Toxicology and overdose of atypical antipsychotics

Journal of Emergency Medicine

Volumn 43, Issue 5, 2012, Pages 906-913

  Minns, Alicia B ^a   Clark, Richard F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

atypical antipsychotic; ingestion; overdose; poisoning

Indexed keywords

ACTIVATED CARBON; ALCOHOL; AMANTADINE; AMISULPRIDE; ARIPIPRAZOLE; ATYPICAL ANTIPSYCHOTIC AGENT; BENZATROPINE; BROMOCRIPTINE; CHLORPROMAZINE; CLOZAPINE; DANTROLENE; DROPERIDOL; FLUPHENAZINE; HALOPERIDOL; INFUSION FLUID; LITHIUM; NEUROLEPTIC AGENT; NORADRENALIN; OLANZAPINE; PALIPERIDONE; PHYSOSTIGMINE; PROCHLORPERAZINE; PROMETHAZINE; QUETIAPINE; RISPERIDONE; SALICYLIC ACID; THIORIDAZINE; UNINDEXED DRUG; VALPROIC ACID; ZIPRASIDONE;

AGITATION; AGRANULOCYTOSIS; BRADYCARDIA; CARDIOTOXICITY; CLINICAL FEATURE; CONFERENCE PAPER; CONVULSION; DELIRIUM; DRUG INTOXICATION; DRUG OVERDOSE; DYSTONIA; EXTRAPYRAMIDAL SYMPTOM; GASTROINTESTINAL SYMPTOM; HEART ARRHYTHMIA; HUMAN; HYPERSALIVATION; HYPOTENSION; MALIGNANT HYPERTHERMIA; METABOLIC SYNDROME X; MYOCARDITIS; NEUROLEPTIC MALIGNANT SYNDROME; NEUROTOXICITY; ORTHOSTATIC HYPOTENSION; PRIORITY JOURNAL; QRS COMPLEX; QT PROLONGATION; SCHIZOPHRENIA; SEDATION; SEIZURE; SIDE EFFECT; SINUS TACHYCARDIA; TACHYCARDIA; TONIC CLONIC SEIZURE; TORSADE DES POINTES; URINE RETENTION;

ANTIPSYCHOTIC AGENTS; ARRHYTHMIAS, CARDIAC; DELIRIUM; DISEASE MANAGEMENT; DRUG OVERDOSE; HUMANS; METABOLIC SYNDROME X; NEUROLEPTIC MALIGNANT SYNDROME;

EID: 84869084282     PISSN: 07364679     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jemermed.2012.03.002     Document Type: Conference Paper

References (49)

