-
1
-
-
52949127312
-
An integrated genomic analysis of human glioblastomamultiforme
-
Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastomamultiforme. Science. 2008;321(5897):1807-1812.
-
(2008)
Science
, vol.321
, Issue.5897
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
-
2
-
-
70149093912
-
Recurring mutations found by sequencing an acute myeloid leukemia genome
-
Mardis ER, Ding L, Dooling DJ, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med. 2009;361(11):1058- 1066.
-
(2009)
N Engl J Med
, vol.361
, Issue.11
, pp. 1058-1066
-
-
Mardis, E.R.1
Ding, L.2
Dooling, D.J.3
-
3
-
-
75449119103
-
Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms
-
Green A, Beer P. Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms. N Engl J Med. 2010;362(4):369-370.
-
(2010)
N Engl J Med
, vol.362
, Issue.4
, pp. 369-370
-
-
Green, A.1
Beer, P.2
-
4
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
Ward PS, Patel J, Wise DR, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 2010;17(3):225-234.
-
(2010)
Cancer Cell
, vol.17
, Issue.3
, pp. 225-234
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
-
5
-
-
67449099808
-
Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers
-
Kang MR, Kim MS, Oh JE, et al. Mutational analysis of IDH1 codon 132 in glioblastomas and other common cancers. Int J Cancer. 2009;125(2):353-355.
-
(2009)
Int J Cancer
, vol.125
, Issue.2
, pp. 353-355
-
-
Kang, M.R.1
Kim, M.S.2
Oh, J.E.3
-
6
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
DOI 10.1126/science.1133427
-
Sjoblom T, Jones S, Wood LD, et al. The consensus coding sequences of human breast and colorectal cancers. Science. 2006;314(5797):268-274. (Pubitemid 44571966)
-
(2006)
Science
, vol.314
, Issue.5797
, pp. 268-274
-
-
Sjoblom, T.1
Jones, S.2
Wood, L.D.3
Parsons, D.W.4
Lin, J.5
Barber, T.D.6
Mandelker, D.7
Leary, R.J.8
Ptak, J.9
Silliman, N.10
Szabo, S.11
Buckhaults, P.12
Farrell, C.13
Meeh, P.14
Markowitz, S.D.15
Willis, J.16
Dawson, D.17
Willson, J.K.V.18
Gazdar, A.F.19
Hartigan, J.20
Wu, L.21
Liu, C.22
Parmigiani, G.23
Park, B.H.24
Bachman, K.E.25
Papadopoulos, N.26
Vogelstein, B.27
Kinzler, K.W.28
Velculescu, V.E.29
more..
-
7
-
-
77955273843
-
IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain
-
Lopez GY, Reitman ZJ, Solomon D, et al. IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain. Biochem Biophys Res Commun. 2010;398(3):585-587.
-
(2010)
Biochem Biophys Res Commun
, vol.398
, Issue.3
, pp. 585-587
-
-
Lopez, G.Y.1
Reitman, Z.J.2
Solomon, D.3
-
8
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360(8):765-773.
-
(2009)
N Engl J Med
, vol.360
, Issue.8
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
-
9
-
-
4043105583
-
Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity
-
DOI 10.1074/jbc.M404298200
-
Xu X, Zhao J, Xu Z, et al. Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity. J Biol Chem. 2004;279(32):33946-33957. (Pubitemid 39063045)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.32
, pp. 33946-33957
-
-
Xu, X.1
Zhao, J.2
Xu, Z.3
Peng, B.4
Huang, Q.5
Arnold, E.6
Ding, J.7
-
10
-
-
70349653793
-
IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas
-
Nobusawa S, Watanabe T, Kleihues P, Ohgaki H. IDH1 mutations as molecular signature and predictive factor of secondary glioblastomas. Clin Cancer Res. 2009;15(19):6002-6007.
