Amisulpride overdose is frequently associated with QT prolongation and torsades de pointes

Journal of Clinical Psychopharmacology

Volumn 30, Issue 4, 2010, Pages 391-395

  Isbister, Geoffrey K ^a,b   Balit, Corrine R ^c   MacLeod, Dawson ^d   Duffull, Stephen B ^e  

^a CALVARY MATER NEWCASTLE HOSPITAL   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c CHILDREN S HOSPITAL AT WESTMEAD   (Australia)

^d AUSTIN HEALTH   (Australia)

^e UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

amisulpride; arrhythmia; overdose; poisoning; QT interval; torsades de pointes

Indexed keywords

AMISULPRIDE; CITALOPRAM; HALOPERIDOL; VALPROIC ACID; NEUROLEPTIC AGENT; SULPIRIDE; SULTOPRIDE;

ADULT; ARTICLE; BRADYCARDIA; CLINICAL RESEARCH; COMA; DYSTONIA; ELECTROCARDIOGRAM; FEMALE; HEART ARREST; HEART RATE; HUMAN; HYPOCALCEMIA; HYPOKALEMIA; HYPOTENSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; QT PROLONGATION; SEIZURE; TORSADE DES POINTES; ANALOGS AND DERIVATIVES; CHEMICALLY INDUCED; COHORT ANALYSIS; DRUG EFFECTS; DRUG OVERDOSE; ELECTROCARDIOGRAPHY; LONG QT SYNDROME; POISON CENTER; PROSPECTIVE STUDY; STATISTICS AND NUMERICAL DATA; YOUNG ADULT;

ADULT; ANTIPSYCHOTIC AGENTS; BRADYCARDIA; COHORT STUDIES; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HUMANS; HYPOTENSION; LONG QT SYNDROME; MALE; OVERDOSE; POISON CONTROL CENTERS; PROSPECTIVE STUDIES; SULPIRIDE; TORSADES DE POINTES; YOUNG ADULT; DRUG OVERDOSE;

EID: 77955173013     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/JCP.0b013e3181e5c14c     Document Type: Article

References (28)

1. Rosenzweig P, Canal M, Patat A, et al. A review of the pharmacokinetics, tolerability and pharmacodynamics of amisulpride in healthy volunteers. Hum Psychopharmacol. 2002;17:1-13.
2. Rein W, Coulouvrat C, Dondey-Nouvel L. Safety profile of amisulpride in short-and long-term use. Acta Psychiatr Scand Suppl. 2000;400: 23-27.
3. Coulouvrat C, Dondey-Nouvel L. Safety of amisulpride (Solian): a review of 11 clinical studies. Int Clin Psychopharmacol. 1999;14:209-218.
4. Isbister GK, Murray L, John S, et al. Amisulpride deliberate self-poisoning causing severe cardiac toxicity including QT prolongation and torsades de pointes. Med J Aust. 2006;184:354-356.
5. Lynch MJ,Woods J, George N, et al. Fatality due to amisulpride toxicity: a case report. Med Sci Law. 2008;48:173-177.
6. Thomas SHL. Drugs and the QT interval. Adverse Drug React Bull. 1997:182:691-694.
7. Buckley NA, Whyte IM, Dawson AH. Cardiotoxicity more common in thioridazine overdose than with other neuroleptics. J Toxicol Clin Toxicol. 1995;33:199-204.
8. Tarabar AF, Hoffman RS, Nelson L. Citalopram overdose: late presentation of torsades de pointes (TdP) with cardiac arrest. J Med Toxicol. 2008;4:101-105.
9. Assimes TL, Malcolm I. Torsade de pointes with sotalol overdose treated successfully with lidocaine. Can J Cardiol. 1998;14:753-756.
10. Isbister GK, Calver L, van Gorp F, et al. Inter-rater reliability of manual QT measurement and prediction of abnormal QT,HR pairs. Clin Toxicol (Phila). 2009;47:884-888.
11. Chan A, Isbister GK, Kirkpatrick CM, et al. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM. 2007;100:609-615.
12. Burns MJ. The pharmacology and toxicology of atypical antipsychotic agents. J Toxicol Clin Toxicol. 2001;39:1-14.
13. Isbister GK, Duffull SB. Quetiapine overdose: predicting intubation, duration of ventilation, cardiac monitoring and the effect of activated charcoal. Int Clin Psychopharmacol. 2009;24:174-180.
14. Morgan M, Hackett LP, Isbister GK. Olanzapine overdose: a series of analytically confirmed cases. Int Clin Psychopharmacol. 2007;22:183-186.
15. Haddad PM, Anderson IM. Antipsychotic-related QTc prolongation, torsade de pointes and sudden death. Drugs. 2002;62:1649-1671.
16. Titier K, Girodet PO, Verdoux H, et al. Atypical antipsychotics: from potassium channels to torsade de pointes and sudden death. Drug Saf. 2005;28:35-51.
17. Chung KJ, Wang YC, Liu BM, et al. Management of ventricular dysrhythmia secondary to trazodone overdose. J Emerg Med. 2008;35:171-174.
18. Hasan RA, Zureikat GY, Nolan BM. Torsade de pointes associated with astemizole overdose treated with magnesium sulfate. Pediatr Emerg Care. 1993;9:23-25.
19. Isbister GK, Friberg LE, Stokes B, et al. Activated charcoal decreases the risk of QT prolongation after citalopram overdose. Ann Emerg Med. 2007;50:593-600, 600.
20. van Gorp F, Whyte IM, Isbister GK. Clinical and ECG effects of escitalopram overdose. Ann Emerg Med. 2009;54:404-408.
21. Meuleman C, Jourdain P, Bellorini M, et al. Citalopram and torsades de pointes. A case report [in French]. Arch Mal Coeur Vaiss. 2001;94:1021-1024.
22. Ward DI. Two cases of amisulpride overdose: a cause for prolonged QT syndrome. Emerg Med Australas. 2005;17:274-276.
23. Isbister GK, Friberg LE, Hackett LP, et al. Pharmacokinetics of quetiapine in overdose and the effect of activated charcoal. Clin Pharmacol Ther. 2007;81:821-827.
24. Friberg LE, Isbister GK, Hackett LP, et al. The population pharmacokinetics of citalopram after deliberate self-poisoning: a Bayesian approach. J Pharmacokinet Pharmacodyn. 2005;32:571-605.
25. Eddleston M, Eyer P, Worek F, et al. Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study. Lancet. 2005;366:1452-1459.
26. Malik M, Camm AJ. Evaluation of drug-induced QT interval prolongation: implications for drug approval and labelling. Drug Saf. 2001;24:323-351.
27. Batchvarov VN, Ghuran A, Smetana P, et al. QT-RR relationship in healthy subjects exhibits substantial intersubject variability and high intrasubject stability. Am J Physiol Heart Circ Physiol. 2002;282:H2356-H2363.
28. Fossa AA, Wisialowski T, Magnano A, et al. Dynamic beat-to-beat modeling of the QT-RR interval relationship: analysis of QT prolongation during alterations of autonomic state versus human ether a-go-go-related gene inhibition. J Pharmacol Exp Ther. 2005;312:1-11.