Vascularized bone grafts within composite tissue allotransplants can autocreate tolerance through mixed chimerism with partial myeloablative conditioning: An experimental study in rats

Plastic and Reconstructive Surgery

Volumn 125, Issue 4, 2010, Pages 1095-1103

  Huang, Wei Chao ^b   Lin, Jeng Yee ^b   Wallace, Christopher Glenn ^b   Chuang, Wen Yu ^b   Wei, Fu Chan ^b   Liao, Shuen Kuei ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOSUPPRESSIVE AGENT; TACROLIMUS;

ALLOTRANSPLANTATION; ANIMAL; ARTICLE; BODY WEIGHT; BONE; BONE MARROW CELL; BONE TRANSPLANTATION; BROWN NORWAY RAT; CYTOLOGY; DRUG EFFECT; GRAFT REJECTION; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; HISTOCOMPATIBILITY; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; LEWIS RAT; MALE; METHODOLOGY; PLASTIC SURGERY; RAT; SKIN TRANSPLANTATION; VASCULARIZATION;

ANIMALS; BODY WEIGHT; BONE AND BONES; BONE MARROW CELLS; BONE TRANSPLANTATION; GRAFT REJECTION; GRAFT SURVIVAL; GRAFT VS HOST DISEASE; IMMUNE TOLERANCE; IMMUNOSUPPRESSIVE AGENTS; MALE; RATS; RATS, INBRED BN; RATS, INBRED LEW; SKIN TRANSPLANTATION; SURGICAL FLAPS; TACROLIMUS; TRANSPLANTATION CHIMERA; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS;

EID: 77951042808     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/PRS.0b013e3181d0ab80     Document Type: Article

References (40)