-
(2009)
Clin Cancer Res
, vol.15
, Issue.19
, pp. 6002-6007
-
-
Nobusawa, S.1
Watanabe, T.2
Kleihues, P.3
Ohgaki, H.4
-
11
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
Dang L, White DW, Gross S, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009;462(7274):739-744.
-
(2009)
Nature
, vol.462
, Issue.7274
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
-
12
-
-
64849098267
-
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
-
Zhao S, Lin Y, XuW, et al. Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science. 2009;324(5924):261-265.
-
(2009)
Science
, vol.324
, Issue.5924
, pp. 261-265
-
-
Zhao, S.1
Xuw, L.Y.2
-
13
-
-
77954736390
-
Oncometabolite? IDH1 discoveries raise possibility of new metabolism targets in brain cancers and leukemia
-
Garber K. Oncometabolite? IDH1 discoveries raise possibility of new metabolism targets in brain cancers and leukemia. J Natl Cancer Inst. 2010;102(13):926-928.
-
(2010)
J Natl Cancer Inst
, vol.102
, Issue.13
, pp. 926-928
-
-
Garber, K.1
-
14
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
-
Xu W, Yang H, Liu Y, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011;19(1):17-30.
-
(2011)
Cancer Cell
, vol.19
, Issue.1
, pp. 17-30
-
-
Xu, W.1
Yang, H.2
Liu, Y.3
-
15
-
-
84855710482
-
Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy
-
Andronesi OC, Kim GS, Gerstner E, et al. Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy. Sci Transl Med. 2012;4(116):116ra114.
-
(2012)
Sci Transl Med
, vol.4
, Issue.116
-
-
Andronesi, O.C.1
Kim, G.S.2
Gerstner, E.3
-
16
-
-
84862776826
-
2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas
-
Choi C, Ganji SK, Deberardinis RJ, et al. 2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas. Nat Med. 2012;18:624-629.
-
(2012)
Nat Med
, vol.18
, pp. 624-629
-
-
Choi, C.1
Ganji, S.K.2
Deberardinis, R.J.3
-
17
-
-
84862907969
-
Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas
-
Elkhaled A, Jalbert LE, Phillips JJ, et al. Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas. Sci Transl Med. 2012;4(116):116ra115.
-
(2012)
Sci Transl Med
, vol.4
, Issue.116
-
-
Elkhaled, A.1
Jalbert, L.E.2
Phillips, J.J.3
-
18
-
-
84858603856
-
Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy
-
Pope WB, Prins RM, Albert Thomas M, et al. Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy. J Neurooncol. 2012;107(1):197-205.
-
(2012)
J Neurooncol
, vol.107
, Issue.1
, pp. 197-205
-
-
Pope, W.B.1
Prins, R.M.2
Albert Thomas, M.3
-
20
-
-
33748084051
-
Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumor grade, whereas uncorrected maps do not
-
Boxerman JL, Schmainda KM, Weisskoff RM. Relative cerebral blood volume maps corrected for contrast agent extravasation significantly correlate with glioma tumor grade, whereas uncorrected maps do not. AJNR Am J Neuroradiol. 2006;27(4):859-867. (Pubitemid 44897737)
-
(2006)
American Journal of Neuroradiology
, vol.27
, Issue.4
, pp. 859-867
-
-
Boxerman, J.L.1
Schmainda, K.M.2
Weisskoff, R.M.3
-
21
-
-
0032588957
-
1H NMR spectroscopy of rat brain at 1 ms echo time
-
DOI 10.1002/(SICI)1522-2594(199904)41:4<649::AID-MRM2>3.0.CO;2-G
-
Tkac I, Starcuk Z, Choi IY, Gruetter R. In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time. Magn Reson Med. 1999;41(4):649-656. (Pubitemid 29205710)
-
(1999)
