When selecting an HLA mismatched stem cell donor consider donor immune status

Current Opinion in Immunology

Volumn 21, Issue 5, 2009, Pages 538-543

  van Rood, Jon J ^a,b   Oudshoorn, Machteld ^a,b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Europdonor Foundation   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN;

ALLOIMMUNITY; ALLOIMMUNIZATION; BREAST FEEDING; DONOR SELECTION; ENVIRONMENTAL EXPOSURE; FETUS CELL; HEMATOPOIETIC STEM CELL; HLA MATCHING; HUMAN; IMMUNE STATUS; IMMUNOLOGICAL TOLERANCE; MATERNAL BLOOD; MICROCHIMERISM; PRENATAL EXPOSURE; REGULATORY T LYMPHOCYTE; REVIEW; SIBLING; STEM CELL TRANSPLANTATION;

DONOR SELECTION; FEMALE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HISTOCOMPATIBILITY TESTING; HLA ANTIGENS; HUMANS; MATERNAL-FETAL EXCHANGE; PREGNANCY; TISSUE DONORS;

EID: 70349739301     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2009.07.016     Document Type: Review

References (29)

1. van Rood J.J., and Oudshoorn M. Eleven million donors in Bone Marrow Donors Worldwide! Time for reassessment?. Bone Marrow Transplant 41 1 (2008) 1-9
2. Rubinstein P. Why cord blood?. Hum Immunol 67 6 (2006) 398-404
3. Eapen M., Rubinstein P., Zhang M., Stevens C., Kurtz J., Andromachi S., Loberiza F.R., Champlin R.E., Klein J.P., Horowitz M.M., et al. Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. Lancet 369 (2007) 1947-1954
4. Barker J.N., Rocha V., and Scaradavou A. Optimizing unrelated donor cord blood transplantation. Biol Blood Marrow Transplant 15 (2009) 154-161
5. Ichinohe T., Teshima T., Matsuoka K., Maruya E., and Saji H. Fetal-maternal micro-chimerism: impact on hematopoietic stem cell transplantation. Curr Opin Immunol 17 (2005) 546-552
6. Petersdorf E.W., and Hansen J.A. New advances in hematopoietic cell transplantation. Curr Opin Hematol 15 6 (2008) 549-554
7. Kawase T., Matsuo K., Kashiwase K., Inoko H., Saji H., Ogawa S., Kato S., Sasazuki T., Kodera Y., and Morishima Y. HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism. Blood 113 (2009) 2851-2858
8. Heemskerk M.B., Cornelissen J.J., Roelen D.L., van Rood J.J., Claas F.H.J., Doxiadis I.I., and Oudshoorn M. Highly diverged MHC class I mismatches are acceptable for haematopoietic stem cell transplantation. Bone Marrow Transplant 40 3 (2007) 193-200
9. van Rood J.J., Eernisse J.G., and van Leeuwen A. Leucocyte antibodies in sera from pregnant women. Nature 181 4625 (1958) 1735-1736
10. Payne R., and Rolfs M.R. Fetomaternal leukocyte incompatibility. J Clin Invest 37 12 (1958) 1756-1763
11. Dankers M.K., Witvliet M.D., Roelen D.L., de Lange P., Korfage N., Persijn G.G., Duquesnoy R., Doxiadis I.I., and Claas F.H.J. The number of amino acid triplet differences between patient and donor is predictive for the antibody reactivity against mismatched human leukocyte antigens. Transplantation 77 8 (2004) 1236-1239
12. Dankers M.K., Roelen D.L., Korfage N., de Lange P., Witvliet M., Sandkuijl L., Doxiadis I.I., and Claas F.H.J. Differential immunogenicity of paternal HLA Class I antigens in pregnant women. Hum Immunol 64 6 (2003) 600-606
13. van Kampen C.A., Versteeg-van der Voort Maarschalk M.F., Langerak-Langerak J., van Beelen E., Roelen D.L., and Claas F.H. Pregnancy can induce long-presisting primed CTLs specific for inherited paternal HLA antigens. Hum Immunol 62 (2001) 201-207
14. Verdijk R.M., Kloosterman A., Pool J., van de Keur M., Naipal A.M., van Halteren A.G., Brand A., Mutis T., and Goulmy E. Pregnancy induces minor histocompatibility antigen-specific cytotoxic T cells: implications for stem cell transplantation and immunotherapy. Blood 103 (2004) 1961-1964
15. Mommaas B., Stegehuis-Kamp J.A., van Halteren A.G., Kester M., Enczmann J., Wernet P., Kögler G., Mutis T., Brand A., and Goulmy E. Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1. Blood 105 4 (2005) 1823-1827
