The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia

Arthritis Research and Therapy

Volumn 13, Issue 2, 2011, Pages

  Lee, Yvonne C ^a   Nassikas, Nicholas J ^a   Clauw, Daniel J ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DULOXETINE; GABAPENTIN; IMIPRAMINE; MILNACIPRAN; NARCOTIC ANALGESIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; PREGABALIN; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ANALGESIA; ANTINOCICEPTION; BLURRED VISION; CENTRAL NERVOUS SYSTEM; CHRONIC PAIN; CONSTIPATION; DIZZINESS; DRUG MECHANISM; FIBROMYALGIA; HUMAN; MOLECULAR MECHANICS; NONHUMAN; OSTEOARTHRITIS; REVIEW; RHEUMATOID ARTHRITIS; SALIVARY GLAND DISEASE; SEDATION; SIDE EFFECT; XEROSTOMIA; ANIMAL; PATHOPHYSIOLOGY;

ANIMALS; ARTHRITIS, RHEUMATOID; CENTRAL NERVOUS SYSTEM; CHRONIC PAIN; FIBROMYALGIA; HUMANS; OSTEOARTHRITIS;

EID: 80052529130     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3306     Document Type: Review

References (86)

1. Borenstein D, Altman R, Bello A, Chatham W, Clauw DJ, Crofford LJ, Croft J, Hassett A, Kozin F, Pisetsky D, Richardson J, Schanberg LE, Starz T, Witter J. Report of the American College of Rheumatology Pain Management Task Force. Arthritis Care Res 2010, 62:590-599.
2. Buskila D. Developments in the scientific and clinical understanding of fibromyalgia. Arthritis Res Ther 2009, 11:242. 10.1186/ar2720, 2787255, 19835639.
3. Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell 2009, 139:267-284. 10.1016/j.cell.2009.09.028, 2852643, 19837031.
4. Schaible HG, Ebersberger A, Von Banchet GS. Mechanisms of pain in arthritis. Ann N Y Acad Sci 2002, 966:343-354. 10.1111/j.1749-6632.2002.tb04234.x, 12114291.
5. Schaible HG, Ebersberger A, Natura G. Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines. Arthritis Res Ther 2011, 13:210.
6. Millan MJ. Descending control of pain. Prog Neurobiol 2002, 66:355-474.
7. Pud D, Granovsky Y, Yarnitsky D. The methodology of experimentally induced diffuse noxious inhibitory control (DNIC)-like effect in humans. Pain 2009, 144:16-19. 10.1016/j.pain.2009.02.015, 19359095.
8. Vanegas H, Schaible HG. Descending control of persistent pain: inhibitory or facilitatory?. Brain Res Brain Res Rev 2004, 46:295-309.
9. Woolf CJ. Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann Intern Med 2004, 140:441-451.
10. Price DD, Staud R, Robinson ME, Mauderli AP, Cannon R, Vierck CJ. Enhanced temporal summation of second pain and its central modulation in fibromyalgia patients. Pain 2002, 99:49-59. 10.1016/S0304-3959(02)00053-2, 12237183.
11. Arendt-Nielsen L, Nielsen J, Petersen-Felix S, Schnider TW, Zbinden AM. Effect of racemic mixture and the (S+)-isomer of ketamine on temporal and spatial summation of pain. Br J Anaesth 1996, 77:625-631.
12. Graven-Nielsen T, Aspegren Kendall S, Henriksson KG, Bengtsson M, Sorensen J, Johnson A, Gerdle B, Arendt-Nielsen L. Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients. Pain 2000, 85:483-491. 10.1016/S0304-3959(99)00308-5, 10781923.
13. Staud R, Nagel S, Robinson ME, Price DD. Enhanced central pain processing of fibromyalgia patients is maintained by muscle afferent input: a randomized, double-blind, placebo-controlled study. Pain 2009, 145:96-104. 10.1016/j.pain.2009.05.020, 2751583, 19540671.
