메뉴 건너뛰기




Volumn 86, Issue 19, 2012, Pages 10841-10851

Control of early theiler's murine encephalomyelitis virus replication in macrophages by interleukin-6 occurs in conjunction with STAT1 activation and nitric oxide production

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; IMMUNOGLOBULIN F(AB) FRAGMENT; INTERLEUKIN 12; INTERLEUKIN 23; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; STAT1 PROTEIN; STAT3 PROTEIN;

EID: 84869037921     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01402-12     Document Type: Article
Times cited : (26)

References (52)
  • 1
    • 35148840598 scopus 로고    scopus 로고
    • TLR3 and TLR7 are involved in expression of IL-23 subunits while TLR3 but not TLR7 is involved in expression of IFN-beta by Theiler's virus-infected RAW264.7 cells
    • Al-Salleeh F, Petro TM. 2007. TLR3 and TLR7 are involved in expression of IL-23 subunits while TLR3 but not TLR7 is involved in expression of IFN-beta by Theiler's virus-infected RAW264.7 cells. Microbes Infect. 9:1384-1392.
    • (2007) Microbes Infect. , vol.9 , pp. 1384-1392
    • Al-Salleeh, F.1    Petro, T.M.2
  • 2
    • 0037135690 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinases 1 and 2 par-ticipate in interleukin-17 plus tumor necrosis factor-alpha-induced stabi-lization of interleukin-6 mRNA in human pancreatic myofibroblasts
    • Andoh A, et al. 2002. Extracellular signal-regulated kinases 1 and 2 par-ticipate in interleukin-17 plus tumor necrosis factor-alpha-induced stabi-lization of interleukin-6 mRNA in human pancreatic myofibroblasts. Biochim. Biophys. Acta 1591:69-74.
    • (2002) Biochim. Biophys. Acta , vol.1591 , pp. 69-74
    • Andoh, A.1
  • 3
    • 0036109516 scopus 로고    scopus 로고
    • Murine coro-navirus replication-induced p38 mitogen-activated protein kinase activa-tion promotes interleukin-6 production and virus replication in cultured cells
    • Banerjee S, Narayanan K, Mizutani T, Makino S. 2002. Murine coro-navirus replication-induced p38 mitogen-activated protein kinase activa-tion promotes interleukin-6 production and virus replication in cultured cells. J. Virol. 76:5937-5948.
    • (2002) J. Virol. , vol.76 , pp. 5937-5948
    • Banerjee, S.1    Narayanan, K.2    Mizutani, T.3    Makino, S.4
  • 4
    • 0035661318 scopus 로고    scopus 로고
    • Angioten-sin II promotes the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser133 through an ERK1/2-dependent mech-anism
    • Cammarota M, Bevilaqua LR, Dunkley PR, Rostas JA. 2001. Angioten-sin II promotes the phosphorylation of cyclic AMP-responsive element binding protein (CREB) at Ser133 through an ERK1/2-dependent mech-anism. J. Neurochem. 79:1122-1128.
    • (2001) J. Neurochem. , vol.79 , pp. 1122-1128
    • Cammarota, M.1    Bevilaqua, L.R.2    Dunkley, P.R.3    Rostas, J.A.4
  • 5
    • 0025304856 scopus 로고
    • Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV)
    • Clatch RJ, Miller SD, Metzner R, Dal Canto MC, Lipton HL. 1990. Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV). Vi-rology 176:244-254.
    • (1990) Vi-rology , vol.176 , pp. 244-254
    • Clatch, R.J.1    Miller, S.D.2    Metzner, R.3    Canto, M.C.D.4    Lipton, H.L.5
  • 6
    • 80053041963 scopus 로고    scopus 로고
    • Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type splicing regulatory protein (KSRP)-dependent translational silencing mechanism
    • Dhamija S, et al. 2011. Interleukin-1 activates synthesis of interleukin-6 by interfering with a KH-type splicing regulatory protein (KSRP)-dependent translational silencing mechanism. J. Biol. Chem. 286:33279-33288.
