Lactide-glycolide polymers as nano-dimensional carriers for drugs

International Journal of Biomedical Nanoscience and Nanotechnology

Volumn 1, Issue 2-4, 2010, Pages 230-246

  Mukherjee, Biswajit ^a   Roy, Gopa ^a   Santra, Kousik ^a   Sahana, Basudev ^a  

^a JADAVPUR UNIVERSITY   (India)

Author keywords

biodegradable polymers; nanoparticles; poly (D, L lactide co glycolide); prolonged release

Indexed keywords

EID: 84868706094     PISSN: 17560799     EISSN: 17560802     Source Type: Journal    
DOI: 10.1504/IJBNN.2010.034653     Document Type: Article

References (69)

1. Agnihotri, S. and Vavia, P. (2009) ‘Diclofenac-loaded biopolymeric nanosuspensions for ophthalmic application’, Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 5, No. 1, pp.90–95.
2. Akerman, M., Chan, W., Laakkonen, P., Bhatia, S. and Ruoslasti, K. (2002) ‘Nanocrystal targeting in vivo’, Proceedings of the National Academy of Sciences, Vol. 99, No. 12, pp.617–621.
3. Alexis, F., Pridgen, E., Molnar, L.K. and Farokhzad, C.O. (2008) ‘Factors affecting the clearance & biodistribution of polymeric nanoparticles’, Molecular. Pharmaceutics, Vol. 5, No. 4, pp.505–515.
4. Anderson, J. and Shive, M. (1997) ‘Biodegradation and biocompatibility of PLA and PLGA microspheres’, Advanced Drug Delivery Reviews, Vol. 28, No. 1, pp.5–24.
5. Anitua, E., Sánchez, M., Orive, G. and Andia, I. (2008) ‘Delivering growth factors for therapeutics’, Trends in Pharmacological Sciences, Vol. 29, No. 1, pp.37–41.
6. Astete, C. and Sabliov, C. (2006) ‘Synthesis and characterization of PLGA nanoparticles’, Journal of Biomaterials Science, Vol. 17, No. 3, pp.247–289.
7. Bala, I., Bhardwaj, V., Hariharan, S., Sitterberg, J., Bakowsky, U. and Ravi Kumar, M. (2005) ‘Design of biodegradable nanoparticles: a novel approach to encapsulating poorly soluble phytochemical ellagic acid’, Nanotechnology, Vol. 16, No. 12, pp.2819–2822.
8. Bawa, R. (2008) ‘Nanoparticle-based therapeutics in humans: a survey’, Nanotechnology Law and Business, Vol. 5, No. 2, pp.135–155.
9. Belbella, A., Vauthier, C., Fessi, H., Devissaguet, J.P. and Puisieux, F. (1996) ‘In vitro degradation of nanospheres from poly (D, L-lactides) of different molecular weights and polydispersities’, International Journal of Pharmaceutics, Vol. 129, Nos. 1–2, pp.95–102.
10. Bilensoy, M. and Hincal, A. (2006) ‘Sterile, injectable cyclodextrin nanoparticles; effects of gamma irradiation and autoclaving’, International Journal of Pharmaceutics, Vol. 311, Nos. 1–2, pp.203–208.
11. Cartiera, M.S., Johnson, M.K., Rajendran, V., Caplan, M.J. and Saltzman, M.W. (2009) ‘The uptake and intracellular fate of PLGA nanoparticles in epithelial cells’, Biomaterials, Vol. 30, No. 14, pp.2790–2798, (References and further reading may be available for this article. To view references and further reading you must purchase this article).
12. Cloninger, M. (2004) ‘Dendrimers and protein cages as nanoparticles in drug delivery’, Drug Discovery Today, Vol. 9, No. 3, pp.111–112.
13. Dai, J., Nagai, T., Wang, X., Zhang, T., Menga, M. and Zhang, Q. (2004) ‘PH-sensitive nanoparticles for improving the oral bioavailability of cyclosporine A’, International Journal of Pharmaceutics, Vol. 280, Nos. 1–2, pp.229–240.
14. Diwan, M., Elamanchili, P., Cao, M. and Samuel, J. (2004) ‘Dose sparing of CpG oligodeoxynucleotide vaccine adjuvants by nanoparticle delivery’, Current Drug Delivery, Vol. 1, No. 4, pp.405–412.
15. Eldridge, J., Gilley, R., Staas, J., Moldoveanu, Z., Meulbroak, J. and Tice, T.R. (1989) ‘Biodegradable microspheres: vaccine delivery system, for oral immunization’, Current Topics in Microbiology and Immunology, Vol. 146, pp.59–66.