Magnetic Resonance in Medicine
, vol.41
, Issue.4
, pp. 649-656
-
-
Tkac, I.1
Starcuk, Z.2
Choi, I.-Y.3
Gruetter, R.4
-
22
-
-
0027375098
-
Estimation of metabolite concentrations from localized in vivo proton NMR spectra
-
DOI 10.1002/mrm.1910300604
-
Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med. 1993;30(6):672-679. (Pubitemid 23360802)
-
(1993)
Magnetic Resonance in Medicine
, vol.30
, Issue.6
, pp. 672-679
-
-
Provencher, S.W.1
-
23
-
-
0142094100
-
13C NMR study of 2-hydroxyglutaric acid and its lactone
-
DOI 10.1002/mrc.1053
-
Bal D, Gryff-Keller A. H-1 and C-13 NMR study of 2-hydroxyglutaric acid and its lactone. Magnetic Resonance in Chemistry. 2002;40(8):533-536. (Pubitemid 37296931)
-
(2002)
Magnetic Resonance in Chemistry
, vol.40
, Issue.8
, pp. 533-536
-
-
Bal, D.1
Gryff-Keller, A.2
-
24
-
-
73349118491
-
PTEN dosage is essential for neurofibroma development and malignant transformation
-
Gregorian C, Nakashima J, Dry SM, et al. PTEN dosage is essential for neurofibroma development and malignant transformation. Proc Natl Acad Sci USA. 2009;106(46):19479-19484.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, Issue.46
, pp. 19479-19484
-
-
Gregorian, C.1
Nakashima, J.2
Dry, S.M.3
-
25
-
-
70449518400
-
Monoclonal antibody specific for IDH1 R132H mutation
-
Capper D, Zentgraf H, Balss J, Hartmann C, von Deimling A. Monoclonal antibody specific for IDH1 R132H mutation. Acta Neuropathol. 2009;118(5):599-601.
-
(2009)
Acta Neuropathol
, vol.118
, Issue.5
, pp. 599-601
-
-
Capper, D.1
Zentgraf, H.2
Balss, J.3
Hartmann, C.4
Von Deimling, A.5
-
26
-
-
0034480955
-
Relationships between choline magnetic resonance spectroscopy, apparent diffusion coefficient and quantitative histopathology in human glioma
-
DOI 10.1023/A:1006431120031
-
Gupta RK, Cloughesy TF, Sinha U, et al. Relationships between choline magnetic resonance spectroscopy, apparent diffusion coefficient and quantitative histopathology in human glioma. J Neurooncol. 2000;50(3):215-226. (Pubitemid 32192873)
-
(2000)
Journal of Neuro-Oncology
, vol.50
, Issue.3
, pp. 215-226
-
-
Gupta, R.K.1
Cloughesy, T.F.2
Sinha, U.3
Garakian, J.4
Lazareff, J.5
Rubino, G.6
Rubino, L.7
Becker, D.P.8
Vinters, H.V.9
Alger, J.R.10
-
27
-
-
52449125686
-
Imaging immune response in vivo: Cytolytic action of genetically altered T cells directed to glioblastoma multiforme
-
Lazovic J, Jensen MC, Ferkassian E, Aguilar B, Raubitschek A, Jacobs RE. Imaging immune response in vivo: cytolytic action of genetically altered T cells directed to glioblastoma multiforme. Clin Cancer Res. 2008;14(12):3832-3839.
-
(2008)
Clin Cancer Res
, vol.14
, Issue.12
, pp. 3832-3839
-
-
Lazovic, J.1
Jensen, M.C.2
Ferkassian, E.3
Aguilar, B.4
Raubitschek, A.5
Jacobs, R.E.6
-
28
-
-
79952741730
-
Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome
-
Reitman ZJ, Jin G, Karoly ED, et al. Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome. Proc Natl Acad Sci USA. 2011;108(8):3270-3275.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.8
, pp. 3270-3275
-
-
Reitman, Z.J.1
Jin, G.2
Karoly, E.D.3
-
29
-
-
80054006943
-
Glutamate release by primary brain tumors induces epileptic activity
-
Buckingham SC, Campbell SL, Haas BR, et al. Glutamate release by primary brain tumors induces epileptic activity. Nat Med. 2011;17(10):1269-1274.
