Indirect evidence that maternal microchimerism in cord blood mediates a graft-versus-leukemia effect in cord blood transplantation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 7, 2012, Pages 2509-2514

  Van Rood, Jon J ^a   Scaradavou, Andromachi ^b   Stevens, Cladd E ^b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NEW YORK BLOOD CENTER   (United States)

Author keywords

Birth order; Cord blood stem cell transplantation

Indexed keywords

HLA A ANTIGEN; HLA B ANTIGEN; HLA DRB1 ANTIGEN;

ACUTE GRAFT VERSUS HOST DISEASE; ARTICLE; BLOOD DONOR; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; EVIDENCE BASED MEDICINE; FETUS; GRAFT VERSUS LEUKEMIA EFFECT; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; MAJOR CLINICAL STUDY; MICROCHIMERISM; PLACENTA; PRIORITY JOURNAL; RISK ASSESSMENT; TREATMENT OUTCOME; UMBILICAL CORD BLOOD;

FEMALE; FETAL BLOOD; GRAFT VS LEUKEMIA EFFECT; HUMANS; RETROSPECTIVE STUDIES;

EID: 84857127232     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1119541109     Document Type: Article

References (42)

1. van Rood JJ, Eernisse JG, van Leeuwen A (1958) Leucocyte antibodies in sera from pregnant women. Nature 181:1735-1736.
2. Payne R, Rolfs MR (1958) Fetomaternal leukocyte incompatibility. J Clin Invest 37: 1756-1763.
3. Bouma GJ, et al. (1996) Pregnancy can induce priming of cytotoxic T lymphocytes specific for paternal HLA antigens that is associated with antibody formation. Transplantation 62:672-678.
4. van Kampen CA, Versteeg-vd Voort Maarschalk MF, Langerak-Langerak J, Roelen DL, Claas FH (2002) Kinetics of the pregnancy-induced humoral and cellular immune response against the paternal HLA class I antigens of the child. Hum Immunol 63:452-458.
5. Verdijk RM, et al. (2004) Pregnancy induces minor histocompatibility antigen-specific cytotoxic T cells: Implications for stem cell transplantation and immunotherapy. Blood 103:1961-1964. (Pubitemid 38268999)
6. van Halteren AG, et al. (2009) Naturally acquired tolerance and sensitization to minor histocompatibility antigens in healthy family members. Blood 114:2263-2272.
7. Stern M, et al. (2008) Survival after T cell-depleted haploidentical stem cell transplantation is improved using the mother as donor. Blood 112:2990-2995.
8. Tamaki S, et al.; Japan Society of Hematopoietic Cell Transplantation (2001) Superior survival of blood and marrow stem cell recipients given maternal grafts over recipients given paternal grafts. Bone Marrow Transplant 28:375-380. (Pubitemid 32834356)
9. Gluckman E, et al. (1989) Hematopoietic reconstitution in a patient with Fanconi's anemia by means of umbilical-cord blood from an HLA-identical sibling. N Engl J Med 321:1174-1178. (Pubitemid 19255814)
10. Broxmeyer HE, Cooper S, Yoder M, Hangoc G (1992) Human umbilical cord blood as a source of transplantable hematopoietic stem and progenitor cells. Curr Top Microbiol Immunol 177:195-204.
11. Rubinstein P (1993) Placental blood-derived hematopoietic stem cell for unrelated bone marrow reconstitution. J Hemother 2:207-210.
12. Rubinstein P, et al. (1995) Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution. Proc Natl Acad Sci USA 92:10119-10122.
13. van Rood JJ, et al. (2009) Reexposure of cord blood to noninherited maternal HLA antigens improves transplant outcome in hematological malignancies. Proc Natl Acad Sci USA 106:19952-19957.
14. Horowitz MM, et al. (1990) Graft-versus-leukemia reactions after bone marrow transplantation. Blood 75:555-562. (Pubitemid 20069191)
15. Eapen M, et al. (2007) Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: A comparison study. Lancet 369:1947-1954. (Pubitemid 46874578)
16. Mold JE, et al. (2008) Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero. Science 322:1562-1565.
17. Mold JE, et al. (2010) Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. Science 330:1695-1699.
18. Barker JN, Scaradavou A, Stevens CE (2010) Combined effect of total nucleated cell dose and HLA match on transplantation outcome in 1061 cord blood recipients with hematologic malignancies. Blood 115:1843-1849.
