HLA-Mismatched, Noninherited Maternal Antigen-Matched Unrelated Cord Blood Transplantations Have Superior Survival: How HLA Typing the Cord Blood Donor's Mother can Move the Field Forward

Biology of Blood and Marrow Transplantation

Volumn 18, Issue 12, 2012, Pages 1773-1775

  Scaradavou, Andromachi ^a,b  

^a NEW YORK BLOOD CENTER   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN; MATERNAL ANTIGEN; UNCLASSIFIED DRUG;

CD8+ T LYMPHOCYTE; CIRCULATION; CORD BLOOD STEM CELL TRANSPLANTATION; FETOPLACENTAL UNIT; GRAFT VERSUS HOST REACTION; HLA MATCHING; HLA TYPING; HUMAN; MICROCHIMERISM; NOTE; REGULATORY T LYMPHOCYTE; STATISTICAL SIGNIFICANCE; SURVIVAL; UMBILICAL CORD BLOOD;

CORD BLOOD STEM CELL TRANSPLANTATION; FEMALE; FETAL BLOOD; HLA ANTIGENS; HUMANS; MALE;

EID: 84869039188     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2012.10.009     Document Type: Note

References (16)

1. van Rood J.J., Oudshoorn M. When selecting a HLA-mismatched stem cell donor, consider donor immune status. Curr Opin Immunol 2009, 21:1-6.
2. van Rood J.J., Eemisse J.G., van Leeuwen A. Leukocyte antibodies in sera from pregnant women. Nature 1958, 181:1735-1736.
3. Mold J.E., Michaelsson J., Burt T.D., et al. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science 2008, 322:1562-1565.
4. Burlingham W., Grailer A.P., Heisey D.M., et al. The effect of tolerance to non-inherited maternal HLA antigens on the survival of renal transplants from sibling donors. N Engl J Med 1998, 339:1657-1664.
5. van Rood J.J., Loberiza F.R., Zhang M.-J., et al. Effect of tolerance to noninherited maternal antigens on the occurrence of graft-versus-host disease after bone marrow transplantation from a parent or an HLA-haploidentical sibling. Blood 2002, 99:1572-1577.
6. + regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med 2003, 9:1144-1150.
7. Mommaas B., Stegehuis-Kamp J.A., van Halteren A.G., et al. Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1. Blood 2005, 105:1823-1827.
8. Van Halteren A.G., Jankowska-Gan E., Joosten A., et al. Naturally acquired tolerance and sensitization to minor histocompatibility antigens in healthy family members. Blood 2009, 114:2263-2272.
9. Dutta P., Burlingham W.J. Microchimerism: tolerance vs sensitization. Curr Opin Organ Transplant 2011, 16:359-365.
10. Scaradavou A., Carrier C., Mollen N., et al. Detection of maternal DNA in placental/umbilical cord blood by locus-specific amplification of the noninherited maternal HLA gene. Blood 1996, 88:1494-1500.
11. Stern M., Ruggeri L., Mancusi A., et al. Survival after T cell-depleted haploidentical stem cell transplantation is improved using the mother as donor. Blood 2008, 112:2990-2995.
12. van Rood J.J., Stevens C.E., Smits J., et al. Reexposure of cord blood to noninherited maternal HLA antigens improves transplant outcome in hematological malignancies and might enhance its anti-leukemic effect. Proc Natl Acad Sci USA 2009, 106:19952-19957.
13. Rocha V., Spellman S., Zhang M.J., et al. Effect of HLA-matching recipients to donor noninherited maternal antigens on outcomes after mismatched umbilical cord blood transplantation for hematologic malignancy. Biol Blood Marrow Transplant 2012, 18:1890-1896.
14. Van Rood J.J., Scaradavou A., Stevens C.E. Indirect evidence that maternal microchimerism in cord blood mediates a graft-versus-leukemia effect in cord blood transplantation. Proc Natl Acad Sci USA 2012, 109:2509-2514.
15. Bone Marrow Donors Worldwide. Newsbites, December 2011. Available from: Accessed October 10, 2012. http://www.BMDW.org.
16. World Marrow Donors Association. Annual report 2011.