14. Ge HY, Nie H, Madeleine P, Danneskiold-Samsoe B, Graven-Nielsen T, Arendt-Nielsen L. Contribution of the local and referred pain from active myofascial trigger points in fibromyalgia syndrome. Pain 2009, 147:233-240. 10.1016/j.pain.2009.09.019, 19819074.
15. Affaitati G, Costantini R, Fabrizio A, Lapenna D, Tafuri E, Giamberardino MA. Effects of treatment of peripheral pain generators in fibromyalgia patients. Eur J Pain 2011, 15:61-69. 10.1016/j.ejpain.2010.09.002, 20889359.
16. Geisser ME, Casey KL, Brucksch CB, Ribbens CM, Appleton BB, Crofford LJ. Perception of noxious and innocuous heat stimulation among healthy women and women with fibromyalgia: association with mood, somatic focus, and catastrophizing. Pain 2003, 102:243-250. 10.1016/S0304-3959(02)00417-7, 12670665.
17. Gracely RH, Petzke F, Wolf JM, Clauw DJ. Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum 2002, 46:1333-1343. 10.1002/art.10225, 12115241.
18. Giesecke T, Gracely RH, Grant MA, Nachemson A, Petzke F, Williams DA, Clauw DJ. Evidence of augmented central pain processing in idiopathic chronic low back pain. Arthritis Rheum 2004, 50:613-623. 10.1002/art.20063, 14872506.
19. Lautenbacher S, Rollman GB. Possible deficiencies of pain modulation in fibromyalgia. Clin J Pain 1997, 13:189-196. 10.1097/00002508-199709000-00003, 9303250.
20. Kosek E, Hansson P. Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects. Pain 1997, 70:41-51. 10.1016/S0304-3959(96)03295-2, 9106808.
21. Julien N, Goffaux P, Arsenault P, Marchand S. Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition. Pain 2005, 114:295-302. 10.1016/j.pain.2004.12.032, 15733656.
22. Russell IJ, Vaeroy H, Javors M, Nyberg F. Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis. Arthritis Rheum 1992, 35:550-556. 10.1002/art.1780350509, 1374252.
23. Baraniuk JN, Whalen G, Cunningham J, Clauw DJ. Cerebrospinal fluid levels of opioid peptides in fibromyalgia and chronic low back pain. BMC Musculoskelet Disord 2004, 5:48-54. 10.1186/1471-2474-5-48, 539267, 15588296.
24. Harris RE, Clauw DJ, Scott DJ, McLean SA, Gracely RH, Zubieta JK. Decreased central mu-opioid receptor availability in fibromyalgia. J Neurosci 2007, 27:10000-10006. 10.1523/JNEUROSCI.2849-07.2007, 17855614.
25. Staud R, Cannon RC, Mauderli AP, Robinson ME, Price DD, Vierck CJ. Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome. Pain 2003, 102:87-95. 10.1016/s0304-3959(02)00344-5, 12620600.
26. Geisser ME, Glass JM, Rajcevska LD, Clauw DJ, Williams DA, Kileny PR, Gracely RH. A psychophysical study of auditory and pressure sensitivity in patients with fibromyalgia and healthy controls. J Pain 2008, 9:417-422. 10.1016/j.jpain.2007.12.006, 18280211.
27. Geisser ME, Strader Donnell C, Petzke F, Gracely RH, Clauw DJ, Williams DA. Comorbid somatic symptoms and functional status in patients with fibromyalgia and chronic fatigue syndrome: sensory amplification as a common mechanism. Psychosomatics 2008, 49:235-242. 10.1176/appi.psy.49.3.235, 18448779.
28. Singer T, Seymour B, O'Doherty J, Kaube H, Dolan RJ, Frith CD. Empathy for pain involves the affective but not sensory components of pain. Science 2004, 303:1157-1162. 10.1126/science.1093535, 14976305.
29. Harris RE, Sundgren PC, Craig AD, Kirshenbaum E, Sen A, Napadow V, Clauw DJ. Elevated insular glutamate in fibromyalgia is associated with experimental pain. Arthritis Rheum 2009, 60:3146-3152. 10.1002/art.24849, 2827610, 19790053.
