Interleukin-1β induces differentiation of human mesenchymal stem cells into osteoblasts via the wnt-5a/receptor tyrosine kinase-like orphan receptor 2 pathway

Arthritis and Rheumatism

Volumn 64, Issue 10, 2012, Pages 3355-3363

  Sonomoto, Koshiro ^a,b   Yamaoka, Kunihiro ^a,b   Oshita, Koichi ^a,b   Fukuyo, Shunsuke ^b   Zhang, Xiangmei ^b   Nakano, Kazuhisa ^b   Okada, Yosuke ^b   Tanaka, Yoshiya ^b  

^a Mitsubishi Tanabe Pharma   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALIZARIN RED S; ALKALINE PHOSPHATASE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; INTERLEUKIN 1BETA; MESSENGER RNA; RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR; RECEPTOR TYROSINE KINASE LIKE ORPHAN RECEPTOR 2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; WNT10B PROTEIN; WNT3A PROTEIN; WNT5A PROTEIN; WNT7B PROTEIN;

ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; BONE TISSUE; CELL DIFFERENTIATION; CELL RENEWAL; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; MESENCHYMAL STEM CELL; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; WNT SIGNALING PATHWAY;

CELL DIFFERENTIATION; CELLS, CULTURED; CORE BINDING FACTOR ALPHA 1 SUBUNIT; HUMANS; INTERLEUKIN-1BETA; MESENCHYMAL STROMAL CELLS; OSTEOBLASTS; OSTEOGENESIS; PROTO-ONCOGENE PROTEINS; RECEPTOR TYROSINE KINASE-LIKE ORPHAN RECEPTORS; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84869006610     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.34555     Document Type: Article

References (35)

