Randomized controlled trial of a traditional preparation of Artemisia annua L. (Annual Wormwood) in the treatment of malaria

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 98, Issue 5, 2004, Pages 318-321

  Mueller, Markus S ^a   Runyambo, Nyabuhanga ^b,d   Wagner, Irmela ^c   Borrmann, Steffen ^c   Dietz, Klaus ^c   Heide, Lutz ^c  

^a DIFAEM German Institute of Medical Mission   (Germany)

^b Institut National de Recherche Biomédicale   (Congo)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d Insp Provinciale de la Sante Publ ^*  (Congo)

Author keywords

Artemisia annua; Artemisinin; Congo; Malaria; Plasmodium falciparum; Traditional antimalarials

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISIA ANNUA EXTRACT; ARTEMISININ; QUININE SULFATE; HERBACEOUS AGENT; QUININE;

ARTEMISIA ANNUA; ARTICLE; CHINESE MEDICINE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG INDICATION; DRUG SAFETY; HERBAL MEDICINE; HUMAN; MAJOR CLINICAL STUDY; MALARIA; MALARIA CONTROL; MEDICINAL PLANT; MONOTHERAPY; PARASITEMIA; SYMPTOMATOLOGY; TEA; TINNITUS; ADULT; MALARIA FALCIPARUM; METHODOLOGY; MULTICENTER STUDY; PHYTOTHERAPY; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME;

ARTEMISIA; ARTEMISIA ANNUA; CINCHONA PUBESCENS; PLASMODIUM FALCIPARUM;

ADULT; ANTIMALARIALS; ARTEMISIA ANNUA; DRUGS, CHINESE HERBAL; HUMANS; MALARIA, FALCIPARUM; PARASITEMIA; PHYTOTHERAPY; PILOT PROJECTS; QUININE; TREATMENT OUTCOME;

EID: 1042294559     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trstmh.2003.09.001     Document Type: Article

References (5)

1. de Vries P.J. Dien T.K. Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria Drugs 52 1996 818-836
2. Guerin P.J. Olliaro P. Nosten F. Druilhe P. Laxminarayan R. Binka F. Kilama W.L. Ford N. White N.J. Malaria: Current status of control, diagnosis, treatment, and a proposed agenda for research and development Lancet Infect. Dis. 2 2002 564-573
3. Mueller M.S. Karhagomba I.B. Hirt H.M. Wemakor E. The potential of Artemisia annua L. as a locally produced remedy for malaria in the tropics: agricultural, chemical and clinical aspects J. Ethnopharmacol. 73 2000 487-493
4. Räth, K., Taxis, K., Gleiter, C.H., Li, S.-M., Heide, L., Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (Annual Wormwood). Am. J. Trop. Med. Hyg., in press.
5. WHO, 1996. Assessment of therapeutic efficacy of antimalarial drugs for uncomplicated falciparum malaria in areas with intense transmission. World Health Organization, Geneva, WHO/MAL/96 1077.