Relationship between inflammation, bone destruction, and osteoproliferation in the HLA-B27/human β2-microglobulin-transgenic rat model of spondylarthritis

Arthritis and Rheumatism

Volumn 64, Issue 10, 2012, Pages 3210-3219

  Van Duivenvoorde, Leonie M ^a   Dorris, Martha L ^b   Satumtira, Nimman ^b   Van Tok, Melissa N ^a   Redlich, Kurt ^c   Tak, Paul P ^a   Taurog, Joel D ^b   Baeten, Dominique L ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF TEXAS AT DALLAS   (United States)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; HLA B27 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DESTRUCTION; BONE MARROW; CONNECTIVE TISSUE; EXPERIMENTAL MODEL; INFLAMMATION; INTERVERTEBRAL DISK; JOINT; LYMPHOCYTIC INFILTRATION; NONHUMAN; OSTEOCLAST; PERIOSTEUM; PRIORITY JOURNAL; RAT; SPINE; SPONDYLARTHRITIS; SPONDYLITIS; SYNOVITIS; TRANSGENIC RAT; VERTEBRA;

ANIMALS; BETA 2-MICROGLOBULIN; BONE AND BONES; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; HLA-B27 ANTIGEN; INFLAMMATION; JOINTS; OSTEOCLASTS; RATS; RATS, TRANSGENIC; SPONDYLARTHRITIS;

EID: 84869057337     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34600     Document Type: Article

References (40)

