An ex vivo model for imprinting: Mutually exclusive binding of Cdx2 and Oct4 as a switch for imprinted and random X-inactivation

Genetics

Volumn 192, Issue 3, 2012, Pages 857-868

  Erwin, Jennifer A ^a,b   del Rosario, Brian ^a,b   Payer, Bernhard ^a,b   Lee, Jeannie T ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; OCTAMER TRANSCRIPTION FACTOR 4; RNA; TAMOXIFEN; TRANSCRIPTION FACTOR CDX2;

ANIMAL CELL; ARTICLE; EMBRYO; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; EX VIVO STUDY; FEMALE; GENOME IMPRINTING; MALE; MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TROPHOBLAST; X CHROMOSOME INACTIVATION;

ALLELES; ANIMALS; EMBRYONIC STEM CELLS; FEMALE; GENOMIC IMPRINTING; HOMEODOMAIN PROTEINS; INTRONS; MALE; MICE; OCTAMER TRANSCRIPTION FACTOR-3; PROTEIN BINDING; RNA, LONG UNTRANSLATED; TRANSCRIPTION FACTORS; TRANSGENES; TROPHOBLASTS; X CHROMOSOME INACTIVATION;

MAMMALIA;

EID: 84869056782     PISSN: 00166731     EISSN: 19432631     Source Type: Journal    
DOI: 10.1534/genetics.112.144121     Document Type: Article

References (52)

