Impairment in functional capacity as an endophenotype candidate in severe mental illness

Schizophrenia Bulletin

Volumn 38, Issue 6, 2012, Pages 1318-1326

  Harvey, Philip D ^a   McClure, Margaret M ^b,c   Patterson, Thomas L ^d   McGrath, John A ^e   Pulver, Ann E ^e   Bowie, Christopher R ^f   Siever, Larry J ^b,c  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c VISN3 MIRECC   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f QUEEN S UNIVERSITY   (Canada)

Author keywords

disability; endophenotypes; schizophrenia

Indexed keywords

BIPOLAR DISORDER; COGNITION; ENDOPHENOTYPE; ENVIRONMENTAL FACTOR; FUNCTIONAL DISEASE; GENETIC SUSCEPTIBILITY; GENETIC TRAIT; HERITABILITY; HUMAN; MENTAL DISEASE; PRIORITY JOURNAL; PSYCHOMETRY; REVIEW; SCHIZOPHRENIA;

ACTIVITIES OF DAILY LIVING; BIPOLAR DISORDER; COGNITION DISORDERS; EMPLOYMENT; ENDOPHENOTYPES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; NEUROPSYCHOLOGICAL TESTS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 84869017600     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbr046     Document Type: Review

References (70)

1. Wiersma D, Wanderling J, Dragomirecka E, et al. Social disability in schizophrenia: its development and prediction over 15 years in incidence cohorts in six European centres. Psychol Med. 2000;30:1155-1167.
2. Ho BC, Andreasen N, Flaum M. Dependence on public financial support early in the course of schizophrenia. Psychiatr Serv. 1997;48:948-950.
3. Tohen M, Zarate CA, Jr., et al. The McLean-Harvard firstepisode mania study: prediction of recovery and first recurrence. Am J Psychiatry. 2003;160:2099-2107.
4. Robinson DG, Woerner MG, McMeniman M, Mendelowitz A, Bilder RM. Symptomatic and functional recovery from a first episode of schizophrenia or schizoaffective disorder. Am J Psychiatry. 2004;161:473-479.
5. Braff DL, Freedman R, Schork NJ, Gottesman II. Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder. Schizophr Bull. 2007;33:21-32.
6. Thaker GK. Endophenotypic studies in schizophrenia: promise and challenges. Schizophr Bull. 2007;33:1-2.
7. Gur RE, Nimgaonkar VL, Almasy L, et al. Neurocognitive endophenotypes in a multiplex multigenerational family study of schizophrenia. Am J Psychiatry. 2007;164:813-819.
8. Greenwood TA, Lazzeroni LC, Murray SS, et al. Analysis of 94 candidate genes and twelve endophenotypes for schizophrenia from the Consortium on the Genetics of Schizophrenia. Am J Psychiatry. In press.
9. Green MF, Kern RS, Braff DL, Mintz J. Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the right stuff? Schizophr Bull. 2000;26:119-136.
10. Tsuang MT, Gilbertson MW, Faraone SV. The genetics of schizophrenia. Current knowledge and future directions. Schizophr Res. 1991;4:157-171.
11. McGue M, Gottesman II. Genetic linkage in schizophrenia: perspectives from genetic epidemiology. Schizophr Bull. 1989;15:453-464.
12. Sullivan PF, Kendler KS, Neale MC. Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry. 2003;60:1187-1192.
13. Kieseppa T, Partonen T, Haukka J, Kaprio J, Lonnqvist J. High concordance of bipolar I disorder in a nationwide sample of twins. Am J Psychiatry. 2004;161:1814-1821.
14. Lichtenstein P, Yip BH, Bjork C, et al. Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study. Lancet. 2009;373:234-239.
15. Risch N. Linkage strategies for genetically complex traits. I. Multilocus models [see comments]. Am J Hum Genet. 1990;46:222-228.
16. Arisoy O, Oral ET. [Genetic studies of bipolar disorder: a review]. Turk Psikiyatri Derg. 2009;20:282-293.
17. Fanous AH, Kendler KS. Genetic heterogeneity, modifier genes, and quantitative phenotypes in psychiatric illness: searching for a framework. Mol Psychiatry. 2005;10:6-13.
18. Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry. 2005;10:40-68.
19. Kendler KS. A gene for.: the nature of gene action in psychiatric disorders. Am J Psychiatry. 2005;162:1243-1252.
20. Harvey PD, Bertisch H, Friedman JI, et al. The course of functional decline in geriatric patients with schizophrenia: cognitive-functional and clinical symptoms as determinants of change. Am J Geriatr Psychiatry. 2003;11:610-619.