1. Khan MA. Update on spondyloarthropathies. Ann Intern Med 2002; 136: 896-907. (Pubitemid 34625702)
2. Vandooren B, Yeremenko N, Noordenbos T, Bras J, Tak PP, Baeten D. Mediators of structural remodeling in peripheral spondylarthritis [review]. Arthritis Rheum 2009; 60: 3534-45.
3. Lories RJ, Baeten DL. Differences in pathophysiology between rheumatoid arthritis and ankylosing spondylitis. Clin Exp Rheumatol 2009;27:S10-4.
4. Dougados M, Baeten D. Spondyloarthritis. Lancet 2011;377: 2127-37.
5. Schett G, Landewe R, Van Der Heijde D. Tumour necrosis factor blockers and structural remodelling in ankylosing spondylitis: what is reality and what is fiction? Ann Rheum Dis 2007; 66: 709-11. (Pubitemid 46846687)
6. Van Der Heijde D, Landewe R, Einstein S, Ory P, Vosse D, Ni L, et al. Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept. Arthritis Rheum 2008; 58: 1324-31. (Pubitemid 351705922)
7. Van Der Heijde D, Landewe R, Baraliakos X, Houben H, van Tubergen A, Williamson P, et al, and the Ankylosing Spondylitis Study for the Evaluation of Recombinant Infliximab Therapy Study Group. Radiographic findings following two years of infliximab therapy in patients with ankylosing spondylitis. Arthritis Rheum 2008; 58: 3063-70.
8. Lories RJ, Derese I, de Bari C, Luyten FP. Evidence for uncoupling of inflammation and joint remodeling in a mouse model of spondylarthritis. Arthritis Rheum 2007; 56: 489-97.
9. Sieper J, Appel H, Braun J, Rudwaleit M. Critical appraisal of assessment of structural damage in ankylosing spondylitis: implications for treatment outcomes [review]. Arthritis Rheum 2008; 58:649-56. (Pubitemid 351364862)
10. Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, et al. Dickkopf-1 is a master regulator of joint remodeling. Nat Med 2007; 13: 156-63.
11. Lories RJ, Luyten FP, de Vlam K. Progress in spondylarthritis: mechanisms of new bone formation in spondyloarthritis. Arthritis Res Ther 2009;11:221.
12. Hammer RE, Maika SD, Richardson JA, Tang JP, Taurog JD. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human -2m: an animal model of HLA-B27- associated human disorders. Cell 1990; 63: 1099-112. (Pubitemid 120034950)
13. Taurog JD, Maika SD, Satumtira N, Dorris ML, McLean IL, Yanagisawa H, et al. Inflammatory disease in HLA-B27 transgenic rats. Immunol Rev 1999; 169: 209-23. (Pubitemid 29338734)
14. Tran TM, Dorris ML, Satumtira N, Richardson JA, Hammer RE, Shang J, et al. Additional human -2-microglobulin curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27-transgenic rats. Arthritis Rheum 2006; 54: 1317-27. (Pubitemid 43672945)
15. Baeten D, Kruithof E, De Rycke L, Vandooren B, Wyns B, Boullart L, et al. Diagnostic classification of spondylarthropathy and rheumatoid arthritis by synovial histopathology: a prospective study in 154 consecutive patients. Arthritis Rheum 2004;50: 2931-41. (Pubitemid 39209532)
16. Baeten D, Demetter P, Cuvelier C, Van Den Bosch F, Kruithof E, Van Damme N, et al. Comparative study of the synovial histology in rheumatoid arthritis, spondyloarthropathy, and osteoarthritis: influence of disease duration and activity. Ann Rheum Dis 2000; 59:945-53.
17. Taurog JD. Animal models of spondyloarthritis. Adv Exp Med Biol 2009; 649: 245-54.
18. Van Duivenvoorde LM, Slobodin GM, Satumtira N, Dorris ML, Tak PP, Baeten DL, et al. Innate immune stimulation triggers early-onset spondyloarthritis in HLA-B27/human beta2 microglobulin transgenic rats [abstract]. Arthritis Rheum 2011;63 Suppl: S387.
19. Baeten D, Kruithof E, De Rycke L, Boots AM, Mielants H, Veys EM, et al. Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy. Arthritis Res Ther 2005;7:R359-69.
20. Kruithof E, Baeten D, De Rycke L, Vandooren B, Foell D, Roth J, et al. Synovial histopathology of psoriatic arthritis, both oligoand polyarticular, resembles spondyloarthropathy more than it does rheumatoid arthritis. Arthritis Res Ther 2005;7:R569-80.
21. Kruithof E, Van Den Bossche V, De Rycke L, Vandooren B, Joos R, Canete JD, et al. Distinct synovial immunopathologic characteristics of juvenile-onset spondylarthritis and other forms of juvenile idiopathic arthritis. Arthritis Rheum 2006; 54: 2594-604. (Pubitemid 44205021)
22. McGonagle D, Gibbon W, Emery P. Classification of inflammatory arthritis by enthesitis. Lancet 1998; 352: 1137-40. (Pubitemid 28448530)
