메뉴 건너뛰기




Volumn 7, Issue 11, 2012, Pages

The Ability of Virulence Factor Expression by Pseudomonas aeruginosa to Predict Clinical Disease in Hospitalized Patients

Author keywords

[No Author keywords available]

Indexed keywords

HOST FACTOR; VIRULENCE FACTOR;

EID: 84869051871     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049578     Document Type: Article
Times cited : (27)

References (52)
  • 1
    • 0035038592 scopus 로고    scopus 로고
    • The impact of hospital-acquired bloodstream infections
    • Wenzel RP, Edmond MB, (2001) The impact of hospital-acquired bloodstream infections. Emerging Infect Dis 7: 174-177.
    • (2001) Emerging Infect Dis , vol.7 , pp. 174-177
    • Wenzel, R.P.1    Edmond, M.B.2
  • 2
    • 24644515282 scopus 로고    scopus 로고
    • Overview of nosocomial infections caused by gram-negative bacilli
    • National Nosocomial Infections Surveillance System
    • Gaynes R, Edwards JR, National Nosocomial Infections Surveillance System, (2005) Overview of nosocomial infections caused by gram-negative bacilli. Clin Infect Dis 41: 848-854.
    • (2005) Clin Infect Dis , vol.41 , pp. 848-854
    • Gaynes, R.1    Edwards, J.R.2
  • 4
    • 0036290198 scopus 로고    scopus 로고
    • Mechanisms of antibiotic resistance of Pseudomonas aeruginosa
    • Lambert PA, (2002) Mechanisms of antibiotic resistance of Pseudomonas aeruginosa. J Royal Soc Med 95: 22-26.
    • (2002) J Royal Soc Med , vol.95 , pp. 22-26
    • Lambert, P.A.1
  • 5
    • 0035708640 scopus 로고    scopus 로고
    • Presence of polyclonal Pseudomonas aeruginosa in an intensive care unit: a 27-month prospective study on molecular epidemiology
    • Cortes P, Mariscal D, Valles J, Rello J, Coll P, (2001) Presence of polyclonal Pseudomonas aeruginosa in an intensive care unit: a 27-month prospective study on molecular epidemiology. Infect Control Hosp Epidemiol 22: 720-723.
    • (2001) Infect Control Hosp Epidemiol , vol.22 , pp. 720-723
    • Cortes, P.1    Mariscal, D.2    Valles, J.3    Rello, J.4    Coll, P.5
  • 6
    • 0242523776 scopus 로고    scopus 로고
    • Bacterial biofilms: an emerging link to disease pathogenesis
    • Parsek MR, Singh PK, (2003) Bacterial biofilms: an emerging link to disease pathogenesis. Ann Rev Microbiol 57: 677-701.
    • (2003) Ann Rev Microbiol , vol.57 , pp. 677-701
    • Parsek, M.R.1    Singh, P.K.2
  • 7
    • 0031923419 scopus 로고    scopus 로고
    • Risks and routes for ventilator-associated pneumonia with Pseudomonas aeruginosa
    • Talon D, Mulin B, Rouget C, Bailly P, Thouverez M, et al. (1998) Risks and routes for ventilator-associated pneumonia with Pseudomonas aeruginosa. Am J Respir Crit Care Med 157: 978-984.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 978-984
    • Talon, D.1    Mulin, B.2    Rouget, C.3    Bailly, P.4    Thouverez, M.5
  • 8
    • 69249157248 scopus 로고    scopus 로고
    • The type III secretion system of Pseudomonas aeruginosa: infection by injection
    • Hauser AR, (2009) The type III secretion system of Pseudomonas aeruginosa: infection by injection. Nat Rev Microbiol 7: 654-665.
    • (2009) Nat Rev Microbiol , vol.7 , pp. 654-665
    • Hauser, A.R.1
  • 10
    • 0036191393 scopus 로고    scopus 로고
    • Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa
    • Hauser A, Cobb E, Bodi M, Mariscal D, Valles J, et al. (2002) Type III protein secretion is associated with poor clinical outcomes in patients with ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Crit Care Med 30: 521-528.
