Effects of exogenous galanin on neuropathic pain state and change of galanin and its receptors in DRG and SDH after sciatic nerve-pinch injury in rat

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Xu, Xiaofeng ^a   Yang, Xiangdong ^b   Zhang, Ping ^a   Chen, Xiuying ^c   Liu, Huaxiang ^b   Li, Zhenzhong ^a  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANDONG UNIVERSITY   (China)

^c SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GALANIN; GALANIN RECEPTOR 1; GALANIN RECEPTOR 2; ANALGESIC AGENT; GALANIN RECEPTOR; PRIMER DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; MALE; MORPHOLOGY; NERVE COMPRESSION; NERVE CONDUCTION; NERVE REGENERATION; NEUROPATHIC PAIN; NEUROPATHOLOGY; NONHUMAN; PROTEIN EXPRESSION; RAT; SCIATIC NERVE; SCIATIC NERVE INJURY; SPINAL CORD DORSAL HORN; SPINAL GANGLION; ANALYSIS OF VARIANCE; ANIMAL; DRUG EFFECT; GENETICS; HYPERALGESIA; ISCHIALGIA; METABOLISM; PATHOLOGY; PHYSIOLOGY; POSTERIOR HORN CELL; REAL TIME POLYMERASE CHAIN REACTION; SCIATIC NEUROPATHY; WESTERN BLOTTING; WISTAR RAT;

ANIMALIA; RATTUS;

ANALGESICS; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; DNA PRIMERS; GALANIN; GANGLIA, SPINAL; HYPERALGESIA; NERVE REGENERATION; POSTERIOR HORN CELLS; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, GALANIN; SCIATIC NEUROPATHY; SCIATICA;

EID: 84862068181     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037621     Document Type: Article

References (49)

