Tyrosine urea muscarinic acetylcholine receptor antagonists: Achiral quaternary ammonium groups

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 23, 2012, Pages 7087-7091

  Jin, Qi ^a   Davis, Roderick S ^a   Bullion, Ann M ^a   Jin, Jian ^a   Wang, Yonghui ^a   Widdowson, Katherine L ^a   Palovich, Michael R ^a   Foley, James J ^a   Schmidt, Dulcie B ^a   Buckley, Peter T ^a   Webb, Edward F ^a   Salmon, Michael ^a   Belmonte, Kristen E ^a   Sarau, Henry M ^a   Busch Petersen, Jakob ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Airway disease; Inhaled; Muscarinic antagonists; Quaternary ammonium salts; Solid phase synthesis

Indexed keywords

2 METHYLIMIDAZO[2,1 B][1,3]THIAZOL 7 IUM DERIVATIVE; MUSCARINIC RECEPTOR BLOCKING AGENT; QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOSPASM; CALCIUM MOBILIZATION; DRUG DELIVERY SYSTEM; DRUG MECHANISM; HYDROPHOBIC INTERACTION CHROMATOGRAPHY; IN VITRO STUDY; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; STEREOCHEMISTRY;

ANIMALS; BRONCHI; MICE; MUSCARINIC ANTAGONISTS; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE; UREA;

ANIMALIA;

EID: 84869087778     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.09.085     Document Type: Article

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