The HtrA protease from Streptococcus pneumoniae digests both denatured proteins and the competence-stimulating peptide

Journal of Biological Chemistry

Volumn 287, Issue 46, 2012, Pages 38449-38459

  Cassone, Marco ^a   Gagne, Alyssa L ^a   Spruce, Lynn A ^a   Seeholzer, Steven H ^a   Sebert, Michael E ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR PROTEINS; COMPETENCE-STIMULATING PEPTIDES; DENATURED PROTEINS; ERROR SENSORS; EXTRACYTOPLASMIC; HTRA PROTEASE; HYDROPHOBIC PATCH; HYDROPHOBIC RESIDUES; ISOFORMS; NON-POLAR; PROTEIN MISFOLDING; STREPTOCOCCUS PNEUMONIAE; STRESS RESPONSE; UNFOLDED PROTEINS;

BIOSYNTHESIS; ERRORS; MASS SPECTROMETRY;

PEPTIDES;

BACTERIAL PROTEIN; COMPETENCE STIMULATING PEPTIDE 1; COMPETENCE STIMULATING PEPTIDE 2; HTRA PROTEIN; PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM CULTURE; ENZYME ACTIVITY; ENZYME PURIFICATION; ENZYME SUBSTRATE; HYDROPHOBICITY; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DENATURATION; STREPTOCOCCUS PNEUMONIAE;

BACTERIAL PHYSIOLOGICAL PHENOMENA; BINDING SITES; CATALYTIC DOMAIN; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE DELETION; KINETICS; MASS SPECTROMETRY; MUTATION; PEPTIDE HYDROLASES; PEPTIDES; POLYMERASE CHAIN REACTION; PROTEIN DENATURATION; PROTEOLYSIS; QUORUM SENSING; SERINE PROTEASES; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIAE;

STREPTOCOCCUS PNEUMONIAE;

EID: 84869073827     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.391482     Document Type: Article

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