19. Stevens CE, Carrier C, Carpenter C, Sung D, Scaradavou A (2011) HLA mismatch direction in cord blood transplantation: Impact on outcome and implications for cord blood unit selection. Blood 118:3969-3978.
20. Bucher C, et al. (2007) Role of primacy of birth in HLA-identical sibling transplantation. Blood 110:468-469. (Pubitemid 47026870)
21. Gratwohl A, et al. (2009) Birth order and outcome after HLA-identical sibling donor transplantation. Blood 114:5569-5570.
22. Marijt WAE, et al. (2003) Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia. Proc Natl Acad Sci USA 100:2742-2747. (Pubitemid 36297569)
23. Willemze R, et al.; Eurocord and of the European Group of Blood and Marrow Transplantation (2010) Is there an impact of killer cell immunoglobulin-like receptors and KIR-ligand incompatibilities on outcomes after unrelated cord blood stem cell transplantation? Best Pract Res Clin Haematol 23:283-290.
24. Roelen DL, et al. (1994) Cytotoxic T lymphocytes against HLA-B antigens are less naive than cytotoxic T lymphocytes against HLA-A antigens. Transplantation 57:446-450. (Pubitemid 24086047)
25. Mommaas B, et al. (2005) Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1. Blood 105:1823-1827. (Pubitemid 40223709)
26. Zelle-Rieser C, et al. (2001) Expression and immunogenicity of oncofetal antigen-immature laminin receptor in human renal cell carcinoma. J Urol 165:1705-1709. (Pubitemid 32410293)
27. Scaradavou A, Carrier C, Mollen N, Stevens C, Rubinstein P (1996) Detection of maternal DNA in placental/umbilical cord blood by locus-specific amplification of the noninherited maternal HLA gene. Blood 88:1494-1500. (Pubitemid 26276828)
28. Nelson JL (1996) Maternal-fetal immunology and autoimmune disease: Is some autoimmune disease auto-alloimmune or allo-autoimmune? Arthritis Rheum 39:191-194
29. Bianchi DW, et al. (2001) Significant fetal-maternal hemorrhage after termination of pregnancy: Implications for development of fetal cell microchimerism. Am J Obstet Gynecol 184:703-706. (Pubitemid 32234987)
30. Sideri A, et al. (2011) An overview of the progress on double umbilical cord blood transplantation. Haematologica 96:1213-1220.
31. Callahan MK, Wolchok JD, Allison JP (2010) Anti-CTLA-4 antibody therapy: Immune monitoring during clinical development of a novel immunotherapy. Semin Oncol 37:473-484.
32. Feitsma AL, et al. (2007) Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development. Proc Natl Acad Sci USA 104:19966-19970.
33. Nelson JL, et al. (2007) Maternal microchimerism in peripheral blood in type 1 diabetes and pancreatic islet beta cell microchimerism. Proc Natl Acad Sci USA 104:1637-1642. (Pubitemid 46214643)
34. Eick AA, et al. (2011) Maternal influenza vaccination and effect on influenza virus infection in young infants. Arch Pediatr Adolesc Med 165:104-111.
35. Klonisch T, Drouin R (2009) Fetal-maternal exchange of multipotent stem/progenitor cells: Microchimerism in diagnosis and disease. Trends Mol Med 15:510-518.
36. Ichinohe T (2010) Long-term feto-maternal microchimerism revisited: Microchimerism and tolerance in hematopoietic stem cell transplantation. Chimerism 1:39-43.
37. Szydlo R, et al. (1997) Results of allogeneic bone marrow transplants for leukemia using donors other than HLA-identical siblings. J Clin Oncol 15:1767-1777. (Pubitemid 27209503)
38. Rubinstein P, et al. (1998) Outcomes among 562 recipients of placental-blood transplants from unrelated donors. N Engl J Med 339:1565-1577. (Pubitemid 28536131)
39. Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481.
40. Klein JP, Moeschberger ML (2003) Survival Analysis: Techniques of Censored and Truncated Data (Springer-Verlag, New York, NY).
41. Fine J, Gray R (1999) A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc 94:496-509.
42. Cox DR (1972) Regression models and life tables. J R Stat Soc [Ser A] 34:187-220.