Pathophysiology of nasal polyposis: The role of desmosomal junctions

American Journal of Rhinology

Volumn 22, Issue 6, 2008, Pages 589-597

  Zuckerman, Jodi D ^a,b   Lee, Winston Y ^a   DelGaudio, John M ^a   Moore, Charles E ^a   Nava, Porfirio ^a   Nusrat, Asma ^a   Parkos, Charles A ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Pathology and Laboratory Medicine ^*  (United States)

Author keywords

Adherens junction; Desmosomal junctions; Epithelial cells; IFN gamma; IL 13; Inflammatory cytokines; Nasal mucosa; Nasal polyposis; Tight junctions; TNF alpha

Indexed keywords

DESMOGLEIN 2; DESMOGLEIN 3; GAMMA INTERFERON; INTERLEUKIN 13; PREDNISONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; BRONCHUS MUCOSA; CELL CULTURE; CELL JUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; DESMOSOME; DOWN REGULATION; ENDOSCOPIC SURGERY; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOPATHOGENESIS; IN VITRO STUDY; INFLAMMATION; INTERNALIZATION; MALE; NASAL BIOPSY; NOSE MUCOSA; NOSE POLYP; NOSE SURGERY; PATHOPHYSIOLOGY; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TH1 CELL; TH2 CELL; TIGHT JUNCTION; WESTERN BLOTTING;

ADULT; AGED; BLOTTING, WESTERN; DESMOGLEIN 2; DESMOGLEIN 3; DESMOSOMES; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-13; MALE; MIDDLE AGED; NASAL POLYPS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 59849125878     PISSN: 10506586     EISSN: None     Source Type: Journal    
DOI: 10.2500/ajr.2008.22.3235     Document Type: Article

References (23)

1. Larsen PL, and Tos M. Origin of nasal polyps: An endoscopic autopsy study. Laryngoscope 114:710-719, 2004.
2. Van Zele T. Differentiation of chronic sinus disease by measurement of inflammatory editors. Allergy 61:1280-1289, 2006.
3. Bernstein JM, and Yankasaks JR. Increased ion transport in cultured nasal polyp epithelial cells. Arch Otolaryngology Head Neck Surg 120:993-996,1994.
4. Bachert C, Gevaert P, Holtappels G, et al. Nasal polyposis: From cytokines to growth. Am J Rhinol 14:279-290, 2000.
5. Tos M. The pathogenetic theories of formation of nasal polyps. Am J Rhinol 4:51-56, 1990.
6. Ahmed SK, Williams JL, Drake-Lee A, and Egginton S. No significant role for angiogenesis in nasal polyposis. Am J Rhihol 22:1:24-27, 2008.
7. Bernstein JM, Noble, B, and Yankasakas, JR. Nasal polyposis: Immunohistochemistry and bioelectrical findings (a hypothesis for the development of nasal polyps). J Allergy Clin Immunol 99:165-175, 1999.
8. Kobayashi TN, Hamano N, Numata T, and Konno A. Trans-epithelial migration of activated eosinophils induces a decrease of E-cadherin expression in cultured human nasal epithelial cells. Clin Exp Allergy 30:807-817, 2000.
9. Huber O. Structure and function of desmosomal proteins and their role in development and disease. Cell Mol Life Sci 60:1872-1890, 2003.
10. Porfirio N, Laukoetter MG, and Hopkins AM. Desmoglein-2: A novel regulator of apoptosis in the intestinal epithelium. Mol Biol Cell 18:565-578, 2007.
11. Parkos CA, Delp C, 4maout A, and Madara JL. Neutzophil migration across a cultured intestinal epithelium: Dependence on a CD11b/CD18-mediated event and enhanced efficiency in physiological direction. J Clin Invest 88:1605-1612, 1991.
12. Larsen PL, and Tos M. Origin of nasal polyp. Laryngoscope 101:305-312,1991.
13. Kucharzik T., et al. Neutrophil transmigration in inflammatory bowel disease is associated with differential expression of epithelial intercellular junctional proteins. Am J Pathol 159:2001-2009, 2001.
14. Laukoetter MG, Bruewer M, and Nusrat A. Asthma. Regulation of the intestinal epithelial barrier by apical junctional complex. Curr Opin Gastroenterol 22:85-89, 2006.
15. Jang YJ, Kim HG, and Koo TW. Localization of ZO-1 and E-cadherin in the nasal polyp epithelium. Eur Arch Otorhinolaryngol 259:465-469, 2002.
16. Takano K, Kojima T, Go M, et al. HLA-DR and CD-11c-positive dendritic cells penetrate beyond well-developed epithelial tight junctions in human nasal mucosa of allergic rhinitis. J Histochem Cytochem 53:611-619, 2005.
17. Shahana S, Jaunmuktane Z, Asplund MS, and Roomans GM. Ultrastructural investigation of epithelial damage in asthmatic and non-asthmatic nasal polyps. Respir Med 100:2018-2028, 2006.
18. Rinia AB, Kostamo FA, Ebbens FA, et al. Nasal polyposis: A cellular based approach to answering questions. Allergy 62:348-358, 2007.
19. Romagnani S. The Th1/Th2 paradigm and allergic disorders. Allergy 53(suppl 46):12-15, 1998.
20. Ramanathan M Jr, Lee WK, Spannhake E, et al. Th2 cytokines associated with chronic rhinosinusitis with polyps down regulate the antimicrobial immune function of human sinonasal epithelial cells. Am J Rhinol 22:115-121, 2008.
21. Ramanthan M, and Lane A. Innate immunity of the sinonasal cavity and its role in chronic rhinosinusitis. Otolaryngol Head Neck Surg 136:348-356, 2007.
22. Watelet JB, Claeys C, Perez-Novo C, et al. Transforming growth factor beta1 in nasal remodeling: Differences between rhinosinusitis and nasal polyposis. Am J Rhinol 18:267-272, 2004.
23. Lezcan-Meza D, Davila-Davila B, Veag-Miranda A, et al. Interleukin-4 and to a lesser extent either IL-13 or IFN-gamma regulate the production of eotaxin-2/CCL 24 in nasal polyps. Allergy 58:1011-1017, 2003.