    • (2002) Crit Care Med , vol.30 , pp. 521-528
    • Hauser, A.1    Cobb, E.2    Bodi, M.3    Mariscal, D.4    Valles, J.5
  • 11
    • 0035877065 scopus 로고    scopus 로고
    • Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections
    • Roy-Burman A, Savel RH, Racine S, Swanson BL, Revadigar NS, et al. (2001) Type III protein secretion is associated with death in lower respiratory and systemic Pseudomonas aeruginosa infections. J Infect Dis 183: 1767-1774.
    • (2001) J Infect Dis , vol.183 , pp. 1767-1774
    • Roy-Burman, A.1    Savel, R.H.2    Racine, S.3    Swanson, B.L.4    Revadigar, N.S.5
  • 12
    • 15544389065 scopus 로고    scopus 로고
    • Role of the Type III secreted exoenzymes S, T and Y in systemic spread of Pseudomonas aeruginosa PA01 in vivo
    • Vance RE, Rietsch A, Mekalanos JJ, (2005) Role of the Type III secreted exoenzymes S, T and Y in systemic spread of Pseudomonas aeruginosa PA01 in vivo. Infect Immun 73: 1705-1713.
    • (2005) Infect Immun , vol.73 , pp. 1705-1713
    • Vance, R.E.1    Rietsch, A.2    Mekalanos, J.J.3
  • 13
    • 15544380187 scopus 로고    scopus 로고
    • Activities of Pseudomonas aeruginosa effectors secreted by the Type III secretion system in vitro and during infection
    • Lee VT, Smith RS, Tummler B, Lory S, (2005) Activities of Pseudomonas aeruginosa effectors secreted by the Type III secretion system in vitro and during infection. Infect Immun 73: 1695-1705.
    • (2005) Infect Immun , vol.73 , pp. 1695-1705
    • Lee, V.T.1    Smith, R.S.2    Tummler, B.3    Lory, S.4
  • 14
    • 9244236027 scopus 로고    scopus 로고
    • Relative contributions of Pseudomonas aeruginosa ExoU, ExoS and ExoT to virulence in the lung
    • Shaver CM, Hauser AR, (2004) Relative contributions of Pseudomonas aeruginosa ExoU, ExoS and ExoT to virulence in the lung. Infect Immun 72: 6969-6977.
    • (2004) Infect Immun , vol.72 , pp. 6969-6977
    • Shaver, C.M.1    Hauser, A.R.2
  • 16
    • 34249864455 scopus 로고    scopus 로고
    • Clinical response to azithromycin in cystic fibrosis correlates with in vitro effects on Pseudomonas aeruginosa phenotypes
    • Nguyen D, Emond MJ, Mayer-Hamblett N, Saiman L, Marshall BC, et al. (2007) Clinical response to azithromycin in cystic fibrosis correlates with in vitro effects on Pseudomonas aeruginosa phenotypes. Pediatric Pulmonology 42: 533-541.
    • (2007) Pediatric Pulmonology , vol.42 , pp. 533-541
    • Nguyen, D.1    Emond, M.J.2    Mayer-Hamblett, N.3    Saiman, L.4    Marshall, B.C.5
  • 17
    • 0028012203 scopus 로고
    • Nonmotility and phagocytic resistance of Pseudomonas aeruginosa isolates from chronically colonized patients with cystic fibrosis
    • Mahenthiralingam E, Campbell ME, Speert DP, (1994) Nonmotility and phagocytic resistance of Pseudomonas aeruginosa isolates from chronically colonized patients with cystic fibrosis. Infect Immun 62: 596-605.
    • (1994) Infect Immun , vol.62 , pp. 596-605
    • Mahenthiralingam, E.1    Campbell, M.E.2    Speert, D.P.3
  • 18
    • 21544481151 scopus 로고    scopus 로고
    • Role of motility and flagellin glycosylation in the pathogenesis of Pseudomonas aeruginosa burn wound infections
    • Arora SK, Neely AN, Blair B, Lory S, Ramphal R, (2005) Role of motility and flagellin glycosylation in the pathogenesis of Pseudomonas aeruginosa burn wound infections. Infect Immun 73: 4395-4398.
    • (2005) Infect Immun , vol.73 , pp. 4395-4398
    • Arora, S.K.1    Neely, A.N.2    Blair, B.3    Lory, S.4    Ramphal, R.5
  • 19
    • 34447257103 scopus 로고    scopus 로고
    • The role of flagellin versus motility in acute lung disease caused by Pseudomonas aeruginosa
    • Balloy V, Verma A, Kuravi SK, Si-Tahar M, Chignard M, et al. (2007) The role of flagellin versus motility in acute lung disease caused by Pseudomonas aeruginosa. J Infect Dis 196: 289-296.
