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Volumn 16, Issue 4, 2011, Pages 359-365

Microchimerism: Tolerance vs. sensitization

Author keywords

microchimerism; noninherited maternal antigens; T regulatory cells; tolerance

Indexed keywords

ANTIGEN; GREEN FLUORESCENT PROTEIN; INTEGRIN; INTERLEUKIN 10; INTERLEUKIN 2; NONINHERITED MATERNAL ANTIGEN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 1;

EID: 80051782868     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e3283484b57     Document Type: Review
Times cited : (40)

References (55)
  • 1
    • 33746517978 scopus 로고    scopus 로고
    • Immunology of placentation in eutherian mammals
    • DOI 10.1038/nri1897, PII NRI1897
    • Moffett A, Loke C. Immunology of placentation in eutherian mammals. Nat Rev Immunol 2006; 6:584-594. (Pubitemid 44134091)
    • (2006) Nature Reviews Immunology , vol.6 , Issue.8 , pp. 584-594
    • Moffett, A.1    Loke, C.2
  • 4
    • 0033559750 scopus 로고    scopus 로고
    • Long-term fetal microchimerism in peripheral blood mononuclear cell subsets in healthy women and women with scleroderma
    • Evans PC, Lambert N, Maloney S, et al. Long-term fetal microchimerism in peripheral blood mononuclear cell subsets in healthy women and women with scleroderma. Blood 1999; 93:2033-2037. (Pubitemid 29128506)
    • (1999) Blood , vol.93 , Issue.6 , pp. 2033-2037
    • Evans, P.C.1    Lambert, N.2    Maloney, S.3    Furst, D.E.4    Moore, J.M.5    Nelson, J.L.6
  • 6
    • 1542373674 scopus 로고    scopus 로고
    • Quantification of Maternal Microchimerism by HLA-Specific Real-Time Polymerase Chain Reaction: Studies of Healthy Women and Women with Scleroderma
    • DOI 10.1002/art.20200
    • Lambert NC, Erickson TD, Yan Z, et al. Quantification of maternal microchimerism by HLA-specific real-time polymerase chain reaction: Studies of healthy women and women with scleroderma. Arthritis Rheum 2004; 50:906-914. (Pubitemid 38326192)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.3 , pp. 906-914
    • Lambert, N.C.1    Erickson, T.D.2    Yan, Z.3    Pang, J.M.4    Guthrie, K.A.5    Furst, D.E.6    Nelson, J.L.7
  • 7
    • 18944372173 scopus 로고    scopus 로고
    • Influence of maternal-fetal histocompatibility and MHC zygosity on maternal microchimerism
    • Kaplan J, Land S. Influence of maternal-fetal histocompatibility and MHC zygosity on maternal microchimerism. J Immunol 2005; 174:7123-7128. (Pubitemid 40705678)
    • (2005) Journal of Immunology , vol.174 , Issue.11 , pp. 7123-7128
    • Kaplan, J.1    Land, S.2
  • 8
    • 0034534071 scopus 로고    scopus 로고
    • Two independent pathways of maternal cell transmission to offspring: Through placenta during pregnancy and by breast-feeding after birth
    • DOI 10.1046/j.1365-2567.2000.00144.x
    • Zhou L, Yoshimura Y, Huang Y, et al. Two independent pathways of maternal cell transmission to offspring: Through placenta during pregnancy and by breast-feeding after birth. Immunology 2000; 101:570-580. (Pubitemid 32001473)
    • (2000) Immunology , vol.101 , Issue.4 , pp. 570-580
    • Zhou, L.1    Yoshimura, Y.2    Huang, Y.-Y.3    Suzuki, R.4    Yokoyama, M.5    Okabe, M.6    Shimamura, M.7
  • 10
    • 70449508554 scopus 로고    scopus 로고
    • Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice
    • This is the first article that directly linked MMc and NIMA-induced Treg cells and showed that maintenance of MMc depended upon oral exposure to NIMA
    • Dutta P, Molitor-Dart M, Bobadilla JL, et al. Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice. Blood 2009; 114:3578-3587. This is the first article that directly linked MMc and NIMA-induced Treg cells and showed that maintenance of MMc depended upon oral exposure to NIMA.
