Early signs of maternal iron deficiency do not influence the iron status of the newborn, but are associated with higher infant birthweight

Acta Obstetricia et Gynecologica Scandinavica

Volumn 88, Issue 1, 2009, Pages 83-90

  Ervasti, Mari ^a   Sankilampi, Ulla ^b   Heinonen, Seppo ^b   Punnonen, Kari ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Birthweight; Hemoglobin; Iron status; Newborn; Pregnancy

Indexed keywords

FERRITIN; HEMOGLOBIN; IRON; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ADULT; ARTICLE; BIOACCUMULATION; BIRTH WEIGHT; CLINICAL ARTICLE; CORRELATION COEFFICIENT; ERYTHROCYTE; FEMALE; FERRITIN BLOOD LEVEL; FETUS GROWTH; FINLAND; GESTATIONAL AGE; HEMOGLOBIN DETERMINATION; HUMAN; INFANCY; IRON BLOOD LEVEL; IRON DEFICIENCY; MATERNAL BLOOD; NEWBORN; NEWBORN PERIOD; NUTRITION; PLACENTA WEIGHT; PREGNANCY OUTCOME; PREGNANT WOMAN; PRIORITY JOURNAL; TRANSFERRIN BLOOD LEVEL; UMBILICAL CORD BLOOD; BLOOD; CHEMISTRY; CROSS-SECTIONAL STUDY; EARLY DIAGNOSIS; FETUS BLOOD; FOLLOW UP; IRON DEFICIENCY ANEMIA; METHODOLOGY; NONPARAMETRIC TEST; PREGNANCY; PREGNANCY COMPLICATION; PRENATAL CARE; PROBABILITY; PROLONGED PREGNANCY; RISK ASSESSMENT;

ADULT; ANEMIA, HYPOCHROMIC; BIRTH WEIGHT; CROSS-SECTIONAL STUDIES; EARLY DIAGNOSIS; FEMALE; FERRITINS; FETAL BLOOD; FOLLOW-UP STUDIES; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PREGNANCY OUTCOME; PREGNANCY, PROLONGED; PRENATAL CARE; PROBABILITY; RISK ASSESSMENT; STATISTICS, NONPARAMETRIC; YOUNG ADULT;

EID: 59249096384     PISSN: 00016349     EISSN: 16000412     Source Type: Journal    
DOI: 10.1080/00016340802595993     Document Type: Article

References (54)