16. Mold J.E., Michaëlsson J., Burt T.D., Muench M.O., Beckerman K.P., Busch M.P., Lee T.H., Nixon D.F., and McCune J.M. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science 322 5907 (2008) 1562-1565. Studying 18-22-week human fetus thymus, lymph nodes, spleens and other organs the authors follow the development of CD4+ Fox P3 T cells, their decline briefly before delivery and their ability after stimulation with allogeneic cells to upregulate Fox P3.
17. Bean M.A., Mickelson E., Yanagida J., Ishioka S., Brannen G.E., and Hansen J.A. Suppressed anti-donor MLC responses in renal transplant candidates conditioned with donor-specific transfusions that carry the recipient's non-inherited maternal HLA haplotype. Transplantation 49 2 (1990) 382-386
18. Cai J., Lee J., Jankowska-Gan E., Derks R., Pool J., Mutis T., Goulmy E., and Burlingham W.J. Minor H antigen HA-1-specific regulator and effector CD8+ T cells, and HA-1 microchimerism, in allograft tolerance. J Exp Med 199 7 (2004) 1017-1023
19. Halteren AGS, Jankowska-Gan E, Joosten A, Blokland E, Pool J, Brand A, Burlingham WJ, Goulmy E: Naturally acquired tolerance and sensitisation to minor histocompatibility antigens in healthy family members. Bone Marrow Transplant 2009, 43(Suppl 1):O426, S82; Blood on line June 8, 2009: doi:10, 1182 /blood-2009-01-200410. A first demonstration that CTLs and CD8+ T regulator cells against mHA can occur simultaneously in healthy adult male and female donors.
20. Owen R.D., Wood H.R., Foord A.G., Sturgeon P., and Baldwin L.G. Evidence for actively acquired tolerance to Rh antigens. Proc Natl Acad Sci U S A 40 6 (1954) 420-424
21. Claas F.H., Gijbels Y., Van der Velden-de Munck, and van Rood J.J. Induction of B cell unresponsiveness to non-inherited maternal HLA antigens during fetal life. Science 241 (1988) 1815-1817
22. Burlingham W.J., Grailer A.P., Heisey D.M., Claas F.H., Norman D., Mohanakumar T., Brennan D.C., de Fijter H., van Gelder T., Pirsch J.D., et al. The effect of tolerance to non-inherited maternal HLA antigens on the survival of renal transplants from sibling donors. N Engl J Med 339 23 (1998) 1657-1664
23. Blaha P., Bigenzahn S., Koporc Z., Schmid M., Langer F., Selzer E., Bergmeister H., Wrba F., Kurtz J., Kiss C., et al. The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade. Blood 101 7 (2003) 2886-2893
24. Smits J.M., Claas F.H., van Houwelingen H.C., and Persijn G.G. Do non-inherited maternal antigens (NIMA) enhance renal graft survival?. Transplant Int 11 (1998) 82-88
25. Gras S., Burrows S.R., Kjer-Nielsen L., Clements C.S., Liu Y.C., Sullivan L.C., Bell M.J., Brooks A.G., Purcell A.W., McCluskey J., et al. The shaping of T cell receptor recognition by self-tolerance. Immunity 30 2 (2009) 193-203
26. Ford M.L., Kirk A.D., and Larsen C.P. Donor-reactive T-cell stimulation history and precursor frequency: barriers to tolerance induction. Transplantation 87 (2009) S69-S74
27. Stern M., Ruggeri L., Mancusi A., Bernardo M.E., de Angelis C., Bucher C., Locatelli F., Aversa F., and Velardi A. Survival after T cell depleted haplo-identical stem cell transplantation is improved using the mother as donor. Blood 112 7 (2008) 2990-2995. By analyzing parental stem cell transplant outcome the authors not only confirm that in T cell depleted grafts NK alloimmunity reduces relapse and GVHD, but also that the few remaining T cells in maternal grafts expand and cause a significant improved survival in all probability because of anti-IPA immunity and possibly tolerance.
28. Schipper R.F., D'Amaro J., and Oudshoorn M. The probability of finding a suitable related donor for bone marrow transplantation in extended families. Blood 87 2 (1996) 800-804
29. Klein T., Yaniv I., Stein J., Narinsky R., Finkelstein Y., and Garty B.Z. Extended family studies for the identification of allogeneic stem cell transplant donors in Jewish and Arabic patients in Israel. Pediatr Transplant 9 1 (2005) 52-55