30. Harris RE, Sundgren PC, Pang Y, Hsu M, Petrou M, Kim SH, McLean SA, Gracely RH, Clauw DJ. Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia. Arthritis Rheum 2008, 58:903-907. 10.1002/art.23223, 18311814.
31. Vargas-Alarcon G, Fragoso JM, Cruz-Robles D, Vargas A, Vargas A, Lao-Villadoniga JI, Garcia-Fructuoso F, Ramos-Kuri M, Hernandez F, Springall R, Bojalil R, Vallejo M, Martinez-Lavin M. Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia. Arthritis Res Ther 2007, 9:R110. 10.1186/ar2316, 2212567, 17961261.
32. Cohen H, Neumann L, Glazer Y, Ebstein RP, Buskila D. The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia. Clin Exp Rheumatol 2009, 27:S51-S56.
33. Bondy B, Spaeth M, Offenbaecher M, Glatzeder K, Stratz T, Schwarz M, de Jonge S, Kruger M, Engel RR, Farber L, Pongratz DE, Ackenheil M. The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia. Neurobiol Dis 1999, 6:433-439.
34. Offenbaecher M, Bondy B, de Jonge S, Glatzeder K, Kruger M, Schoeps P, Ackenheil M. Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region. Arthritis Rheum 1999, 42:2482-2488. 10.1002/1529-0131(199911)42:11<2482::AID-ANR27>3.0.CO;2-B, 10555044.
35. Buskila D, Sarzi-Puttini P. Biology and therapy of fibromyalgia. Genetic aspects of fibromyalgia syndrome. Arthritis Res Ther 2006, 8:218-222. 10.1186/ar2005, 1779444, 16887010.
36. Tander B, Gunes S, Boke O, Alayli G, Kara N, Bagci H, Canturk F. Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. Rheumatol Int 2008, 28:685-691. 10.1007/s00296-008-0525-8, 18196244.
37. Potvin S, Larouche A, Normand E, Souza JB, Gaumond I, Marchand S, Grignon S. No relationship between the ins del polymorphism of the serotonin transporter promoter and pain perception in fibromyalgia patients and healthy controls. Eur J Pain 2010, 14:742-746. 10.1016/j.ejpain.2009.12.004, 20080425.
38. Gursoy S. Absence of association of the serotonin transporter gene polymorphism with the mentally healthy subset of fibromyalgia patients. Clin Rheumatol 2002, 21:194-197. 10.1007/s10067-002-8284-5, 12111622.
39. Cook DB, Lange G, Ciccone DS, Liu WC, Steffener J, Natelson BH. Functional imaging of pain in patients with primary fibromyalgia. J Rheumatol 2004, 31:364-378.
40. Jensen KB, Kosek E, Petzke F, Carville S, Fransson P, Marcus H, Williams SC, Choy E, Giesecke T, Mainguy Y, Gracely R, Ingvar M. Evidence of dysfunctional pain inhibition in fibromyalgia reflected in rACC during provoked pain. Pain 2009, 144:95-100. 10.1016/j.pain.2009.03.018, 19410366.
41. Napadow V, LaCount L, Park K, As-Sanie S, Clauw DJ, Harris RE. Intrinsic brain connectivity in fibromyalgia is associated with chronic pain intensity. Arthritis Rheum 2010, 62:2545-2555. 10.1002/art.27497, 20506181.
42. Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, Gabriel S, Hirsch R, Hochberg MC, Hunder GG, Jordan JM, Katz JN, Kremers HM, Wolfe F. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum 2008, 58:26-35. 10.1002/art.23176, 18163497.
43. Bedson J, Croft PR. The discordance between clinical and radiographic knee osteoarthritis: a systematic search and summary of the literature. BMC Musculoskelet Disord 2008, 9:116-126. 10.1186/1471-2474-9-116, 2542996, 18764949.
44. Neogi T, Felson D, Niu J, Nevitt M, Lewis CE, Aliabadi P, Sack B, Torner J, Bradley L, Zhang Y. Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies. BMJ 2009, 339:b2844-b2850. 10.1136/bmj.b2844, 2730438, 19700505.
