β-Lactam synthon-interceded diastereoselective synthesis of functionalized octahydroindole-based molecular scaffolds and their in vitro cytotoxic evaluation

European Journal of Medicinal Chemistry

Volumn 58, Issue , 2012, Pages 513-518

  Singh, Pardeep ^a   Raj, Raghu ^a   Bhargava, Gaurav ^b   Hendricks, Denver T ^c   Handa, Sachin ^d   Slaughter, Legrande M ^d   Kumar, Vipan ^a  

^a GURU NANAK DEV UNIVERSITY   (India)

^b I K GUJRAL PUNJAB TECHNICAL UNIVERSITY   (India)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

Lactam synthon protocol; Cytotoxicity; Diastereoselectivity; Iodocyclization; Octahydroindoles

Indexed keywords

1 ( 4 CHLOROPHENYL) 7 IODO 2 ( 4 METHOXYPHENYL)OCTAHYDROINDOLE 3,4 DICARBOXYLIC ACID DIMETHYL ESTER; 1 ( 4 CHLOROPHENYL) 7 IODO 2 PHENYLOCTAHYDROINDOLE 3,4 DICARBOXYLIC ACID DIMETHYL ESTER; 1,2 BIS( 4 CHLOROPHENYL) 7 IODOOCTAHYDROINDOLE 3,4 DICARBOXYLIC ACID DIMETHYL ESTER; 2 ( 4 CHLOROPHENYL) 7 IODO 1 PHENYLOCTAHYDROINDOLE 3,4 DICARBOXYLIC ACID DIMETHYL ESTER; 7 IODO 1,2 DIPHENYLOCTAHYDROINDOLE 3,4 DICARBOXYLIC ACID DIMETHYL ESTER; 7 IODO 2 ( 4 METHOXYPHENYL) 1 PHENYLOCTAHYDROINDOLE 3,4 DICARBOXYLIC ACID DIMETHYL ESTER; 7 IODO 2 ( 4 METHOXYPHENYL) 1,4 TOLYLOCTAHYDROINDOLE 3,4 DICARBOXYLIC ACID DIMETHYL ESTER; 7 IODO 2 PHENYL 1,4 TOLYLOCTAHYDROINDOLE 3,4 DICARBOXYLIC ACID DIMETHYL ESTER; ANTINEOPLASTIC AGENT; BETA LACTAM DERIVATIVE; INDOLE DERIVATIVE; METAL; MOLECULAR SCAFFOLD; OCTAHYDROINDOLE; OCTAHYDROPYRROLO[4,3,2 DE]ISOQUINOLINE 3,5 DIONE; SYNTHON; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CATALYSIS; CONTROLLED STUDY; CYTOTOXICITY; DIASTEREOISOMER; DRUG POTENCY; ESOPHAGUS CANCER; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; ONE POT SYNTHESIS; PHASE TRANSITION; STEREOCHEMISTRY;

ANTINEOPLASTIC AGENTS; BETA-LACTAMS; CELL LINE, TUMOR; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDOLES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84869142384     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.10.049     Document Type: Article

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