    • (2011) J. Biol. Chem. , vol.286 , pp. 33279-33288
    • Dhamija, S.1
  • 8
  • 9
    • 0027949041 scopus 로고
    • Identification of interleukin-6 (IL-6)-expressing neurons in the cerebellum and hippocampus of normal adult rats
    • Gadient RA, Otten U. 1994. Identification of interleukin-6 (IL-6)-expressing neurons in the cerebellum and hippocampus of normal adult rats. Neurosci. Lett. 182:243-246.
    • (1994) Neurosci. Lett. , vol.182 , pp. 243-246
    • Gadient, R.A.1    Otten, U.2
  • 10
    • 0033032092 scopus 로고    scopus 로고
    • Transcriptional regulation of the interleukin-6 gene in mesangial cells
    • Grassl C, Luckow B, Schlondorff D, Dendorfer U. 1999. Transcriptional regulation of the interleukin-6 gene in mesangial cells. J. Am. Soc. Neph-rol. 10:1466-1477.
    • (1999) J. Am. Soc. Neph-rol. , vol.10 , pp. 1466-1477
    • Grassl, C.1    Luckow, B.2    Schlondorff, D.3    Dendorfer, U.4
  • 11
    • 0024466595 scopus 로고
    • Inter-leukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats
    • Hama T, Miyamoto M, Tsukui H, Nishio C, Hatanaka H. 1989. Inter-leukin-6 as a neurotrophic factor for promoting the survival of cultured basal forebrain cholinergic neurons from postnatal rats. Neurosci. Lett. 104:340-344.
    • (1989) Neurosci. Lett. , vol.104 , pp. 340-344
    • Hama, T.1    Miyamoto, M.2    Tsukui, H.3    Nishio, C.4    Hatanaka, H.5
  • 12
    • 81055157812 scopus 로고    scopus 로고
    • Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection
    • Harker JA, Lewis GM, Mack L, Zuniga EI. 2011. Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science 334:825-829.
    • (2011) Science , vol.334 , pp. 825-829
    • Harker, J.A.1    Lewis, G.M.2    Mack, L.3    Zuniga, E.I.4
  • 13
    • 0029991793 scopus 로고    scopus 로고
    • Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130
    • Hemmann U, et al. 1996. Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. J. Biol. Chem. 271:12999-13007.
    • (1996) J. Biol. Chem. , vol.271 , pp. 12999-13007
    • Hemmann, U.1
  • 14
    • 63049129392 scopus 로고    scopus 로고
    • Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection
    • Hou W, Kang HS, Kim BS. 2009. Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection. J. Exp. Med. 206:313-328.
    • (2009) J. Exp. Med. , vol.206 , pp. 313-328
    • Hou, W.1    Kang, H.S.2    Kim, B.S.3
  • 15
    • 0027336689 scopus 로고
    • Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages
    • Hsieh CS, et al. 1993. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547-549.
    • (1993) Science , vol.260 , pp. 547-549
    • Hsieh, C.S.1
  • 16
    • 0036694589 scopus 로고    scopus 로고
    • IL-6 in autoimmune disease and chronic inflammatory proliferative disease
    • Ishihara K, Hirano T. 2002. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev. 13:357-368.
    • (2002) Cytokine Growth Factor Rev. , vol.13 , pp. 357-368
    • Ishihara, K.1    Hirano, T.2
  • 17
    • 35448932890 scopus 로고    scopus 로고
    • Differential virus replication, cytokine production, and antigen-presenting function by microglia from susceptible and resis-tant mice infected with Theiler's virus
    • Jin Y-H, et al. 2007. Differential virus replication, cytokine production, and antigen-presenting function by microglia from susceptible and resis-tant mice infected with Theiler's virus. J. Virol. 81:11690-11702.
    • (2007) J. Virol. , vol.81 , pp. 11690-11702
    • Jin, Y.-H.1
  • 18
    • 66149158158 scopus 로고    scopus 로고
    • Interleukin-12 (IL-12), but not IL-23, deficiency ameliorates viral encephalitis without affecting viral control
    • Kapil P, et al. 2009. Interleukin-12 (IL-12), but not IL-23, deficiency ameliorates viral encephalitis without affecting viral control. J. Virol. 83: 5978-5986.
