Risperidone overdose causes extrapyramidal effects but not cardiac toxicity

Journal of Clinical Psychopharmacology

Volumn 30, Issue 4, 2010, Pages 387-390

  Page, Colin B ^a   Calver, Leonie A ^a   Isbister, Geoffrey K ^a,b,c  

^a CALVARY MATER NEWCASTLE HOSPITAL   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

Author keywords

overdose; risperidone

Indexed keywords

RISPERIDONE; NEUROLEPTIC AGENT;

ADOLESCENT; ADULT; ARTICLE; CARDIOTOXICITY; CLINICAL FEATURE; DRUG OVERDOSE; DYSTONIA; ELECTROCARDIOGRAM; EXTRAPYRAMIDAL SYMPTOM; FEMALE; HEART RATE; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; QRS COMPLEX; TACHYCARDIA; CHEMICALLY INDUCED; ELECTROCARDIOGRAPHY; EXTRAPYRAMIDAL SYNDROME; FACTUAL DATABASE; LENGTH OF STAY; RETROSPECTIVE STUDY; YOUNG ADULT;

ADOLESCENT; ADULT; ANTIPSYCHOTIC AGENTS; BASAL GANGLIA DISEASES; DATABASES, FACTUAL; DRUG OVERDOSE; DYSTONIA; ELECTROCARDIOGRAPHY; FEMALE; HUMANS; LENGTH OF STAY; MALE; RETROSPECTIVE STUDIES; RISPERIDONE; TACHYCARDIA; YOUNG ADULT;

EID: 77955141480     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/JCP.0b013e3181e5f7a5     Document Type: Article

References (30)

1. Risperidone [product information]. MIMS Australia. Available at: www.mims.com.au. Accessed August 2009.
2. Moore NC, Shukla P. Risperidone overdose. Am J Psychiatry. 1997;154(2):289-290.
3. Catalano G, Catalano MC, Taylor W. Acute risperidone overdose. Clin Neuropharmacol. 1997;20:82-85.
4. Kopala LC, Day C, Dillman B, et al. A case of risperidone overdose in early schizophrenia: a review of potential complications. J Psychiatry Neurosci. 1998;23:305-308.
5. Ravin DS, Levenson JW. Fatal cardiac event following initiation of risperidone therapy. Ann Pharmacother. 1997;31:867-870.
6. Himstreet JE, Daya M. Hypotension and orthostasis following a risperidone overdose. Ann Pharmacother. 1998;32:267.
7. Rassam S, Srinivasa R. Respiratory depression after accidental risperidone overdose. Am J Emerg Med. 2002;20:570.
8. Akyol A, Senel C, Ulusoy H, et al. Delayed respiratory depression after risperidone overdose. Anesth Analg. 2005;101:1490-1491.
9. Satish HP, Payne H, Potter F, et al. Delayed respiratory depression after accidental risperidone overdose. Paediatr Perinat Drug Ther. 2008;8: 154-156.
10. Marti V. Sudden cardiac death due to risperidone therapy in a patient with possible hypertrophic cardiomyopathy. Ann Pharmacother. 2005;39:973.
11. Burns MJ. The pharmacology and toxicology of atypical antipsychotic agents. Clin Toxicol. 2001;39:1-14.
12. Campbell M, Rapoport JL, Simpson GM. Antipsychotics in children and adolescents. J Am Acad Child Adolesc Psychiatry. 1999;38: 537-545.
13. Isbister GK, Balit CR, Kilham HA. Antipsychotic poisoning in young children: a systematic review. Drug Saf. 2005;28:1029-1044.
14. Cheslik TA, Erramouspe J. Extrapyramidal symptoms following accidental ingestion of risperidone in a child. Ann Pharmacother. 1996;30:360-363.
15. Acri AA, Henretig FM. Effects of risperidone in overdose. Am J Emerg Med. 1998;16:498-501.
16. Kuspis D, Dean B, Krenzelok EP. Risperidone overdose assessment. Clin Toxicol. 1995;33:552. NACCT Abstracts.
17. Vecchio FL, Hamilton RJ, Hoffman RJ. Risperidone overdose. Am J Emerg Med. 1996;14:95-96.
18. Brown K, Levy H, Brenner C, et al. Overdose of risperidone. Ann Emerg Med. 1993;10:1908-1910.
19. Duenas-Laita A, Castro-Villamor MA, Martin-Escudero JC, et al. New clinical manifestations of acute risperidone poisoning. Clin Toxicol. 1999;37:893-894.
20. Trenton AJ, Currier GW, Zwemer FL. Fatalities associated with therapeutic use and overdose of atypical antipsychotics. CNS Drugs. 2003;17:307-324.
21. Blaschke D, Parwani AS, Huemer M, et al. Torsade de pointes during combined treatment with citalopram and risperidone. Pharmacopsychiatry. 2007;40:294-295.
22. Tei Y, Morita T, Inoue S, et al. Torsades de pointes caused by a small dose of risperidone in a terminally ill cancer patient. Psychosomatics. 2004;45:450-451.
23. Whyte IM, Buckley NA, Dawson AH. Data collection in clinical toxicology: are there too many variables? Clin Toxicology. 2002; 40:223-230.
24. Buckley NA, Whyte IM, Dawson AH, et al. Preformatted admission charts for poisoning admissions facilitate clinical assessment and research. Ann Emerg Med. 1999;34:476-482.
25. Isbister GK, Friberg LE, Stokes B, et al. Activated charcoal decreases the risk of QT prolongation after citalopram overdose. Ann Emerg Med. 2007;50:593-600.
26. Isbister GK. Electrocardiogram changes and arrhythmias in venlafaxine overdose. Br J Clin Pharmacol. 2009;67:572-576.
27. Isbister GK, Calver L, Van Gorp F, et al. Inter-rater reliability of manual QT measurement and prediction of abnormal QT,HR pairs. Clin Toxicol. 2009;47:884-888.
28. Chan A, Isbister GK, Kirkpatrick CM, et al. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM. 2007;100:609-615.
29. Friberg LE, Isbister GK, Hackett LP, et al. The population pharmacokinetics of Citalopram after deliberate self-poisoning: a Bayesian approach. J Pharmacokinet Pharmacodyn. 2005;32:571-605.
30. Isbister GK, Friberg LE, Hackett LP, et al. Pharmacokinetics of quetiapine in overdose and the effect of activated charcoal. Clin Pharmacol Ther. 2007;81:821-827.