    • (2007) J Infect Dis , vol.196 , pp. 289-296
    • Balloy, V.1    Verma, A.2    Kuravi, S.K.3    Si-Tahar, M.4    Chignard, M.5
  • 20
    • 0031975347 scopus 로고    scopus 로고
    • Role of flagella in pathogenesis of Pseudomonas aeruginosa pulmonary infection
    • Feldman M, Bryan R, Rajan S, Scheffler L, Brunnert S, et al. (1998) Role of flagella in pathogenesis of Pseudomonas aeruginosa pulmonary infection. Infect Immun 66: 43-51.
    • (1998) Infect Immun , vol.66 , pp. 43-51
    • Feldman, M.1    Bryan, R.2    Rajan, S.3    Scheffler, L.4    Brunnert, S.5
  • 21
    • 0028920724 scopus 로고
    • Role of Pseudomonas aeruginosa pili in acute pulmonary infection
    • Tang H, Kays M, Prince A, (1995) Role of Pseudomonas aeruginosa pili in acute pulmonary infection. Infect Immun 63: 1278-1285.
    • (1995) Infect Immun , vol.63 , pp. 1278-1285
    • Tang, H.1    Kays, M.2    Prince, A.3
  • 22
    • 0029929646 scopus 로고    scopus 로고
    • Production of extracellular virulence factors by Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections
    • Hamood AN, Griswold JA, Duhan CM, (1996) Production of extracellular virulence factors by Pseudomonas aeruginosa isolates obtained from tracheal, urinary tract, and wound infections. J Surg Res 61: 425-432.
    • (1996) J Surg Res , vol.61 , pp. 425-432
    • Hamood, A.N.1    Griswold, J.A.2    Duhan, C.M.3
  • 23
    • 66549087843 scopus 로고    scopus 로고
    • Clearance of Pseudomonas aeruginosa from a healthy ocular surface involves surfactant protein D and is compromised by bacterial elastase in a murine null-infection model
    • Mun JJ, Tam C, Kowbel D, Hawgood S, Barnett MJ, et al. (2009) Clearance of Pseudomonas aeruginosa from a healthy ocular surface involves surfactant protein D and is compromised by bacterial elastase in a murine null-infection model. Infect Immun 77: 2392-2398.
    • (2009) Infect Immun , vol.77 , pp. 2392-2398
    • Mun, J.J.1    Tam, C.2    Kowbel, D.3    Hawgood, S.4    Barnett, M.J.5
  • 24
    • 0030794058 scopus 로고    scopus 로고
    • Contribution of Proteases and LasR to the Virulence of Pseudomonas aeruginosa during Corneal Infections
    • Preston M, Seed P, Toder D, Iglewski B, Ohman D, et al. (1997) Contribution of Proteases and LasR to the Virulence of Pseudomonas aeruginosa during Corneal Infections. Infection and Immunity 65: 3086-3090.
    • (1997) Infection and Immunity , vol.65 , pp. 3086-3090
    • Preston, M.1    Seed, P.2    Toder, D.3    Iglewski, B.4    Ohman, D.5
  • 25
    • 0022538733 scopus 로고
    • Phenotypic comparison of Pseudomonas aeruginosa strains isolated from a variety of clinical sites
    • Woods DE, Schaffer MS, Rabin HR, Campbell GD, Sokol PA, (1986) Phenotypic comparison of Pseudomonas aeruginosa strains isolated from a variety of clinical sites. J Clin Microbiol 24: 260-264.
    • (1986) J Clin Microbiol , vol.24 , pp. 260-264
    • Woods, D.E.1    Schaffer, M.S.2    Rabin, H.R.3    Campbell, G.D.4    Sokol, P.A.5
  • 26
    • 10744225048 scopus 로고    scopus 로고
    • The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes
    • He J, Baldini RL, Deziel E, Saucier M, Zhang Q, et al. (2004) The broad host range pathogen Pseudomonas aeruginosa strain PA14 carries two pathogenicity islands harboring plant and animal virulence genes. Proc Natl Acad Sci U S A 101: 2530-2535.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 2530-2535
    • He, J.1    Baldini, R.L.2    Deziel, E.3    Saucier, M.4    Zhang, Q.5
  • 27
    • 55749102738 scopus 로고    scopus 로고
    • Hybrid pathogenicity island PAGI-5 contributes to the highly virulent phenotype of a Pseudomonas aeruginosa isolate in mammals
    • Battle SE, Meyer F, Rello J, Kung VL, Hauser AR, (2008) Hybrid pathogenicity island PAGI-5 contributes to the highly virulent phenotype of a Pseudomonas aeruginosa isolate in mammals. J Bacteriol 190: 7130-7140.
