Synthesis and preliminary biological evaluation of new derivatives of the marine alkaloid leucettamine B as kinase inhibitors

European Journal of Medicinal Chemistry

Volumn 45, Issue 2, 2010, Pages 805-810

  Debdab, Mansour ^a   Renault, Stéven ^a   Lozach, Olivier ^b   Meijer, Laurent ^b   Paquin, Ludovic ^a   Carreaux, François ^a   Bazureau, Jean Pierre ^a  

^a UNIVERSITÉ DE RENNES 1   (France)

^b Protein Phosphorylation and Human Disease Group   (France)

Author keywords

Kinase inhibitors; Leucettamine B; Marine alkaloid; Microwave irradiation; Reductive amination; Solvent free; Sulfur nitrogen displacement

Indexed keywords

5 [(1,3 BENZODIOXO 5 YL)METHYLENE] 3 METHYL 2 [(2 (Z) BENZYLIDENEAMINO)ETHYLAMINO] 3,5 DIHYDRO 4H IMIDAZOL 4 ONE; 5 [(1,3 BENZODIOXO 5 YL)METHYLENE] 3 METHYL 2 [(2 (Z)(1,3 BENZODIOXOL 5 YL)METHYLENEAMINO]ETHYLAMINO] 3,5 DIHYDRO 4H IMIDAZOL 4 ONE; 5 [(1,3 BENZODIOXO 5 YL)METHYLENE] 3 METHYL 2 [2 (Z)(4 NITROBENZYLIDENEAMINO)ETHYLAMINO] 3,5 DIHYDRO 4H IMIDAZOL 4 ONE; 5 [(1,3 BENZODIOXO 5 YL)METHYLENE] 3 METHYL 2 [2(Z)(3,4,5 TRIMETHOXYBENZYLIDENEAMINO)ETHYLAMINO] 3,5 DIHYDRO 4H IMIDAZOL 4 ONE; 5 [(1,3 BENZODIOXO 5 YL)METHYLENE] 3 METHYL 2 [2(Z)(4 CHLOROBENZYLIDENEAMINO)ETHYLAMINO] 3,5 DIHYDRO 4H IMIDAZOL 4 ONE; 5 [(1,3 BENZODIOXO 5 YL)METHYLENE] 3 METHYL 2 [2(Z)(4 METHOXYBENZYLIDENEAMINO)ETHYLAMINO] 3,5 DIHYDRO 4H IMIDAZO 4 ONE; 5 [(1,3 BENZODIOXO 5 YL)METHYLENE] 3 METHYL 2 [[2 (Z)(2,3 DIHYDROBENZO[1,4]DIOXIN 6 YL)METHYLENEAMINO]ETHYLAMINO] 3,5 DIHYDRO 4H IMIDAAZOL 4 ONE; 5 [(1,3 BENZODIOXO 5 YL)METHYLENE] 3 METHYL 2 [[2 (Z)(2,3 DIHYDROFURAN 5 YL)METHYLENEAMINO)ETHYLAMINO] 3,5 DIHYDRO 4H IMIDAZOL 4 ONE; 5 BENZO[1,3] DIOXO 5 YLMETHYLENE 2 ETHYLSULFANYL 3,5 DIHYDROIMIDAZOL 4 ONE; ALKALOID DERIVATIVE; CASEIN KINASE IALPHA; CYCLIN DEPENDENT KINASE 5; ETHYLENEDIAMINE; GLYCOGEN SYNTHASE KINASE 3ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; IMIDAZOLE DERIVATIVE; LEUCETTAMINE B; LEUCETTAMINE B DERIVATIVE; NITROGEN; PROTEIN KINASE INHIBITOR; SULFUR; UNCLASSIFIED DRUG;

AMINATION; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL BOND; DEPROTECTION REACTION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MICROWAVE IRRADIATION; PROTON NUCLEAR MAGNETIC RESONANCE; THIN LAYER CHROMATOGRAPHY;

ALKALOIDS; BENZODIOXOLES; IMIDAZOLINES; OCEANS AND SEAS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES;

EID: 73849133993     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.10.009     Document Type: Article

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