Combined treatment with regulatory T cells and vascularized bone marrow transplantation creates mixed chimerism and induces donor-specific tolerance to vascularized composite allografts without cytoreductive conditioning

Journal of Surgical Research

Volumn 178, Issue 2, 2012, Pages 974-981

  Lin, Jeng Yee ^a,b   Tsai, Feng Chou ^b   Wallace, Christopher Glenn ^a,c   Huang, Wei Chao ^a,c   Wei, Fu Chan ^a,c   Liao, Shuen Kuei ^a,b  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Graft versus host disease; Mixed chimerism; Regulatory T cells; Treg; Vascularized bone marrow transplantation; Vascularized composite allograft

Indexed keywords

ABATACEPT; CD40 LIGAND MONOCLONAL ANTIBODY; RAPAMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TRANSPLANTATION; CD4+ CD25+ T LYMPHOCYTE; CELL ISOLATION; CELL LINEAGE; CELL SELECTION; CELL STIMULATION; CELL SURVIVAL; CHIMERA; CONTROLLED STUDY; CYTOREDUCTIVE CONDITIONING; DONOR; FLOW CYTOMETRY; GRAFT RECIPIENT; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC CELL; HINDLIMB; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL TOLERANCE; LYMPH NODE; MALE; MYELOABLATIVE CONDITIONING; NONHUMAN; PRIORITY JOURNAL; RAT; REGULATORY T LYMPHOCYTE; SPLEEN; VASCULARIZATION; VASCULARIZED COMPOSITE ALLOGRAFT;

ANIMALS; BONE MARROW TRANSPLANTATION; CTLA-4 ANTIGEN; IMMUNE TOLERANCE; MALE; RATS; RATS, INBRED BN; RATS, INBRED LEW; T-LYMPHOCYTES, REGULATORY; TISSUE DONORS; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS;

EID: 84869095117     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2012.06.061     Document Type: Article

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