    • (2008) J Bacteriol , vol.190 , pp. 7130-7140
    • Battle, S.E.1    Meyer, F.2    Rello, J.3    Kung, V.L.4    Hauser, A.R.5
  • 29
    • 33750924336 scopus 로고    scopus 로고
    • Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial
    • Lee DG, Urbach JM, Wu G, Liberati NT, Feinbaum RL, et al. (2006) Genomic analysis reveals that Pseudomonas aeruginosa virulence is combinatorial. Genome Biol 7: R90.91-R90.14.
    • (2006) Genome Biol , vol.7 , pp. 14-91
    • Lee, D.G.1    Urbach, J.M.2    Wu, G.3    Liberati, N.T.4    Feinbaum, R.L.5
  • 31
    • 77950217695 scopus 로고    scopus 로고
    • Pathogenicity islands PAPI-1 and PAPI-2 contribute individually and synergistically to the virulence of Pseudomonas aeruginosa strain PA14
    • Harrison EM, Carter ME, Luck S, Ou HY, Deng Z, et al. (2010) Pathogenicity islands PAPI-1 and PAPI-2 contribute individually and synergistically to the virulence of Pseudomonas aeruginosa strain PA14. Infect Immun 78: 1437-1446.
    • (2010) Infect Immun , vol.78 , pp. 1437-1446
    • Harrison, E.M.1    Carter, M.E.2    Luck, S.3    Ou, H.Y.4    Deng, Z.5
  • 32
    • 79959813634 scopus 로고    scopus 로고
    • Key two-component regulatory systems that control biofilm formation in Pseudomonas aeruginosa
    • Mikkelsen H, Sivaneson M, Filloux A, (2011) Key two-component regulatory systems that control biofilm formation in Pseudomonas aeruginosa. Environ Microbiol 13: 1666-1681.
    • (2011) Environ Microbiol , vol.13 , pp. 1666-1681
    • Mikkelsen, H.1    Sivaneson, M.2    Filloux, A.3
  • 33
    • 84877928728 scopus 로고    scopus 로고
    • Type 3 secretion system effector genotype and secretion phenotype of longitudinally collected Pseudomonas aeruginosa isolates from young children diagnosed with cystic fibrosis following newborn screening
    • Hu H, Harmer C, Anuj S, Wainwright CE, Manos J, et al. (2012) Type 3 secretion system effector genotype and secretion phenotype of longitudinally collected Pseudomonas aeruginosa isolates from young children diagnosed with cystic fibrosis following newborn screening. Clin Microbiol Infect: no-no.
    • (2012) Clin Microbiol Infect
    • Hu, H.1    Harmer, C.2    Anuj, S.3    Wainwright, C.E.4    Manos, J.5
  • 34
    • 8644222052 scopus 로고    scopus 로고
    • Type III secretion phenotypes of Pseudomonas aeruginosa strains change during infection of individuals with Cystic Fibrosis
    • Jain M, Ramirez D, Seshadri R, Cullina JF, Powers CA, et al. (2004) Type III secretion phenotypes of Pseudomonas aeruginosa strains change during infection of individuals with Cystic Fibrosis. J Clin Microbiol 42: 5229-5237.
    • (2004) J Clin Microbiol , vol.42 , pp. 5229-5237
    • Jain, M.1    Ramirez, D.2    Seshadri, R.3    Cullina, J.F.4    Powers, C.A.5
  • 37
    • 30044452446 scopus 로고    scopus 로고
    • An indirect enzyme-linked immunosorbent assay for rapid and quantitative detection of type III virulence phenotypes of Pseudomonas aeruginosa isolates
    • Li L, Ledizet M, Kar K, Koski RA, Kazmierczak BI, (2005) An indirect enzyme-linked immunosorbent assay for rapid and quantitative detection of type III virulence phenotypes of Pseudomonas aeruginosa isolates. Ann Clin Microbiol Antimicrobiol 4: 22-35.