-
(2011)
Nat Med
, vol.17
, Issue.10
, pp. 1269-1274
-
-
Buckingham, S.C.1
Campbell, S.L.2
Haas, B.R.3
-
30
-
-
34249845298
-
Best cases from the AFIP: Glioblastoma multiforme
-
Altman DA, Atkinson DS, Jr., Brat DJ. Best cases from the AFIP: glioblastoma multiforme. Radiographics. 2007;27(3):883-888.
-
(2007)
Radiographics
, vol.27
, Issue.3
, pp. 883-888
-
-
Altman, D.A.1
Atkinson Jr., D.S.2
Brat, D.J.3
-
31
-
-
34447632643
-
Angiogenesis in brain tumours
-
DOI 10.1038/nrn2175, PII NRN2175
-
Jain RK, di Tomaso E, Duda DG, Loeffler JS, Sorensen AG, Batchelor TT. Angiogenesis in brain tumours. Nat Rev Neurosci. 2007;8(8):610-622. (Pubitemid 47093931)
-
(2007)
Nature Reviews Neuroscience
, vol.8
, Issue.8
, pp. 610-622
-
-
Jain, R.K.1
Di Tomaso, E.2
Duda, D.G.3
Loeffler, J.S.4
Sorensen, A.G.5
Batchelor, T.T.6
-
32
-
-
33645692860
-
D-2-Hydroxyglutaric aciduria: Unravelling the biochemical pathway and the genetic defect
-
Struys EA. D-2-Hydroxyglutaric aciduria: unravelling the biochemical pathway and the genetic defect. J Inherit Metab Dis. 2006;29(1):21-29.
-
(2006)
J Inherit Metab Dis
, vol.29
, Issue.1
, pp. 21-29
-
-
Struys, E.A.1
-
33
-
-
0036823408
-
White matter disease in cerebral organic acid disorders: Clinical implications and suggested pathomechanisms
-
DOI 10.1055/s-2002-36741
-
Kolker S, Mayatepek E, Hoffmann GF. White matter disease in cerebral organic acid disorders: clinical implications and suggested pathomechanisms. Neuropediatrics. 2002;33(5):225-231. (Pubitemid 36134195)
-
(2002)
Neuropediatrics
, vol.33
, Issue.5
, pp. 225-231
-
-
Kolker, S.1
Mayatepek, E.2
Hoffmann, G.F.3
-
34
-
-
26244435816
-
Mitochondrial energy metabolism is markedly impaired by D-2-hydroxyglutaric acid in rat tissues
-
DOI 10.1016/j.ymgme.2005.05.002, PII S1096719205001599, ASHG 2005 Meeting Salt Lake City
-
Latini A, da Silva CG, Ferreira GC, et al. Mitochondrial energy metabolism is markedly impaired by D-2-hydroxyglutaric acid in rat tissues. Mol Genet Metab. 2005;86(1-2):188-199. (Pubitemid 41412175)
-
(2005)
Molecular Genetics and Metabolism
, vol.86
, Issue.1-2
, pp. 188-199
-
-
Latini, A.1
Da Silva, C.G.2
Ferreira, G.C.3
Schuck, P.F.4
Scussiato, K.5
Sarkis, J.J.6
Dutra Filho, C.S.7
Wyse, A.T.S.8
Wannmacher, C.M.D.9
Wajner, M.10
-
35
-
-
84865291187
-
Relationship between tumor enhancement, edema, IDH1 mutational status, MGMT promoter methylation, and survival in glioblastoma
-
Carrillo JA, Lai A, Nghiemphu PL, et al. Relationship between tumor enhancement, edema, IDH1 mutational status, MGMT promoter methylation, and survival in glioblastoma. AJNR Am J Neuroradiol. 2012;33:1349-1355.
-
(2012)
AJNR Am J Neuroradiol
, vol.33
, pp. 1349-1355
-
-
Carrillo, J.A.1
Lai, A.2
Nghiemphu, P.L.3
|