    • (2009) J. Virol. , vol.83 , pp. 5978-5986
    • Kapil, P.1
  • 19
    • 1442333588 scopus 로고    scopus 로고
    • Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differen-tially modulates cytokine expression
    • Kim SH, Kim J, Sharma RP. 2004. Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differen-tially modulates cytokine expression. Pharmacol. Res. 49:433-439.
    • (2004) Pharmacol. Res. , vol.49 , pp. 433-439
    • Kim, S.H.1    Kim, J.2    Sharma, R.P.3
  • 20
    • 43249092876 scopus 로고    scopus 로고
    • Colocalization of the IL-12 receptor and FγRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-γ
    • Kondadasula SV, et al. 2008. Colocalization of the IL-12 receptor and FcγRIIIa to natural killer cell lipid rafts leads to activation of ERK and enhanced production of interferon-γ. Blood 111:4173-4183.
    • (2008) Blood , vol.111 , pp. 4173-4183
    • Kondadasula, S.V.1
  • 21
    • 0032864051 scopus 로고    scopus 로고
    • Role of MAP kinase pathways in mediating IL-6 production in human primary mesangial and proximal tubular cells
    • Leonard M, Ryan MP, Watson AJ, Schramek H, Healy E. 1999. Role of MAP kinase pathways in mediating IL-6 production in human primary mesangial and proximal tubular cells. Kidney Int. 56:1366-1377.
    • (1999) Kidney Int. , vol.56 , pp. 1366-1377
    • Leonard, M.1    Ryan, M.P.2    Watson, A.J.3    Schramek, H.4    Healy, E.5
  • 22
    • 0029923456 scopus 로고    scopus 로고
    • Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha
    • Li X, Leung S, Qureshi S, Darnell JE, Jr, Stark GR. 1996. Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. J. Biol. Chem. 271:5790-5794.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5790-5794
    • Li, X.1    Leung, S.2    Qureshi, S.3    Darnell Jr., J.E.4    Stark, G.R.5
  • 23
    • 0032538891 scopus 로고    scopus 로고
    • Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7
    • Marie I, Durbin JE, Levy DE. 1998. Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7. EMBO J. 17:6660-6669.
    • (1998) EMBO J. , vol.17 , pp. 6660-6669
    • Marie, I.1    Durbin, J.E.2    Levy, D.E.3
  • 24
    • 84555205600 scopus 로고    scopus 로고
    • IL-6/IL-6 receptor system and its role in physiological and pathological conditions
    • Lond.
    • Mihara M, Hashizume M, Yoshida H, Suzuki M, Shiina M. 2011. IL-6/IL-6 receptor system and its role in physiological and pathological conditions. Clin. Sci. (Lond.) 122:143-159.
    • (2011) Clin. Sci. , vol.122 , pp. 143-159
    • Mihara, M.1    Hashizume, M.2    Yoshida, H.3    Suzuki, M.4    Shiina, M.5
  • 25
    • 0033564842 scopus 로고    scopus 로고
    • The Th1/Th2 balance does not account for the difference of susceptibility of mouse strains to Theiler's virus persistent infection
    • Monteyne P, Bihl F, Levillayer F, Brahic M, Bureau JF. 1999. The Th1/Th2 balance does not account for the difference of susceptibility of mouse strains to Theiler's virus persistent infection. J. Immunol. 162: 7330-7334.
    • (1999) J. Immunol. , vol.162 , pp. 7330-7334
    • Monteyne, P.1    Bihl, F.2    Levillayer, F.3    Brahic, M.4    Bureau, J.F.5
  • 26
    • 80052025352 scopus 로고    scopus 로고
    • IRF3 polymor-phisms induce different innate anti-Theiler's virus immune responses in RAW264.7 macrophages
    • Moore TC, Al-Salleeh FM, Brown DM, Petro TM. 2011. IRF3 polymor-phisms induce different innate anti-Theiler's virus immune responses in RAW264.7 macrophages. Virology 418:40-48.
    • (2011) Virology , vol.418 , pp. 40-48
    • Moore, T.C.1    Al-Salleeh, F.M.2    Brown, D.M.3    Petro, T.M.4
  • 27
    • 0028173010 scopus 로고
    • L-N6-(1-Iminoethyl)lysine: A selective inhibitor of inducible nitric oxide synthase
    • Moore WM, et al. 1994. L-N6-(1-Iminoethyl)lysine: A selective inhibitor of inducible nitric oxide synthase. J. Med. Chem. 37:3886-3888.