1. Vivoli E, Di Cesare Mannelli L, Salvicchi A, Bartolini A, Koverech A, et al. (2010) Acetyl-L-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy. Neuroscience 167: 1168-1174.
2. Gidal BE, (2006) New and emerging treatment options for neuropathic pain. Am J Manag Care 12: S269-S278.
3. Rose K, Ooi L, Dalle C, Robertson B, Wood IC, et al. (2011) Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury. Pain 152: 742-754.
4. Vanelderen P, Rouwette T, Kozicz T, Roubos E, Van Zundert J, et al. (2010) The role of brain-derived neurotrophic factor in different animal models of neuropathic pain. Eur J Pain 14: 473.e1-9.
5. Hirose K, Iwakura N, Orita S, Yamashita M, Inoue G, et al. (2010) Evaluation of behavior and neuropeptide markers of pain in a simple, sciatic nerve-pinch pain model in rats. Eur Spine J 19: 1746-1752.
6. Shimoshige Y, Enomoto R, Aoki T, Matsuoka N, Kaneko S, (2010) The involvement of aldose reductase in alterations to neurotrophin receptors and neuronal cytoskeletal protein mRNA levels in the dorsal root ganglion of streptozotocin-induced diabetic rats. Biol Pharm Bull 33: 67-71.
7. Ohsawa M, Kamei J, (2010) RhoA/Rho kinase signaling in the spinal cord and diabetic painful neuropathy. Eur J Pharmacol 644: 1-4.
8. Ramos KM, Jiang Y, Svensson CI, Calcutt NA, (2007) Pathogenesis of spinally mediated hyperalgesia in diabetes. Diabetes 56: 1569-1576.
9. Aoyama R, Okada Y, Yokota S, Yasui Y, Fukuda K, et al. (2011) Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn. Pain 152: 2085-2097.
10. Guan Y, Wacnik PW, Yang F, Carteret AF, Chung CY, et al. (2010) Spinal cord stimulation-induced analgesia: electrical stimulation of dorsal column and dorsal roots attenuates dorsal horn neuronal excitability in neuropathic rats. Anesthesiology 113: 1392-1405.
11. Lapirot O, Melin C, Modolo A, Nicolas C, Messaoudi Y, et al. (2011) Tonic and phasic descending dopaminergic controls of nociceptive transmission in the medullary dorsal horn. Pain 152: 1821-1831.
12. Quintero L, Cardenas R, Suarez-Roca H, (2011) Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. Pain 152: 1909-1922.
13. Campbell JN, Meyer RA, (2006) Mechanisms of neuropathic pain. Neuron 52: 77-92.
14. Navarro X, Vivo M, Valero-Cabre A, (2007) Neural plasticity after peripheral nerve injury and regeneration. Prog Neurobiol 82: 163-201.
15. Flatters SJ, Fox AJ, Dickenson AH, (2002) Nerve injury induces plasticity that results in spinal inhibitory effects of galanin. Pain 98: 249-258.
16. Xiong W, Gao L, Sapra A, Yu LC, (2005) Antinociceptive role of galanin in the spinal cord of rats with inflammation, an involvement of opioid systems. Regul Pept 132: 85-90.
17. Brumovsky P, Hygge-Blakeman K, Villar MJ, Watanabe M, Wiesenfeld-Hallin Z, et al. (2006) Phenotyping of sensory and sympathetic ganglion neurons of a galanin-overexpressing mouse-possible implications for pain processing. J Chem Neuroanat 31: 243-262.
18. Lang R, Gundlach AL, Kofler B, (2007) The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease. Pharmacol Ther 115: 177-207.
19. Liu Z, Li Z, (2009) Nerve growth factor and norepinephrine regulate galanin expression in primary cultured dorsal root ganglion neurons. Pharm Biol 47: 634-639.
20. Liu Z, Li Z, (2008) Regulation of galanin and galanin receptor 2 expression by capsaicin in primary cultured dorsal root ganglion neurons. In Vitro Cell Dev Biol Anim 44: 379-384.
21. Shi TJ, Hua XY, Lu X, Malkmus S, Kinney J, et al. (2006) Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. Eur J Neurosci 23: 627-636.
22. Pope RJ, Holmes FE, Kerr NC, Wynick D, (2010) Characterisation of the nociceptive phenotype of suppressible galanin overexpressing transgenic mice. Mol Pain 6: 67.
23. Kato A, Ohkubo T, Kitamura K, (2002) Algogen-specific pain processing in mouse spinal cord: differential involvement of voltage-dependent Ca(2+) channels in synaptic transmission. Br J Pharmacol 135: 1336-1342.
24. Pfaffl MW, (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45.
25. An K, Xu Y, Yang H, Shu HH, Xiang HB, et al. (2010) Subarachnoid transplantation of immortalized galanin-overexpressing astrocytes attenuates chronic neuropathic pain. Eur J Pain 14: 595-601.
26. Coronel MF, Brumovsky PR, Hokfelt T, Villar MJ, (2008) Differential galanin upregulation in dorsal root ganglia and spinal cord after graded single ligature nerve constriction of the rat sciatic nerve. J Chem Neuroanat 35: 94-100.