1. J.M. Kane, and C.U. Correll Past and present progress in the pharmacologic treatment of schizophrenia J Clin Psychiatry 71 2010 1115 1124
2. M.J. Burns The pharmacology and toxicology of atypical antipsychotic agents J Toxicol Clin Toxicol 39 2001 1 14
3. C.Z. MacVane, and M.R. Barumann Unintentional ingestion of ziprasidone in a 22-month old Pediatr Emerg Care 27 2009 460 462
4. D. DuBois Toxicology and overdose of atypical antipsychotic medications in children: does new necessarily mean safer? Curr Opin Pediatr 17 2005 227 233
5. th annual report Clin Toxicol (Phila) 48 2010 979 1178
6. A. Ngo, M. Ciranni, and K.R. Olson Acute quetiapine overdose in adults: a 5-year retrospective case series Ann Emerg Med 52 2008 541 547
7. S. Kapur, and P. Seeman Antipsychotic agents differ in how fast they come off the dopamine D2 receptors. Implications for atypical antipsychotic action J Psychiatry Neurosci 25 2000 161 166
8. S. Kumra, J.V. Oberstar, and L. Sikich Efficacy and tolerability of second-generation antipsychotics in children and adolescents with schizophrenia Schizophr Bull 34 2008 60 71
9. H.H. Tan, J. Hoppe, and K. Heard A systematic review of cardiovascular effects following atypical antipsychotic overdose Am J Emerg Med 27 2009 607 616
10. U. Reulbach, C. Dütsch, and T. Biermann Managing an effective treatment for neuroleptic malignant syndrome Crit Care 11 2007 1 6
11. J.N. Troller, X. Chen, and P.S. Sachdev Neuroleptic malignant syndrome associated with atypical antipsychotic drugs CNS Drugs 23 2009 477 492
12. D.P. Seitz, and S.S. Gill Neuroleptic malignant syndrome complicating antipsychotic treatment of delirium or agitation in medical and surgical patients: case reports and a review of the literature Psychosomatics 50 2009 8 15
13. J. Ananth, S. Prameswaran, and S. Gunatilake Neuroleptic malignant syndrome and atypical antipsychotic drugs J Clin Psychiatry 65 2004 464 470
14. J.R. Strawn, P.E. Keck, and S.N. Caroff Neuroleptic malignant syndrome Am J Psychiatry 164 2007 870 876
15. A.B. Schneir, S.R. Offerman, and B.T. Ly Complications of diagnostic physostigmine administration to emergency department patients Ann Emerg Med 42 2003 14 19
16. S. Sicouri, and C. Antzelevitch Sudden cardiac death secondary to antidepressant and antipsychotic drugs Expert Opinion Drug Safety 7 2008 181 194
17. P.M. Haddad, and I.M. Anderson Antipsychotic-related QTc prolongation, torsade de pointes and sudden death Drugs 62 2002 1649 1671
18. D.M. Roden Drug-induced prolongation of the QT interval N Engl J Med 350 2004 1013 1022
19. J.G. Reilly, S.A. Ayis, and I.N. Ferrier QTc-interval abnormalities and psychotropic drug therapy in psychiatric patients Lancet 355 2000 1048 1052
20. S. Gautam, and P.S. Meena Drug-emergent metabolic syndrome in patients with schizophrenia receiving atypical (second-generation) antipsychotics Ind J Psychiatry 53 2011 128 133
21. D.E. Casey, D.W. Haupt, and J.W. Newcomer Antipsychotic-induced weight gain and metabolic abnormalities: implications for increased mortality in patients with schizophrenia J Clin Psychiatry 65 Suppl 7 2004 4 18
22. J.W. Newcomer Second-generation (atypical) antipsychotics and metabolic effects CNS Drugs 19 Suppl 1 2005 1 93
23. R.J. Baldessarini, and F.R. Frankenburg Clozapine: a novel antipsychotic agent N Engl J Med 324 1991 746 754
24. M. Beal Clozapine update West J Med 160 1994 53 54
25. D.B. Merrill, S.E. Ahmari, J.M.E. Bradford, and J.A. Lieberman Myocarditis during clozapine treatment Am J Psychiatry 163 2006 204 208
26. A.J. Rosenfeld, T. Gibbs, R. Ivie, L. Clarke, and D.B. Merrill Successful clozapine retrial after suspected myocarditis Am J Psychiatry 167 2010 350 351
27. C.B. Page, L.A. Calver, and G.K. Isbister Risperidone overdose causes extrapyramidal effects but not cardiac toxicity J Clin Psychopharmacol 30 2010 387 390
28. A. Akyol, A.C. Senel, and H. Ulusoy Delayed respiratory depression after risperidone overdose Anesth Analg 101 2005 1490 1491
29. S. Ballesteros, M.A. Martinez, M.A. Ballesteros, C.S. de la Torre, and J.C. Rodríguez-Borregán A severe case of olanzapine overdose with analytical data Clin Toxicol (Phila) 45 2007 412 415
30. K. Komossa, C. Rummel-Kluge, and H. Hunger Olanzapine versus other atypical antipsychotics for schizophrenia Cochrane Database Syst Rev 3 2010 CD006654
31. G.H. Tse, M.H. Warner, and W.S. Waring Prolonged toxicity after massive olanzapine overdose: two cases with confirmatory laboratory data J Toxicol Sci 33 2008 363 365
32. W.S. Waring, J. Wrate, and D.N. Bateman Olanzapine overdose is associated with acute muscle toxicity Hum Exp Toxicol 25 2006 735 740
33. K. Komossa, C. Rummel-Kluge, and H. Hunger Ziprasidone versus other atypical antipsychotics for schizophrenia Cochrane Database Syst Rev 4 2009 CD006627
34. R.M. Carnahan, B.C. Lund, and P.J. Perry Ziprasidone, a new atypical antipsychotic drug Pharmacotherapy 21 2001 717 730
35. A. Alipour, R. Cruz, and R.S. Lott Torsade de pointes after ziprasidone overdose with coingestants J Clin Psychopharmacol 30 2010 76 77
36. A.F. Manini, D. Raspberry, R.S. Hoffman, and L.S. Nelson QT prolongation and Torsade de pointes following overdose of ziprasidone and amantadine J Med Toxicol 3 2007 178 181
37. T.W. Heinrich, L.A. Biblo, and J. Schneider Torsades de pointes associated with ziprasidone Psychosomatics 47 2006 264 268
38. M.S. Gomez-Criado, M. Bernardo, and T. de Florez Ziprasidone overdose: cases recorded in the database of Pfizer-Spain and literature review Pharmacotherapy 25 2005 1660 1665
39. B. Lo, and A. Pizon Delayed presentation of an aripiprazole overdose Clin Toxicol (Phila) 46 2008 348 349
40. S.D. Carstairs, and S.R. Williams Overdose of aripiprazole, a new type of antipsychotic J Emerg Med 28 2005 311 313
41. A.M. Lofton, and W. Klein-Schwartz Atypical experience: a case series of pediatric aripiprazole exposures Clin Toxicol (Phila) 43 2005 151 153
42. F. LoVecchio, D. Watts, and J. Winchell One year experience with aripiprazole exposures Am J Emerg Med 23 2005 585 586
43. K. Komossa, C. Rummel-Kluge, and H. Hunger Amisulpride versus other atypical antipsychotics for schizophrenia Cochrane Database Syst Rev 1 2010 CD006624
44. G.K. Isbister, C.R. Balit, D. Macleod, and S.B. Duffull Amisulpride overdose is frequently associated with QT prolongation and Torsades de Points J Clin Psychopharmacol 30 2010 391 395
45. C.M. Chwieduk, and G.M. Keating Paliperidone extended release: a review of its use in the management of schizophrenia Drugs 70 2010 1295 1317
46. M. Levine, F. Lovecchio, P. Tafoya, and R. Graham Paliperidone overdose with delayed onset of toxicity Ann Emerg Med 58 2011 80 82
47. W. Schmidt, and K. Lang Life-threatening dysrhythmias in severe thioridazine poisoning treated with physostigmine and transient atrial pacing Crit Care Med 25 1997 1925 1930
48. J. Picard, and T. Meek Lipid emulsion to treat overdose of local anesthetic: the gift of the glob Anesthesia 61 2006 107 109
49. R.F. Grace, and S.D. Newell Paradoxical and severe hypotension in response to adrenaline infusions in massive quetiapine overdose: the case for lipid rescue Crit Care Resusc 11 2009 162