21. McGurk SR, Moriarty PJ, Harvey PD, et al. Relationship of cognitive functioning, adaptive life skills, and negative symptom severity in poor-outcome geriatric schizophrenia patients. J Neuropsychiatry Clin Neurosci. 2000;12:257-264.
22. Rempfer MV, Hamera EK, Brown CE, Cromwell RL. The relations between cognition and the independent living skill of shopping in people with schizophrenia. Psychiatry Res. 2003;117:103-112.
23. Smith TE, Hull JW, Huppert JD, Silverstein SM. Recovery from psychosis in schizophrenia and schizoaffective disorder: symptoms and neurocognitive rate-limiters for the development of social behavior skills. Schizophr Res. 2002; 55:229-237.
24. Seidman LJ, Kremen WS, Koren D, Faraone SV, Goldstein JM, Tsuang MT. A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses. Schizophr Res. 2002;53:31-44.
25. Bearden CE, Hoffman KM, Cannon TD. The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review. Bipolar Disord. 2001;3:106-150 discussion 151-103.
26. Reichenberg A, Harvey PD, Bowie CR, et al. Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders. Schizophr Bull. 2009;35:1022-1029.
27. Quraishi S, Frangou S. Neuropsychology of bipolar disorder: a review. J Affect Disord. 2002;72:209-226.
28. Wingo AP, Harvey PD, Baldessarini RJ. Neurocognitive impairment in bipolar disorder patients: functional implications. Bipolar Disord. 2009;11:113-125.
29. Morice R. Cognitive inflexibility and pre-frontal dysfunction in schizophrenia and mania. Br J Psychiatry. 1990;157:50-54.
30. Green MF, Nuechterlein KH, Mintz J. Backward masking in schizophrenia and mania. I. Specifying a mechanism. Arch Gen Psychiatry. 1994;51:939-944.
31. Green MF, Nuechterlein KH, Mintz J. Backward masking in schizophrenia and mania. II. Specifying the visual channels. Arch Gen Psychiatry. 1994;51:945-951.
32. Hoff AL, Shukla S, Aronson T, et al. Failure to differentiate bipolar disorder from schizophrenia on measures of neuropsychological function. Schizophr Res. 1990;3:253-260.
33. Huxley N, Baldessarini RJ. Disability and its treatment in bipolar disorder patients. Bipolar Disord. 2007;9:183-196.
34. Coryell W, Scheftner W, Keller M, Endicott J, Maser J, Klerman GL. The enduring psychosocial consequences of mania and depression. Am J Psychiatry. 1993;150:720-727.
35. MacQueen GM, Young LT, Joffe RT. A review of psychosocial outcome in patients with bipolar disorder. Acta Psychiatr Scand. 2001;103:163-170.
36. Badner JA, Gershon ES. Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry. 2002;7:405-411.
37. Potash JB, Chiu YF, MacKinnon DF, et al. Familial aggregation of psychotic symptoms in a replication set of 69 bipolar disorder pedigrees. Am J Med Genet. 2003;116B:90-97.
38. Pulver AE, Mulle J, Nestadt G, et al. Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes. Mol Psychiatry. 2000;5:650-653.
39. Berrettini W. Evidence for shared susceptibility in bipolar disorder and schizophrenia. Am J Med Genet. 2003;123C:59-64.
40. Blackwood DH, Fordyce A, Walker MT, St. Clair DM, Porteous DJ, Muir WJ. Schizophrenia and affective disorders-cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet. 2001;72:428-433.
41. Hodgkinson CA, Goldman D, Jaeger J, et al. Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder. Am J Hum Genet. 2004;75:862-872.
42. Wang KS, Liu XF, Aragam N. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. Schizophr Res. 2010;124:192-199.
43. Psychiatric GCSC. A framework for interpreting genomewide association studies of psychiatric disorders. Mol Psychiatry. 2009;14:10-17.
44. Burdick KE, Funke B, Goldberg JF, et al. COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Bipolar Disord. 2007;9:370-376.
45. Keefe RS, Silverman JM, Mohs RC, et al. Eye tracking, attention, and schizotypal symptoms in nonpsychotic relatives of patients with schizophrenia see comments. Arch Gen Psychiatry. 1997;54:169-176.
46. Sitskoorn MM, Aleman A, Ebisch SJ, Appels MC, Kahn RS. Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis. Schizophr Res. 2004;71:285-295.
47. Reichenberg A, Weiser M, Rapp MA, et al. Premorbid intraindividual variability in intellectual performance and risk for schizophrenia: a population-based study. Schizophr Res. 2006;85:49-57.