    • (2009) Blood , vol.114 , pp. 3578-3587
    • Dutta, P.1    Molitor-Dart, M.2    Bobadilla, J.L.3
  • 11
    • 40449125573 scopus 로고    scopus 로고
    • Pregnancy allows the transfer and differentiation of fetal lymphoid progenitors into functional T and B cells in mothers
    • Khosrotehrani K, Leduc M, Bachy V, et al. Pregnancy allows the transfer and differentiation of fetal lymphoid progenitors into functional T and B cells in mothers. J Immunol 2008; 180:889-897.
    • (2008) J Immunol , vol.180 , pp. 889-897
    • Khosrotehrani, K.1    Leduc, M.2    Bachy, V.3
  • 14
    • 70350708148 scopus 로고    scopus 로고
    • Chimeric maternal cells with tissue-specific antigen expression and morphology are common in infant tissues
    • Stevens AMHH, Kiefer MM, Rutledge JC, Nelson JL. Chimeric maternal cells with tissue-specific antigen expression and morphology are common in infant tissues. Pediatr Dev Pathol 2009; 337-346.
    • (2009) Pediatr Dev Pathol , pp. 337-346
    • Stevens, A.M.H.H.1    Kiefer, M.M.2    Rutledge, J.C.3    Nelson, J.L.4
  • 15
    • 68849105728 scopus 로고    scopus 로고
    • Tolerance to noninherited maternal antigens in mice and humans
    • Dutta P, Burlingham WJ. Tolerance to noninherited maternal antigens in mice and humans. Curr Opin Organ Transplant 2009; 14:439-447.
    • (2009) Curr Opin Organ Transplant , vol.14 , pp. 439-447
    • Dutta, P.1    Burlingham, W.J.2
  • 17
    • 3042751641 scopus 로고    scopus 로고
    • Microchimerism in female bone marrow and bone decades after fetal mesenchymal stem-cell trafficking in pregnancy
    • DOI 10.1016/S0140-6736(04)16631-2, PII S0140673604166312
    • O'Donoghue K, Chan J, de la Fuente J, et al. Microchimerism in female bone marrow and bone decades after fetal mesenchymal stem-cell trafficking in pregnancy. Lancet 2004; 364:179-182. (Pubitemid 38891690)
    • (2004) Lancet , vol.364 , Issue.9429 , pp. 179-182
    • O'Donoghue, K.1    Chan, J.2    De La Fuente, J.3    Kennea, N.4    Sandison, A.5    Anderson, J.R.6    Roberts, I.A.G.7    Fisk, N.M.8
  • 18
    • 79952275609 scopus 로고    scopus 로고
    • Fetal microchimerism persists at high levels in c-kit stem cells in sensitized mothers
    • Dutta P, Dart ML, Schumacher SM, Burlingham WJ. Fetal microchimerism persists at high levels in c-kit stem cells in sensitized mothers. Chimerism 2010; 1:51-55.
    • (2010) Chimerism , vol.1 , pp. 51-55
    • Dutta, P.1    Dart, M.L.2    Schumacher, S.M.3    Burlingham, W.J.4
  • 19
    • 40949140546 scopus 로고    scopus 로고
    • Trafficking of multipotent mesenchymal stromal cells from maternal circulation through the placenta involves vascular endothelial growth factor receptor-1 and integrins
    • Chen CP, Lee MY, Huang JP, et al. Trafficking of multipotent mesenchymal stromal cells from maternal circulation through the placenta involves vascular endothelial growth factor receptor-1 and integrins. Stem Cells 2008; 26:550-561.
    • (2008) Stem Cells , vol.26 , pp. 550-561
    • Chen, C.P.1    Lee, M.Y.2    Huang, J.P.3
  • 20
    • 79952271813 scopus 로고    scopus 로고
    • Stem cell microchimerism and tolerance to noninherited maternal antigens
    • The progenitor cells of maternal origin persist in adult offspring and included maternally derived bone marrow and cardiac stem cells suggesting a role of maternally derived stem cells in maintaining MMc in heart parenchyma as well as in blood
    • Dutta P, Burlingham WJ. Stem cell microchimerism and tolerance to noninherited maternal antigens. Chimerism 2010; 1:2-10. The progenitor cells of maternal origin persist in adult offspring and included maternally derived bone marrow and cardiac stem cells suggesting a role of maternally derived stem cells in maintaining MMc in heart parenchyma as well as in blood.
