In vitro susceptibility of Plasmodium falciparum Welch field isolates to infusions prepared from Artemisia annua L. cultivated in the Brazilian Amazon

Memorias do Instituto Oswaldo Cruz

Volumn 107, Issue 7, 2012, Pages 859-866

  e Silva, Luiz Francisco Rocha ^a,b,c   de Magalhães, Pedro Melillo ^d   Costa, Mônica Regina Farias ^e   Alecrim, Maria das Graças Costa ^e   Chaves, Francisco Célio Maia ^f   Hidalgo, Ari de Freitas ^g   Pohlit, Adrian Martin ^a   Vieira, Pedro Paulo Ribeiro ^b,e  

^a INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA   (Brazil)

^b UNIVERSIDADE DO ESTADO DO AMAZONAS   (Brazil)

^c Centro Universitário Do Norte   (Brazil)

^d UNIVERSITY OF CAMPINAS   (Brazil)

^e FUNDAÇÃO DE MEDICINA TROPICAL DR HEITOR VIEIRA DOURADO   (Brazil)

^f EMBRAPA CERRADOS   (Brazil)

^g FEDERAL UNIVERSITY OF AMAZONAS   (Brazil)

Author keywords

Amazon Region; Antiplasmodial; Artemisia annua L.; Field isolate; In vitro; Infusion

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; ARTEMISININ DERIVATIVE; CHLOROQUINE; PLANT EXTRACT; QUININE;

ARTEMISIA ANNUA; ARTICLE; BRAZIL; CHEMISTRY; DRUG EFFECT; DRUG POTENTIATION; DRUG SENSITIVITY; IC 50; METHODOLOGY; PLASMODIUM FALCIPARUM;

ANTIMALARIALS; ARTEMISIA ANNUA; ARTEMISININS; BRAZIL; CHLOROQUINE; DRUG SYNERGISM; INHIBITORY CONCENTRATION 50; PARASITIC SENSITIVITY TESTS; PLANT EXTRACTS; PLASMODIUM FALCIPARUM; QUININE;

ARTEMISIA ANNUA; PLASMODIUM FALCIPARUM;

EID: 84869170774     PISSN: 00740276     EISSN: 16788060     Source Type: Journal    
DOI: 10.1590/S0074-02762012000700004     Document Type: Article

References (35)

