A TRIM5α exon 2 polymorphism is associated with protection from HIV-1 infection in the Pumwani sex worker cohort

AIDS

Volumn 24, Issue 12, 2010, Pages 1813-1821

  Price, Heather ^a   Lacap, Philip ^a   Tuff, Jeff ^a   Wachihi, Charles ^b   Kimani, Joshua ^b   Ball, Terry B ^a,c   Luo, Ma ^a,c   Plummer, Francis A ^a,c  

^a PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^b UNIVERSITY OF NAIROBI   (Kenya)

^c UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Disease association; Disease resistance; HIV 1; Sex workers; Singlenucleotide polymorphism; Taxonomy based sequence analysis; TRIM5

Indexed keywords

ARGININE; GLUTAMINE; TRIPARTITE MOTIF PROTEIN 5; CARRIER PROTEIN; TRIM5 PROTEIN, HUMAN;

ARTICLE; CODON; CONTROLLED STUDY; DISEASE COURSE; EXON; FEMALE; GENE AMPLIFICATION; GENE FREQUENCY; GENOMIC FRAGMENT; HAPLOTYPE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; KENYA; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN POLYMORPHISM; SEROCONVERSION; SINGLE NUCLEOTIDE POLYMORPHISM; VIRUS RESISTANCE; ADULT; COHORT ANALYSIS; GENETICS; GENOTYPE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; INNATE IMMUNITY; PHYSIOLOGY; PROSTITUTION; SEXUAL BEHAVIOR;

ADULT; CARRIER PROTEINS; COHORT STUDIES; EXONS; FEMALE; GENOTYPE; HAPLOTYPES; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, INNATE; KENYA; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSTITUTION; SEXUAL BEHAVIOR;

EID: 77954758455     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0b013e32833b5256     Document Type: Article

References (26)

1. AIDS Epidemic Update 2007. Available at: http://www.unaids. org/en/KnowledgeCentre/HIVData/EpiUpdate/EpiUpdArchive/2007/. Accessed January 28, 2008.
2. Bieniasz PD. Intrinsic immunity: a front-line defense against viral attack. Nature Immunol 2004; 5:1109-1115.
3. Speelmon EC, Livingston-Rosanoff D, Li SS, Vu Q, Bui J, Geraghty DE, et al. Genetic association of the antiviral restriction factor TRIM5a with human immunodeficiency virus type 1 infection. J Virol 2006; 80:2463-2471.
4. Stremlau M, Owens CM, Perron MJ, Kiessling M, Autissier P, Sodroski J. The cytoplasmic body component TRIM5a restricts HIV-1 infection in old world monkeys. Lett Nature 2004; 427:848-853.
5. Yap MW, Nisole S, Lynch C, Stoye JP. Trim5(protein restricts both HIV-1 and murine leukemia virus. Proc Natl Acad Sci USA 2004; 101:10786-10791.
6. Perron MJ, Stremlau M, Song B, Ulm W, Mulligan RC, Sodroski J. TRIM5alpha mediates the postentry block to n-tropic murine leukemia viruses in human cells. Proc Natl Acad Sci USA 2004; 101:1827-11832.
7. Lee K, KewalRamani VN. In defense of the cell: TRIM5a interception of mammalian retroviruses. Proc Natl Acad Sci USA 2004; 101:10496-10497.
8. Sokolskaja E, Berthoux L, Luban J. Cyclophilin A and TRIM5a independently regulate human immunodeficiency virus type 1 infectivity in human cells. J Virol 2006; 80:2855-2862.
9. Stremlau M, Perron M, Lee M, Li M, Song B, Javanbakht H, et al. Specific recognition and accelerated uncoating of retroviral capsids by the TRIM5a restriction factor. Proc Natl Acad Sci USA 2006; 103:5514-5519.
10. Ohkura S, Yap MW, Sheldon T, Stove JP. All three variable regions of the TRIM5alpha B30.3 domain can contribute to the specificity of retrovirus restriction. J Virol 2006; 80:8554-8565.
11. Song B, Gold B, O'Huigin C, Javanbakht H, Li X, Stremlau M, et al. The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates. J Virol 2005; 79:6111-6121.
12. Perez-Cabellero D, Hatziioannou T, Yang A, Cowan S, Bieniasz PD. Human tripartite motif 5(domains responsible for retro-virus restriction activity and specificity. J Virol 2005; 79:8969-8978.
13. Yap MW, Nisole S, Stoye JP. A single amino acid change in the SPRY domain of human Trim5a leads to HIV-1 restriction. Curr Biol 2005; 15:73-78.
14. Mische CC, Javanbakht H, Song B, Diaz-Griffero F, Stremlau M, Strack B, et al. Retroviral restriction factor TRIM5alpha is a trimer. J Virol 2005; 79:14446-14450.
15. Wu X, Anderson JL, Campbell EM, Joseph AM, Hope TJ. Proteasome inhibitors uncouple rhesus TRIM5alpha restriction of HIV-1 reverse transcription and infection. Proc Natl Acad Sci USA 2006; 103:7465-7470.
16. Javanbakht H, Diaz-Griffero F, Stremlau M, Si Z, Sodroski J. The contribution of the ring and b-box 2 domains to retroviral restriction mediated by monkey TRIM5a. J Biol Chem 2005; 280:26933-26940.
17. Van Manen D, Rits MAN, Beugeling C, Van Dort K, Schuite-maker H, Kootstra NA. The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection. PloS Pathog 2008; 4:1-8.
18. Javanbakht H, An P, Gold B, Peterson DC, O'Huigin C, Nelson GW, et al. Effects of human TRIM5a polymorphisms on anti-retroviral function and susceptibility to human immunodeficiency virus infection. Virology 2006; 354:15-27.
19. Nakayama EE, Carpentier W, Costagliola D, Shioda T, Iwamoto A, Debre P, et al. Wild type and H43Y variant of human TRIM5alpha show similar anti-human immunodeficiency virus type 1 activity both in vivo and in vitro. Immunogenetics 2007; 59:511-515.
20. Fowke KR, Nagelkerke NJ, Kimani J, Simonsen JN, Anzala AO, Bwayo JJ, et al. Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya. Lancet 1996; 348:1347-1351.
21. Xue H, Yang G. Weights in Horvitz-Thompson statistic for complex samples. Wei Sheng Yan Jiu 2000; 29:61-63.
22. Li X, Sodroksi J. The TRIM5(b-box 2 domain promotes cooperative binding to the retroviral capsid by mediating higher-order self-association. J Virol 2008; 82:11495-11502.
23. Richardson MW, Carroll RG, Stremlau M, Korokhov N, Hu-meau LM, Silvestri G, et al. Mode of transmission affects the sensitivity of human immunodeficiency virus type 1 to restriction by Rhesus TRIM5a. J Virol 2008; 82:11117-11128.
24. Sourisseau M, Sol-Foulon N, Porrot F, Blanchet F, Schwartz O. Inefficient human immunodeficiency virus replication in mobile lymphocytes. J Virol 2007; 81:1000-1012.
25. Rajsbaum R, Stove JP, O'Garra A. Type 1 interferon-dependent and independent expression of tripartite motif proteins in immune cells. Eur J Immunol 2008; 38:619-630.
26. Carthegena L, Parise MC, Ringeard M, Chelbi-Alix MK, Hazan U, Nisole S. Implication of TRIM5alpha and TRIMCyp in interferon-induced anti-retroviral restriction activities. Retrovirology 2008; 5:59.