A multiplexed sirna screening strategy to identify genes in the PARP pathway

Journal of Biomolecular Screening

Volumn 17, Issue 10, 2012, Pages 1316-1328

  Stec, Erica ^a   Locco, Louis ^a   Szymanski, Stacey ^a   Bartz, Steven R ^b   Toniatti, Carlo ^c   Needham, Rachel H V ^d   Palmieri, Anthony ^d   Carleton, Michael ^d   Cleary, Michele A ^d   Jackson, Aimee L ^d   Linsley, Peter S ^d   Strulovici, Berta ^a   Ferrer, Marc ^a   Santini, Francesca ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b RNA Therapeutics   (United States)

^c IRBM   (Italy)

^d Rosetta Inpharmatics ^*  (United States)

Author keywords

biomarkers; cancer and cancer drugs; cell based assays; high content screening; RNA interference; RNAi; shRNA

Indexed keywords

NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; SMALL INTERFERING RNA;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CELL SURVIVAL; DNA REPAIR; GENETIC IDENTIFICATION; GENETIC SCREENING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

APOPTOSIS; CELL DIVISION; CELL PROLIFERATION; CELL SURVIVAL; DNA REPAIR; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HELA CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; POLY(ADP-RIBOSE) POLYMERASES; REPRODUCIBILITY OF RESULTS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION;

EID: 84869004963     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057112453071     Document Type: Article

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