Fatp1 Deficiency Affects Retinal Light Response and Dark Adaptation, and Induces Age-Related Alterations

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Chekroud, Karim ^a   Guillou, Laurent ^a   Grégoire, Stephane ^b   Ducharme, Gilles ^c   Brun, Emilie ^a   Cazevieille, Chantal ^d   Bretillon, Lionel ^b   Hamel, Christian P ^a   Brabet, Philippe ^a   Pequignot, Marie O ^a  

^a INSERM   (France)

^b CEMAGREF   (France)

^c UNIVERSITÉ DE MONTPELLIER   (France)

^d UNIV MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; FATTY ACID TRANSPORTER; FATTY ACID TRANSPORTER 1; FATTY ACID TRANSPORTER 4; UNCLASSIFIED DRUG;

ADULT ANIMAL; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B WAVE; BLEACHING; BRUCH MEMBRANE; CHOROID VASCULARIZATION; CONTROLLED STUDY; DARK ADAPTATION; ELECTRORETINOGRAM; FATP1 GENE; IN VIVO STUDY; LIPID COMPOSITION; MOUSE; NONHUMAN; PHOTORECEPTOR; PHOTORECEPTOR OUTER SEGMENT; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINA; RETINAL LIGHT RESPONSE; TRANSMISSION ELECTRON MICROSCOPY; VISION;

AGING; ANIMALS; CIS-TRANS-ISOMERASES; DARK ADAPTATION; DNA PRIMERS; ELECTRORETINOGRAPHY; FATTY ACID TRANSPORT PROTEINS; FATTY ACIDS; FLUORESCENCE; HISTOLOGICAL TECHNIQUES; LIGHT; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON, TRANSMISSION; POLYMERASE CHAIN REACTION; RETINA; RETINAL PIGMENT EPITHELIUM; RHODOPSIN; STATISTICS, NONPARAMETRIC;

MUS;

EID: 84869223751     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0050231     Document Type: Article

References (39)