45. Wessel J. The reliability and validity of pain threshold measurements in osteoarthritis of the knee. Scand J Rheumatol 1995, 24:238-242. 10.3109/03009749509100881, 7481589.
46. Farrell M, Gibson S, McMeeken J, Helme R. Pain and hyperalgesia in osteoarthritis of the hands. J Rheumatol 2000, 27:441-447.
47. Kosek E, Ordeberg G. Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief. Pain 2000, 88:69-78. 10.1016/S0304-3959(00)00310-9, 11098101.
48. Gwilym SE, Keltner JR, Warnaby CE, Carr AJ, Chizh B, Chessell I, Tracey I. Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients. Arthritis Rheum 2009, 61:1226-1234. 10.1002/art.24837, 19714588.
49. Arendt-Nielsen L, Nie H, Laursen MB, Laursen BS, Madeleine P, Simonsen OH, Graven-Nielsen T. Sensitization in patients with painful knee osteoarthritis. Pain 2010, 149:573-581. 10.1016/j.pain.2010.04.003, 20418016.
50. O'Driscoll SL, Jayson MI. Pain threshold analysis in patients with osteoarthrosis of hip. Br Med J 1974, 3:714-715. 10.1136/bmj.3.5933.714, 1611850, 4414976.
51. Bajaj P, Bajaj P, Graven-Nielsen T, Arendt-Nielsen L. Osteoarthritis and its association with muscle hyperalgesia: an experimental controlled study. Pain 2001, 93:107-114. 10.1016/S0304-3959(01)00300-1, 11427321.
52. Imamura M, Imamura ST, Kaziyama HH, Targino RA, Hsing WT, de Souza LP, Cutait MM, Fregni F, Camanho GL. Impact of nervous system hyperalgesia on pain, disability, and quality of life in patients with knee osteoarthritis: a controlled analysis. Arthritis Rheum 2008, 59:1424-1431. 10.1002/art.24120, 18821657.
53. Kulkarni B, Bentley DE, Elliott R, Julyan PJ, Boger E, Watson A, Boyle Y, El-Deredy W, Jones AK. Arthritic pain is processed in brain areas concerned with emotions and fear. Arthritis Rheum 2007, 56:1345-1354. 10.1002/art.22460, 17393440.
54. Wolfe F, Michaud K. Assessment of pain in rheumatoid arthritis: minimal clinically significant difference, predictors, and the effect of anti-tumor necrosis factor therapy. J Rheumatol 2007, 34:1674-1683.
55. Rupp I, Boshuizen HC, Roorda LD, Dinant HJ, Jacobi CE, van den Bos G. Course of patient-reported health outcomes in rheumatoid arthritis: comparison of longitudinal and cross-sectional approaches. J Rheumatol 2006, 33:228-233.
56. Huskisson EC, Hart FD. Pain threshold and arthritis. Br Med J 1972, 4:193-195. 10.1136/bmj.4.5834.193, 1786498, 5082544.
57. Gerecz-Simon EM, Tunks ER, Heale JA, Kean WF, Buchanan WW. Measurement of pain threshold in patients with rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and healthy controls. Clin Rheumatol 1989, 8:467-474. 10.1007/BF02032098, 2612115.
58. Konttinen YT, Honkanen VE, Gronblad M, Keinonen M, Santavirta N, Santavirta S. The relation of extraarticular tenderness to inflammatory joint disease and personality in patients with rheumatoid arthritis. J Rheumatol 1992, 19:851-855.
59. Leffler AS, Kosek E, Lerndal T, Nordmark B, Hansson P. Somatosensory perception and function of diffuse noxious inhibitory controls (DNIC) in patients suffering from rheumatoid arthritis. Eur J Pain 2002, 6:161-176. 10.1053/eujp.2001.0313, 11900476.