    • (1994) J. Med. Chem. , vol.37 , pp. 3886-3888
    • Moore, W.M.1
  • 28
    • 66649119445 scopus 로고    scopus 로고
    • A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages
    • Mott KR, Underhill D, Wechsler SL, Town T, Ghiasi H. 2009. A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages. Virol. J. 6:56.
    • (2009) Virol. J. , vol.6 , pp. 56
    • Mott, K.R.1    Underhill, D.2    Wechsler, S.L.3    Town, T.4    Ghiasi, H.5
  • 29
    • 0030997409 scopus 로고    scopus 로고
    • Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon-γ-induced MAPK activation that is mediated by p21ras
    • Nishiya T, et al. 1997. Activation of Stat1 and subsequent transcription of inducible nitric oxide synthase gene in C6 glioma cells is independent of interferon-γ-induced MAPK activation that is mediated by p21ras. FEBS Lett. 408:33-38.
    • (1997) FEBS Lett. , vol.408 , pp. 33-38
    • Nishiya, T.1
  • 30
    • 77956315094 scopus 로고    scopus 로고
    • Alternate mechanisms of initial pattern rec-ognition drive differential immune responses to related poxviruses
    • O'Gorman WE, et al. 2010. Alternate mechanisms of initial pattern rec-ognition drive differential immune responses to related poxviruses. Cell Host Microbe 8:174-185.
    • (2010) Cell Host Microbe , vol.8 , pp. 174-185
    • O'orman, W.E.1
  • 31
    • 80855138451 scopus 로고    scopus 로고
    • Interleukin-6 treatment induces beta-cell apoptosis via STAT-3-mediated nitric oxide production
    • Oh YS, Lee Y-J, Park EY, Jun H-S. 2011. Interleukin-6 treatment induces beta-cell apoptosis via STAT-3-mediated nitric oxide production. Diabe-tes Metab. Res. Rev. 27:813-819.
    • (2011) Diabe-tes Metab. Res. Rev. , vol.27 , pp. 813-819
    • Oh, Y.S.1    Lee, Y.-J.2    Park, E.Y.3    Jun, H.-S.4
  • 32
    • 0031920882 scopus 로고    scopus 로고
    • IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligo-dendrocyte glycoprotein
    • Okuda Y, et al. 1998. IL-6-deficient mice are resistant to the induction of experimental autoimmune encephalomyelitis provoked by myelin oligo-dendrocyte glycoprotein. Int. Immunol. 10:703-708.
    • (1998) Int. Immunol. , vol.10 , pp. 703-708
    • Okuda, Y.1
  • 34
    • 0037689117 scopus 로고    scopus 로고
    • Infection with Theiler's murine encephalomyelitis virus directly induces proinflammatory cyto-kines in primary astrocytes via NF-{kappa}B activation: potential role for the initiation of demyelinating disease
    • Palma JP, Kwon D, Clipstone NA, Kim BS. 2003. Infection with Theiler's murine encephalomyelitis virus directly induces proinflammatory cyto-kines in primary astrocytes via NF-{kappa}B activation: potential role for the initiation of demyelinating disease. J. Virol. 77:6322-6331.
    • (2003) J. Virol. , vol.77 , pp. 6322-6331
    • Palma, J.P.1    Kwon, D.2    Clipstone, N.A.3    Kim, B.S.4
  • 35
    • 0037439877 scopus 로고    scopus 로고
    • Interleukin-6 protects anterior horn neurons from lethal virus-induced injury
    • Pavelko KD, et al. 2003. Interleukin-6 protects anterior horn neurons from lethal virus-induced injury. J. Neurosci. 23:481-492.