48. Sorensen HJ, Mortensen EL, Parnas J, Mednick SA. Premorbid neurocognitive functioning in schizophrenia spectrum disorder. Schizophr Bull. 2006;32:578-583.
49. Heinrichs RW. The primacy of cognition in schizophrenia. Am Psychol. 2005;60:229-242.
50. Gur RE, Calkins ME, Gur RC, et al. The consortium on the genetics of schizophrenia: neurocognitive endophenotypes. Schizophr Bull. 2007;33:49-68.
51. Bora E, Yucel M, Pantelis C. Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives. J Affect Disord. 2009;113:1-20.
52. Glahn DC, Almasy L, Barguil M, et al. Neurocognitive endophenotypes for bipolar disorder identified in multiplex multigenerational families. Arch Gen Psychiatry. 2010;67:168-177.
53. Greenwood TA, Braff DL, Light GA, et al. Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophrenia. Arch Gen Psychiatry. 2007;64:1242-1250.
54. Goldberg TE, Egan MF, Gscheidle T, et al. Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia. Arch Gen Psychiatry. 2003;60:889-896.
55. Larrison-Faucher AL, Matorin AA, Sereno AB. Nicotine reduces antisaccade errors in task impaired schizophrenic subjects. Prog Neuropsychopharmacol Biol Psychiatry. 2004; 28:505-516.
56. Avila MT, Adami HM, McMahon RP, Thaker GK. Using neurophysiological markers of genetic risk to define the boundaries of the schizophrenia spectrum phenotype. Schizophr Bull. 2003;29:299-309.
57. Hallmayer JF, Jablensky A, Michie P, et al. Linkage analysis of candidate regions using a composite neurocognitive phenotype correlated with schizophrenia. Mol Psychiatry. 2003;8:511-523.
58. Kendler KS, McGuire M, Gruenberg AM, Walsh D. Schizotypal symptoms and signs in the Roscommon Family Study: their factor structure and familial relationship with psychotic and affective disorders. Arch Gen Psychiatry. 1995;52:296-303.
59. McGrath JA, Avramopoulos D, Lasseter VK, et al. Familiality of novel factorial dimensions of schizophrenia. Arch Gen Psychiatry. 2009;66:591-600.
60. Rosenheck R, Leslie D, Keefe R, et al. Barriers to employment for people with schizophrenia. Am J Psychiatry. 2006;163:411-417.
61. Heaton RK, Pendleton MG. Use of neuropsychological tests to predict adult patients' everyday functioning. J Consult Clin Psychol. 1981;49:807-821.
62. Green MF. What are the functional consequences of neurocognitive deficits in schizophrenia? Am J Psychiatry. 1996; 153:321-330.
63. Albert SM, Marder K, Dooneief G, et al. Neuropsychologic impairment in early HIV infection. A risk factor for work disability. Arch Neurol. 1995;52:525-530.
64. Leung WW, Bowie CR, Harvey PD. Functional implications of neuropsychological normality and symptom remission in older outpatients diagnosed with schizophrenia: a crosssectional study. J Int Neuropsychol Soc. 2008;14:479-488.
65. Harvey PD, Helldin L, Bowie CR, et al. Performance-based measurement of functional disability in schizophrenia: a cross-national study in the United States and Sweden. Am J Psychiatry. 2009;166:821-827.
66. Mausbach BT, Harvey PD, Pulver AE, et al. Relationship of the brief UCSD Performance-based Skills Assessment (UPSA-B) to multiple indicators of functioning in people with schizophrenia and bipolar disorder. Bipol Disord. 2010;12:45-55.
67. Bowie CR, Depp C, McGrath JA, et al. Prediction of realworld functional disability in chronic mental disorders: a comparison of schizophrenia and bipolar disorder. Am J Psychiatry. 2010;167:1116-1124.
68. Bowie CR, Leung WW, Reichenberg A, et al. Predicting schizophrenia patients' real-world behavior with specific neuropsychological and functional capacity measures. Biol Psychiatry. 2008;63:505-511.
69. Leifker FR, Bowie CR, Harvey PD. Determinants of everyday outcomes in schizophrenia: the influences of cognitive impairment, functional capacity, and symptoms. Schizophr Res. 2009;115:82-87.
70. Leifker FR, Patterson TL, Bowie CR, Mausbach BT, Harvey PD. Psychometric properties of performance-based measurements of functional capacity: test-retest reliability, practice effects, and potential sensitivity to change. Schizophr Res. 2010;119:246-252.