60. Wendler J, Hummel T, Reissinger M, Manger B, Pauli E, Kalden JR, Kobal G. Patients with rheumatoid arthritis adapt differently to repetitive painful stimuli compared to healthy controls. J Clin Neurosci 2001, 8:272-277. 10.1054/jocn.1999.0775, 11386807.
61. Morris VH, Cruwys SC, Kidd BL. Characterisation of capsaicin-induced mechanical hyperalgesia as a marker for altered nociceptive processing in patients with rheumatoid arthritis. Pain 1997, 71:179-186. 10.1016/S0304-3959(97)03361-7, 9211479.
62. Jones AK, Derbyshire SW. Reduced cortical responses to noxious heat in patients with rheumatoid arthritis. Ann Rheum Dis 1997, 56:601-607. 10.1136/ard.56.10.601, 1752267, 9389221.
63. Schwienhardt P, Kalk N, Wartolowska K, Chessel I, Wordsworth P, Tracey I. Investigation into the neural correlates of emotional augmentation of clinical pain. Neuroimage 2008, 40:759-766. 10.1016/j.neuroimage.2007.12.016, 18221890.
64. Jones AK, Cunningham VJ, Ha-Kawa S, Fujiwara T, Luthra SK, Silva S, Derbyshire S, Jones T. Changes in central opioid receptor binding in relation to inflammation and pain in patients with rheumatoid arthritis. Br J Rheumatol 1994, 33:909-916. 10.1093/rheumatology/33.10.909, 7921749.
65. Lee YC, Chibnik LB, Lu B, Wasan AD, Edwards RR, Fossel AH, Helfgott SM, Solomon DH, Clauw DJ, Karlson EW. The relationship between disease activity, sleep, psychiatric distress and pain sensitivity in rheumatoid arthritis: a cross-sectional study. Arthritis Res Ther 2009, 11:R160. 10.1186/ar2842, 2787262, 19874580.
66. Smith MT, Edwards RR, McCann UD, Haythornthwaite JA. The effects of sleep deprivation on pain inhibition and spontaneous pain in women. Sleep 2007, 30:494-505.
67. Edwards RR, Grace E, Peterson S, Klick B, Haythornthwaite JA, Smith MT. Sleep continuity and architecture: associations with pain-inhibitory processes in patients with temporomandibular joint disorder. Eur J Pain 2009, 13:1043-1047. 10.1016/j.ejpain.2008.12.007, 2791089, 19168380.
68. Nishishinya B, Urrutia G, Walitt B, Rodriguez A, Bonfill X, Alegre C, Darko G. Amitriptyline in the treatment of fibromyalgia: a systematic review of its efficacy. Rheumatology (Oxford) 2008, 47:1741-1746.
69. Gringras M. A clinical trial of Tofranil in rheumatic pain in general practice. J Int Med Res 1976, 4:41-49.
70. Macfarlane JG, Jalali S, Grace EM. Trimipramine in rheumatoid arthritis: a randomized double-blind trial in relieving pain and joint tenderness. Curr Med Res Opin 1986, 10:89-93. 10.1185/03007998609110424, 3519096.
71. Sarzi Puttini P, Cazzola M, Boccassini L, Ciniselli G, Santandrea S, Caruso I, Benvenuti C. A comparison of dothiepin versus placebo in the treatment of pain in rheumatoid arthritis and the association of pain with depression. J Int Med Res 1988, 16:331-337.
72. Frank RG, Kashani JH, Parker JC, Beck NC, Brownlee-Duffeck M, Elliott TR, Haut AE, Atwood C, Smith E, Kay DR. Antidepressant analgesia in rheumatoid arthritis. J Rheumatol 1988, 15:1632-1638.
73. Ash G, Dickens CM, Creed FH, Jayson MI, Tomenson B. The effects of dothiepin on subjects with rheumatoid arthritis and depression. Rheumatology (Oxford) 1999, 38:959-967.
74. Chuck AJ, Swannell AJ, House AO, Pownall R. The effects of dothiepin on subjects with rheumatoid arthritis and depression. Rheumatology (Oxford) 2000, 39:1425-1427.