16. Eldridge, J., Staas, J., Meulbroek, J., McGhee, J., Tice, T. and Gilley, R. (1991) ‘Biodegradable microspheres as a vaccine delivery system’, Molecular Immunology, Vol. 28, No. 3, pp.287–294.
17. Ermak, T., Dougherty, E., Bhagat, H., Kabok, Z. and Pappo, J. (1995) ‘Uptake and transport of copolymer biodegradable microspheres by rabbit Peyer’s patch M cells’, Journal of Cell and Tissue Research, Vol. 279, No. 2, pp.433–436.
18. Faraday, M. (1857) ‘Experimental relations of gold (and other metals) to light’, The Philosophical Transactions of the Royal Society, London, Vol. 147, pp.145–181.
19. Fast, J. and Mecozzi, S. (2009) ‘Nanoemulsions for intravenous drug delivery’, in Nanotechnology in Drug Delivery (ed.): Biotechnology: Pharmaceutical Aspects, Vol. 10, pp.461–489.
20. Feng, S., Mu, L., Win, K. and Huang, G. (2004) ‘Nanoparticles of biodegradable polymers for clinical administration of paclitaxel’, Current Medicinal Chemistry, Vol. 11, No. 4, pp.413–424.
21. Frutos, G and Villa, R.M. (2004) ‘Nonlinear mixed-effects model for the dissolution assays of drugs’, Journal of Control Release, Vol. 10, No. 94(2–3), pp.381–389.
22. Giannavola, C., Bucolo, C., Maltese, A., Paulino, D., Angela, V.M., Puglisi, G.V., Lee, L.V.H. and Fresta, M. (2003) ‘Influence of preparation condition on acyclovir loaded poly-D,L-lactide nanospheres and effect of PEG coating on ocular drug bioavailability’, Pharmaceutical Research, Vol. 20, No. 4, pp.584–590.
23. Grizzi, I., Garreau, H., Li, S. and Vert, M. (1995) ‘Hydrolytic degradation of devices based on poly(D,L-lactic acid) size-dependence’, Biomaterials, Vol. 16, No. 4, pp.305–311.
24. Guerra, G., Cerrai, P., Tricoli, M., Maltinti, S., Anguillesi, I. and Barbani, N. (1999) ‘Fibers by bioresorbable poly(ester-ether-ester)s as potential suture threads: a preliminary investigation’, Journal of Material Science: Materials in Medicine, Vol. 10, No. 10, pp.659–662.
25. Gupta, P.N., Khatri, K., Goyal, A.K., Mishra, N. and Vyas, S.P. (2007) ‘M-cell targeted biodegradable PLGA nanoparticles for oral immunization against hepatitis’, Journal of Drug Targeting, Vol. 15, No. 10, pp.701–713.
26. Han, S., Lee, J., Kim, D., Cho, S. and Yuk, S. (2005) ‘Hydrophilized poly(lactide-co-glycolide) nanoparticles with core/shell structure for protein delivery’, Science and Technology of Advanced Materials, Vol. 6, No. 5, pp.468–474.
27. Haque, M. and Saif, M. (2005) ‘Thermo-mechanical properties of nano-scale freestanding aluminum films’, Thin Solid Films, Vol. 484, Nos. 1–2, pp.364–368.
28. Hora, M.S., Rana, R.K., Nunberg, J.H., Tice, T.R., Gilley, R.M. and Hudson, M.E. (1990) ‘Controlled release of interleukin-2 from biodegradable microspheres’, Bio/Technology, Vol. 9, No. 8, pp.755–758.
29. Ichihara, T., Sakamoto, K., Mori, K. and Akagi, M. (1989) ‘Transcatheter arterial chemoembolization therapy for hepatocellular carcinomausing polylactic acid microspheres containing aclarubicin hydrochloride’, Cancer Research, Vol. 49, No. 15, pp.4357–4362.
30. Jain, R. (2000) ‘The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices’, Biomaterials, Vol. 21, No. 23, pp.2475–2490.
31. Jasmine, D., De, S., Zhou, W. and Labhasetwar, V. (2001) ‘Biodegradable nanospheres: therapeutic applications’, Biomedical Polymers and Polymer Therapeutics, pp.19–31, Springer, US.
32. Jung, T., Kamm, W., Breitenbach, A., Kaiserling, E., Xiao, J. and Kissel, T. (2000) ‘Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake?’, European Journal of Pharmaceutics and Biopharmaceutics, Vol. 50, No. 1, pp.147–160.
33. Kanchan, V. and Panda, A. (2007) ‘Interactions of antigen-loaded polylactide particles with macrophages and their correlation with the immune response’, Biomaterials, Vol. 28, No. 35, pp.5344–5357.
