Simultaneous analysis of artemisinin and flavonoids of several extracts of Artemisia annua L. obtained from a commercial sample and a selected cultivar

Phytomedicine

Volumn 13, Issue 7, 2006, Pages 487-493

  Bilia, A R ^a   Melillo de Malgalhaes, P ^b   Bergonzi, M C ^a   Vincieri, F F ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Artemisia annua L.; Artemisinin; Commercial sample and selected cultivars; Extracts; Flavonoids; HPLC DAD MS

Indexed keywords

ARTEMETIN; ARTEMISIA ANNUA EXTRACT; ARTEMISININ; CASTICIN; CHRYSOPLENETIN; CHRYSOSPLENOL D; CIRSILINEOL; EUPATIN; FLAVONOID; HEMIN; HERBACEOUS AGENT; SOLVENT; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTEMISIA ANNUA; ARTICLE; CHEMICAL REACTION; COMMERCIAL PHENOMENA; COMPLEX FORMATION; CULTIVAR; DIODE; DRUG DETERMINATION; DRUG EFFICACY; DRUG POTENTIATION; DRUG SYNTHESIS; DRUG USE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; QUANTUM YIELD; SAMPLE;

ANTIMALARIALS; ARTEMISIA ANNUA; ARTEMISININS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLAVONOIDS; PLANT EXTRACTS; SESQUITERPENES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

ARTEMISIA ANNUA;

EID: 33746886589     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2006.01.008     Document Type: Article

References (24)

1. Bhakuni R.S., Jain D.C., Sharma R.P., and Kumar S. Secondary metabolites of Artemisia annua and their biological activity. Curr. Sci. 80 (2001) 35-48
2. Bilia A.R., Lazari D., Messori L., Taglioli V., Temperini C., and Vincieri F.F. Simple and rapid physico-chemical methods to examine action of antimalarial drugs with hemin: its application to Artemisia annua constituents. Life Sci. 70 (2002) 769-778
3. Brown G.D., Liang G.Y., and Sy L.K. Terpenoids from the seeds of Artemisia annua. Phytochemistry 64 (2003) 303-323
4. De Vries P.J., and Dien T.K. Clinical pharmacology and therapeutic potential of artemisinin and its derivates in the treatment of malaria. Drugs 52 (1996) 818-836
5. Delabays, N. Biologie de la reproduction chez l'Artemisia annua L. et génetique de la production en Artemisinine. Ph.D. Thesis, University of Lausanne, 1997.
6. Dharam C.J., Ajay K.M., Madan M.G., Anil K.S., Ram K.V., Ajai P.G., and Sushil K. Isolation of high artemisinin-yielding clones of Artemisia annua. Phytochemistry 43 (1996) 993-1001
7. Elford B.C., Roberts M.F., Phillipson J.D., and Wilson R.J. Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones. Trans. R. Soc. Trop. Med. Hyg. 81 (1987) 434-436
8. Elsohly H.N., Croom E.M., and Elsohly M.A. Analysis of the antimalarial sesquiterpene artemisinin in Artemisia annua by high-performance liquid chromatography (HPLC) with postcolumn derivatization and ultraviolet detection. Pharm. Res. 4 (1987) 258-260
9. Heppner, D.G., Ballou, W.R., 1998. Malaria in 1998: Advances in Diagnosis, Drugs and Vaccine Development, Tropical and Travel Association.
10. Hien T.T., and White N.J. Qinghaosu. Lancet 341 (1993) 603-608
11. Klayman D.L. Qinghaosu (artemisinin): an antimalarial drug from China. Science 228 (1985) 1049-1055
12. Klayman D.L., Lin A.J., Acton N., Scovill J.P., Hoch J.M., Milhous W.K., Theoharides A.D., and Dobek A.S. Isolation of artemisinin (qinghaosu) from Artemisia annua growing in the United States. J. Nat. Prod. 47 (1984) 715-717
13. Laughlin J. Agricultural production of artemisinin - a review. Trans. R. Soc. Trop. Med. Hyg. 88 (1994) 21
14. Liu K.C.S.C., Yang S.L., Roberts M.F., Elford B.C., and Phillipson J.D. Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures. Plant Cell Rep. 11 (1992) 637
15. Magalhães, P.M., Delabays, N., Sartoratto, A., 1997. Ciencia e Cultura. J. Braz. Assoc. Adv. Sci. 49(5/6).
16. Phillipson J.D. New drugs from nature - it could be yew. Phytother. Res. 13 (1999) 2
17. Pras N., Visser J.F., Batterman S., Woerdenbag H.J., Maligré T.M., and Lugt C.B. Laboratory selection of Artemisia annua L. for high yielding types. Phytochem. Anal. 2 (1991) 80-83
18. Sy L.K., and Brown G.D. Deoxyarteannuin B, dihydro-deoxyarteannuin B and trans-5-hydroxy-2-isopropenyl-5-methylhex-3-en-1-ol from Artemisia anuua. Phytochemistry 58 (2001) 1159-1166
19. Tang HQ., Hu J., Yang L., and Tan R.X. Terpenoids and flavonoids from Artemisia species. Planta Med. 66 (2000) 391-393
20. van Agtmael M.A., Eggelte T.A., and van Boxtel C.J. Artemisinin drugs in the treatment of malaria: from medicinal harb to registered medication. TiPS 20 (1999) 199-205
21. Vandenberghe D.R., Vergauwe A.N., Van Montagu M., and Van Den Eeckhout E.G. Simultaneous determination of artemisinin and its bioprecursors in Artemisia annua. J. Nat. Prod. 58 (1995) 798-803
22. Williamson E.M. Synergy and other interactions in phytomedicines. Phytomedicine 8 5 (2001) 401
23. Woerdenbag H.J., Pras N., Bos R., Visser J.F., Hendricks H., and Malingré T.M. Analysis of artemisinin and related sesquiterpenoids from Artemisia annua L. by combined gas chromatography/mass spectrometry. Phytochem. Anal. 2 (1991) 215-219
24. World Health Organization, The World Health Report. Fighting disease, fostering development (1996), WHO, Geneva, Switzerland