75. Yarnitsky D, Granovsky Y, Fadel S, Sprecher E, Granot M. Endogenous analgesia and SSNRI towards individually tailored pain therapy. Proceedings of the 12th World Congress on Pain: 2008; Glasgow, Scotland 2008, Seattle, WA: IASP Press.
76. Arnold LM, Lu Y, Crofford LJ, Wohlreich M, Detke MJ, Iyengar S, Goldstein DJ. A double-blind, multicenter trial comparing duloxetine with placebo in the treatment of fibromyalgia patients with or without major depressive disorder. Arthritis Rheum 2004, 50:2974-2984. 10.1002/art.20485, 15457467.
77. Arnold LM, Rosen A, Pritchett YL, D'Souza DN, Goldstein DJ, Iyengar S, Wernicke JF. A randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorder. Pain 2005, 119:5-15. 10.1016/j.pain.2005.06.031, 16298061.
78. Russell IJ, Mease PJ, Smith TR, Kajdasz DK, Wohlreich MM, Detke MJ, Walker DJ, Chappell AS, Arnold LM. Efficacy and safety of duloxetine for treatment of fibromyalgia in patients with or without major depressive disorder: results from a 6-month, randomized, double-blind, placebo-controlled, fixeddose trial. Pain 2008, 136:432-444. 10.1016/j.pain.2008.02.024, 18395345.
79. Gendreau RM, Thorn MD, Gendreau JF, Kranzler JD, Ribeiro S, Gracely RH, Williams DA, Mease PJ, McLean SA, Clauw DJ. Efficacy of milnacipran in patients with fibromyalgia. J Rheumatol 2005, 32:1975-1985.
80. Mease PJ, Clauw DJ, Gendreau RM, Rao SG, Kranzier J, Chen W, Palmer RH. The efficacy and safety of milnacipran for treatment of fibromyalgia: a randomized, double-blind, placebo-controlled trial. J Rheumatol 2009, 36:398-409. 10.3899/jrheum.080734, 19132781.
81. Clauw DJ, Mease P, Palmer RH, Gendreau RM, Wang Y. Milnacipran for the treatment of fibromyalgia in adults: a 15-week, multicenter, randomized, double-blind, placebo-controlled, multiple-dose clinical trial. Clin Ther 2008, 30:1988-2004. 10.1016/j.clinthera.2008.11.009, 19108787.
82. Chappell AS, Ossanna MJ, Liu-Seifert H, Iyengar S, Skljarevski V, Li LC, Bennett RM, Collins H. Duloxetine, a centrally acting analgesic, in the treatment of patients with osteoarthritis knee pain: a 13-week, randomized, placebocontrolled trial. Pain 2009, 146:253-260. 10.1016/j.pain.2009.06.024, 19625125.
83. Crofford LJ, Rowbotham MC, Mease PJ, Russell IJ, Dworkin RH, Corbin AE, Young JP, LaMoreaux LK, Martin SA, Sharma U. Pregabalin for the treatment of fibromyalgia syndrome: results of a randomized, doubleblind, placebo-controlled trial. Arthritis Rheum 2005, 52:1264-1273. 10.1002/art.20983, 15818684.
84. Crofford LJ, Mease PJ, Simpson SL, Young JP, Martin SA, Haig GM, Sharma U. Fibromyalgia relapse evaluation and efficacy for durability of meaningful relief (FREEDOM): a 6-month, double-blind, placebo-controlled trial with pregabalin. Pain 2008, 136:419-431. 10.1016/j.pain.2008.02.027, 18400400.
85. Moore RA, Straube S, Wiffen PJ, Derry S, McQuay HJ. Pregabalin for acute and chronic pain in adults. Cochrane Database Syst Rev 2009, 3:CD007076.
86. Rahman W, Bauer CS, Bannister K, Vonsy JL, Dolphin AC, Dickenson AH. Descending serotonergic facilitation and the antinociceptive effects of pregabalin in a rat model of osteoarthritic pain. Mol Pain 2009, 5:45-61. 10.1186/1744-8069-5-45, 2744671, 19664204.