    • (2010) Chimerism , vol.1 , pp. 2-10
    • Dutta, P.1    Burlingham, W.J.2
  • 21
    • 79952667750 scopus 로고    scopus 로고
    • Mesenchymal stromal cells are present in the heart and promote growth of adult stem cells in vitro
    • The article describes a novel cardiac stem cell population; MSCs promote growth of these cardiac stem cells, which give rise to endothelium, smooth muscle, and cardiomyocytes
    • Lushaj EB, Anstadt E, Haworth R, et al. Mesenchymal stromal cells are present in the heart and promote growth of adult stem cells in vitro. Cytotherapy 2011; 13:400-406. The article describes a novel cardiac stem cell population; MSCs promote growth of these cardiac stem cells, which give rise to endothelium, smooth muscle, and cardiomyocytes.
    • (2011) Cytotherapy , vol.13 , pp. 400-406
    • Lushaj, E.B.1    Anstadt, E.2    Haworth, R.3
  • 22
    • 79251564071 scopus 로고    scopus 로고
    • Transplantation tolerance to a single noninherited MHC class I maternal alloantigen studied in a TCRtransgenic mouse model
    • Akiyama Y, Caucheteux SM, Vernochet C, et al. Transplantation tolerance to a single noninherited MHC class I maternal alloantigen studied in a TCRtransgenic mouse model. J Immunol 2011; 186:1442-1449.
    • (2011) J Immunol , vol.186 , pp. 1442-1449
    • Akiyama, Y.1    Caucheteux, S.M.2    Vernochet, C.3
  • 23
    • 0026666567 scopus 로고
    • Systemic chimerism in human female recipients of male livers
    • Starzl TE, Demetris AJ, Trucco M, et al. Systemic chimerism in human female recipients of male livers. Lancet 1992; 340:876-877.
    • (1992) Lancet , vol.340 , pp. 876-877
    • Starzl, T.E.1    Demetris, A.J.2    Trucco, M.3
  • 24
    • 0029072806 scopus 로고
    • Microchimerism linked to cytotoxic T lymphocyte functional unresponsiveness (clonal anergy) in a tolerant renal transplant recipient
    • Burlingham WJ, Grailer AP, Fechner JH Jr, et al. Microchimerism linked to cytotoxic T lymphocyte functional unresponsiveness (clonal anergy) in a tolerant renal transplant recipient. Transplantation 1995; 59:1147-1155.
    • (1995) Transplantation , vol.59 , pp. 1147-1155
    • Burlingham, W.J.1    Grailer, A.P.2    Fechner Jr., J.H.3
  • 26
    • 33947233247 scopus 로고    scopus 로고
    • Capture of target cell membrane components via trogocytosis is triggered by a selected set of surface molecules on T or B cells
    • Hudrisier D, Aucher A, Puaux AL, et al. Capture of target cell membrane components via trogocytosis is triggered by a selected set of surface molecules on T or B cells. J Immunol 2007; 178:3637-3647. (Pubitemid 46417631)
    • (2007) Journal of Immunology , vol.178 , Issue.6 , pp. 3637-3647
    • Hudrisier, D.1    Aucher, A.2    Puaux, A.-L.3    Bordier, C.4    Joly, E.5
  • 29
    • 34248674014 scopus 로고    scopus 로고
    • Intercellular transfer of MHC and immunological molecules: Molecular mechanisms and biological significance
    • DOI 10.1111/j.1600-6143.2007.01816.x
    • Smyth LA, Afzali B, Tsang J, et al. Intercellular transfer of MHC and immunological molecules: Molecular mechanisms and biological significance. Am J Transplant 2007; 7:1442-1449. (Pubitemid 46776254)
    • (2007) American Journal of Transplantation , vol.7 , Issue.6 , pp. 1442-1449
    • Smyth, L.A.1    Afzali, B.2    Tsang, J.3    Lombardi, G.4    Lechler, R.I.5
  • 30
    • 34548153822 scopus 로고    scopus 로고
    • Intercellular exchanges of membrane patches (trogocytosis) highlight the next level of immune plasticity