1. Lipsky PE, Van Der Heijde DM, St Clair EW, Furst DE, Breedveld FC, Kalden JR, et al, for the Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. Infliximab and methotrexate in the treatment of rheumatoid arthritis. N Engl J Med 2000; 343: 1594-602. (Pubitemid 32162982)
2. Klareskog L, Van Der Heijde D, de Jager JP, Gough A, Kalden J, Malaise M, et al. Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet 2004; 363: 675-81. (Pubitemid 38296553)
3. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143-7. (Pubitemid 29282067)
4. Djouad F, Fritz V, Apparailly F, Louis-Plence P, Bony C, Sany J, et al. Reversal of the immunosuppressive properties of mesenchymal stem cells by tumor necrosis factor - in collagen-induced arthritis. Arthritis Rheum 2005; 52: 1595-603. (Pubitemid 40663952)
5. Augello A, Tasso R, Negrini SM, Cancedda R, Pennesi G. Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis. Arthritis Rheum 2007; 56: 1175-86. (Pubitemid 46608642)
6. Zappia E, Casazza S, Pedemonte E, Benvenuto F, Bonanni I, Gerdoni E, et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 2005; 106: 1755-61. (Pubitemid 41208591)
7. Urban VS, Kiss J, Kovacs J, Gocza E, Vas V, Monostori E, et al. Mesenchymal stem cells cooperate with bone marrow cells in therapy of diabetes. Stem Cells 2008; 26: 244-53.
8. Bang OY, Lee JS, Lee PH, Lee G. Autologous mesenchymal stem cell transplantation in stroke patients. Ann Neurol 2005;57: 874-82. (Pubitemid 40798626)
9. Horwitz EM, Gordon PL, Koo WK, Marx JC, Neel MD, McNall RY, et al. Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone. Proc Natl Acad Sci U S A 2002; 99: 8932-7. (Pubitemid 34693661)
10. Guo CA, Liu XG, Huo JZ, Jiang C, Wen XJ, Chen ZR. Novel gene-modified-tissue engineering of cartilage using stable transforming growth factor-1-transfected mesenchymal stem cells grown on chitosan scaffolds. J Biosci Bioeng 2007; 103: 547-56.
11. Le Blanc K, Rasmusson I, Sundberg B, Gotherstrom C, Hassan M, Uzunel M, et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 2004; 363: 1439-41. (Pubitemid 38586721)
12. Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008; 371: 1579-86. (Pubitemid 351626841)
13. Hare JM, Traverse JH, Henry TD, Dib N, Strumpf RK, Schulman SP, et al. A randomized, double-blind, placebo-controlled, doseescalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol 2009; 54: 2277-86.
14. Da Silva Meirelles L, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 2006; 119: 2204-13. (Pubitemid 43960310)
15. Gorman JD, Sack KE, Davis JC Jr. Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor -. N Engl J Med 2002; 346: 1349-56. (Pubitemid 34754607)
16. Chen Y, Alman BA. Wnt pathway, an essential role in bone regeneration. J Cell Biochem 2009; 106: 353-62.
17. Kubota T, Michigami T, Ozono K. Wnt signaling in bone metabolism. J Bone Miner Metab 2009; 27: 265-71.
18. Boland GM, Perkins G, Hall DJ, Tuan RS. Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J Cell Biochem 2004; 93: 1210-30. (Pubitemid 44264134)
19. Hartmann C, Tabin CJ. Dual roles of Wnt signaling during chondrogenesis in the chicken limb. Development 2000;127: 3141-59. (Pubitemid 30611906)
20. Ling L, Nurcombe V, Cool SM. Wnt signaling controls the fate of mesenchymal stem cells. Gene 2009; 433: 1-7.
21. Moon RT, Bowerman B, Boutros M, Perrimon N. The promise and perils of Wnt signaling through -catenin. Science 2002;296: 1644-6. (Pubitemid 34579151)
22. Kanakaraj P, Schafer PH, Cavender DE, Wu Y, Ngo K, Grealish PF, et al. Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production. J Exp Med 1998; 187: 2073-9.
23. Taichman RS, Hauschka PV. Effects of interleukin-1 - and tumor necrosis factor-on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro. Inflammation 1992;16: 587-601.
24. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G. Osf2/ Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 1997; 89: 747-54. (Pubitemid 27516177)
25. Saitoh T, Katoh M. Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNF-in MKN45 cells and up-regulation of WNT5B by -estradiol in MCF-7 cells. Int J Mol Med 2002; 10: 345-9.
26. Katoh M. STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer. Int J Mol Med 2007; 19: 273-8.
27. Takada I, Kouzmenko AP, Kato S. PPAR-signaling crosstalk in mesenchymal stem cells. PPAR Res 2010;pii:341671.
28. Sen M, Lauterbach K, El-Gabalawy H, Firestein GS, Corr M, Carson DA. Expression and function of wingless and frizzled homologs in rheumatoid arthritis. Proc Natl Acad Sci U S A 2000; 97: 2791-6. (Pubitemid 30159250)
29. Hughes KR, Sablitzky F, Mahida YR. Expression profiling of Wnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells. Inflamm Bowel Dis 2011; 17: 213-20.
30. Weeraratna AT, Jiang Y, Hostetter G, Rosenblatt K, Duray P, Bittner M, et al. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 2002; 1: 279-88. (Pubitemid 41039152)
31. Huang CL, Liu D, Nakano J, Ishikawa S, Kontani K, Yokomise H, et al. Wnt5a expression is associated with the tumor proliferation and the stromal vascular endothelial growth factor: an expression in non-small-cell lung cancer. J Clin Oncol 2005; 23: 8765-73. (Pubitemid 46211522)
32. Kurayoshi M, Oue N, Yamamoto H, Kishida M, Inoue A, Asahara T, et al. Expression of Wnt-5a is correlated with aggressiveness of gastric cancer by stimulating cell migration and invasion. Cancer Res 2006; 66: 10439-48. (Pubitemid 44799765)
33. Takada I, Mihara M, Suzawa M, Ohtake F, Kobayashi S, Igarashi M, et al. A histone lysine methyltransferase activated by noncanonical Wnt signaling suppresses PPAR-transactivation. Nat Cell Biol 2007; 9: 1273-85. (Pubitemid 350042359)
34. Matsuguchi T, Chiba N, Bandow K, Kakimoto K, Masuda A, Ohnishi T. JNK activity is essential for Atf4 expression and late-stage osteoblast differentiation. J Bone Miner Res 2009;24: 398-410.
35. Oshita K, Yamaoka K, Udagawa N, Fukuyo S, Sonomoto K, Maeshima K, et al. Human mesenchymal stem cells inhibit osteoclastogenesis through osteoprotegerin production. Arthritis Rheum 2011; 63: 1658-67.