1. Alecrim MGC 1981. Estudo da resistência do P. falciparum às drogas antimaláricas in vivo e in vitro na Amazônia, MSc Thesis, Universidade de Brasília, Brasília, 116 pp.
2. Andrade-Neto VF, Pohlit AM, Pinto ACS, Silva ECC, Nogueira KL, Melo MRS, Henrique MC, Amorim RCN, Silva LFR, Costa MRF, Nunomura RCS, Nunomura SM, Alecrim WD, Alecrim MGC, Chaves FCM, Vieira PPR 2007. In vitro inhibition of Plasmodium falciparum by substances isolated from Amazonian antimalarial plants. Mem Inst Oswaldo Cruz 102: 359-365.
3. Atemnkeng AM, Chimanuka B, Dejaegher B, Heyden YV, Plaizier-Vercammen J 2009. Evaluation of Artemisia annua infusion efficacy for the treatment of malaria in Plasmodium chabaudi chabaudi infected mice. Exp Parasitol 122: 344-348.
4. Baraldi R, Isacchi B, Predieri S, Marconi G, Vinvieri FF, Bilia AR 2008. Distribution of artemisinin and bioactive flavonoids from A. annua during plant growth. Biochem System Ecol 36: 340-348.
5. Bhakuni RS, Jain DC, Sharma RP, Kumar S 2001. Secondary metabolites of Artemisia annua and their biological activity. Curr Sci 80: 35-48.
6. Bilia AR, Melillo de Magalhães P, Bergonzi MC, Vincieri FF 2006. Simultaneous analysis of artemisinin and flavonoids of several extracts of Artemisia annua L. obtained from a commercial sample and a selected cultivar. Phytomedicine 13: 487-493.
7. Celeghini RMS, Silva AP, Sousa IMO, Foglio MAM 2006. Evaluation of Artemisia annua L. clean-up methods for artemisinin quantification by HPLC. Rev Bras Pl Med 8: 119-122.
8. Chiyaka C, Garira W, Dube S 2009. Effects of treatment and drug resistance on the transmission dynamics of malaria in endemic areas. Theor Popul Biol 75: 14-29.
9. Ferreira I, Martinelli A, Rodrigues L, do Carmo E, do Rosário V, Póvoa M, Cravo P 2008. Plasmodium falciparum from Pará state (Brazil) shows satisfactory in vitro response to artemisinin derivatives and absence of the S769N mutation in the SERCA-type PfATPase6. Trop Med Int Health 13: 199-207.
10. Ferreira ID, Lopes D, Martinelli A, Ferreira C, Rosário VE, Cravo P 2007. In vitro assessment of artesunate, artemether and amodiaquine susceptibility and molecular analysis of putative resistance associated mutations of Plasmodium falciparum from São Tomé and Príncipe. Trop Med Int Health 1: 353-362.
11. Ferreira JFS, Laughlin JC, Delabays N, Magalhaes PM 2005. Cultivation and genetics of Artemisia annua L. for increased production of the antimalarial artemisinin. Plant Genetic Resources 3: 206-229.
12. Gama BE, Lacerda MVG, Daniel-Ribeiro CT, Ferreira-da-Cruz MF 2011. Chemoresistance of Plasmodium falciparum and Plasmodium vivax parasites in Brazil: consequences on disease morbidity and control. Mem Inst Oswaldo Cruz 106 (Suppl. I): 159-166.
13. Girard MP, Reed Z, Friede M, Kieny MP 2007. A review of human vaccine research and development: malaria. Vaccine 25: 1567-1580.
14. Hsu E 2006. The history of qing hao in Chinese materia medica. Trans R Soc Trop Med Hyg 100: 505-508.
15. Jambou R, Legrand E, Niang M, Khim N, Lim P, Volney B, Ekala MT, Bouchier C, Esterre P, Fandeur T, Mercereau-Puijalon O 2005. Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6. Lancet 366: 1960-1963.
16. Lambros C, Vanderberg JP 1979. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol 65: 418-420.
17. Magalhães PM, Delabays N, Sartoratto A 1997. New hybrid lines of antimalarial species Artemisia annua L. guarantee its growth in Brazil. Cien Cult 49: 413-415.
18. Marchese JA, Rehder VLG, Sartoratto A 2001. Quantificação de artemisinina em A. annua-Uma comparação entre as técnicas de cromatografia em camada delgada com detecção densitométrica e cromatografia líquida de alta eficiência com detecção no ultravioleta. Rev Bras Pl Med 4: 81-87.
19. Mueller MS, Karhagomba IB, Hirt HM, Wernakor E, Li SM, Heide L 2000. The potential of Artemisia annua L. as a locally produced remedy for malaria in the Tropics: agricultural, chemical and clinical aspects. J Ethnopharmacol 73: 487-493.
20. Mueller MS, Runyambo N, Wagner I, Borrmann S, Dietz K, Heide L 2004. Randomized controlled trial of a traditional preparation of Artemisia annua L. (Annual Wormwood) in the treatment of malaria. Trans R Soc Trop Med Hyg 98: 318-321.
21. Oliveira TC, Silva DAO, Rostkowska C, Béla SR, Ferro EAV, Mellilo-de-Magalhães P, Mineo JR 2009. Toxoplasma gondii: effects of Artemisia annua L. on susceptibility to infection in experimental models in vitro and in vivo. Exp Parasitol 122: 233-241.
22. Oliveira-Ferreira J, Lacerda MV, Brasil P, Ladislau JL, Tauil PL, Daniel-Ribeiro CT 2010. Malaria in Brazil: an overview. Malaria J 9: 115.
23. Räth K, Taxis K, Walz G, Gleiter CH, LI SM, Heide L 2004. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (Annual Wormwood). Am J Trop Med Hyg 770: 128-132.
24. Ridder S, Kooy F, Verpoorte R 2008. Artemisia annua as a self-reliant treatment for malaria in developing countries. J Ethnopharmacol 120: 302-314.
25. Rieckmann KH, Vampbell GH, Sax LJ 1978. Drug sensitivity of P. falciparum, an "in vitro" microtechnique. Lancet 7: 22-23.
26. Rodrigues RAF, Foglio MA, Júnior SB, Santos AS, Rehder VLG 2006. Otimização do processo de extração e isolamento do antimalárico artemisinina a partir de Artemisia annua L. Quim Nova 29: 368-372.
27. Sanchez PA, Bandy DE, Villachia JH, Nicholaids JJ 1982. Amazon Basin soils: management for continuous crop production. Science 216: 821-827.
28. Träger W, Jensen JB 1976. Human malaria parasites in continuous culture. Science 193: 673-75.
29. Trape JF, Pison G, Spiegel A, Enel C 2002. Combating malaria in Africa. Trends Parasitol 18: 224-230.
30. Vale N, Moreira R, Gomes P 2005. Quimioterapia da malária um século no desenvolvimento de antimaláricos. Qui Nova 99: 57-69.
31. Vieira PP, Ferreira MU, Alecrim MG, Alecrim WD, da Silva LH, Sihuincha MM, Joy DA, Mu J, Su XZ, Zalis MG 2004. Pfcrt polymorphism and the spread of chloroquine resistance in Plasmodium falciparum populations across the Amazon Basin. J Infect Dis 190: 417-424.
32. WHO-World Health Organization 2005. World Malaria Report 2005. Available from: whqlibdoc. who. int/publications/2005/9241593199_eng. pdf.
33. WHO-World Health Organization 2007. Field application of in vitro assays for the sensitivity of human malaria parasites to antimalarial drugs. Library Cataloguing-in-Publication Data. Available from: whqlibdoc. who. int/publications/2007/9789241595155_eng. pdf.
34. WHO-World Health Organization 2010. World Malaria Report 2010. Available from: who. int/malaria/world_malaria_report_2010/en/index. html.
35. Willcox M, Bodeker G, Bourdy G, Dhingra V, Falquet J, Ferreira JFS, Graz B, Hirt HM, Hsu E, Magalhães PM, Damien P, Wright CW 2004. Artemisia annua as a traditional herbal antimalarial. In M Willcox (ed.), Traditional medicinal plants and malaria, CRC Press, Boca Ranton, p. 43-59.