    • (2003) J. Neurosci. , vol.23 , pp. 481-492
    • Pavelko, K.D.1
  • 36
    • 24944439902 scopus 로고    scopus 로고
    • Increased expression of interleukin-6 by vasoactive intestinal peptide is associated with regulation of CREB, AP-1 and C/EBP, but not NF-kappaB, in mouse calvarial osteoblasts
    • Persson E, Voznesensky OS, Huang YF, Lerner UH. 2005. Increased expression of interleukin-6 by vasoactive intestinal peptide is associated with regulation of CREB, AP-1 and C/EBP, but not NF-kappaB, in mouse calvarial osteoblasts. Bone 37:513-529.
    • (2005) Bone , vol.37 , pp. 513-529
    • Persson, E.1    Voznesensky, O.S.2    Huang, Y.F.3    Lerner, U.H.4
  • 37
    • 15244341962 scopus 로고    scopus 로고
    • Disparate expression of IL-12 by SJL/J and B10.S mac-rophages during Theiler's virus infection is associated with activity of TLR7 and mitogen-activated protein kinases
    • Petro TM. 2005. Disparate expression of IL-12 by SJL/J and B10.S mac-rophages during Theiler's virus infection is associated with activity of TLR7 and mitogen-activated protein kinases. Microbes Infect. 7:224-232.
    • (2005) Microbes Infect. , vol.7 , pp. 224-232
    • Petro, T.M.1
  • 38
    • 11144285387 scopus 로고    scopus 로고
    • ERK-MAP-kinases differentially regulate expression of IL-23 p19 compared with p40 and IFN-beta in Theiler's virus-infected RAW264.7 cells
    • Petro TM. 2005. ERK-MAP-kinases differentially regulate expression of IL-23 p19 compared with p40 and IFN-beta in Theiler's virus-infected RAW264.7 cells. Immunol. Lett. 97:47-53.
    • (2005) Immunol. Lett. , vol.97 , pp. 47-53
    • Petro, T.M.1
  • 39
    • 0027939355 scopus 로고
    • Recom-binant human IL-6 suppresses demyelination in a viral model of multiple sclerosis
    • Rodriguez M, Pavelko KD, McKinney CW, Leibowitz JL. 1994. Recom-binant human IL-6 suppresses demyelination in a viral model of multiple sclerosis. J. Immunol. 153:3811-3821.
    • (1994) J. Immunol. , vol.153 , pp. 3811-3821
    • Rodriguez, M.1    Pavelko, K.D.2    Mckinney, C.W.3    Leibowitz, J.L.4
  • 40
    • 0032534730 scopus 로고    scopus 로고
    • IL-6-deficient mice are resistant to experimental autoimmune encephalomy-elitis: Roles of IL-6 in the activation and differentiation of autoreactive T cells
    • Samoilova EB, Horton JL, Hilliard B, Liu T-ST, Chen Y. 1998. IL-6-deficient mice are resistant to experimental autoimmune encephalomy-elitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J. Immunol. 161:6480-6486.
    • (1998) J. Immunol. , vol.161 , pp. 6480-6486
    • Samoilova, E.B.1    Horton, J.L.2    Hilliard, B.3    Liu, T.-S.4    Chen, Y.5
  • 41
    • 0031906220 scopus 로고    scopus 로고
    • Nitric oxide inhibits rhinovirus-induced cytokine production and viral replication in a human respiratory epithelial cell line
    • Sanders SP, Siekierski ES, Porter JD, Richards SM, Proud D. 1998. Nitric oxide inhibits rhinovirus-induced cytokine production and viral replication in a human respiratory epithelial cell line. J. Virol. 72:934-942.
    • (1998) J. Virol. , vol.72 , pp. 934-942
    • Sanders, S.P.1    Siekierski, E.S.2    Porter, J.D.3    Richards, S.M.4    Proud, D.5
  • 42
    • 0031160086 scopus 로고    scopus 로고
    • IL-6 induction of protein-DNA complexes via a novel regulatory region of the inducible nitric oxide synthase gene promoter: Role of octamer binding proteins
    • Sawada T, Falk LA, Rao P, Murphy WJ, Pluznik DH. 1997. IL-6 induction of protein-DNA complexes via a novel regulatory region of the inducible nitric oxide synthase gene promoter: role of octamer binding proteins. J. Immunol. 158:5267-5276.