23. McGonagle D, Gibbon W, O'Connor P, Green M, Pease C, Emery P. Characteristic magnetic resonance imaging entheseal changes of knee synovitis in spondylarthropathy. Arthritis Rheum 1998;41: 694-700. (Pubitemid 28214988)
24. McGonagle D, Lories RJ, Tan AL, Benjamin M. The concept of a "synovio-entheseal complex" and its implications for understanding joint inflammation and damage in psoriatic arthritis and beyond. Arthritis Rheum 2007; 56: 2482-91. (Pubitemid 47237267)
25. Lories RJ, Matthys P, de Vlam K, Derese I, Luyten FP. Ankylosing enthesitis, dactylitis, and onychoperiostitis in male DBA/1 mice: a model of psoriatic arthritis. Ann Rheum Dis 2004; 63: 595-8. (Pubitemid 38530208)
26. Francois RJ, Gardner DL, Degrave EJ, Bywaters EG. Histopathologic evidence that sacroiliitis in ankylosing spondylitis is not merely enthesitis: systematic study of specimens from patients and control subjects. Arthritis Rheum 2000; 43: 2011-24.
27. Muche B, Bollow M, Francois RJ, Sieper J, Hamm B, Braun J. Anatomic structures involved in early- and late-stage sacroiliitis in spondylarthritis: a detailed analysis by contrast-enhanced magnetic resonance imaging. Arthritis Rheum 2003; 48: 1374-84. (Pubitemid 36554536)
28. Gong Y, Zheng N, Chen SB, Xiao ZY, Wu MY, Liu Y, et al. Ten years' experience with needle biopsy in the early diagnosis of sacroiliitis. Arthritis Rheum 2012; 64: 1399-406.
29. Appel H, Maier R, Loddenkemper C, Kayser R, Meier O, Hempfing A, et al. Immunohistochemical analysis of osteoblasts in zygapophyseal joints of patients with ankylosing spondylitis reveal repair mechanisms similar to osteoarthritis. J Rheumatol 2010;37: 823-8.
30. Redlich K, Hayer S, Maier A, Dunstan CR, Tohidast-Akrad M, Lang S, et al. Tumor necrosis factor -mediated joint destruction is inhibited by targeting osteoclasts with osteoprotegerin. Arthritis Rheum 2002; 46: 785-92. (Pubitemid 34214261)
31. Ritchlin CT, Haas-Smith SA, Li P, Hicks DG, Schwarz EM. Mechanisms of TNF- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis. J Clin Invest 2003;111: 821-31.
32. Vandooren B, Cantaert T, Noordenbos T, Tak PP, Baeten D. The abundant synovial expression of the RANK/RANKL/ osteoprotegerin system in peripheral spondylarthritis is partially disconnected from inflammation. Arthritis Rheum 2008;58: 718-29. (Pubitemid 351364869)
33. Uderhardt S, Diarra D, Katzenbeisser J, David JP, Zwerina J, Richards W, et al. Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints. Ann Rheum Dis 2010; 69: 592-7.
34. Gladman DD, Mease PJ, Ritchlin CT, Choy EH, Sharp JT, Ory PA, et al. Adalimumab for long-term treatment of psoriatic arthritis: forty-eight week data from the Adalimumab Effectiveness in Psoriatic Arthritis Trial. Arthritis Rheum 2007; 56: 476-88.
35. Kavanaugh A, Antoni CE, Gladman D, Wassenberg S, Zhou B, Beutler A, et al. The Infliximab Multinational Psoriatic Arthritis Controlled Trial (IMPACT): results of radiographic analyses after 1 year. Ann Rheum Dis 2006; 65: 1038-43. (Pubitemid 44133266)
36. Van Der Heijde D, Kavanaugh A, Gladman DD, Antoni C, Krueger GG, Guzzo C, et al, for the IMPACT 2 Study Group. Infliximab inhibits progression of radiographic damage in patients with active psoriatic arthritis through one year of treatment: results from the Induction and Maintenance Psoriatic Arthritis Clinical Trial 2. Arthritis Rheum 2007; 56: 2698-707. (Pubitemid 47237288)
37. McGonagle D, Wakefield RJ, Tan AL, D'Agostino MA, Toumi H, Hayashi K, et al. Distinct topography of erosion and new bone formation in Achilles tendon enthesitis: implications for understanding the link between inflammation and bone formation in spondylarthritis. Arthritis Rheum 2008; 58: 2694-9.
38. Milia AF, Ibba-Manneschi L, Manetti M, Benelli G, Generini S, Messerini L, et al. Evidence for the prevention of enthesitis in HLA-B27/h-2m transgenic rats treated with a monoclonal antibody against TNF-. J Cell Mol Med 2011; 15: 270-9.
39. Lories RJ, Derese I, Luyten FP. Inhibition of osteoclasts does not prevent joint ankylosis in a mouse model of spondyloarthritis. Rheumatology (Oxford) 2008; 47: 605-8. (Pubitemid 351619197)
40. Schett G, Stolina M, Dwyer D, Zack D, Uderhardt S, Kronke G, et al. Tumor necrosis factor - and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis. Arthritis Rheum 2009; 60: 2644-54.