1. WHO. Iron deficiency anaemia. Assessment, prevention, and control. A guide for programme managers. Geneva: WHO, 2001.
2. Steer PJ, Alam MA, Wadsworth J, Welch A. Relation between maternal haemoglobin concentration and birth weight in different ethnic groups. Br Med J. 1995;310:489-91.
3. Rush D. Nutrition and maternal mortality in the developing world. Am J Clin Nutr. 2000;72:212S-40S.
4. van den Broek N, Letsky EA. Etiology of anemia in pregnancy in south Malawi. Am J Clin Nutr. 2000;72:247S-56S.
5. Xiong X, Buekens P, Alexander S, Demianczuk N, Wollast E. Anemia during pregnancy and birth outcome: a meta-analysis. Am J Perinatol. 2000;17:137-46.
6. Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. J Nutr. 2001;131:649S-68S.
7. Tamura T, Goldenberg R, Hou J, Johnston K, Cliver S, Ramey S, et al. Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age. J Pediatr. 2002;140:165-70.
8. Lozoff B, Georgieff MK. Iron deficiency and brain development. Semin Pediatr Neurol. 2006;13:158-65.
9. Rioux FM, LeBlanc CP. Iron supplementation during pregnancy: what are the risks and benefits of current practices? Appl Physiol Nutr Metab. 2007;32:282-8.
10. Ziaei S, Norrozi M, Faghihzadeh S, Jafarbegloo E. A randomised placebo-controlled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin ≥13.2 g/dl. Br J Obstet Gynaecol. 2007;114:684-8.
11. Murphy JF, O'Riordan JO, Newcombe RG, Coles EC, Pearson JF. Relation of haemoglobin levels in first and second trimesters to outcome of pregnancy. Lancet. 1986;1:992-5.
12. Goldenberg RL, Tamura T, DuBard M, Johnston KE, Copper RL, Neggers Y. Plasma ferritin and pregnancy outcome. Am J Obstet Gynecol. 1996;175:1356-9.
13. Tarim E, Kilicdag E, Bagis T, Ergin T. High maternal hemoglobin and ferritin values as risk factors for gestational diabetes. Int J Gynecol Obstet. 2004;84:259-61.
14. Chen X, Scholl TO, Stein TP. Association of elevated serum ferritin levels and the risk of gestational diabetes mellitus in pregnant women. Diabetes Care. 2006;29:1077-82.
15. Bencaiova G, Krafft A, Burkhardt T, Zimmerman R. Hemoglobinopathies, body iron stores and gestational diabetes mellitus. Haematologica. 2007;90:1138-9.
16. Lao TT, Tam K-F, Chan LY. Third trimester iron status and pregnancy outcome in non-anaemic women; pregnancy unfavourably affected by maternal iron excess. Hum Reprod. 2000;15:1843-8.
17. Hou J, Cliver SP, Tamura T, Johnston KE, Goldenberg R. Maternal serum ferritin and fetal growth. Obstet Gynecol. 2000;95:447-52.
18. Jaime-Perez JC, Herrera-Garza JL, Gomez-Almaguer D. Suboptimal fetal iron acquisition under a maternal environment. Arch Med Res. 2005;36:598-602.
19. Schümann K, Ettle T, Szegner B, Elsenhans B, Solomons NW. On risks and benefits of iron supplementation recommendations for iron intake revisited. J Trace Elem Med Biol. 2007;21:147-68.
20. Reveiz L, Gyte GML, Cuervo LG. Treatments for irondeficiency anaemia in pregnancy. Cochrane Database Syst Rev. 2007; Issue 2: Art. No.:CD003094. DOI: 10.1002/14651858.CD003094.pub2.
21. Scholl T, Reilly T. Anemia, iron and pregnancy outcome. J Nutr. 2000;130:443S-7S.
22. Ervasti M, Kotisaari S, Heinonen S, Punnonen K. Use of advanced red blood cell and reticulocyte indices improves the accuracy in diagnosing iron deficiency in pregnant women at term. Eur J Haematol. 2007;79:539-45.
23. Guyatt G, Oxman A, Ali M, Willan A, McIlroy W, Patterson C. Laboratory diagnosis of iron-deficiency anemia: an overview. J Gen Intern Med. 1992;7:145-53.
24. Punnonen K, Irjala K, Rajamäki A. Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood. 1997;89:1052-7.
25. Brugnara C. Iron deficiency and erythropoiesis: new diagnostic approaches. Clin Chem. 2003;49:1573-8.
26. Franck S, Linssen J, Messinger M, Thomas L. Potential utility of Ret-Y in the diagnosis of iron-restricted erythropoiesis. Clin Chem. 2004;50:1240-2.
27. Thomas L, Franck S, Messinger M, Linssen J, Thomé M, Thomas C. Reticulocyte hemoglobin measurement - comparison of two methods in the diagnosis of iron-restricted erythropoiesis. Clin Chem Lab Med. 2005;43:1193-202.
28. Kotisaari S, Romppanen J, Penttilä I, Punnonen K. The Advia 120 red blood cell and reticulocyte indices are useful in diagnosis of iron-deficiency anemia. Eur J Haematol. 2002;68:150-6.
29. Mohandas N, Kim YR, Tycko DH, Orlik J, Wyatt J, Groner W. Accurate and independent measurement of volume and hemoglobin concentration of individual red cells by laser light scattering. Blood. 1986;68:506-13.
30. Fishbane S, Shapiro W, Dutka P, Valenzuela OF, Faubert J. A randomized trial of iron deficiency testing strategies in hemodialysis patients. Kidney Int. 2001;60:2406-11.
