63-68.
35. Salomon RA, Farias RN. 1995. The peptide antibiotic microcin 25 is important through the TonB pathway and the SbmA protein. J. Bacteriol. 177:3323-3325.
36. Smith MW, Tyreman DR, Payne GM, Marshall NJ, Payne JW. 1999. Substrate specificity of the periplasmic dipeptide-binding protein from Escherichia coli: experimental basis for the design of peptide prodrugs. Microbiology 145:2891-2901.
37. Spellberg B, et al. 2008. The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America. Clin. Infect. Dis. 46:155-164.
38. Splith K, Neundorf I. 2011. Antimicrobial peptides with cell-penetrating peptide properties and vice versa. Eur. Biophys. J. 40:387-397.
39. Tilley LD, et al. 2006. Gene-specific effects of antisense phosphorodiamidate morpholino oligomer-peptide conjugates on Escherichia coli and Salmonella enterica serovar Typhimurium in pure culture and in tissue culture. Antimicrob. Agents Chemother. 50:2789-2796.
40. Tilley LD, Mellbye BL, Puckett SE, Iversen PL, Geller BL. 2007. Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli. J. Antimicrob. Chemother. 59:66-73.
41. Vaara M, Porro M. 1996. Group of peptides that act synergistically with hydrophobic antibiotics against gram-negative enteric bacteria. Antimicrob. Agents Chemother. 40:1801-1805.
42. Yeaman MR, Yount NY. 2003. Mechanisms of antimicrobial peptide action and resistance. Pharmacol. Rev. 55:27-55.
43. Yorgey P, et al. 1994. Posttranslational modifications in microcin B17 define an additional class of DNA gyrase inhibitor. Proc. Natl. Acad. Sci. U. S. A. 91:4519-4523.