    • DOI 10.1016/j.trim.2006.09.032, PII S0966327406001250, Transplant Immunology: New ways of Immunotolerance
    • Caumartin J, Lemaoult J, Carosella ED. Intercellular exchanges of membrane patches (trogocytosis) highlight the next level of immune plasticity. Transpl Immunol 2006; 17:20-22. (Pubitemid 44828805)
    • (2006) Transplant Immunology , vol.17 , Issue.1 , pp. 20-22
    • Caumartin, J.1    LeMaoult, J.2    Carosella, E.D.3
  • 31
    • 33847340782 scopus 로고    scopus 로고
    • Immune regulation by pretenders: Cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells
    • DOI 10.1182/blood-2006-05-024547
    • LeMaoult J, Caumartin J, Daouya M, et al. Immune regulation by pretenders: Cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells. Blood 2007; 109:2040-2048. (Pubitemid 46348204)
    • (2007) Blood , vol.109 , Issue.5 , pp. 2040-2048
    • LeMaoult, J.1    Caumartin, J.2    Daouya, M.3    Favier, B.4    Le Rond, S.5    Gonzalez, A.6    Carosella, E.D.7
  • 32
    • 0027527572 scopus 로고
    • The correlation of prolonged survival of maternal skin grafts with the presence of naturally transferred maternal T cells
    • Zhang L, Miller RG. The correlation of prolonged survival of maternal skin grafts with the presence of naturally transferred maternal T cells. Transplantation 1993; 56:918-921. (Pubitemid 23321529)
    • (1993) Transplantation , vol.56 , Issue.4 , pp. 918-921
    • Zhang, L.1    Miller, R.G.2
  • 34
    • 53749090220 scopus 로고    scopus 로고
    • Tolerance induction or sensitization in mice exposed to noninherited maternal antigens (NIMA)
    • Molitor-Dart ML, Andrassy J, Haynes LD, Burlingham WJ. Tolerance induction or sensitization in mice exposed to noninherited maternal antigens (NIMA). Am J Transplant 2008; 8:2307-2315.
    • (2008) Am J Transplant , vol.8 , pp. 2307-2315
    • Molitor-Dart, M.L.1    Andrassy, J.2    Haynes, L.D.3    Burlingham, W.J.4
  • 35
    • 77953287830 scopus 로고    scopus 로고
    • Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice
    • Behrens M, Trejo T, Luthra H, et al. Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice. J Autoimmun 2010; 35:1-9.
    • (2010) J Autoimmun , vol.35 , pp. 1-9
    • Behrens, M.1    Trejo, T.2    Luthra, H.3
  • 36
    • 30144445540 scopus 로고    scopus 로고
    • + T-cell-dependent mechanism
    • DOI 10.1182/blood-2005-07-3045
    • Matsuoka K, Ichinohe T, Hashimoto D, et al. Fetal tolerance to maternal antigens improves the outcome of allogeneic bone marrow transplantation by a CD4+ CD25+ T-cell-dependent mechanism. Blood 2006; 107:404-409. (Pubitemid 43053570)
    • (2006) Blood , vol.107 , Issue.1 , pp. 404-409
    • Matsuoka, K.-I.1    Ichinohe, T.2    Hashimoto, D.3    Asakura, S.4    Tanimoto, M.5    Teshima, T.6
  • 37
    • 38449087281 scopus 로고    scopus 로고
    • Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: Relevance to mechanism of heart allograft tolerance
    • Molitor-Dart ML, Andrassy J, Kwun J, et al. Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: Relevance to mechanism of heart allograft tolerance. J Immunol 2007; 179:6749-6761.
    • (2007) J Immunol , vol.179 , pp. 6749-6761
    • Molitor-Dart, M.L.1    Andrassy, J.2    Kwun, J.3
  • 38
    • 57349108583 scopus 로고    scopus 로고
    • Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero
    • Mold JE, Michaelsson J, Burt TD, et al. Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science 2008; 322:1562-1565.