    • (1997) J. Immunol. , vol.158 , pp. 5267-5276
    • Sawada, T.1    Falk, L.A.2    Rao, P.3    Murphy, W.J.4    Pluznik, D.H.5
  • 43
    • 0027423232 scopus 로고
    • Cellular local-ization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain
    • Schobitz B, de Kloet ER, Sutanto W, Holsboer F. 1993. Cellular local-ization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain. Eur. J. Neurosci. 5:1426-1435.
    • (1993) Eur. J. Neurosci. , vol.5 , pp. 1426-1435
    • Schobitz, B.1    de Kloet, E.R.2    Sutanto, W.3    Holsboer, F.4
  • 45
    • 0032852479 scopus 로고    scopus 로고
    • CREB: A stimulus-induced transcrip-tion factor activated by a diverse array of extracellular signals
    • Shaywitz AJ, Greenberg ME. 1999. CREB: a stimulus-induced transcrip-tion factor activated by a diverse array of extracellular signals. Annu. Rev. Biochem. 68:821-861.
    • (1999) Annu. Rev. Biochem. , vol.68 , pp. 821-861
    • Shaywitz, A.J.1    Greenberg, M.E.2
  • 46
    • 84870686240 scopus 로고    scopus 로고
    • Critical roles for both STAT1-dependent and elitis: Roles of IL-6 in the activation and differentiation of autoreactive T cells
    • Shresta S, et al. 2005. Critical roles for both STAT1-dependent and elitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J. Immunol. 161:6480-6486.
    • (2005) J. Immunol. , vol.161 , pp. 6480-6486
    • Shresta, S.1
  • 47
    • 79957949411 scopus 로고    scopus 로고
    • Interleukin-6, a mental cytokine
    • Spooren A, et al. 2011. Interleukin-6, a mental cytokine. Brain Res. Rev. 67:157-183.
    • (2011) Brain Res. Rev. , vol.67 , pp. 157-183
    • Spooren, A.1
  • 48
    • 0025610846 scopus 로고
    • Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice
    • Starnes HF, Jr, et al. 1990. Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice. J. Immunol. 145:4185-4191.
    • (1990) J. Immunol. , vol.145 , pp. 4185-4191
    • Starnes Jr., H.F.1
  • 49
    • 0033561678 scopus 로고    scopus 로고
    • Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-kappa B-dependent IL-6 expression in human monocytes
    • Tuyt LM, et al. 1999. Extracellular-regulated kinase 1/2, Jun N-terminal kinase, and c-Jun are involved in NF-kappa B-dependent IL-6 expression in human monocytes. J. Immunol. 162:4893-4902.
    • (1999) J. Immunol. , vol.162 , pp. 4893-4902
    • Tuyt, L.M.1
  • 50
    • 79958703380 scopus 로고    scopus 로고
    • miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kB
    • Xu Z, et al. 2011. miR-365, a novel negative regulator of interleukin-6 gene expression, is cooperatively regulated by Sp1 and NF-kB. J. Biol. Chem. 286:21401-21412.
    • (2011) J. Biol. Chem. , vol.286 , pp. 21401-21412
    • Xu, Z.1
  • 51
    • 0035853827 scopus 로고    scopus 로고
    • cAMP-dependent protein kinase induces cAMP-response element-binding protein phosphorylation via an intracellular calcium release/ERK-dependent pathway in striatal neurons
    • Zanassi P, et al. 2001. cAMP-dependent protein kinase induces cAMP-response element-binding protein phosphorylation via an intracellular calcium release/ERK-dependent pathway in striatal neurons. J. Biol. Chem. 276:11487-11495.
    • (2001) J. Biol. Chem. , vol.276 , pp. 11487-11495
    • Zanassi, P.1
  • 52
    • 33644816943 scopus 로고    scopus 로고
    • Increased myelinating capacity of embryonic stem cell derived oligodendrocyte precursors after treatment by interleukin-6/ soluble interleukin-6 receptor fusion protein
    • Zhang P-L, et al. 2006. Increased myelinating capacity of embryonic stem cell derived oligodendrocyte precursors after treatment by interleukin-6/ soluble interleukin-6 receptor fusion protein. Mol. Cell Neurosci. 31:387-398.
    • (2006) Mol. Cell Neurosci. , vol.31 , pp. 387-398
    • Zhang, P.-L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.