    • (2005) Ann Clin Microbiol Antimicrobiol , vol.4 , pp. 22-35
    • Li, L.1    Ledizet, M.2    Kar, K.3    Koski, R.A.4    Kazmierczak, B.I.5
  • 38
    • 77951651340 scopus 로고    scopus 로고
    • Swarming motility, secretion of type 3 effectors and biofilm formation phenotypes exhibited within a large cohort of Pseudomonas aeruginosa clinical isolates
    • Murray TS, Ledizet M, Kazmierczak BI, (2010) Swarming motility, secretion of type 3 effectors and biofilm formation phenotypes exhibited within a large cohort of Pseudomonas aeruginosa clinical isolates. J Med Microbiol 59: 511-520.
    • (2010) J Med Microbiol , vol.59 , pp. 511-520
    • Murray, T.S.1    Ledizet, M.2    Kazmierczak, B.I.3
  • 39
    • 69849114488 scopus 로고    scopus 로고
    • Growing and analyzing static biofilms
    • In: Coico R, Kowalik T, Quarles J, Stevenson B, Taylor RK, editors, John Wiley & Sons, Inc
    • Merritt JH, Kadouri DE, Otoole GA (2005) Growing and analyzing static biofilms. In: Coico R, Kowalik T, Quarles J, Stevenson B, Taylor RK, editors. Current Protocols in Microbiology: John Wiley & Sons, Inc. 1B.1.1-1B.1.17.
    • (2005) Current Protocols in Microbiology , pp. 1-17
    • Merritt, J.H.1    Kadouri, D.E.2    Otoole, G.A.3
  • 40
    • 0035869555 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa protease IV enzyme assays and comparison to the Pseudomonas proteases
    • Caballero AR, Moreau JM, Engel LS, Marquart ME, Hill JM, et al. (2001) Pseudomonas aeruginosa protease IV enzyme assays and comparison to the Pseudomonas proteases. Anal Biochem 290: 330-337.
    • (2001) Anal Biochem , vol.290 , pp. 330-337
    • Caballero, A.R.1    Moreau, J.M.2    Engel, L.S.3    Marquart, M.E.4    Hill, J.M.5
  • 41
    • 77952217223 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa
    • In: Mandell GL, Bennett JE, Dolin R, editors, 7th ed. Philadelphia, PA: Churchill Livingstone Elsevier
    • Pier GB, Ramphal R (2010) Pseudomonas aeruginosa. In: Mandell GL, Bennett JE, Dolin R, editors. Mandell, Douglas, and Bennett's principles and practice of infectious diseases. 7th ed. Philadelphia, PA: Churchill Livingstone Elsevier. 2835-2860.
    • (2010) Mandell, Douglas, and Bennett's principles and practice of infectious diseases , pp. 2835-2860
    • Pier, G.B.1    Ramphal, R.2
  • 42
    • 77954374364 scopus 로고    scopus 로고
    • The Pseudomonas aeruginosa pathogenicity island PAPI-1 is transferred via a novel type IV pilus
    • Carter MQ, Chen J, Lory S, (2010) The Pseudomonas aeruginosa pathogenicity island PAPI-1 is transferred via a novel type IV pilus. J Bacteriol 192: 3249-3258.
    • (2010) J Bacteriol , vol.192 , pp. 3249-3258
    • Carter, M.Q.1    Chen, J.2    Lory, S.3
  • 43
    • 0037322193 scopus 로고    scopus 로고
    • Coordinate regulation of bacterial genes by a novel adenylate cyclase signaling pathway
    • Wolfgang MC, Lee VT, Gilmore ME, Lory S, (2003) Coordinate regulation of bacterial genes by a novel adenylate cyclase signaling pathway. Devlop Cell 4: 253-263.
    • (2003) Devlop Cell , vol.4 , pp. 253-263
    • Wolfgang, M.C.1    Lee, V.T.2    Gilmore, M.E.3    Lory, S.4
  • 45
    • 67651119892 scopus 로고    scopus 로고
    • Quorum sensing is necessary for the virulence of Pseudomonas aeruginosa during urinary tract infection
    • Kumar R, Chhibber S, Harjai K, (2009) Quorum sensing is necessary for the virulence of Pseudomonas aeruginosa during urinary tract infection. Kidney Int 76: 286-292.