1. Simo R, Villarroel M, Corraliza L, Hernandez C, Garcia-Ramirez M, (2010) The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier-implications for the pathogenesis of diabetic retinopathy. J Biomed Biotechnol 2010: 190724.
2. Martinez-Morales JR, Rodrigo I, Bovolenta P, (2004) Eye development: a view from the retina pigmented epithelium. Bioessays 26: 766-777.
3. Xiao Q, Hartzell HC, Yu K, (2010) Bestrophins and retinopathies. Pflugers Arch 460: 559-569.
4. Kevany BM, Palczewski K, (2010) Phagocytosis of retinal rod and cone photoreceptors. Physiology (Bethesda) 25: 8-15.
5. Bazan NG, (2006) Cell survival matters: docosahexaenoic acid signaling, neuroprotection and photoreceptors. Trends Neurosci 29: 263-271.
6. Jin M, Li S, Moghrabi WN, Sun H, Travis GH, (2005) Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium. Cell 122: 449-459.
7. Moiseyev G, Chen Y, Takahashi Y, Wu BX, Ma JX, (2005) RPE65 is the isomerohydrolase in the retinoid visual cycle. Proc Natl Acad Sci U S A 102: 12413-12418.
8. Thompson DA, Gal A, (2003) Vitamin A metabolism in the retinal pigment epithelium: genes, mutations, and diseases. Prog Retin Eye Res 22: 683-703.
9. Sparrow JR, Hicks D, Hamel CP, (2010) The retinal pigment epithelium in health and disease. Curr Mol Med 10: 802-823.
10. Wu L, Nagasaki T, Sparrow JR, (2010) Photoreceptor cell degeneration in Abcr (-/-) mice. Adv Exp Med Biol 664: 533-539.
11. Doege H, Stahl A, (2006) Protein-mediated fatty acid uptake: novel insights from in vivo models. Physiology (Bethesda) 21: 259-268.
12. Guignard TJ, Jin M, Pequignot MO, Li S, Chassigneux Y, et al. (2010) FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase. J Biol Chem 285: 18759-18768.
13. Kim JK, Gimeno RE, Higashimori T, Kim HJ, Choi H, et al. (2004) Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. J Clin Invest 113: 756-763.
14. Provost AC, Vede L, Bigot K, Keller N, Tailleux A, et al. (2009) Morphologic and electroretinographic phenotype of SR-BI knockout mice after a long-term atherogenic diet. Invest Ophthalmol Vis Sci 50: 3931-3942.
15. Chekroud K, Arndt C, Basset D, Hamel CP, Brabet P, et al. (2011) Simple and efficient: validation of a cotton wick electrode for animal electroretinography. Ophthalmic Research 45: 174-179.
16. Suzuki T, Fujita Y, Noda Y, Miyata S, (1986) A simple procedure for the extraction of the native chromophore of visual pigments: the formaldehyde method. Vision Res 26: 425-429.
17. Folch J, Lees M, Sloane Stanley GH, (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497-509.
18. Morrison WR, Smith LM, (1964) Preparation of Fatty Acid Methyl Esters and Dimethylacetals from Lipids with Boron Fluoride-Methanol. J Lipid Res 5: 600-608.
19. Johnson RA, Wichern DW (2001) Applied Multivariate Statistical Analysis. 5th edition ed: Prentice Hall.
20. Bush RA, Malnoe A, Reme CE, Williams TP, (1994) Dietary deficiency of N-3 fatty acids alters rhodopsin content and function in the rat retina. Invest Ophthalmol Vis Sci 35: 91-100.
21. Neuringer M, Connor WE, Lin DS, Barstad L, Luck S, (1986) Biochemical and functional effects of prenatal and postnatal omega 3 fatty acid deficiency on retina and brain in rhesus monkeys. Proc Natl Acad Sci U S A 83: 4021-4025.
22. Pawlosky RJ, Denkins Y, Ward G, Salem N Jr, (1997) Retinal and brain accretion of long-chain polyunsaturated fatty acids in developing felines: the effects of corn oil-based maternal diets. Am J Clin Nutr 65: 465-472.
23. Schmidt-Erfurth U, Rudolf M, Funk M, Hofmann-Rummelt C, Franz-Haas NS, et al. (2008) Ultrastructural changes in a murine model of graded Bruch membrane lipoidal degeneration and corresponding VEGF164 detection. Invest Ophthalmol Vis Sci 49: 390-398.
24. Chabowski A, Coort SL, Calles-Escandon J, Tandon NN, Glatz JF, et al. (2005) The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR. FEBS Lett 579: 2428-2432.
25. Gimeno RE, (2007) Fatty acid transport proteins. Curr Opin Lipidol 18: 271-276.
26. Gertow K, Pietilainen KH, Yki-Jarvinen H, Kaprio J, Rissanen A, et al. (2004) Expression of fatty-acid-handling proteins in human adipose tissue in relation to obesity and insulin resistance. Diabetologia 47: 1118-1125.
27. Hirsch D, Stahl A, Lodish HF, (1998) A family of fatty acid transporters conserved from mycobacterium to man. Proc Natl Acad Sci U S A 95: 8625-8629.
28. Gambis A, Dourlen P, Steller H, Mollereau B, (2011) Two-color in vivo imaging of photoreceptor apoptosis and development in Drosophila. Dev Biol 351: 128-134.
29. Guitart M, Andreu AL, Garcia-Arumi E, Briones P, Quintana E, et al. (2009) FATP1 localizes to mitochondria and enhances pyruvate dehydrogenase activity in skeletal myotubes. Mitochondrion 9: 266-272.
30. Sebastian D, Guitart M, Garcia-Martinez C, Mauvezin C, Orellana-Gavalda JM, et al. (2009) Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells. J Lipid Res 50: 1789-1799.
31. Ellis JM, Li LO, Wu PC, Koves TR, Ilkayeva O, et al. (2010) Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. Cell Metab 12: 53-64.
32. Holloway GP, Chou CJ, Lally J, Stellingwerff T, Maher AC, et al. (2011) Increasing skeletal muscle fatty acid transport protein 1 (FATP1) targets fatty acids to oxidation and does not predispose mice to diet-induced insulin resistance. Diabetologia 54: 1457-1467.
33. Li LO, Ellis JM, Paich HA, Wang S, Gong N, et al. (2009) Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition. J Biol Chem 284: 27816-27826.
34. Sarks S, Cherepanoff S, Killingsworth M, Sarks J, (2007) Relationship of Basal laminar deposit and membranous debris to the clinical presentation of early age-related macular degeneration. Invest Ophthalmol Vis Sci 48: 968-977.
35. Dithmar S, Curcio CA, Le NA, Brown S, Grossniklaus HE, (2000) Ultrastructural changes in Bruch's membrane of apolipoprotein E-deficient mice. Invest Ophthalmol Vis Sci 41: 2035-2042.
36. Houssier M, Raoul W, Lavalette S, Keller N, Guillonneau X, et al. (2008) CD36 deficiency leads to choroidal involution via COX2 down-regulation in rodents. PLoS Med 5: e39.
37. Picard E, Houssier M, Bujold K, Sapieha P, Lubell W, et al. (2010) CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits. Aging (Albany NY) 2: 981-989.
38. Rudolf M, Winkler B, Aherrahou Z, Doehring LC, Kaczmarek P, et al. (2005) Increased expression of vascular endothelial growth factor associated with accumulation of lipids in Bruch's membrane of LDL receptor knockout mice. Br J Ophthalmol 89: 1627-1630.
39. Zhao Z, Chen Y, Wang J, Sternberg P, Freeman ML, et al. (2011) Age-related retinopathy in NRF2-deficient mice. PLoS One 6: e19456.