1. Barker JH, Francois CG, Frank JM, Maldonado C. Composite tissue allotransplantation. Transplantation 2002;73:832-835.
2. Wendt JR, Ulich TR, Ruzics EP, Hostetler JR. Indefinite survival of human skin allografts in patients with long-term immunosuppression. Ann Plast Surg. 1994;32:411-417.
3. Bain JR. Peripheral nerve and neuromuscular allotransplantation: Current status. Microsurgery 2000;20:384-388.
4. Levi DM, Tzakis AG, Kato T, et al. Transplantation of the abdominal wall. Lancet 2003;361:2173-2176.
5. Guimberteau JC, Baudet J, Panconi B, Boileau R, Potaux L. Human allotransplant of a digital flexion system vascularized on the ulnar pedicle: A preliminary report and 1-year follow- up of two cases. Plast Reconstr Surg. 1992;89:1135-1147.
6. Hofmann GO, Kirschner MH, Brauns L, Wagner FD, Land W, Buhren V. Vascularized knee joint transplantation in man: A report on the first cases. Transpl Int. 1998;11(Suppl 1): S487-S490.
7. StromeM, Stein J, Esclamado R, et al. Laryngeal transplantation and 40-month follow-up. N Engl J Med. 2001;344:1676-1679.
8. Dubernard JM, Owen E, Herzberg G, et al. The first transplantation of a hand in humans: Early results (in French). Chirurgie 1999;124:358-365.
9. Cooney WP, Hentz VR. Successful hand transplantation: One year follow-up. N Engl J Med. 2001;344:65.
10. Jones JW, Gruber SA, Barker JH, Breidenbach WC. Successful hand transplantation: One-year follow-up. Louisville Hand Transplant Team. N Engl J Med. 2000;343:468-473.
11. Dubernard JM, Lengele B, Morelon E, et al. Outcomes 18 months after the first human partial face transplantation. N Engl J Med. 2007;357:2451-2460.
12. Petit F, Minns AB, Dubernard JM, Hettiaratchy S, Lee WP. Composite tissue allotransplantation and reconstructive surgery: First clinical applications. Ann Surg. 2003;237:19-25.
13. Baluja P, Haragsim L, Laszik Z. Chronic allograft nephropathy. Adv Chronic Kidney Dis. 2006;13:56-61.
14. Majzoub RK, Cunningham M, Grossi F, Maldonado C, Banis JC, Barker JH. Investigation of risk acceptance in hand transplantation. J Hand Surg (Am.) 2006;31:295-302.
15. Walsh PT, Taylor DK, Turka LA. Tregs and transplantation tolerance. J Clin Invest. 2004;114:1398-1403.
16. Prabhune KA, Gorantla VS, Maldonado C, Perez-Abadia G, Barker JH, Ildstad ST. Mixed allogeneic chimerism and tolerance to composite tissue allografts. Microsurgery 2000;20: 441-447.
17. Ildstad ST, Wren SM, Bluestone JA, Barbieri SA, Sachs DH. Characterization of mixed allogeneic chimeras: Immunocompetence, in vitro reactivity, and genetic specificity of tolerance. J Exp Med. 1985;162:231-244.
18. Sykes M, Shimizu I, Kawahara T. Mixed hematopoietic chimerism for the simultaneous induction of T and B cell tolerance. Transplantation 2005;79(Suppl):S28-S29.
19. Foster RD, Ascher NL, McCalmont TH, Neipp M, Anthony JP, Mathes SJ. Mixed allogeneic chimerism as a reliable model for composite tissue allograft tolerance induction across major and minor histocompatibility barriers. Transplantation 2001;72:791-797.
20. Foster RD, Fan L, Neipp M, et al. Donor-specific tolerance induction in composite tissue allografts. Am J Surg. 1998;176: 418-421.
21. Gammie JS, Pham SM. Simultaneous donor bone marrow and cardiac transplantation: Can tolerance be induced with the development of chimerism? Curr Opin Cardiol. 1999;14: 126-132.
22. Hewitt CW, Ramsamooj R, Patel MP, Yazdi B, Achauer BM, Black KS. Development of stable mixed T cell chimerism and transplantation tolerance without immune modulation in recipients of vascularized bone marrow allografts. Transplantation 1990;50:766-772.
23. Siemionow M, Oke R, Ozer K, Izycki D, Prajapati R. Induction of donor-specific tolerance in rat hind-limb allografts under antilymphocyte serum and cyclosporine A protocol. J Hand Surg (Am.) 2002;27:1095-1103.
24. Hewitt CW, Englesbe MJ, Tatem L, et al. Graft-versus-host disease in extremity transplantation: Digital image analysis of bone marrow in situ. Ann Plast Surg. 1995;35:108-112.
25. Adamson LA, Huang WC, Breidenbach W, et al. A modified model of hindlimb osteomyocutaneous flap for the study of tolerance to composite tissue allografts. Microsurgery 2007; 27:630-636.
26. Billingham RE, Neaves WB. Exchange of skin grafts among monozygotic quadruplets in armadillos. J Exp Zool. 1980;213: 257-260.
27. Xu H, Chilton PM, Huang Y, Schanie CL, Ildstad ST. Production of donor T cells is critical for induction of donorspecific tolerance and maintenance of chimerism. J Immunol. 2004;172:1463-1471.
28. Gorantla VS, Prabhune KA, Perez-Abadia G, et al. Composite tissue allotransplantation in chimeric hosts: Part I. Prevention of graft-versus-host disease. Transplantation 2003;75:922-932.
29. Lanzetta M, Nolli R, Borgonovo A, et al. Hand transplantation: Ethics, immunosuppression and indications. J Hand Surg (Br.) 2001;26:511-516.
30. Gordon CR, Tai CY, Suzuki H, et al. Review of vascularized bone marrow transplantation: Current status and future clinical applications. Microsurgery 2007;27:348-353.
31. Hotokebuchi T, Arai K, Takagishi K, Arita C, Sugioka Y, Kaibara N. Limb allografts in rats immunosuppressed with cyclosporine: As a whole-joint allograft. Plast Reconstr Surg. 1989;83:1027-1036.
32. Hewitt CW, Black KS, Dowdy S, et al. Composite tissue (limb) allografts in rats: III. Development of donor-host lymphoid chimeras in long-term survivors. Transplantation 1986;41:39-43.
33. Arai K, Hotokebuchi T, Miyahara H, et al. Limb allografts in rats immunosuppressed with FK506: I. Reversal of rejection and indefinite survival. Transplantation 1989;48:782-786.
34. Benhaim P, Anthony JP, Lin LY, McCalmont TH, Mathes SJ. A long-term study of allogeneic rat hindlimb transplants immunosuppressed with RS-61443. Transplantation 1993;56: 911-917.
35. Benhaim P, Anthony JP, Ferreira L, Borsanyi JP, Mathes SJ. Use of combination of low-dose cyclosporine and RS-61443 in a rat hindlimb model of composite tissue allotransplantation. Transplantation 1996;61:527-532.
36. Starzl TE, Demetris AJ, Murase N, Ildstad S, Ricordi C, Trucco M. Cell migration, chimerism, and graft acceptance. Lancet 1992;339:1579-1582.
37. Gammie JS, Li S, Zeevi A, Demetris AJ, Ildstad ST, Pham SM. Tacrolimus-based partial conditioning produces stable mixed lymphohematopoietic chimerism and tolerance for cardiac allografts. Circulation 1998;98:II163-II168.
38. Gorantla VS, Barker JH, Jones JW Jr, Prabhune K, Maldonado C, Granger DK. Immunosuppressive agents in transplantation: Mechanisms of action and current anti-rejection strategies. Microsurgery 2000;20:420-429.
39. Brouha PC, Perez-Abadia G, Francois C, et al. Lymphadenectomy prior to rat hind limb allotransplantation prevents graft-versus-host disease in chimeric hosts. Transpl Int. 2004; 17:341-350.
40. Siemionow MZ, Izycki DM, Zielinski M. Donor-specific tolerance in fully major histocompatibility major histocompatibility complex-mismatched limb allograft transplants under an anti-alphabeta T-cell receptor monoclonal antibody and cyclosporine A protocol. Transplantation 2003;76:1662-1668.