34. Kim, B., Kim, C. and Lee, K. (2008) ‘The intracellular uptake ability of chitosan-coated poly(D,L-lactideco-glycolide) nanoparticles’, Archives of Pharmacal Research, Vol. 31, No. 8, pp.1050–1054.
35. Kim, H., Chung, C., Kim, Y. and Rhee, Y. (2005a) ‘Preparation and hydrolytic degradation of semi-interpenetrating networks of poly(3-hydroxyundecenoate) and poly(lactide-co-glycolide)’, International Journal of Biological Macromolecules, Vol. 37, No. 5, pp.221–226.
36. Kim, S.H., Ji, H.J., Ki, W.C., Tae, G.A. (2005b) ‘Target-specific cellular uptake of PLGA nanoparticles coated with poly(L-lysine)-poly(ethylene glycol)-folate conjugate’, Langmuir, Vol. 21, No. 19, pp.8852–8857.
37. Langer, R. (1990) ‘New methods of drug delivery’, Science, Vol. 249, No. 4976, pp.1527–1533.
38. Lewis, D.H. (1990) ‘Controlled release of bioactive agents from lactide/glycolide polymers’, in Chasin, M. and Langer, R. (Ed.): Biodegradable Polymers as Drug Delivery Systems, pp.1–41, Dekker, New York.
39. Liu, X., Heng, W., Paul, A., Li, Q. and Chan, L. (2006) ‘Novel polymeric microspheres containing norcantharidin for chemoembolization’, Journal of Controlled Release, Vol. 116, No. 1, pp.35–41.
40. Mohanraj, V.J. and Chen, Y. (2006) ‘Nanoparticles – a review’, Tropical Journal of Pharmaceutical Research, Vol. 5, No. 1, pp.561–573.
41. Mukherjee, B., Patra, B., Layek, B. and Mukherjee, A. (2007) ‘Sustained release of acyclovir from nano-liposomes and nano-niosomes:an in vitro study’, International Journal of Nanomedicine, Vol. 2, No. 2, pp.213–225.
42. Mukherjee, B., Santra, K., Pattnaik, G. and Ghosh, S. (2008) ‘Preparation, characterization and in-vitro evaluation of sustained release protein-loaded nanoparticles based on biodegradable polymers’, International Journal of Nanomedicine, Vol. 3, No. 4, pp.487–496.
43. Nair, L. and Laurencin, C. (2007) ‘Biodegradable polymers as biomaterials’, Progress in Polymer Science, Vol. 32, Nos. 8–9, pp.762–798.
44. Panyam, J. and Labhasetwar, V. (2003) ‘Biodegradable nanoparticles for drug and gene delivery to cells and tissue’, Advanced Drug Delivery Reviews, Vol. 55, No. 3, pp.329–347.
45. Peppas, L. (1995) ‘Recent advances on the use of biodegradable microparticles and nanoparticles in controlled drug delivery’, International Journal of Pharmaceutics, Vol. 116, No. 1, pp.1–9.
46. Pillai, O. and Panchagnula, R. (2001) ‘Polymers in drug delivery’, Current Opinion in Chemical Biology, Vol. 5, No. 4, pp.447–451.
47. Pillai, R., Somayaji, S., Rabinovich, M., Hudson, M. and Gonsalves, K. (2008) ‘Nafcillin-loaded PLGA nanoparticles for treatment of osteomyelitis’, Biomedical Materials, Vol. 3, No. 3, pp.1–7.
48. Pitukmanorom, P., Yong, T. and Ying, J. (2008) ‘Tunable release of proteins with polymer-inorganic nanocomposite microspheres’, Advanced Materials, Vol. 20, No. 18, pp.3504–3509.
49. Rogers, W.J., Meyer, C.H. and Krame, C.M. (2006) ‘Technology insight: in vivo cell tracking by use of MRI’, Nature Clinical Practice Cardiovascular Medicine, Vol. 3, No. 10, pp.554–562.
50. Roskos, K. and Maskiewicz, R. (2002) ‘Degradable controlled release systems useful for protein delivery’, Pharmaceutical Biotechnology, Vol. 10, Protein Delivery: Physical Systems, pp.45–92, Springer.
51. Sanders, L., McRae, G., Vitale, K. and Kell, B. (1985) ‘Controlled delivery of an LHRH analogue from biodegradable injectable microspheres’, Journal of Controlled Release, Vol. 2, pp.187–195.
52. Sehra, S. and Dhake, A. (2005) ‘Formulation and evaluation of sustained release microspheres of poly-lactide-co-glycolide containing tamoxifen citrate’, Journal of Microencapsulation, Vol. 22, No. 5, pp.521–528.
53. Shen, F., Li, M., Win, Y. and Guofeng, H. (2004) ‘Nanoparticles of biodegradable polymers for clinical administration of paclitaxel’, Current Medicinal Chemistry, Vol. 11, No. 4, pp.413–424.