1. Barlow, D. P., 2011 Genomic imprinting: A mammalian epigenetic discovery model. Annu. Rev. Genet. 45: 379-403.
2. Brockdorff, N., A. Ashworth, G. F. Kay, V. M. McCabe, D. P. Norris et al., 1992 The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell 71: 515-526.
3. Brown, C. J., B. D. Hendrich, J. L. Rupert, R. G. Lafreniere, Y. Xing et al., 1992 The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell 71: 527-542.
4. Cattanach, B. M., and J. H. Isaacson, 1967 Controlling elements in the mouse X chromosome. Genetics 57: 331-346.
5. Chadwick, L. H., and H. F. Willard, 2005 Genetic and parent-oforigin influences on X chromosome choice in Xce heterozygous mice. Mamm. Genome 16: 691-699.
6. Donohoe, M. E., S. S. Silva, S. F. Pinter, N. Xu, and J. T. Lee, 2009 The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting. Nature 460: 128-132.
7. Edwards, C. A., and A. C. Ferguson-Smith, 2007 Mechanisms regulating imprinted genes in clusters. Curr. Opin. Cell Biol. 19: 281-289.
8. Goto, Y., and N. Takagi, 2000 Maternally inherited X chromosome is not inactivated in mouse blastocysts due to parental imprinting. Chromosome Res. 8: 101-109.
9. Harper, M. F., and M. Monk, 1982 Preferential paternal X inactivation in extraembryonic tissues of early mouse embryos. J. Embryol. Exp. Morphol. 67: 127-135.
10. Huynh, K. D., and J. T. Lee, 2003 Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos. Nature 426: 857-862.
11. Huynh, K. D., and J. T. Lee, 2004 A continuity of X-chromosome silence from gamete to zygote. Cold Spring Harb. Symp. Quant. Biol. 69: 103-112.
12. Kalantry, S., S. Purushothaman, R. B. Bowen, J. Starmer, and T. Magnuson, 2009 Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation. Nature 460: 647-651.
13. Lee, J. T., 2000 Disruption of imprinted X inactivation by parentof-origin effects at Tsix. Cell 103: 17-27.
14. Lee, J. T., and N. Lu, 1999 Targeted mutagenesis of Tsix leads to nonrandom X inactivation. Cell 99: 47-57.
15. Lee, J. T., L. S. Davidow, and D. Warshawsky, 1999 Tsix, a gene antisense to Xist at the X-inactivation centre. Nat. Genet. 21: 400-404.
16. Lee, T. L., R. G. Jenner, L. A. Boyer, M. G. Guenther, S. S Levine et al., 2006 Control of developmental regulators by polycomb in human embryonic stem cells. Cell 125: 301-313.
17. Luikenhuis, S., A. Wutz, and R. Jaenisch, 2001 Antisense transcription through the Xist locus mediates Tsix function in embryonic stem cells. Mol. Cell. Biol. 21: 8512-8520.
18. Macfarlan, T. S., W. D. Gifford, S. Driscoll, K. Lettieri, H. M. Rowe et al., 2012 Embryonic stem cell potency fluctuates with endogenous retrovirus activity. Nature 487: 57-63.
19. Maherali, N., R. Sridharan, W. Xie, J. Utikal, S. Eminli et al., 2007 Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 1: 55-70.
20. Mak, W., T. B. Nesterova, M. de Napoles, R. Appanah, S. Yamanaka et al., 2004 Reactivation of the paternal X chromosome in early mouse embryos. Science 303: 666-669.
21. Marahrens, Y., B. Panning, J. Dausman, W. Strauss, and R. Jaenisch, 1997 Xist-deficient mice are defective in dosage compensation but not spermatogenesis. Genes Dev. 11: 156-166.
22. Monk, M., and M. I. Harper, 1979 Sequential X chromosome inactivation coupled with cellular differentiation in early mouse embryos. Nature 281: 311-313.
23. Murakami, K., K. Araki, S. Ohtsuka, T. Wakayama, and H. Niwa, 2011 Choice of random rather than imprinted X inactivation in female embryonic stem cell-derived extra-embryonic cells. Development 138: 197-202.
24. Namekawa, S. H., P. J. Park, L. F. Zhang, J. E. Shima, J. R. McCarrey et al., 2006 Postmeiotic sex chromatin in the male germline of mice. Curr. Biol. 16: 660-667.
25. Namekawa, S. H., B. Payer, K. D. Huynh, R. Jaenisch, and J. T. Lee, 2010 Two-step imprinted X inactivation: repeat vs. genic silencing in the mouse. Mol. Cell. Biol. 30: 3187-3205.
26. Navarro, P., I. Chambers, V. Karwacki-Neisius, C. Chureau, C. Morey et al., 2008 Molecular coupling of Xist regulation and pluripotency. Science 321: 1693-1695.
27. Nichols, J., B. Zevnik, K. Anastassiadis, H. Niwa, D. Klewe-Nebenius et al., 1998 Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95: 379-391.
28. Nishiyama, A., and L. Xin, A. A.M. Sharov Thomas, G. Mowrer et al., 2009 Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5: 420-433.
29. Niwa, H., Y. Toyooka, D. Shimosato, D. Strumpf, K. Takahashi et al., 2005 Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell 123: 917-929.
30. Ogawa, Y., and J. T. Lee, 2003 Xite, X-inactivation intergenic transcription elements that regulate the probability of choice. Mol. Cell 11: 731-743.
31. Okamoto, I., S. Tan, and N. Takagi, 2000 X-chromosome inactivation in XX androgenetic mouse embryos surviving implantation. Development 127: 4137-4145.
32. Okamoto, I., A. P. Otte, C. D. Allis, D. Reinberg, and E. Heard, 2004 Epigenetic dynamics of imprinted X inactivation during early mouse development. Science 303: 644-649.
33. Okamoto, I., D. Arnaud, P. Le Baccon, A. P. Otte, C. M. Disteche et al., 2005 Evidence for de novo imprinted X-chromosome inactivation independent of meiotic inactivation in mice. Nature 438: 369-373.
34. Palmieri, S. L., W. Peter, H. Hess, and H. R. Scholer, 1994 Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev. Biol. 166: 259-267.
35. Payer, B., and J. T. Lee, 2008 X chromosome dosage compensation: how mammals keep the balance. Annu. Rev. Genet. 42: 733-772.
36. Sado, T., 2000 X inactivation in the mouse embryo deficient for Dnmt1: distinct effect of hypomethylation on imprinted and random X inactivation. Dev. Biol. 225: 294-303.
37. Sado, T., 2005 Imprinted X inactivation and reprogramming in the preimplantation mouse embryo. Hum. Mol. Genet. 14: R59-R64.
38. Sado, T., Z. Wang, H. Sasaki, and E. Li, 2001 Regulation of imprinted X-chromosome inactivation in mice by Tsix. Development 128: 1275-1286.
39. Sado, T., M. Okano, E. Li, and H. Sasaki, 2004 De novo DNA methylation is dispensable for the initiation and propagation of X chromosome inactivation. Development 131: 975-982.
40. Starmer, J., and T. Magnuson, 2009 A new model for random X chromosome inactivation. Development 136: 1-10.
41. Stavropoulos, N., N. Lu, and J. T. Lee, 2001 A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice. Proc. Natl. Acad. Sci. USA 98: 10232-10237.
42. Strumpf, D., C. A. Mao, Y. Yamanaka, A. Ralston, K. Chawengsaksophak et al., 2005 Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development 132: 2093-2102.
43. Tada, T., M. Tada, and N. Takagi, 1993 X chromosome retains the memory of its parental origin in murine embryonic stem cells. Development 119: 813-821.
44. Tada, T., Y. Obata, M. Tada, Y. Goto, N. Nakatsuji et al., 2000 Imprint switching for non-random X-chromosome inactivation during mouse oocyte growth. Development 127: 3101-3105.
45. Takagi, N., 2003 Imprinted X-chromosome inactivation: enlightenment from embryos in vivo. Semin. Cell Dev. Biol. 14: 319-329.
46. Takagi, N., and H. Sasaki, 1975 Preferential inactivation of the paternally derived X-chromosome in the extraembryonic membranes of the mouse. Nature 256: 640-642.
47. Tan, S.-S., E. A. Williams, and P. P. L. Tam, 1993 X-chromosome inactivation occurs at different times in different tissues of the post-implantation mouse embryo. Nat. Genet. 3: 170-174.
48. Tanaka, S., T. Kunath, A. K. Hadjantonakis, A. Nagy, and J. Rossant, 1998 Promotion of trophoblast stem cell proliferation by FGF4. Science 282: 2072-2075.
49. Tian, D., S. Sun, and J. T. Lee, 2010 The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation. Cell 143: 390-403.
50. Wan, L. B., and M. S. Bartolomei, 2008 Regulation of imprinting in clusters: noncoding RNAs vs. insulators. Adv. Genet. 61: 207-223.
51. Wutz, A., and J. Gribnau, 2007 X inactivation Xplained. Curr. Opin. Genet. Dev. 17: 387-393.
52. Wutz, A., and R. Jaenisch, 2000 A shift from reversible to irreversible X inactivation is triggered during ES cell differentiation. Mol. Cell 5: 695-705.