FK506 potentiates steroid-induced T-cell apoptosis

Transplantation

Volumn 64, Issue 9, 1997, Pages 1365-1369

  Migita, Kiyoshi ^a   Eguchi, Katsumi ^a   Kawabe, Yojiro ^a   Origuchi, Tomoki ^a   Tominaga, Masahiro ^a   Nagataki, Shigenobu ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; DEXAMETHASONE; DNA FRAGMENT; TACROLIMUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOIMMUNITY; CELL ISOLATION; DNA TRANSCRIPTION; ELECTROPHORESIS; GRAFT VERSUS HOST REACTION; HELPER CELL; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPPRESSOR CELL; THYMOCYTE;

ADULT; ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; APOPTOSIS; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MICE; MICE, INBRED BALB C; T-LYMPHOCYTES; TACROLIMUS;

EID: 0030712978     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199711150-00022     Document Type: Article

References (27)

1. Thomson AW. FK506: profile of an important new immunosuppressant. Transplant Rev 1990; 4: 1.
2. Tocci MJ, Matkovich DA, Kwoek D, et al. The immunosuppressant FK506 selectively inhibits expression of early T cell activation gene. J Immunol 1989; 143: 718.
3. Yoshimura N, Matsui S, Hamashima T, Oka T. The effect of a new immunosuppressive agent, FK506, on human lymphocyte response in vitro: inhibition of the production of IL-2 and γ-IFN, but not B cell-stimulating factor 2. Transplantation 1989; 47: 356.
4. Starzl TE, Todo S, Fung J, Demetris AJ, Venkataramman R, Jain A. FK506 for liver, kidney, and pancreas transplantation. Lancet 1989; ii: 1000.
5. Tzakis AG, Abu-Elmagd K, Fung JJ. FK506 rescue in chronic graft-versus-host disease after bone marrow transplantation. Transplant Proc 1991; 23: 3225.
6. Japanese FK506 study group. A multicenter clinical open trial of FK506 in refractory uveitis, including Behcet's disease. Transplant Proc 1991; 23: 3343.
7. O'Keefe SJ, Tamura T, Kincaid RL, Tocci MJ, O'Neill EA. FK506 and CsA-sensitive activation of interleukin-2 promoter by calcineurin. Nature 1992; 356: 692.
8. Cupps TR, Fauci AS. Corticosteroid-mediated immunoregulation in man. Immunol Rev 1982; 65: 133.
9. Evans RM. The steroid and thyroid hormone receptor superfamily. Science 1988; 240: 889.
10. Beato M. Gene regulation by steroid hormone. Cell 1989; 56: 335.
11. Smith DE, Toft DO. Steroid receptors and their associated proteins. Mol Endocrinol 1993; 7: 4.
12. Pratt WB. The role of heat shock proteins in regulation the function and trafficking of glucocorticoid receptor. J Biol Chem 1993; 268: 21455.
13. Sanchez ER. Hsp56: a novel heat shock protein associated with untransformed steroid receptor complex. J Biol Chem 1990; 266: 16436.
14. Tai PK, Albers MW, Chang H, Faber LE, Schreiber SL. Association of a 59-kilodalton immunophilin with the glucocorticoid receptor complex. Science 1992; 256: 1315.
15. Yem AW, Tomasselli AG, Heinrikson RL, et al. The hsp56 component of steroid receptor complexes binds to the immobilized FK506 and shows homology to FKBP-12 and FKBP-13. J Biol Chem 1992; 267: 2868.
16. Tsai P-K K, Albers MW, McDonnell DP, Chang H, Schreiber SL, Faber LE. Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506. Biochemistry 1994; 33: 10666.
17. Wyillie AH. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 1980; 284: 556.
18. Tuosto L, Cundari E, Montani MSG, Piccolella E. Analysis of susceptibility of human T lymphocytes to dexamethasone-induced apoptosis. Eur J Immunol 1994; 24: 1061.
19. Perandones CE, Illera VA, Peckham D, Stunz L, Ashman R. Regulation of apoptosis in vitro in mature murine spleen T cells. J Immunol 1993; 151: 3521.
20. Renoir JM, Radanyi C, Faber LE, Baulieu EE. The non-DNA-binding hetero-oligomeric form of mammalian steroid hormone receptors contains a hsp90-bound 59-kilodalton protein. J Biol Chem 1990; 265: 10740.
21. Rexin M, Busch W, Gehring U. Protein components of the non-activated glucocorticoid receptor. J Biol Chem 1991; 266: 24601.
22. Lanza L, Scudeletti M, Puppo F, et al. Prednisolone increases apoptosis in vitro activated human peripheral blood T lymphocytes. Clin Exp Immunol 1996; 103: 482.
23. McCarthy SA, Cacchione RN, Mainuaring MS, Cairns JS. The effects of immunosuppressive drugs on the regulation of activation-induced apoptotic cell death in thymocytes. Transplantation 1992; 54: 543.
24. Gottschalk AR, Boise LH, Thompson CB, Quintas J. Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. Proc Natl Acad Sci USA 1994; 91: 7450.
25. Cohen JJ, Duke RC, Fadok VA, Sellins KS. Apoptosis and programmed cell death in immunity. Annu Rev Immunol 1992; 10: 267.
26. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995; 267: 1456.
27. Nagata S, Goldstein P. The Fas death factor. Science 1995; 267: 1449.