Synthesis of N,N′-bis(5-arylidene-4-oxo-3,5-dihydro-4H-imidazol-2-yl) diamines bearing various linkers and biological evaluation as potential inhibitors of kinases

European Journal of Medicinal Chemistry

Volumn 58, Issue , 2012, Pages 581-590

  Coulibaly, Wacothon Karime ^a,b   Paquin, Ludovic ^a   Bénie, Anoubilé ^b   Bekro, Yves Alain ^b   Durieu, Emilie ^c   Meijer, Laurent ^d   Bazureau, Jean Pierre ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b UNIVERSITÉ NANGUI ABROGOUA   (Côte d’Ivoire)

^c STATION BIOLOGIQUE   (France)

^d Centre de Perharidy   (France)

Author keywords

5 Arylidene imidazolinone; Diamino linker; Kinase inhibitors; Microwave irradiation; N,N bis(5 arylidene 4 oxo 3,5 dihydro 4H imidazol 2 yl)diamine; Solvent free; Sulphur nitrogen displacement

Indexed keywords

(5) 2 ETHYLSULFANYL 3 METHYL 5 (4 METHYLOXYBENZYLIDENE) 3,5 DIHYDRO 4H IMIDAZOL 4 ONE; (5) 2 ETHYLSULFANYL 3 METHYL 5 (4 PHENYLMETHYLOXYBENZYLIDENE) 3,5 DIHYDRO 4H IMIDAZOL 4 ONE; (5) 3 BUTYL 5 (4 METHOXYBENZYLIDENE) 2 THIOXO IMIDAZOLIDIN 4 ONE; (5) 3 METHYL 5 (4 PHENYLMETHYLOXYBENZYLIDENE) 2 THIOXO IMIDAZOLIDIN 4 ONE; (5) 5 (4 BUTYLOXYBENZYLIDENE) 2 ETHYLSULFANYL 3 METHYL 3,5 DIHYDRO 4H IMIDAZOL 4 ONE; (5) 5 (4 BUTYLOXYBENZYLIDENE) 3 METHYL 2 THIOXO IMIDAZOLIDIN 4 ONE; (5) 5 (4 METHOXYBENZYLIDENE) 3 METHYL 2 THIOXO IMIDAZOLIDIN 4 ONE; (5) 5 (BENZO [1,3] DIOXOL 5 YL)METHYLENE 2 ETHYLSULFANYL 3 METHYL 3,5 DIHYDRO 4H IMIDAZOL 4 ONE; (5) 5 (BENZO [1,3] DIOXOL 5 YL)METHYLENE 3 BUTYL 2 THIOXO IMIDAZOLIDIN 4 ONE; (5) 5 (BENZO [1,3] DIOXOL 5 YL)METHYLENE 3 METHYL 2 THIOXO IMIDAZOLIDIN 4 ONE; (5) 5 ARYLIDENE 2 ETHYLSULFANYL 3,5 DIHYDRO 4H IMIDAZOL 4 ONE; (5) 5 BENZYLIDENE 2 ETHYLSULFANYL 3 METHYL 3,5 DIHYDRO 4H IMIDAZOL 4 ONE; (5) 5 BENZYLIDENE 3 METHYL 2 THIOXO IMIDAZOLIDIN 4 ONE; 1,2 BIS [(5) 3 METHYL 5 (4 METHOXYPHENYL)METHYLENE 4 OXO 3,5 DIHYDRO 4H IMIDAZOL 2 YL]ETHYLENE DIAMINE; 1,2 BIS [(5) 5 (1,3 BENZODIOXOL 5 YL)METHYLENE 3 METHYL 4 OXO 3,5 DIHYDRO 4H IMIDAZOL 2 YL]ETHYLENE DIAMINE; 1,2 BIS [(5) 5 (4 BENZYLOXYPHENYL)METHYLENE 3 METHYL 4 OXO 3,5 DIHYDRO 4H IMIDAZOL 2 YL]ETHYLENE DIAMINE; 1,2 BIS [(5) 5 (4 BUTYLOXYPHENYL)METHYLENE 3 METHYL 4 OXO 3,5 DIHYDRO 4H IMIDAZOL 2 YL]ETHYLENE DIAMINE; 1,4 BIS [(5) 3 METHYL 5 (4 METHOXYPHENYL)METHYLENE 4 OXO 3,5 DIHYDRO 4H IMIDAZOL 2 YL]PIPERAZINE; 1,4 BIS [(5) 5 (1,3 BENZODIOXOL 5 YL)METHYLENE 3 METHYL 4 OXO 3,5 DIHYDRO 4H IMIDAZOL 2 YL]PIPERAZINE; 1,4 BIS [(5) 5 (4 BENZYLOXYPHENYL)METHYLENE 3 BUTYL 4 OXO 3,5 DIHYDRO 4H IMIDAZOL 2 YL]PIPERAZINE; 1,4 BIS [(5) 5 (4 BENZYLOXYPHENYL)METHYLENE 3 METHYL 4 OXO 3,5 DIHYDRO 4H IMIDAZOL 2 YL]PIPERAZINE; 1,4 BIS [(5) 5 PHENYLMETHYLENE 3 METHYL 4 OXO 3,5 DIHYDRO 4H IMIDAZOL 2 YL]PIPERAZINE; 4 BENZYLOXYBENZALDEHYDE; 4 BUTYLOXYBENZALDEHYDE; ETHYLENEDIAMINE; N,N' BIS (3 AMINOPROPYL)PIPERAZINE; N,N' BIS (5 ARYLIDENE 4 OXO 3,5 DIHYDRO 4H IMIDAZOL 2 YL)DIAMINE; PIPERAZINE; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; CHEMICAL REACTION; DRUG IDENTIFICATION; DRUG SCREENING; DRUG SYNTHESIS; IC 50; MICROWAVE RADIATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; DIAMINES; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOGEN SYNTHASE KINASE 3; MICE; MICROWAVES; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 84869129800     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.08.044     Document Type: Article

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