27. Djouhri L, Koutsikou S, Fang X, McMullan S, Lawson SN, (2006) Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors. J Neurosci 26: 1281-1292.
28. Liu CN, Wall PD, Ben-Dor E, Michaelis M, Amir R, et al. (2000) Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury. Pain 85: 503-521.
29. Jiang LY, Li SR, Zhao FY, Spanswick D, Lin MT, (2010) Norepinephrine can act via alpha(2)-adrenoceptors to reduce the hyper-excitability of spinal dorsal horn neurons following chronic nerve injury. J Formos Med Assoc 109: 438-445.
30. Lu Y, Perl ER, (2007) Selective action of noradrenaline and serotonin on neurones of the spinal superficial dorsal horn in the rat. J Physiol 582: 127-136.
31. Patil SB, Brock JH, Colman DR, Huntley GW, (2011) Neuropathic pain- and glial derived neurotrophic factor-associated regulation of cadherins in spinal circuits of the dorsal horn. Pain 152: 924-935.
32. Kerekes N, Mennicken F, O'Donnell D, Hokfelt T, Hill RH, (2003) Galanin increases membrane excitability and enhances Ca(2+) currents in adult, acutely dissociated dorsal root ganglion neurons. Eur J Neurosci 18: 2957-2966.
33. Xu XJ, Hokfelt T, Wiesenfeld-Hallin Z, (2010) Galanin and spinal pain mechanisms: past, present, and future. Exs 102: 39-50.
34. Brumovsky P, Mennicken F, O'Donnell D, Hokfelt T, (2006) Differential distribution and regulation of galanin receptors- 1 and-2 in the rat lumbar spinal cord. Brain Res 1085: 111-120.
35. Hua XY, Hayes CS, Hofer A, Fitzsimmons B, Kilk K, et al. (2004) Galanin acts at GalR1 receptors in spinal antinociception: synergy with morphine and AP-5. J Pharmacol Exp Ther 308: 574-582.
36. Hua XY, Salgado KF, Gu G, Fitzsimmons B, Kondo I, et al. (2005) Mechanisms of antinociception of spinal galanin: how does galanin inhibit spinal sensitization? Neuropeptides 39: 211-216.
37. Jin WY, Liu Z, Liu D, Yu LC, (2010) Antinociceptive effects of galanin in the central nucleus of amygdala of rats, an involvement of opioid receptors. Brain res 1320: 16-21.
38. Hulse RP, Wynick D, Donaldson LF, (2011) Activation of the galanin receptor 2 in the periphery reverses nerve injury-induced allodynia. Mol pain 7: 26.
39. Kato R, Kiryu-Seo S, Kiyama H, (2002) Damage-induced neuronal endopeptidase (DINE/ECEL) expression is regulated by leukemia inhibitory factor and deprivation of nerve growth factor in rat sensory ganglia after nerve injury. J Neurosci 22: 9410-9418.
40. Wilson-Gerwing TD, Verge VM, (2006) Neurotrophin-3 attenuates galanin expression in the chronic constriction injury model of neuropathic pain. Neuroscience 141: 2075-2085.
41. Hobson SA, Bacon A, Elliot-Hunt CR, Holmes FE, Kerr NC, et al. (2010) Galanin acts as a trophic factor to the central and peripheral nervous systems. Exs 102: 25-38.
42. Xu X, Jiang H, Liu H, Zhang W, Xu X, Li Z, (2012) The effects of galanin on dorsal root ganglion neurons with high glucose treatment in vitro. Brain Res Bull 87: 85-93.
43. Alier KA, Chen Y, Sollenberg UE, Langel U, Smith PA, (2008) Selective stimulation of GalR1 and GalR2 in rat substantia gelatinosa reveals a cellular basis for the anti- and pro-nociceptive actions of galanin. Pain 137: 138-146.
44. Landry M, Bouali-Benazzouz R, Andre C, Shi TJ, Leger C, et al. (2006) Galanin receptor 1 is expressed in a subpopulation of glutamatergic interneurons in the dorsal horn of the rat spinal cord. J Comp Neurol 499: 391-403.
45. Wittau N, Grosse R, Kalkbrenner F, Gohla A, Schultz G, et al. (2000) The galanin receptor type 2 initiates multiple signaling pathways in small cell lung cancer cells by coupling to G(q), G(i) and G(12) proteins. Oncogene 19: 4199-4209.
46. Abbosh C, Lawkowski A, Zaben M, Gray W, (2011) GalR2/3 mediates proliferative and trophic effects of galanin on postnatal hippocampal precursors. J Neurochem 117: 425-436.
47. O'Meara G, Coumis U, Ma SY, Kehr J, Mahoney S, et al. (2000) Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons. Proc Natl Acad Sci USA 97: 11569-11574.
48. Zhang X, Xu ZO, Shi TJ, Landry M, Holmberg K, et al. (1998) Regulation of expression of galanin and galanin receptors in dorsal root ganglia and spinal cord after axotomy and inflammation. Ann N Y Acad Sci 863: 402-13.
49. Atlasi MA, Mehdizadeh M, Bahadori MH, Joghataei MT, (2009) Morphological identification of cell death in dorsal root ganglion neurons following peripheral nerve injury and repair in adult rat. Iran Biomed J 13: 65-72.