    • (2009) Kidney Int , vol.76 , pp. 286-292
    • Kumar, R.1    Chhibber, S.2    Harjai, K.3
  • 46
    • 0242500352 scopus 로고    scopus 로고
    • Use of the Galleria mellonella Caterpillar as a Model Host To Study the Role of the Type III Secretion System in Pseudomonas aeruginosa Pathogenesis
    • Miyata S, Casey M, Frank DW, Ausubel FM, Drenkard E, (2003) Use of the Galleria mellonella Caterpillar as a Model Host To Study the Role of the Type III Secretion System in Pseudomonas aeruginosa Pathogenesis. Infect Immun 71: 2404-2413.
    • (2003) Infect Immun , vol.71 , pp. 2404-2413
    • Miyata, S.1    Casey, M.2    Frank, D.W.3    Ausubel, F.M.4    Drenkard, E.5
  • 47
    • 9644295892 scopus 로고    scopus 로고
    • National Nosocomial Infection Surveillance (NNIS) System report, data summary from January 1992 through June 2004, issued October 2004
    • National Nosocomial Infection Surveillance System
    • National Nosocomial Infection Surveillance System, (2004) National Nosocomial Infection Surveillance (NNIS) System report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 32: 470-485.
    • (2004) Am J Infect Control , vol.32 , pp. 470-485
  • 48
    • 40149107330 scopus 로고    scopus 로고
    • Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen
    • Arnoldo A, Curak J, Kittanakom S, Chevelev I, Lee VT, et al. (2008) Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen. PLoS Genet 4: e1000005.
    • (2008) PLoS Genet , vol.4
    • Arnoldo, A.1    Curak, J.2    Kittanakom, S.3    Chevelev, I.4    Lee, V.T.5
  • 49
    • 33847704986 scopus 로고    scopus 로고
    • Pseudolipasin A is a specific inhibitor for phospholipase A2 activity of Pseudomonas aeruginosa cytotoxin ExoU
    • Lee VT, Pukatzki S, Sato H, Kikawada E, Kazimirova AA, et al. (2007) Pseudolipasin A is a specific inhibitor for phospholipase A2 activity of Pseudomonas aeruginosa cytotoxin ExoU. Infect Immun 75: 1089-1098.
    • (2007) Infect Immun , vol.75 , pp. 1089-1098
    • Lee, V.T.1    Pukatzki, S.2    Sato, H.3    Kikawada, E.4    Kazimirova, A.A.5
  • 50
    • 0032907634 scopus 로고    scopus 로고
    • Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury
    • Sawa T, Yahr TL, Ohara M, Kurahashi K, Gropper MA, et al. (1999) Active and passive immunization with the Pseudomonas V antigen protects against type III intoxication and lung injury. Nat Med 5: 392-398.
    • (1999) Nat Med , vol.5 , pp. 392-398
    • Sawa, T.1    Yahr, T.L.2    Ohara, M.3    Kurahashi, K.4    Gropper, M.A.5
  • 51
    • 0034877753 scopus 로고    scopus 로고
    • PcrV immunization enhances survival of burned Pseudomonas aeruginosa-infected mice
    • Holder IA, Neely AN, Frank DW, (2001) PcrV immunization enhances survival of burned Pseudomonas aeruginosa-infected mice. Infect Immun 69: 5908-5910.
    • (2001) Infect Immun , vol.69 , pp. 5908-5910
    • Holder, I.A.1    Neely, A.N.2    Frank, D.W.3
  • 52
    • 84864289317 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of an anti-PcrV PEGylated monoclonal antibody fragment in mechanically ventilated patients colonized with Pseudomonas aeruginosa: A randomized,double-blind, placebo-controlled trial*
    • Francois B, Luyt CE, Dugard A, Wolff M, Diehl JL, et al. (2012) Safety and pharmacokinetics of an anti-PcrV PEGylated monoclonal antibody fragment in mechanically ventilated patients colonized with Pseudomonas aeruginosa: A randomized,double-blind, placebo-controlled trial*. Crit Care Med 40: 2320-2326.
    • (2012) Crit Care Med , vol.40 , pp. 2320-2326
    • Francois, B.1    Luyt, C.E.2    Dugard, A.3    Wolff, M.4    Diehl, J.L.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.