31. David O, Grillo A, Ceoloni B, Cavallo F, Podda G, Biancotti PP, et al. Analysis of red cell parameters on the Sysmex XE 2100 and ADVIA 120 in iron deficiency and in uraemic chronic disease. Scand J Clin Lab Invest. 2006;66:113-20.
32. Katodritou E, Terpos E, Zervas K, Speletas M, Kapetanos D, Kartsios C, et al. Hypochromic erythrocytes (%): a reliable marker for recognizing iron-restricted erythropoiesis and predicting response to erythropoietin in anemic patients with myeloma and lymphoma. Ann Hematol. 2007;86:369-76.
33. Brugnara C, Zurakowski D, DiCanzio J, Boyd T, Platt O. Reticulocyte hemoglobin content to diagnose iron deficiency in children. JAMA. 1999;281:2225-30.
34. Radtke H, Meyer T, Kalus U, Röcker L, Salama A, Kiesewetter H, et al. Rapid identification of iron deficiency in blood donors with red cell indexes provided by Advia 120. Transfusion. 2005;45:5-10.
35. Ullrich C, Wu A, Armsby C, Rieber S, Wingerter S, Brugnara C, et al. Screening healthy infants for iron deficiency using reticulocyte hemoglobin content. JAMA. 2005;294:924-30.
36. Stoffman N, Brugnara C, Woods ER. An algorithm using reticulocyte hemoglobin content (CHr) measurement in screening adolescent for iron deficiency. J Adolesc Health. 2005;36:529. e1-e6.
37. Ervasti M, Kotisaari S, Sankilampi U, Heinonen S, Punnonen K. The relationship between red blood cell and reticulocyte indices and serum markers of iron status in the cord blood of newborns. Clin Chem Lab Med. 2007;45:1000-3.
38. Ervasti M, Sankilampi U, Heinonen S, Punnonen K. Novel red cell indices indicating reduced availability of iron are associated with high erythropoietin concentration and low pH level in the venous cord blood of newborns. Pediatr Res. 2008;64:135-40.
39. Ervasti M, Kotisaari S, Heinonen S, Punnonen K. Elevated serum erythropoietin concentration is associated with coordinated changes in red blood cell and reticulocyte indices of pregnant women at term. Scand J Clin Lab Invest. 2008;68:160-5.
40. Clayton PE, Cianfarani S, Czernichow P, Johannsson G, Rapaport R, Rogol A. CONSENSUS STATEMENT: Managements of the child born small for gestational age through to adulthood: a consensus statement of the International Societies of Pediatric Endochrinology and the Growth Hormone Research Society. J Clin Endocrinol Metab. 2007;92:804-10.
41. Kotisaari S, Romppanen J, Ågren U, Eskelinen S, Punnonen K. Reticulocyte indices rapidly reflect an increase in iron availability for erythropoiesis. Haematologica. 2003;88:1422-3.
42. Rao R, Georgieff MK. Iron in fetal and neonatal nutrition. Semin Fetal Neonatal Med. 2007;12:54-63.
43. Nathan DG, Oski FA. Hematology of infancy and childhood, 4th edn. Philadelphia, PA: Saunders; 1993.
44. Milman N, Bergholt T, Byg K-E, Eriksen L, Graudal N. Iron status and iron balance during pregnancy. A critical reappraisal of iron supplementation. Acta Obstet Gynecol Scand. 1999;78:749-57.
45. Godfrey KM, Redman CWG, Barker DJP, Osmond C. The effect of maternal anaemia and iron deficiency on the ratio of fetal weight to placental weight. Br J Obstet Gynaecol. 1991;98:886-91.
46. Krafft A, Huch R, Breymann C. Impact of parturition on iron status in nonanaemic iron deficiency. Eur J Clin Invest. 2003;33:919-23.
47. Harthoorn-Lasthuizen EJ, Lindemans J, Langenhuijsen MMAC. Does iron-deficient erythropoiesis in pregnancy influence fetal iron supply? Acta Obstet Gynecol Scand. 2001;80:392-6.
48. Choi JW, Kim CS, Pai SH. Erythropoietic activity and soluble transferrin receptor level in neonates and maternal blood. Acta Paediatr. 2000;89:675-9.
49. Verner AM, Manderson J, Lappin TRJ, McCance DR, Halliday HL, Sweet DG. Influence of maternal diabetes mellitus on fetal iron status. Arch Dis Child Fetal Neonatal Ed. 2007;92:F399-401.
50. Petry CD, Eaton MA, Wobken JD, Mills MM, Johnson DE, Georgieff MK. Iron deficiency of liver, heart, and brain in newborn infants of diabetic mothers. J Pediatr. 1992;121:109-14.
51. Petry CD, Wobken JD, McKay H, Eaton MA, Seybold VS, Johnson DE, et al. Placental transferrin receptor in diabetic pregnancies with increased fetal iron demand. Am J Physiol. 1994;267:E507-14.
52. Davis RJ, Corvera S, Czech MP. Insulin stimulates cellular iron uptake and causes the redistribution of intracellular transferrin receptors to the plasma membrane. J Biol Chem. 1986;261:8708-11.
53. Fernández-Real JM, López-Bermejo A, Ricart W. Cross-talk between iron metabolism and diabetes. Diabetes. 2002;51:2348-54.
54. Lao TT, Ho L-F. Impact of iron deficiency anemia on prevalence of gestational diabetes mellitus. Diabetes Care. 2004;27:650-6.