    • (2008) Science , vol.322 , pp. 1562-1565
    • Mold, J.E.1    Michaelsson, J.2    Burt, T.D.3
  • 39
    • 63249089059 scopus 로고    scopus 로고
    • A lesson in Tolerance-Maternal Instruction to Fetal Cells
    • This is a review of Mold et al. [38] and provides a new model for in utero NIMAinduced tolerance
    • Burlingham WJ. A lesson in Tolerance-Maternal Instruction to Fetal Cells. New Engl J Med 2009; 360:1355-1357. This is a review of Mold et al. [38] and provides a new model for in utero NIMAinduced tolerance.
    • (2009) New Engl J Med , vol.360 , pp. 1355-1357
    • Burlingham, W.J.1
  • 40
    • 68849102342 scopus 로고    scopus 로고
    • Naturally acquired tolerance and sensitization to minor histocompatibility antigens in healthy family members
    • van Halteren AG, Jankowska-Gan E, Joosten A, et al. Naturally acquired tolerance and sensitization to minor histocompatibility antigens in healthy family members. Blood 2009; 114:2263-2272.
    • (2009) Blood , vol.114 , pp. 2263-2272
    • Van Halteren, A.G.1    Jankowska-Gan, E.2    Joosten, A.3
  • 41
    • 79958812374 scopus 로고    scopus 로고
    • Pretransplant immune regulation predicts allograft tolerance
    • Epub ahead of print] This article reports that NIMA-induced tolerance can be predicted before transplantation, enumerating indirect pathway Treg cells by bystander suppression assay.
    • Dutta P, Dart M, Roenneburg DA, et al. Pretransplant immune regulation predicts allograft tolerance. Am J Transplant 2011. [Epub ahead of print]
    • Am J Transplant 2011.
    • Dutta, P.1    Dart, M.2    Roenneburg, D.A.3
  • 42
    • 0032521267 scopus 로고    scopus 로고
    • Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose
    • Bemelman F, Honey K, Adams E, et al. Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose. J Immunol 1998; 160:2645-2648. (Pubitemid 28136714)
    • (1998) Journal of Immunology , vol.160 , Issue.6 , pp. 2645-2648
    • Bemelman, F.1    Honey, K.2    Adams, E.3    Cobbold, S.4    Waldmann, H.5
  • 43
    • 61849098239 scopus 로고    scopus 로고
    • Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens
    • The article reports that both in-utero and oral exposures are important in NIMAinduced tolerance in a bone marrow graft model; oral exposure to NIMA alone induced some degree of tolerance in mice
    • Aoyama K, Koyama M, Matsuoka K, et al. Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens. Blood 2009; 113:1829-1833. The article reports that both in-utero and oral exposures are important in NIMAinduced tolerance in a bone marrow graft model; oral exposure to NIMA alone induced some degree of tolerance in mice.
    • (2009) Blood , vol.113 , pp. 1829-1833
    • Aoyama, K.1    Koyama, M.2    Matsuoka, K.3
  • 44
    • 1642382026 scopus 로고    scopus 로고
    • HLA class I noninherited maternal antigens in cord blood and breast milk
    • DOI 10.1016/j.humimm.2003.12.006, PII S0198885904000035
    • Molitor ML, Haynes LD, Jankowska-Gan E, et al. HLA class I noninherited maternal antigens in cord blood and breast milk. Hum Immunol 2004; 65:231-239. (Pubitemid 38369261)
    • (2004) Human Immunology , vol.65 , Issue.3 , pp. 231-239
    • Molitor, M.L.1    Haynes, L.D.2    Jankowska-Gan, E.3    Mulder, A.4    Burlingham, W.J.5
  • 45
    • 0037372887 scopus 로고    scopus 로고
    • Induction of low dose oral tolerance in monocyte chemoattractant protein-1- and CCR2-deficient mice
    • Gonnella PA, Kodali D, Weiner HL. Induction of low dose oral tolerance in monocyte chemoattractant protein-1-and CCR2-deficient mice. J Immunol 2003; 170:2316-2322. (Pubitemid 36245617)
    • (2003) Journal of Immunology , vol.170 , Issue.5 , pp. 2316-2322
    • Gonnella, P.A.1    Kodali, D.2    Weiner, H.L.3
  • 46
    • 0030587132 scopus 로고    scopus 로고
    • High Dose Oral Tolerance in Ovalbumin TCR-Transgenic Mice: Systemic Neutralization of IL-12 Augments TGF-Secretion and T Cell Apoptosis
    • Marth T, Strober W, Kelsall BL. High dose oral tolerance in ovalbumin TCRtransgenic mice: Systemic neutralization of IL-12 augments TGF-beta secretion and T cell apoptosis. J Immunol 1996; 157:2348-2357. (Pubitemid 126450444)
    • (1996) Journal of Immunology , vol.157 , Issue.6 , pp. 2348-2357
    • Marth, T.1    Strober, W.2    Kelsall, B.L.3
  • 47
    • 55849142632 scopus 로고    scopus 로고
    • Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice
    • Tsang JY, Tanriver Y, Jiang S, et al. Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice. J Clin Invest 2008; 118:3619-3628.
