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Volumn 57, Issue 6, 2012, Pages 1368-1369

Rapamycin impacts positively on longevity, despite glucose intolerance induction

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; MEMBRANE PROTEIN; MLST8 PROTEIN; RAPAMYCIN; UNCLASSIFIED DRUG;

EID: 84869217809     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.06.038     Document Type: Note
Times cited : (2)

References (10)
  • 1
    • 84859117806 scopus 로고    scopus 로고
    • Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
    • D.W. Lamming, L. Ye, P. Katajisto, M.D. Goncalves, M. Saitoh, and D.M. Stevens Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity Science 335 2012 1638 1643
    • (2012) Science , vol.335 , pp. 1638-1643
    • Lamming, D.W.1    Ye, L.2    Katajisto, P.3    Goncalves, M.D.4    Saitoh, M.5    Stevens, D.M.6
  • 2
    • 34249679614 scopus 로고    scopus 로고
    • MTOR Complex1-S6K1 signaling: At the crossroads of obesity, diabetes and cancer
    • S.G. Dann, A. Selvaraj, and G. Thomas mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer Trends Mol Med 13 2007 252 259
    • (2007) Trends Mol Med , vol.13 , pp. 252-259
    • Dann, S.G.1    Selvaraj, A.2    Thomas, G.3
  • 3
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    • S.H. Um, F. Frigerio, M. Watanabe, F. Picard, M. Joaquin, and M. Sticker Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity Nature 431 2004 200 205
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1    Frigerio, F.2    Watanabe, M.3    Picard, F.4    Joaquin, M.5    Sticker, M.6
  • 5
    • 77949318560 scopus 로고    scopus 로고
    • Metabolic reprogramming, caloric restriction and aging
    • R.M. Anderson, and R. Weindruch Metabolic reprogramming, caloric restriction and aging Trends Endocrinol Metab 21 2010 134 141
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 134-141
    • Anderson, R.M.1    Weindruch, R.2
  • 7
    • 77953218866 scopus 로고    scopus 로고
    • Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue
    • V.P. Houde, S. Brule, W.T. Festuccia, P.G. Blanchard, K. Bellmann, and Y. Deshaies Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue Diabetes 59 2010 1338 1348
    • (2010) Diabetes , vol.59 , pp. 1338-1348
    • Houde, V.P.1    Brule, S.2    Festuccia, W.T.3    Blanchard, P.G.4    Bellmann, K.5    Deshaies, Y.6
  • 8
    • 42449104351 scopus 로고    scopus 로고
    • MTOR Inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
    • M. Fraenkel, M. Ketzinel-Gilad, Y. Ariav, O. Pappo, M. Karaca, and J. Castel mTOR Inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes Diabetes 57 2008 945 957
    • (2008) Diabetes , vol.57 , pp. 945-957
    • Fraenkel, M.1    Ketzinel-Gilad, M.2    Ariav, Y.3    Pappo, O.4    Karaca, M.5    Castel, J.6
  • 9
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • D.E. Harrison, R. Strong, Z.D. Sharp, J.F. Nelson, C.M. Astle, and K. Flurkey Rapamycin fed late in life extends lifespan in genetically heterogeneous mice Nature 460 2009 392 395
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3    Nelson, J.F.4    Astle, C.M.5    Flurkey, K.6
  • 10
    • 0037942739 scopus 로고    scopus 로고
    • Extended longevity in mice lacking the insulin receptor in adipose tissue
    • M. Bluher, B.B. Kahn, and C.R. Kahn Extended longevity in mice lacking the insulin receptor in adipose tissue Science 299 2003 572 574
    • (2003) Science , vol.299 , pp. 572-574
    • Bluher, M.1    Kahn, B.B.2    Kahn, C.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.