54. Singh, M., Singh, A. and Talwar, G. (1991) ‘Controlled delivery of diphtheria toxoid using biodegradable poly(DL-lactide) microcapsules’, Pharmaceutical Research, Vol. 8, No. 7, pp.958–961.
55. Smola, M., Vandamme, T. and Sokolowski, A. (2008) ‘Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases’, International Journal of Nanomedicine, Vol. 3, No. 1, pp.1–19.
56. Song, C., Labhasetwar, V., Murphy, H., Qu, X., Humphrey, W.R., Shebuski, R.J. and Levya, R.J. (1997) ‘Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery’, Journal of Controlled Release, Vol. 43, Nos. 2–3, pp.197–212.
57. Song, C., Labhasetwar, V., Xiumin, C., Underwood, T. and Levy, R. (1998) ‘Arterial uptake of biodegradable nanoparticles for intravascular local drug delivery: results with an acute dog model’, Journal of Controlled Release, Vol. 54, No. 2, pp.201–211.
58. Sung, J.C., Pulliam, B.L. and Edwards, D.A. (2007) ‘Nanoparticles for drug delivery to the lungs’, TRENDS I Biotechnology, Vol. 25, No. 12, pp.563–569.
59. Takenaga, M., Yamaguchi, Y., Kitagawa, A., Ogawa, Y., Mizushima, Y. and Igarashi, R. (2002) ‘A novel sustained-release formulation of insulin with dramatic reduction in initial rapid release’, Journal of Controlled Release, Vol. 79, Nos. 1–3, pp.81–91.
60. Tse, M.T., Blatchford, C. and Alpar, O.H. (2004) ‘Evaluation of different buffers on plasmid DNA encapsulation into PLGA microparticles’, Vaccine, Vol. 22, No. 19, pp.2406–2412.
61. Ubrich, N., Bouillot, P., Pellerin, C., Hoffman, M. and Maincen, P. (2004) ‘Preparation and characterization of propranolol hydrochloride nanoparticles: a comparative study’, Journal of Controlled Release, Vol. 97, No. 2, pp.291–300.
62. Vicari, L., Musumeci, T., Giannone, I., Adamo, L., Conticello, C., Maria, R.D., Pignatello, R., Puglisi, G. and Gulisano, M. (2008) ‘Paclitaxel loading in PLGA nanospheres affected the in vitro drug cell accumulation and antiproliferative activity’, BMC Cancer, Vol. 8, No. 212.
63. Wada, R., Hyon, S-H., Ikada, Y., Nakao, Y., Yoshikawa, H. and Muranishi, S. (1988) ‘Lactic acid oligomer microspheres containing an anticancer agent for selective lymphatic delivery: I. in vitro studies’, Journal of Bioactive and Compatible Polymers, Vol. 3, No. 2, pp.126–136.
64. Wang, H., Li, Y., Zuo, Y., Li, J., Ma, S. and Cheng, L. (2007) ‘Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering’, Biomaterials, Vol. 28, No. 22, pp.3338–3348.
65. Win, K.Y. and Feng, S.S. (2005) ‘Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs’, Biomaterials, Vol. 26, No. 15, pp.2713–2722.
66. Xu, J., Wang, Y., Li, Y., Yang, X., Zhang, P., Hou, H., Shi, Y. and Song, C. (2007) ‘Inhibitory efficacy of intravitreal dexamethasone acetate-loaded PLGA nanoparticles on choroidal neovascularization in a laser-induced rat model’, Journal of Ocular Pharmacology and Therapeutics, Vol. 23, No. 6, pp.527–540.
67. Yamamoto, H., Kuno, Y., Sugimoto, S., Takeuchi, H. and Kawashima, Y. (2005) ‘Surface-modified PLGA nanospheres with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions’, Journal of Control Release, Vol. 102, No. 2, pp.373–381.
68. Yin, J., Noda, Y. and Yotsuyanagi, T. (2006) ‘Properties of poly(lactic-co-glycolic acid) nanospheres containing protease inhibitors: camostat mesilate and nafamostat mesilate’, International Journal of Pharmaceutics, Vol. 314, No. 1, pp.46–55.
69. Zou, W., Liu, C., Chen, Z. and Zhang, N. (2009) ‘Pharmaceutical nanotechnology studies on bioadhesive PLGA nanoparticles: a promising gene delivery system for efficient gene therapy to lung cancer’, International Journal of Pharmaceutics, Vol. 370, Nos. 1–2, pp.187–195.