    • (2008) J Clin Invest , vol.118 , pp. 3619-3628
    • Tsang, J.Y.1    Tanriver, Y.2    Jiang, S.3
  • 49
    • 0001458342 scopus 로고
    • Evidence for actively acquired tolerance to rh antigens
    • Owen RD, Wood HR, Foord AG, et al. Evidence for actively acquired tolerance to rh antigens. Proc Natl Acad Sci U S A 1954; 40:420-424.
    • (1954) Proc Natl Acad Sci U S A , vol.40 , pp. 420-424
    • Owen, R.D.1    Wood, H.R.2    Foord, A.G.3
  • 50
    • 45949111602 scopus 로고    scopus 로고
    • Development of either split tolerance or robust tolerance along with humoral tolerance to donor and third-party alloantigens in nonmyeloablative mixed chimeras
    • Chan WF, Razavy H, Luo B, et al. Development of either split tolerance or robust tolerance along with humoral tolerance to donor and third-party alloantigens in nonmyeloablative mixed chimeras. J Immunol 2008; 180: 5177-5186.
    • (2008) J Immunol , vol.180 , pp. 5177-5186
    • Chan, W.F.1    Razavy, H.2    Luo, B.3
  • 51
    • 0032560034 scopus 로고    scopus 로고
    • Identification of fetal DNA and cells in skin lesions from women with systemic sclerosis
    • DOI 10.1056/NEJM199804233381704
    • Artlett CM, Smith JB, Jimenez SA. Identification of fetal DNA and cells in skin lesions from women with systemic sclerosis. N Engl J Med 1998; 338:1186-1191. (Pubitemid 28180747)
    • (1998) New England Journal of Medicine , vol.338 , Issue.17 , pp. 1186-1191
    • Artlett, C.M.1    Smith, J.B.2    Jimenez, S.A.3
  • 52
    • 0034791957 scopus 로고    scopus 로고
    • Quantitative analysis of microchimerism in systemic sclerosis skin tissue
    • DOI 10.1007/s004030100245
    • Ohtsuka T, Miyamoto Y, Yamakage A, Yamazaki S. Quantitative analysis of microchimerism in systemic sclerosis skin tissue. Arch Dermatol Res 2001; 293:387-391. (Pubitemid 32939418)
    • (2001) Archives of Dermatological Research , vol.293 , Issue.8 , pp. 387-391
    • Ohtsuka, T.1    Miyamoto, Y.2    Yamakage, A.3    Yamazaki, S.4
  • 54
    • 0005984244 scopus 로고
    • Actively acquired tolerance of foreign cells
    • Billingham RE, Brent L, Medawar PB. Actively acquired tolerance of foreign cells. Nature 1953; 172:603-606.
    • (1953) Nature , vol.172 , pp. 603-606
    • Billingham, R.E.1    Brent, L.2    Medawar, P.B.3
  • 55
    • 78650352931 scopus 로고    scopus 로고
    • Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans
    • This article elegantly showed that human fetal HSCs are biased to produce regulatory T cells compared with HSCs obtained from adults. This supports a 'layered' development of cellular immunity in humans
    • Mold JE, Venkatasubrahmanyam S, Burt TD, et al. Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. Science 2010; 330:1695-1699. This article elegantly showed that human fetal HSCs are biased to produce regulatory T cells compared with HSCs obtained from adults. This supports a 'layered' development of cellular immunity in humans.
    • (2010) Science , vol.330 , pp. 1695-1699
    • Mold, J.E.1    Venkatasubrahmanyam, S.2    Burt, T.D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.